| D-methionine improves cisplatin-induced anorexia and dyspepsia syndrome by attenuating intestinal tryptophan hydroxylase 1 activity and increasing plasma leptin concentration. | D-methionine improves cisplatin-induced anorexia and dyspepsia syndrome by attenuating intestinal tryptophan hydroxylase 1 activity and increasing plasma leptin concentration.
Wong YS, Lin MY, Liu PF, Ko JL, Huang GT, Tu DG, Ou CC. | 06/26/2021 |
| Protein acetylation derepresses Serotonin Synthesis to potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling. | Protein acetylation derepresses Serotonin Synthesis to potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling.
Zhang Y, Wang S, Zhang L, Zhou F, Zhu K, Zhu Q, Liu Q, Liu Y, Jiang L, Ning G, Bi Y, Zhou L, Wang X., Free PMC Article | 05/8/2021 |
| Investigating the complex interplay between genotype and high-fat-diet feeding in the lactating mammary gland using the Tph1 and Ldlr knockout models. | Investigating the complex interplay between genotype and high-fat-diet feeding in the lactating mammary gland using the Tph1 and Ldlr knockout models.
Cheng AA, Li W, Walker TM, Silvers C, Arendt LM, Hernandez LL., Free PMC Article | 03/28/2021 |
| Interleukin-33 Induces the Enzyme Tryptophan Hydroxylase 1 to Promote Inflammatory Group 2 Innate Lymphoid Cell-Mediated Immunity. | Interleukin-33 Induces the Enzyme Tryptophan Hydroxylase 1 to Promote Inflammatory Group 2 Innate Lymphoid Cell-Mediated Immunity.
Flamar AL, Klose CSN, Moeller JB, Mahlakõiv T, Bessman NJ, Zhang W, Moriyama S, Stokic-Trtica V, Rankin LC, Putzel GG, Rodewald HR, He Z, Chen L, Lira SA, Karsenty G, Artis D., Free PMC Article | 11/21/2020 |
| Mast cell Tph1 promotes obesity and insulin resistance. | Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance.
Yabut JM, Desjardins EM, Chan EJ, Day EA, Leroux JM, Wang B, Crane ED, Wong W, Morrison KM, Crane JD, Khan WI, Steinberg GR., Free PMC Article | 04/25/2020 |
| Overexpression of tryptophan hydroxylase-1 (TPH-1), an enzyme involved in 5-methoxytryptophan synthesis, reduces renal injury by attenuating renal inflammation and fibrosis, whereas TPH-1 deficiency exacerbates renal injury and fibrosis by activating NF-kappaB and inhibiting Nrf2 pathways. | Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan.
Chen DQ, Cao G, Chen H, Argyopoulos CP, Yu H, Su W, Chen L, Samuels DC, Zhuang S, Bayliss GP, Zhao S, Yu XY, Vaziri ND, Wang M, Liu D, Mao JR, Ma SX, Zhao J, Zhang Y, Shang YQ, Kang H, Ye F, Cheng XH, Li XR, Zhang L, Meng MX, Guo Y, Zhao YY., Free PMC Article | 04/20/2019 |
| Both gut-specific Tph1 knockout mice and liver-specific Htr2a knockout mice are resistant to high fat diet-induced hepatic steatosis, without affecting systemic energy homeostasis. | Serotonin signals through a gut-liver axis to regulate hepatic steatosis.
Choi W, Namkung J, Hwang I, Kim H, Lim A, Park HJ, Lee HW, Han KH, Park S, Jeong JS, Bang G, Kim YH, Yadav VK, Karsenty G, Ju YS, Choi C, Suh JM, Park JY, Park S, Kim H., Free PMC Article | 12/22/2018 |
| Data suggest that central melanocortin-4 receptor (MC4-R) and tryptophan hydroxylase (TPH) are involved in the efferent neuronal control of the kidneys. | Delineation of the central melanocortin circuitry controlling the kidneys by a virally mediated transsynaptic tracing study in transgenic mouse model.
Liu TT, Liu BW, He ZG, Feng L, Liu SG, Xiang HB., Free PMC Article | 02/24/2018 |
| Prolactin-induced Tph1 expression. | Expression mechanism of tryptophan hydroxylase 1 in mouse islets during pregnancy.
Iida H, Ogihara T, Min MK, Hara A, Kim YG, Fujimaki K, Tamaki M, Fujitani Y, Kim H, Watada H. | 04/2/2016 |
| Tph1-deficient mice fed a high-fat diet (HFD) are protected from obesity, insulin resistance and nonalcoholic fatty liver disease (NAFLD) while exhibiting greater energy expenditure by brown adipose tissue. | Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis.
Crane JD, Palanivel R, Mottillo EP, Bujak AL, Wang H, Ford RJ, Collins A, Blümer RM, Fullerton MD, Yabut JM, Kim JJ, Ghia JE, Hamza SM, Morrison KM, Schertzer JD, Dyck JR, Khan WI, Steinberg GR., Free PMC Article | 04/11/2015 |
| Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities. | Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities.
Suidan GL, Duerschmied D, Dillon GM, Vanderhorst V, Hampton TG, Wong SL, Voorhees JR, Wagner DD., Free PMC Article | 11/2/2013 |
| ZBP-89 directly binds to the Tph1 promoter, which is required for its basal and butyrate-inducible expression. | ZBP-89 regulates expression of tryptophan hydroxylase I and mucosal defense against Salmonella typhimurium in mice.
