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    Zeb1 zinc finger E-box binding homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 21417, updated on 21-Oct-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Human trophoblast-derived exosomes attenuate doxorubicin-induced cardiac injury by regulating miR-200b and downstream Zeb1.

    Human trophoblast-derived exosomes attenuate doxorubicin-induced cardiac injury by regulating miR-200b and downstream Zeb1.
    Ni J, Liu Y, Kang L, Wang L, Han Z, Wang K, Xu B, Gu R., Free PMC Article

    10/2/2021
    Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia.

    Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia.
    Almotiri A, Alzahrani H, Menendez-Gonzalez JB, Abdelfattah A, Alotaibi B, Saleh L, Greene A, Georgiou M, Gibbs A, Alsayari A, Taha S, Thomas LA, Shah D, Edkins S, Giles P, Stemmler MP, Brabletz S, Brabletz T, Boyd AS, Siebzehnrubl FA, Rodrigues NP., Free PMC Article

    09/11/2021
    Zinc-Dependent Regulation of ZEB1 and YAP1 Coactivation Promotes Epithelial-Mesenchymal Transition Plasticity and Metastasis in Pancreatic Cancer.

    Zinc-Dependent Regulation of ZEB1 and YAP1 Coactivation Promotes Epithelial-Mesenchymal Transition Plasticity and Metastasis in Pancreatic Cancer.
    Liu M, Zhang Y, Yang J, Zhan H, Zhou Z, Jiang Y, Shi X, Fan X, Zhang J, Luo W, Fung KA, Xu C, Bronze MS, Houchen CW, Li M.,

    09/4/2021
    Nr4a1 promotes cell adhesion and fusion by regulating Zeb1 transcript levels in myoblasts.

    Nr4a1 promotes cell adhesion and fusion by regulating Zeb1 transcript levels in myoblasts.
    Liu Y, Liu N, Yu Y, Wang D.

    07/24/2021
    Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure.

    Inactivation of <i>Zeb1</i> in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure.
    Carpinelli MR, de Vries ME, Auden A, Butt T, Deng Z, Partridge DD, Miles LB, Georgy SR, Haigh JJ, Darido C, Brabletz S, Brabletz T, Stemmler MP, Dworkin S, Jane SM., Free PMC Article

    02/2/2021
    MicroRNA-708 represses hepatic stellate cells activation and proliferation by targeting ZEB1 through Wnt/beta-catenin pathway.

    MicroRNA-708 represses hepatic stellate cells activation and proliferation by targeting ZEB1 through Wnt/β-catenin pathway.
    Yang J, Tao Q, Zhou Y, Chen Q, Li L, Hu S, Liu Y, Zhang Y, Shu J, Zhang X, Zhang L, Zhang L.

    11/28/2020
    Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1.

    Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1.
    Jiang H, Zhou C, Zhang Z, Wang Q, Wei H, Shi W, Li J, Wang Z, Ou Y, Wang W, Wang H, Zhang Q, Sun W, Sun P, Yang S., Free PMC Article

    11/21/2020
    Inactivation of endothelial ZEB1 impedes tumor progression and sensitizes tumors to conventional therapies.

    Inactivation of endothelial ZEB1 impedes tumor progression and sensitizes tumors to conventional therapies.
    Fu R, Li Y, Jiang N, Ren BX, Zang CZ, Liu LJ, Lv WC, Li HM, Weiss S, Li ZY, Lu T, Wu ZQ., Free PMC Article

    11/21/2020
    Zeb1 is important for proper cleavage plane orientation of dividing progenitors and neuronal migration in the mouse neocortex.

    Zeb1 is important for proper cleavage plane orientation of dividing progenitors and neuronal migration in the mouse neocortex.
    Liu J, Liu Y, Shao J, Li Y, Qin L, Shen H, Xie Y, Xia W, Gao WQ., Free PMC Article

    09/12/2020
    Zeb1 is expressed in a prostate basal cell subpopulation.

    Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate.
    Wang X, Xu H, Cheng C, Ji Z, Zhao H, Sheng Y, Li X, Wang J, Shu Y, He Y, Fan L, Dong B, Xue W, Wai Chua C, Wu D, Gao WQ, He Zhu H., Free PMC Article

    05/16/2020
    ZEB1 is predominantly expressed in CD31 endothelium in the bone.Zeb1 role in the bone angiogenesis and bone formation.

    Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis.
    Fu R, Lv WC, Xu Y, Gong MY, Chen XJ, Jiang N, Xu Y, Yao QQ, Di L, Lu T, Wang LM, Mo R, Wu ZQ., Free PMC Article

    04/25/2020
    Under hyperglycemic conditions, ZEB1 lost its ability to bind E-cadherin promoter. Keratinocyte E-cadherin, thus upregulated, resisted EMT required for wound healing. Diabetic wound healing was improved in ZEB(+/-) as well as in db/db mice subjected to ZEB1 knockdown.

    Cutaneous Epithelial to Mesenchymal Transition Activator ZEB1 Regulates Wound Angiogenesis and Closure in a Glycemic Status-Dependent Manner.
    Singh K, Sinha M, Pal D, Tabasum S, Gnyawali SC, Khona D, Sarkar S, Mohanty SK, Soto-Gonzalez F, Khanna S, Roy S, Sen CK., Free PMC Article

    03/21/2020
    TRPV1 is a potential therapeutic target in hepatocellular carcinoma and exerts effects on cellular plasticity with modulation of Ovol2, Zeb1 and Sox10.

