| The embryonic patterning gene Dbx1 governs the survival of the auditory midbrain via Tcf7l2-Ap2delta transcriptional cascade. | The embryonic patterning gene Dbx1 governs the survival of the auditory midbrain via Tcf7l2-Ap2δ transcriptional cascade.
Tran HN, Nguyen QH, Jeong JE, Loi DL, Nam YH, Kang TH, Yoon J, Baek K, Jeong Y., | 06/13/2023 |
| TCF7L2 acts as a molecular switch in midbrain to control mammal vocalization through its DNA binding domain but not transcription activation domain. | TCF7L2 acts as a molecular switch in midbrain to control mammal vocalization through its DNA binding domain but not transcription activation domain.
Qi H, Luo L, Lu C, Chen R, Zhou X, Zhang X, Jia Y., Free PMC Article | 05/28/2023 |
| Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice. | Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice.
Lee DS, An TH, Kim H, Jung E, Kim G, Oh SY, Kim JS, Chun HJ, Jung J, Lee EW, Han BS, Han DH, Lee YH, Han TS, Hur K, Lee CH, Kim DS, Kim WK, Park JW, Koo SH, Seong JK, Lee SC, Kim H, Bae KH, Oh KJ., Free PMC Article | 03/28/2023 |
| TCF7l2, a nuclear marker that labels premyelinating oligodendrocytes and promotes oligodendroglial lineage progression. | TCF7l2, a nuclear marker that labels premyelinating oligodendrocytes and promotes oligodendroglial lineage progression.
Guo F, Wang Y., Free PMC Article | 12/24/2022 |
| TCF7L2 promotes ER stress signaling in diabetic retinopathy. | TCF7L2 promotes ER stress signaling in diabetic retinopathy.
Wu K, Zhou K, Zhao M, Xiang L, Mei T, Xu W, Shang B, Liu X, Lai Y, Lin M, Luo J, Zhao L. | 07/16/2022 |
| T-cell factor 7L2 is a novel regulator of osteoblast functions that acts in part by modulation of hypoxia signaling. | T-cell factor 7L2 is a novel regulator of osteoblast functions that acts in part by modulation of hypoxia signaling.
Mohan S, Kesavan C., Free PMC Article | 06/18/2022 |
| TCF7L2 transcriptionally regulates Fgf15 to maintain bile acid and lipid homeostasis through gut-liver crosstalk. | TCF7L2 transcriptionally regulates Fgf15 to maintain bile acid and lipid homeostasis through gut-liver crosstalk.
Bhat N, Esteghamat F, Chaube BK, Gunawardhana K, Mani M, Thames C, Jain D, Ginsberg HN, Fernandes-Hernando C, Mani A., Free PMC Article | 03/5/2022 |
| TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state. | TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state.
Doumpas N, Söderholm S, Narula S, Moreira S, Doble BW, Cantù C, Basler K. | 02/19/2022 |
| A beta-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells. | A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells.
Guo Q, Kim A, Li B, Ransick A, Bugacov H, Chen X, Lindström N, Brown A, Oxburgh L, Ren B, McMahon AP., Free PMC Article | 02/5/2022 |
| Adipocyte-specific deletion of Tcf7l2 induces dysregulated lipid metabolism and impairs glucose tolerance in mice. | Adipocyte-specific deletion of Tcf7l2 induces dysregulated lipid metabolism and impairs glucose tolerance in mice.
Nguyen-Tu MS, Martinez-Sanchez A, Leclerc I, Rutter GA, da Silva Xavier G., Free PMC Article | 01/8/2022 |
| MiR-205 is up-regulated in islets of diabetes-susceptible mice and targets the diabetes gene Tcf7l2. | MiR-205 is up-regulated in islets of diabetes-susceptible mice and targets the diabetes gene Tcf7l2.
Ouni M, Gottmann P, Westholm E, Schwerbel K, Jähnert M, Stadion M, Rittig K, Vogel H, Schürmann A. | 08/28/2021 |
| The Wnt Effector TCF7l2 Promotes Oligodendroglial Differentiation by Repressing Autocrine BMP4-Mediated Signaling. | The Wnt Effector TCF7l2 Promotes Oligodendroglial Differentiation by Repressing Autocrine BMP4-Mediated Signaling.
Zhang S, Wang Y, Zhu X, Song L, Zhan X, Ma E, McDonough J, Fu H, Cambi F, Grinspan J, Guo F., Free PMC Article | 06/19/2021 |
| beta-Catenin-TCF/LEF signaling promotes steady-state and emergency granulopoiesis via G-CSF receptor upregulation. | β-Catenin-TCF/LEF signaling promotes steady-state and emergency granulopoiesis via G-CSF receptor upregulation.
Danek P, Kardosova M, Janeckova L, Karkoulia E, Vanickova K, Fabisik M, Lozano-Asencio C, Benoukraf T, Tirado-Magallanes R, Zhou Q, Burocziova M, Rahmatova S, Pytlik R, Brdicka T, Tenen DG, Korinek V, Alberich-Jorda M., Free PMC Article | 04/17/2021 |
| TCF7L2 regulates postmitotic differentiation programmes and excitability patterns in the thalamus. | TCF7L2 regulates postmitotic differentiation programmes and excitability patterns in the thalamus.
