| Transcription factor Tcf21 modulates urinary bladder size and differentiation. | Transcription factor Tcf21 modulates urinary bladder size and differentiation.
Mann EA, Mogle MS, Park JS, Reddy P. | 02/21/2024 |
| Single cell G-protein coupled receptor profiling of activated kidney fibroblasts expressing transcription factor 21. | Single cell G-protein coupled receptor profiling of activated kidney fibroblasts expressing transcription factor 21.
Kaur H, Yerra VG, Batchu SN, Tran DT, Kabir MDG, Liu Y, Advani SL, Sedrak P, Geldenhuys L, Tennankore KK, Poyah P, Siddiqi FS, Advani A. | 11/1/2023 |
| Transcription factor 21 accelerates vascular calcification in mice by activating the IL-6/STAT3 signaling pathway and the interplay between VSMCs and ECs. | Transcription factor 21 accelerates vascular calcification in mice by activating the IL-6/STAT3 signaling pathway and the interplay between VSMCs and ECs.
Zhao XK, Zhu MM, Wang SN, Zhang TT, Wei XN, Wang CY, Zheng J, Zhu WY, Jiang MX, Xu SW, Yang XX, Duan YJ, Zhang BC, Han JH, Miao QR, Hu H, Chen YL., | 09/12/2023 |
| Tcf21 marks visceral adipose mesenchymal progenitors and functions as a rate-limiting factor during visceral adipose tissue development. | Tcf21 marks visceral adipose mesenchymal progenitors and functions as a rate-limiting factor during visceral adipose tissue development.
Liu Q, Li C, Deng B, Gao P, Wang L, Li Y, Shiri M, Alkaifi F, Zhao J, Stephens JM, Simintiras CA, Francis J, Sun J, Fu X., Free PMC Article | 04/4/2023 |
| Novel TCF21[high] pericyte subpopulation promotes colorectal cancer metastasis by remodelling perivascular matrix. | Novel TCF21(high) pericyte subpopulation promotes colorectal cancer metastasis by remodelling perivascular matrix.
Li X, Pan J, Liu T, Yin W, Miao Q, Zhao Z, Gao Y, Zheng W, Li H, Deng R, Huang D, Qiu S, Zhang Y, Qi Q, Deng L, Huang M, Tang PM, Cao Y, Chen M, Ye W, Zhang D., Free PMC Article | 03/15/2023 |
| Stromal Transcription Factor 21 Regulates Development of the Renal Stroma via Interaction with Wnt/beta-Catenin Signaling. | Stromal Transcription Factor 21 Regulates Development of the Renal Stroma via Interaction with Wnt/β-Catenin Signaling.
Finer G, Maezawa Y, Ide S, Onay T, Souma T, Scott R, Liang X, Zhao X, Gadhvi G, Winter DR, Quaggin SE, Hayashida T., Free PMC Article | 08/20/2022 |
| Studies on the Role of the Transcription Factor Tcf21 in the Transdifferentiation of Parietal Epithelial Cells into Podocyte-Like Cells. | Studies on the Role of the Transcription Factor Tcf21 in the Transdifferentiation of Parietal Epithelial Cells into Podocyte-Like Cells.
Kliewe F, Kuss AW, Siegerist F, Schröder S, Schordan S, Artelt N, Kindt F, Amann K, Lindenmeyer MT, Endlich K, Endlich N. | 08/28/2021 |
| TCF21(+) mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice. | TCF21(+) mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice.
Shen YC, Shami AN, Moritz L, Larose H, Manske GL, Ma Q, Zheng X, Sukhwani M, Czerwinski M, Sultan C, Chen H, Gurczynski SJ, Spence JR, Orwig KE, Tallquist M, Li JZ, Hammoud SS., Free PMC Article | 07/24/2021 |
| A Deactivation Factor of Fibrogenic Hepatic Stellate Cells Induces Regression of Liver Fibrosis in Mice. | A Deactivation Factor of Fibrogenic Hepatic Stellate Cells Induces Regression of Liver Fibrosis in Mice.
Nakano Y, Kamiya A, Sumiyoshi H, Tsuruya K, Kagawa T, Inagaki Y. | 04/17/2021 |
| After E15.5, Tcf21 progenitor cells exclusively become lipofibroblasts and interstitial fibroblasts. Lipid metabolism genes were highly expressed in perinatal and adult Tcf21 lineage cells. Overexpression of Tcf21 in primary neonatal lung fibroblasts led to increases in intracellular neutral lipids, suggesting a regulatory role for Tcf21 in lipofibroblast function. | The Tcf21 lineage constitutes the lung lipofibroblast population.
Park J, Ivey MJ, Deana Y, Riggsbee KL, Sörensen E, Schwabl V, Sjöberg C, Hjertberg T, Park GY, Swonger JM, Rosengreen T, Morty RE, Ahlbrecht K, Tallquist MD., Free PMC Article | 02/22/2020 |
| findings indicate that Tcf21 has distinct roles in the cap mesenchyme and stromal mesenchyme compartments during kidney development and suggest that Tcf21 regulates key molecular pathways required for branching morphogenesis | Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development.
Ide S, Finer G, Maezawa Y, Onay T, Souma T, Scott R, Ide K, Akimoto Y, Li C, Ye M, Zhao X, Baba Y, Minamizuka T, Jin J, Takemoto M, Yokote K, Quaggin SE., Free PMC Article | 09/7/2019 |
| Upon high fat diet exposure, PKR1 (tcf-/-) mice displayed excessive fat deposition in the atrioventricular groove, perivascular area, and pericardium, which was accompanied by an impaired vascular network and cardiac dysfunction. | Prokineticin receptor-1-dependent paracrine and autocrine pathways control cardiac tcf21(+) fibroblast progenitor cell transformation into adipocytes and vascular cells.