    Targeting TRPV1 on cellular plasticity regulated by Ovol 2 and Zeb 1 in hepatocellular carcinoma.
    Xie C, Liu G, Li M, Fang Y, Qian K, Tang Y, Wu X, Lei X, Li X, Liu Q, Liu G, Liu J, Zhang Y, Huang Z, Hu Z, Cao Z, Hu J, Huang S, Zhong D, Huang J, Wu F, Wang J, Mori M, Yamamoto H, Wang J, Xu X.

    02/8/2020
    Results demonstrate the importance of ZEB1 in microglia-orchestrated neuroinflammation and suggest a potential means for reducing stroke-induced neurological injury.

    Upregulation of Microglial ZEB1 Ameliorates Brain Damage after Acute Ischemic Stroke.
    Li D, Lang W, Zhou C, Wu C, Zhang F, Liu Q, Yang S, Hao J.

    11/9/2019
    Zeb1 could be targeted in DCs to modulate T-cell mediated adaptive immune responses.

    Importance of EMT Factor ZEB1 in cDC1 "MutuDC Line" Mediated Induction of Th1 Immune Response.
    Smita S, Ahad A, Ghosh A, Biswas VK, Koga MM, Gupta B, Acha-Orbea H, Raghav SK., Free PMC Article

    10/5/2019
    Data show the expression of Zeb1 and Numb were both significantly higher in LLC-symmetric cell division than LLC-asymmetric cell division cells.

    Zeb1 Regulates the Symmetric Division of Mouse Lewis Lung Carcinoma Stem Cells through Numb mediated by miR-31.
    Wang J, Zhou T, Sun Z, Ye T, Zhou S, Li J, Liu Y, Kong L, Tang J, Liu D, Xing HR., Free PMC Article

    09/14/2019
    ZEB1 initiates a miR-181b-regulated ceRNA network to drive metastasis.

    The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network.
    Tan X, Banerjee P, Liu X, Yu J, Gibbons DL, Wu P, Scott KL, Diao L, Zheng X, Wang J, Jalali A, Suraokar M, Fujimoto J, Behrens C, Liu X, Liu CG, Creighton CJ, Wistuba II, Kurie JM., Free PMC Article

    09/14/2019
    simultaneous deletion of Zeb1 encoding an EMT-promoting factor restores directional migration to Ovol2-deficient Bu-HFSCs. Taken together, our findings highlight the important function of an Ovol2-Zeb1 EMT-regulatory circuit in controlling the directional migration of epithelial stem and progenitor cells to facilitate adult skin epithelial regeneration and repair.

    An Ovol2-Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation.
    Haensel D, Sun P, MacLean AL, Ma X, Zhou Y, Stemmler MP, Brabletz S, Berx G, Plikus MV, Nie Q, Brabletz T, Dai X., Free PMC Article

    08/17/2019
    ZEB1/CtBP and FOXO3 have opposing transcriptional activities and regulate muscle atrophy-related genes

    Regulation of muscle atrophy-related genes by the opposing transcriptional activities of ZEB1/CtBP and FOXO3.
    Ninfali C, Siles L, Darling DS, Postigo A., Free PMC Article

    07/13/2019
    the transforming growth factor beta (TGF-beta) and miR-200 family members, which counterregulate the coordinated expression of Zeb1 and Zeb2 during the epithelial-to-mesenchymal transition, inversely regulated Zeb1 and Zeb2 expression in CD8(+) T cells.

    ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8<sup>+</sup> T cell fates.
    Guan T, Dominguez CX, Amezquita RA, Laidlaw BJ, Cheng J, Henao-Mejia J, Williams A, Flavell RA, Lu J, Kaech SM., Free PMC Article

    06/22/2019
    Zeb1-expressing stromal myofibroblasts enable a heterotypic collaboration with the Kras-fated epithelial compartment, thus supporting pancreatic malignancy.

    Zeb1 in Stromal Myofibroblasts Promotes <i>Kras</i>-Driven Development of Pancreatic Cancer.
    Sangrador I, Molero X, Campbell F, Franch-Expósito S, Rovira-Rigau M, Samper E, Domínguez-Fraile M, Fillat C, Castells A, Vaquero EC.

    06/15/2019
    disrupting the in vivo regulation of Zeb1 by miR-200c is sufficient to drive epithelial-to-mesenchymal transition, thus highlighting the importance of this axis in tumor progression and invasion.

    Genetic dissection of the miR-200-Zeb1 axis reveals its importance in tumor differentiation and invasion.
    Title AC, Hong SJ, Pires ND, Hasenöhrl L, Godbersen S, Stokar-Regenscheit N, Bartel DP, Stoffel M., Free PMC Article

    04/27/2019
    Zeb1 and Zo1 are coexpressed, at least at the mRNA level, independent of hypoxia status in a mimetic system of the blood-brain barrier.

    The effect of hypoxia on ZEB1 expression in a mimetic system of the blood-brain barrier.
    Leduc-Galindo D, Qvist P, Tóth AE, Fryland T, Nielsen MS, Børglum AD, Christensen JH.

    04/13/2019
    ZEB1 protects skeletal muscle from damage and is required for its regeneration.

    ZEB1 protects skeletal muscle from damage and is required for its regeneration.
    Siles L, Ninfali C, Cortés M, Darling DS, Postigo A., Free PMC Article

    04/6/2019
    In the development of LPS-induced early pulmonary fibrosis, miR-200b/c was downregulated, whereas ZEB1/2 was upregulated; miR-200b/c exerts a protective effect by targeting ZEB1/2.

    miR-200b/c attenuates lipopolysaccharide-induced early pulmonary fibrosis by targeting ZEB1/2 via p38 MAPK and TGF-β/smad3 signaling pathways.
    Cao Y, Liu Y, Ping F, Yi L, Zeng Z, Li Y.

    02/9/2019
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