| TNFalpha: TNFR1 signaling inhibits maturation and maintains the pro-inflammatory programming of monocyte-derived macrophages in murine chronic granulomatous disease. | TNFα: TNFR1 signaling inhibits maturation and maintains the pro-inflammatory programming of monocyte-derived macrophages in murine chronic granulomatous disease.
Gibbings SL, Haist KC, Redente EF, Henson PM, Bratton DL., Free PMC Article | 04/17/2024 |
| Reparative Dentin Formation Following Dental Pulp Capping is Mediated by TNFR1 In Vivo. | Reparative Dentin Formation Following Dental Pulp Capping is Mediated by TNFR1 In Vivo.
Almeida-Junior LA, Araujo LDC, Lamarque GCC, Arnez MFM, Kapila YL, Silva LABD, Paula-Silva FWG. | 10/26/2023 |
| Autoimmune Valvular Carditis Requires Endothelial Cell TNFR1 Expression. | Autoimmune Valvular Carditis Requires Endothelial Cell TNFR1 Expression.
Faragher JL, Auger JL, Osinski V, Meier LA, Engelson BJ, Firulyova MM, Gonzalez-Torres MI, Brombacher F, Zaitsev K, Marath A, Binstadt BA., | 08/25/2023 |
| Bivalent structure of a TNFR2-selective and agonistic TNF-alpha mutein Fc-fusion protein enhances the expansion activity of regulatory T cells. | Bivalent structure of a TNFR2-selective and agonistic TNF-α mutein Fc-fusion protein enhances the expansion activity of regulatory T cells.
Inoue M, Tsuji Y, Ueno R, Miyamoto D, Tanaka K, Moriyasu Y, Shibata S, Okuda M, Ando D, Abe Y, Kamada H, Tsunoda SI., Free PMC Article | 08/25/2023 |
| Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis. | Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis.
Fiedler T, Fairless R, Pichi K, Fischer R, Richter F, Kontermann RE, Pfizenmaier K, Diem R, Williams SK., Free PMC Article | 05/15/2023 |
| Murine neonatal dermal fibroblast acquires a lymphoid tissue organizer cell-like activity upon synergistic activation of TNF-alpha receptor and LTbeta receptor. | Murine neonatal dermal fibroblast acquires a lymphoid tissue organizer cell-like activity upon synergistic activation of TNF-α receptor and LTβ receptor.
Jin L, Gao W, Chen P, Zhao W, Zhao Y, Li D, Zhou J, Yu B, Dong G. | 01/7/2023 |
| Loss of tumor necrosis factor (TNF)-receptor 1 and TNF-receptor 2 partially replicate effects of TNF deficiency on dendritic spines of granule cells in mouse dentate gyrus. | Loss of tumor necrosis factor (TNF)-receptor 1 and TNF-receptor 2 partially replicate effects of TNF deficiency on dendritic spines of granule cells in mouse dentate gyrus.
Smilovic D, Rietsche M, Fellenz M, Drakew A, Vuksic M, Deller T. | 12/24/2022 |
| Absence of Tumor Necrosis Factor Receptor 1 Inhibits Osteoclast Activity in Apical Dental Resorption Caused by Endodontic Infection in Mice. | Absence of Tumor Necrosis Factor Receptor 1 Inhibits Osteoclast Activity in Apical Dental Resorption Caused by Endodontic Infection in Mice.
de Carvalho MS, de Almeida-Junior LA, Silva-Sousa AC, Sousa-Neto MD, Lucisano MP, Arnez MFM, da Silva LAB, Paula-Silva FWG. | 10/29/2022 |
| Sensitization of colonic nociceptors by TNFalpha is dependent on TNFR1 expression and p38 MAPK activity. | Sensitization of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity.
Barker KH, Higham JP, Pattison LA, Taylor TS, Chessell IP, Welsh F, Smith ESJ, Bulmer DC., Free PMC Article | 09/17/2022 |
| TRAPS mutations in Tnfrsf1a decrease the responsiveness to TNFalpha via reduced cell surface expression of TNFR1. | TRAPS mutations in Tnfrsf1a decrease the responsiveness to TNFα via reduced cell surface expression of TNFR1.
Akagi T, Hiramatsu-Asano S, Ikeda K, Hirano H, Tsuji S, Yahagi A, Iseki M, Matsuyama M, Mak TW, Nakano K, Ishihara K, Morita Y, Mukai T., Free PMC Article | 08/13/2022 |
| STAT3 regulates inflammatory cytokine production downstream of TNFR1 by inducing expression of TNFAIP3/A20. | STAT3 regulates inflammatory cytokine production downstream of TNFR1 by inducing expression of TNFAIP3/A20.
Antonia RJ, Karelehto E, Toriguchi K, Matli M, Warren RS, Pfeffer LM, Donner DB., Free PMC Article | 08/13/2022 |
| TNFR2 Depletion Reduces Psoriatic Inflammation in Mice by Downregulating Specific Dendritic Cell Populations in Lymph Nodes and Inhibiting IL-23/IL-17 Pathways. | TNFR2 Depletion Reduces Psoriatic Inflammation in Mice by Downregulating Specific Dendritic Cell Populations in Lymph Nodes and Inhibiting IL-23/IL-17 Pathways.