Lipiec MA, Bem J, Koziński K, Chakraborty C, Urban-Ciećko J, Zajkowski T, Dąbrowski M, Szewczyk ŁM, Toval A, Ferran JL, Nagalski A, Wiśniewska MB., Free PMC Article | 03/27/2021 |
| Transcription factor 7-like 2 promotes osteogenic differentiation and boron-induced bone repair via lipocalin 2. | Transcription factor 7-like 2 promotes osteogenic differentiation and boron-induced bone repair via lipocalin 2.
Yin C, Jia X, Zhao Q, Zhao Z, Wang J, Zhang Y, Li Z, Sun H, Li Z. | 01/9/2021 |
| Enhancement of beta-catenin/T-cell factor 4 signaling causes susceptibility to cardiac arrhythmia by suppressing NaV1.5 expression in mice. | Enhancement of β-catenin/T-cell factor 4 signaling causes susceptibility to cardiac arrhythmia by suppressing Na(V)1.5 expression in mice.
Huo R, Hu C, Zhao L, Sun L, Wang N, Lu Y, Ye B, Deb A, Li F, Xu H., Free PMC Article | 12/19/2020 |
| Loss-of-function studies revealed that Tcf7l2 was the key transcription factor that Wnt operate through during retinoic acid-induced embryonic stem cells differentiation. | Wnt Signaling Modulates Routes of Retinoic Acid-Induced Differentiation of Embryonic Stem Cells.
Wang S, Huang H, Xiang H, Gu B, Li W, Chen L, Zhang M. | 07/25/2020 |
| we conclude that LF3, an inhibitor of b-catenin/TCF4 interaction, elevates NaV1.5 expression, leading to increase Na(+) channel activity in HL-1 cardiomyocytes. | A small-molecule LF3 abrogates β-catenin/TCF4-mediated suppression of Na(V)1.5 expression in HL-1 cardiomyocytes.
Zhao L, Sun L, Lu Y, Li F, Xu H., Free PMC Article | 07/18/2020 |
| Tcf7l2 promotes cementum formation through the NF-kappaB pathway. | Transcription factor 7-like 2-associated signaling mechanism in regulating cementum generation by the NF-κB pathway.
Zhao Z, Dai J, Yin C, Wang X, Wang J, Jia X, Zhao Q, Fu H, Zhang Y, Xia H. | 06/6/2020 |
| Conditional deletion of TCF7L2 in adipocytes led to impaired glucose tolerance, impaired insulin sensitivity, promoted weight gain, and increased adipose tissue mass. | Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism.
Geoghegan G, Simcox J, Seldin MM, Parnell TJ, Stubben C, Just S, Begaye L, Lusis AJ, Villanueva CJ., Free PMC Article | 04/18/2020 |
| Findings reveal a crucial role for the diabetes-associated transcription factor TCF7L2 in regulating the function of nicotinic acetylcholine receptors in the habenula and in controlling nicotine intake. | Habenular TCF7L2 links nicotine addiction to diabetes.
Duncan A, Heyer MP, Ishikawa M, Caligiuri SPB, Liu XA, Chen Z, Micioni Di Bonaventura MV, Elayouby KS, Ables JL, Howe WM, Bali P, Fillinger C, Williams M, O'Connor RM, Wang Z, Lu Q, Kamenecka TM, Ma'ayan A, O'Neill HC, Ibanez-Tallon I, Geurts AM, Kenny PJ., Free PMC Article | 03/28/2020 |
| The developmental Wnt signaling pathway effector beta-catenin/ TCF7L2 mediates hepatic functions of the sex hormone estradiol in regulating lipid metabolism. | The developmental Wnt signaling pathway effector β-catenin/TCF mediates hepatic functions of the sex hormone estradiol in regulating lipid metabolism.
Tian L, Shao W, Ip W, Song Z, Badakhshi Y, Jin T., Free PMC Article | 02/29/2020 |
| role of TCF7L2 in regulation of vascular smooth muscle cell plasticity and protection against arterial disease. | TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal Hyperplasia.
Srivastava R, Rolyan H, Xie Y, Li N, Bhat N, Hong L, Esteghamat F, Adeniran A, Geirsson A, Zhang J, Ge G, Nobrega M, Martin KA, Mani A., Free PMC Article | 12/7/2019 |
| The Tcf7l2 may be involved in neurological defects associated with alcohol exposure via dysregulation of many genes through Wnt signaling. | Coordinated Tcf7l2 regulation in a mouse model implicates Wnt signaling in fetal alcohol spectrum disorders.
Chater-Diehl E, Sokolowski D, Alberry B, Singh SM. | 11/23/2019 |
| Data indicate a function of GATA binding protein 4 (GATA4) as a cardiac repressor of the transcription factor 7-like 2 protein (TCF7L2)/beta-catenin complex. | A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
Iyer LM, Nagarajan S, Woelfer M, Schoger E, Khadjeh S, Zafiriou MP, Kari V, Herting J, Pang ST, Weber T, Rathjens FS, Fischer TH, Toischer K, Hasenfuss G, Noack C, Johnsen SA, Zelarayán LC., Free PMC Article | 08/3/2019 |