TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization. | TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization. Tang J, Kang Y, Zhou Y, Shang N, Li X, Wang H, Lan J, Wang S, Wu L, Peng Y., Free PMC Article | 02/9/2024 |
The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of Metalloproteinase-Matrix Metalloproteinase Activity During Abdominal Aortic Aneurysm Development. | The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of Metalloproteinase-Matrix Metalloproteinase Activity During Abdominal Aortic Aneurysm Development. Davis FM, Melvin WJ, Mangum K, Tsoi LC, Joshi AD, Cai Q, Henke PK, Gudjonsson JE, Gallagher KA., | 08/11/2023 |
Noncanonical Activity of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) Improves Cognition and Synapse Density in Aging. | Noncanonical Activity of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) Improves Cognition and Synapse Density in Aging. Britton R, Wasley T, Harish R, Holz C, Hall J, Yee DC, Melton Witt J, Booth EA, Braithwaite S, Czirr E, Kerrisk Campbell M., Free PMC Article | 06/24/2023 |
TIMP2 facilitates CIRI through activating NLRP3-mediated pyroptosis. | TIMP2 facilitates CIRI through activating NLRP3-mediated pyroptosis. Shi S, Zhang C, Liu J., Free PMC Article | 05/30/2023 |
Bioorthogonal PEGylation Prolongs the Elimination Half-Life of N-TIMP2 While Retaining MMP Inhibition. | Bioorthogonal PEGylation Prolongs the Elimination Half-Life of N-TIMP2 While Retaining MMP Inhibition. Hayun H, Arkadash V, Sananes A, Arbely E, Stepensky D, Papo N. | 05/28/2022 |
TIMP2 mediates endoplasmic reticulum stress contributing to sepsis-induced acute kidney injury. | TIMP2 mediates endoplasmic reticulum stress contributing to sepsis-induced acute kidney injury. Jiang N, Huang R, Zhang J, Xu D, Li T, Sun Z, Su L, Peng Z. | 03/12/2022 |
TIMP-2 suppresses tumor growth and metastasis in murine model of triple-negative breast cancer. | TIMP-2 suppresses tumor growth and metastasis in murine model of triple-negative breast cancer. Peeney D, Jensen SM, Castro NP, Kumar S, Noonan S, Handler C, Kuznetsov A, Shih J, Tran AD, Salomon DS, Stetler-Stevenson WG., Free PMC Article | 08/22/2020 |
Current study elucidated the distinct nature of the inhibitory effect on IS as a result of overexpressed miR-410 whereby the conferral of neuroprotection was observed in oxidative stress-induced apoptosis post IS through the TIMP2-dependent repression of the MAPK pathway in mice. | MicroRNA-410 inhibition of the TIMP2-dependent MAPK pathway confers neuroprotection against oxidative stress-induced apoptosis after ischemic stroke in mice. Liu NN, Dong ZL, Han LL. | 10/5/2019 |
Glycosaminoglycan, CaG can strengthen ECM by increasing activity of TIMP-2 and adhesion activity on collagen known to inhibit changes of extracellular matrix, leading to tumor cell invasion and progression | Anti-cancer effect of dung beetle glycosaminoglycans on melanoma. Ahn MY, Kim BJ, Kim HJ, Jin JM, Yoon HJ, Hwang JS, Park KK., Free PMC Article | 04/20/2019 |
the protein expression levels of TIMP-2 and PBEF in cloned placentae, were examined. | Aberrant Expression of TIMP-2 and PBEF Genes in the Placentae of Cloned Mice Due to Epigenetic Reprogramming Error. Kim HR, Lee JE, Oqani RK, Kim SY, Wakayama T, Li C, Sa SJ, Woo JS, Jin DI., Free PMC Article | 07/1/2017 |
demonstrate that TIMP-2 plays a greater protective role than TIMP-1 during the pathogenesis of atherosclerosis | Differential effects of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 on atherosclerosis and monocyte/macrophage invasion. Di Gregoli K, George SJ, Jackson CL, Newby AC, Johnson JL., Free PMC Article | 12/17/2016 |
Further investigation of MMP2 inhibitors of TIMP2/TIMP4 showed an upregulated TIMP2 expression, but not TIMP4. low-dose pre-radiation attenuates the skin inflammation and ROS production induced by medium-dose UV radiation | Low-dose UVB irradiation prevents MMP2-induced skin hyperplasia by inhibiting inflammation and ROS. Dang L, Wang Y, Xue Y, He L, Li Y, Xiong J. | 05/14/2016 |
TIMP2 and TIMP3 play fundamental and differential roles in mediating pathological remodelling, independent from their MMP-inhibitory function | Differential role of TIMP2 and TIMP3 in cardiac hypertrophy, fibrosis, and diastolic dysfunction. Fan D, Takawale A, Basu R, Patel V, Lee J, Kandalam V, Wang X, Oudit GY, Kassiri Z. | 05/30/2015 |