Qureshi R, Kindo M, Arora H, Boulberdaa M, Steenman M, Nebigil CG., Free PMC Article | 07/6/2019 |
| These results suggest that TCF21 contributes to the proinflammatory environment in VIS fat depots and to active ECM remodeling of these depots by regulating IL6 expression and MMP-dependent ECM remodeling in a spatiotemporally coordinated manner. | Transcription factor 21 (TCF21) promotes proinflammatory interleukin 6 expression and extracellular matrix remodeling in visceral adipose stem cells.
Akama T, Chun TH., Free PMC Article | 12/29/2018 |
| Periostin-expressing myofibroblasts in the heart derive from tissue-resident fibroblasts of the Tcf21 lineage and are necessary for adaptive healing and fibrosis. | Genetic lineage tracing defines myofibroblast origin and function in the injured heart.
Kanisicak O, Khalil H, Ivey MJ, Karch J, Maliken BD, Correll RN, Brody MJ, J Lin SC, Aronow BJ, Tallquist MD, Molkentin JD., Free PMC Article | 09/1/2018 |
| During normal heart development, spatio-temporal differences in contribution of WT-1 and Tcf21-LacZ + cells to right versus left ventricular myocardium occur parallel to myocardial thickening. | Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction.
Vicente-Steijn R, Scherptong RW, Kruithof BP, Duim SN, Goumans MJ, Wisse LJ, Zhou B, Pu WT, Poelmann RE, Schalij MJ, Tallquist MD, Gittenberger-de Groot AC, Jongbloed MR., Free PMC Article | 05/28/2016 |
| TCF21 may have a role regulating the differentiation state of SMC precursor cells that migrate into vascular lesions and contribute to the fibrous cap and more broadly, in view of the association of this gene with human Coronary Artery Disease | Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap.
Nurnberg ST, Cheng K, Raiesdana A, Kundu R, Miller CL, Kim JB, Arora K, Carcamo-Oribe I, Xiong Y, Tellakula N, Nanda V, Murthy N, Boisvert WA, Hedin U, Perisic L, Aldi S, Maegdefessel L, Pjanic M, Owens GK, Tallquist MD, Quertermous T., Free PMC Article | 04/9/2016 |
| Our results demonstrate a critical role for Tcf21 in the differentiation and maintenance of podocytes. | Loss of the podocyte-expressed transcription factor Tcf21/Pod1 results in podocyte differentiation defects and FSGS.
Maezawa Y, Onay T, Scott RP, Keir LS, Dimke H, Li C, Eremina V, Maezawa Y, Jeansson M, Shan J, Binnie M, Lewin M, Ghosh A, Miner JH, Vainio SJ, Quaggin SE., Free PMC Article | 01/10/2015 |
| Data indicate that loss of Pod1/Tcf21 leads to epicardial blistering, increased smooth muscle cell differentiation on the surface of the heart, and a paucity of interstitial fibroblasts, with neonatal lethality. | Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart.
Braitsch CM, Combs MD, Quaggin SE, Yutzey KE., Free PMC Article | 11/3/2012 |
| The majority of Tcf21-expressing epicardial cells are committed to the cardiac fibroblast lineage prior to initiation of epicardial epithelial-to-mesenchymal transition. | The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors.
Acharya A, Baek ST, Huang G, Eskiocak B, Goetsch S, Sung CY, Banfi S, Sauer MF, Olsen GS, Duffield JS, Olson EN, Tallquist MD., Free PMC Article | 08/11/2012 |
| Data show that correct levels of expression of Myf5 and MyoD during mouse craniofacial development result from activation by musculin and TCF21 through direct binding to specific enhancers. | Musculin and TCF21 coordinate the maintenance of myogenic regulatory factor expression levels during mouse craniofacial development.
Moncaut N, Cross JW, Siligan C, Keith A, Taylor K, Rigby PW, Carvajal JJ., Free PMC Article | 05/12/2012 |
| The data suggest that Pod1 may negatively regulate Rxfp2 expression in the developing glomerulus to promote cell proliferation. | Regulation of Rxfp2 (Lgr8) expression in the mouse fetal kidney by the transcription factor Pod1 (Tcf 21).
Familari M, Vu D, Parry LJ. | 01/21/2010 |
| Pod1 increased E2A binding to a calponin promoter E-box sequence. Overexpression of Pod1 & E2A resulted in increased smooth muscle and myofibroblast gene expression including calponin, SM22alpha, alphaSMA, fibronectin, & connective tissue growth factor. | Pod1 induces myofibroblast differentiation in mesenchymal progenitor cells from mouse kidney.
Plotkin M, Mudunuri V. | 01/21/2010 |
| Identificaation of differentially expressed genes in glomeruli from Pod1 knockout (KO) mice that die in the perinatal period with multiple renal defects | Rapid isolation of glomeruli coupled with gene expression profiling identifies downstream targets in Pod1 knockout mice.
Cui S, Li C, Ema M, Weinstein J, Quaggin SE. | 01/21/2010 |
| Pod-1, which controls androgen receptor transcription and function, may play an important role in the development and function of the testis. | Modulation of the expression and transactivation of androgen receptor by the basic helix-loop-helix transcription factor Pod-1 through recruitment of histone deacetylase 1.
Hong CY, Gong EY, Kim K, Suh JH, Ko HM, Lee HJ, Choi HS, Lee K. | 01/21/2010 |
| Essential for gonadal development, part of a transcriptional network that orchestrates cell fate decisions in gonadal progenitors. | Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice.
Cui S, Ross A, Stallings N, Parker KL, Capel B, Quaggin SE. | 01/21/2010 |