Essien BE, Grasberger H, Romain RD, Law DJ, Veniaminova NA, Saqui-Salces M, El-Zaatari M, Tessier A, Hayes MM, Yang AC, Merchant JL., Free PMC Article | 08/3/2013 |
| TPH1 deficiency or inhibition reduces allergic airway inflammation. Platelet-derived 5-HT is pivotal in AAI and lack of 5-HT leads to impaired Th2 priming capacity of bone marrow dendritic cells. | Production of serotonin by tryptophan hydroxylase 1 and release via platelets contribute to allergic airway inflammation.
Dürk T, Duerschmied D, Müller T, Grimm M, Reuter S, Vieira RP, Ayata K, Cicko S, Sorichter S, Walther DJ, Virchow JC, Taube C, Idzko M. | 04/27/2013 |
| Data indicate that tryptophan hydroxylase (Tph)1-deficient mice, lacking non-neuronal serotonin, showed mild leukocytosis. | Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice.
Duerschmied D, Suidan GL, Demers M, Herr N, Carbo C, Brill A, Cifuni SM, Mauler M, Cicko S, Bader M, Idzko M, Bode C, Wagner DD., Free PMC Article | 04/6/2013 |
| Data show that Tph-1 (tryptophan hydroxylase-1) is a potent regulator of immunity. | Tryptophan hydroxylase-1 regulates immune tolerance and inflammation.
Nowak EC, de Vries VC, Wasiuk A, Ahonen C, Bennett KA, Le Mercier I, Ha DG, Noelle RJ., Free PMC Article | 01/26/2013 |
| Parallel to Tph1 mRNA and protein induction, islet serotonin content increased to a peak level that was 200-fold higher than basal. Interestingly, only a subpopulation of the beta cells was serotonin-positive in vitro and in vivo. | Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy.
Schraenen A, Lemaire K, de Faudeur G, Hendrickx N, Granvik M, Van Lommel L, Mallet J, Vodjdani G, Gilon P, Binart N, in't Veld P, Schuit F., Free PMC Article | 02/26/2011 |
| In mice no significant TPH1 expression was detected in the brain. | Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice.
Gutknecht L, Kriegebaum C, Waider J, Schmitt A, Lesch KP. | 01/21/2010 |
| substantially reduced peripheral 5-HT levels in Tph1/Tph2 double knockout, but not TPH2KO mice | Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants.
Savelieva KV, Zhao S, Pogorelov VM, Rajan I, Yang Q, Cullinan E, Lanthorn TH., Free PMC Article | 01/21/2010 |
| Cardiomyopathy is more severe in adult Tph1 knockout mice born to homozygous mothers than to heterozygous mothers. | Maternal serotonin influences cardiac function in adult offspring.
Fligny C, Fromes Y, Bonnin P, Darmon M, Bayard E, Launay JM, Côté F, Mallet J, Vodjdani G. | 01/21/2010 |
| In a genetic model of serotonin deficiency (Tph1(-/-)) in mice, serotonin shown to be crucial for the growth of s.c. colon cancer allografts in vivo. | Serotonin regulates macrophage-mediated angiogenesis in a mouse model of colon cancer allografts.
Nocito A, Dahm F, Jochum W, Jang JH, Georgiev P, Bader M, Graf R, Clavien PA. | 01/21/2010 |
| Tph1 knockout mice used to show that serotonin plays a role in the pathogenesis of steatohepatitis. | Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis.
Nocito A, Dahm F, Jochum W, Jang JH, Georgiev P, Bader M, Renner EL, Clavien PA. | 01/21/2010 |
| nonneuronal tph1 gene has a role in cardiac function with peripheral serotonin | Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function.
Côté F, Thévenot E, Fligny C, Fromes Y, Darmon M, Ripoche MA, Bayard E, Hanoun N, Saurini F, Lechat P, Dandolo L, Hamon M, Mallet J, Vodjdani G., Free PMC Article | 01/21/2010 |
| Tryptophan hydroxylase 1 and peripheral serotonin play an essential role in the development of hypoxia-induced elevations in pulmonary pressures and hypoxia-induced pulmonary vascular remodeling. | Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension.
Morecroft I, Dempsie Y, Bader M, Walther DJ, Kotnik K, Loughlin L, Nilsen M, MacLean MR. | 01/21/2010 |
| TPH1 is expressed preferentially during late developmental brain stages. Low raphe nuclei 5-HT contents were seen during development in NZW & SWR mice with common functional polymorphisms in TPH1. TPH1 may influence behavior later in life. | Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels.
Nakamura K, Sugawara Y, Sawabe K, Ohashi A, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Nishimura H, Hasegawa H, Hirose S., Free PMC Article | 01/21/2010 |
| Review. TPH1 is expressed in the pineal gland and the enterochromaffin cells. Loss of TPH1 gene expression, and thus of peripheral 5-HT, leads to a cardiac dysfunction phenotype. | [Abnormal cardiac activity in mice in the absence of peripheral serotonin synthesis].
Côté F, Fligny C, Mallet J, Vodjdani G. | 01/21/2010 |