Reduced beta(2)GP I plays a role in diabetic mice related to vascular protection, inhibiting vascular lipid deposition, and plaque formation by reducing MMPs/TIMPs expression through down-regulation of the p38MAPK signaling pathway. | Effects of reduced β2-glycoprotein I on the expression of aortic matrix metalloproteinases and tissue inhibitor matrix metalloproteinases in diabetic mice. Xu J, Wang P, Wang T, Wang M, Chen S, Yu P, Yu D., Free PMC Article | 05/23/2015 |
High TIMP2 expression is associated with liver fibrosis. | Overexpression of miR-483-5p/3p cooperate to inhibit mouse liver fibrosis by suppressing the TGF-β stimulated HSCs in transgenic mice. Li F, Ma N, Zhao R, Wu G, Zhang Y, Qiao Y, Han D, Xu Y, Xiang Y, Yan B, Jin J, Lv G, Wang L, Xu C, Gao X, Luo S., Free PMC Article | 04/18/2015 |
TIMP2 promotes kidney injury through metalloproteinase (MMP)2 activation | TIMP2 and TIMP3 have divergent roles in early renal tubulointerstitial injury. Wang Z, Famulski K, Lee J, Das SK, Wang X, Halloran P, Oudit GY, Kassiri Z. | 10/4/2014 |
Gene expression of Mmp-12 and Mmp-13, and Timp-1 was strongly upregulated at all time points in RD compared with controls. Timp-2, Mmp-2, and Mmp-9 expression was modest. | Retinal MMP-12, MMP-13, TIMP-1, and TIMP-2 expression in murine experimental retinal detachment. Kim B, Abdel-Rahman MH, Wang T, Pouly S, Mahmoud AM, Cebulla CM., Free PMC Article | 05/24/2014 |
Data indicate a significantly increased expression of type I collagen, TIMP-2, TGF-beta, PAI-1 and RAGE in diabetic db/db cells. | Cardiac fibroblast-dependent extracellular matrix accumulation is associated with diastolic stiffness in type 2 diabetes. Hutchinson KR, Lord CK, West TA, Stewart JA Jr., Free PMC Article | 04/26/2014 |
This study suggests that miR-17 participates in the regulation of cardiac matrix remodeling and provides a novel therapeutic approach using miR-17 inhibitors to prevent remodeling and heart failure after MI. | miR-17 targets tissue inhibitor of metalloproteinase 1 and 2 to modulate cardiac matrix remodeling. Li SH, Guo J, Wu J, Sun Z, Han M, Shan SW, Deng Z, Yang BB, Weisel RD, Li RK. | 12/21/2013 |
results suggest that genetic ablation of tissue inhibitor of matrix metalloproteinase-2 decreases the expression of pro-angiogenic matrix metalloproteinases-2 and increases anti-angiogenic factors resulting in ventricular remodelling and heart failure | TIMP-2 mutant decreases MMP-2 activity and augments pressure overload induced LV dysfunction and heart failure. Givvimani S, Kundu S, Narayanan N, Armaghan F, Qipshidze N, Pushpakumar S, Vacek TP, Tyagi SC., Free PMC Article | 10/19/2013 |
In neural stem cells, TIMP-2 acts as key effector of the proneurogenic response to inducing stimuli such as Marimastat. | The matrix metalloproteinase inhibitor marimastat promotes neural progenitor cell differentiation into neurons by gelatinase-independent TIMP-2-dependent mechanisms. Sinno M, Biagioni S, Ajmone-Cat MA, Pafumi I, Caramanica P, Medda V, Tonti G, Minghetti L, Mannello F, Cacci E. | 06/29/2013 |
Spread of Lewis lung carcinoma cells from serum to lungs was associated with increased serum content of TIMP-1 and TIMP-2. | Tissue inhibitors of matrix metalloproteinases 1 and 2 and matrix metalloproteinase activity in the serum and lungs of mice with lewis lung carcinoma. Kisarova YA, Korolenko TA. | 04/6/2013 |
Results show enhanced expression and widespread distribution of MMP-2, MMP-9 and their tissue inhibitors TIMP-1 and TIMP-2 in thymus from infected animals. | Thymic alterations induced by Plasmodium berghei: expression of matrix metalloproteinases and their tissue inhibitors. Lima AC, Francelin C, Ferrucci DL, Stach-Machado DR, Verinaud L. | 04/6/2013 |
Chuanxiong can ameliorate the age changes in aortic morphology, reduce the production of ROS and AGEs in vascular tissue, inhibit MMP-2 activity and regulate MMP-2/TIMP-2 equilibrium. | [Experimental study on extracts from ginseng, notoginseng and chuanxiong for delaying vascular aging in senescent mice]. Lei Y, Yang J, Zhao H. | 02/9/2013 |
these findings suggest that reduction of TIMP2 levels and increased angiogenesis are possible primary events in osteoarthritis progression. | TIMP2 deficient mice develop accelerated osteoarthritis via promotion of angiogenesis upon destabilization of the medial meniscus. Mi M, Shi S, Li T, Holz J, Lee YJ, Sheu TJ, Liao Q, Xiao T. | 09/22/2012 |