Chandrasekharan UM, Kaur R, Harvey JE, Braley C, Rai V, Lee M, de Windt N, Hsieh J, Jaini R, Bayik D, Scheraga RG, Fernandez AP, DiCorleto PE, Husni ME., Free PMC Article | 07/30/2022 |
| Distinct Role of TNFR1 and TNFR2 in Protective Immunity Against Orientia tsutsugamushi Infection in Mice. | Distinct Role of TNFR1 and TNFR2 in Protective Immunity Against Orientia tsutsugamushi Infection in Mice.
Liang Y, Fisher J, Gonzales C, Trent B, Card G, Sun J, Tumanov AV, Soong L., Free PMC Article | 07/30/2022 |
| Zika virus-induced TNF-alpha signaling dysregulates expression of neurologic genes associated with psychiatric disorders. | Zika virus-induced TNF-α signaling dysregulates expression of neurologic genes associated with psychiatric disorders.
Kung PL, Chou TW, Lindman M, Chang NP, Estevez I, Buckley BD, Atkins C, Daniels BP., Free PMC Article | 05/14/2022 |
| Inhibition of two-pore channels in antigen-presenting cells promotes the expansion of TNFR2-expressing CD4(+)Foxp3(+) regulatory T cells. | Inhibition of two-pore channels in antigen-presenting cells promotes the expansion of TNFR2-expressing CD4(+)Foxp3(+) regulatory T cells.
He T, Yang D, Li XQ, Jiang M, Islam MS, Chen S, Chen Y, Yang Y, Chou CK, Trivett AL, Oppenheim JJ, Chen X., Free PMC Article | 04/23/2022 |
| Effector memory CD4(+) T cells induce damaging innate inflammation and autoimmune pathology by engaging CD40 and TNFR on myeloid cells. | Effector memory CD4(+) T cells induce damaging innate inflammation and autoimmune pathology by engaging CD40 and TNFR on myeloid cells.
McDaniel MM, Chawla AS, Jain A, Meibers HE, Saha I, Gao Y, Jain V, Roskin K, Way SS, Pasare C., Free PMC Article | 03/12/2022 |
| Angiotensin II-induced renal angiotensinogen formation is enhanced in mice lacking tumor necrosis factor-alpha type 1 receptor. | Angiotensin II-induced renal angiotensinogen formation is enhanced in mice lacking tumor necrosis factor-alpha type 1 receptor.
Majid DSA, Mahaffey E, Castillo A, Prieto MC, Navar LG., Free PMC Article | 03/5/2022 |
| Angiotensin II-induced natriuresis is attenuated in knockout mice lacking the receptors for tumor necrosis factor-alpha. | Angiotensin II-induced natriuresis is attenuated in knockout mice lacking the receptors for tumor necrosis factor-α.
Majid DSA, Castillo A., Free PMC Article | 03/5/2022 |
| The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation. | The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation.
Richter F, Williams SK, John K, Huber C, Vaslin C, Zanker H, Fairless R, Pichi K, Marhenke S, Vogel A, Dhaen MA, Herrmann S, Herrmann A, Pfizenmaier K, Bantel H, Diem R, Kontermann RE, Fischer R., Free PMC Article | 12/25/2021 |
| A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5. | A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5.
Zhang Y, Huang K, Zhang Y, Han T, Li L, Ruan C, Sun YH, Shi W, Han W, Wu SQ, Song J, Liu J, Han J., Free PMC Article | 11/22/2021 |
| Immune control of Mycobacterium tuberculosis is dependent on both soluble TNFRp55 and soluble TNFRp75. | Immune control of Mycobacterium tuberculosis is dependent on both soluble TNFRp55 and soluble TNFRp75.
Keeton R, du Toit JP, Hsu NJ, Dube F, Jacobs M., Free PMC Article | 11/13/2021 |
| TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice. | TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice.
Liu CY, Tam SS, Huang Y, Dubé PE, Alhosh R, Girish N, Punit S, Nataneli S, Li F, Bender JM, Washington MK, Polk DB., Free PMC Article | 10/23/2021 |
| Effects of TNFalpha receptor TNF-Rp55- or TNF-Rp75- deficiency on corneal neovascularization and lymphangiogenesis in the mouse. | Effects of TNFα receptor TNF-Rp55- or TNF-Rp75- deficiency on corneal neovascularization and lymphangiogenesis in the mouse.
Maier AB, Reichhart N, Gonnermann J, Kociok N, Riechardt AI, Gundlach E, Strauß O, Joussen AM., Free PMC Article | 09/18/2021 |
| TNFR2 is required for RIP1-dependent cell death in human leukemia. | TNFR2 is required for RIP1-dependent cell death in human leukemia.
Aguadé-Gorgorió J, McComb S, Eckert C, Guinot A, Marovca B, Mezzatesta C, Jenni S, Abduli L, Schrappe M, Dobay MP, Stanulla M, von Stackelberg A, Cario G, Bourquin JP, Bornhauser BC., Free PMC Article | 08/21/2021 |
| Tumor necrosis factor alpha receptor 1 deficiency in hepatocytes does not protect from non-alcoholic steatohepatitis, but attenuates insulin resistance in mice. | Tumor necrosis factor alpha receptor 1 deficiency in hepatocytes does not protect from non-alcoholic steatohepatitis, but attenuates insulin resistance in mice.
Bluemel S, Wang Y, Lee S, Schnabl B., Free PMC Article | 07/10/2021 |