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    FBP1 fructose-bisphosphatase 1 [ Homo sapiens (human) ]

    Gene ID: 2203, updated on 19-Sep-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    FBP1 enhances the radiosensitivity by suppressing glycolysis via the FBXW7/mTOR axis in nasopharyngeal carcinoma cells.

    FBP1 enhances the radiosensitivity by suppressing glycolysis via the FBXW7/mTOR axis in nasopharyngeal carcinoma cells.
    Zhang P, Shao Y, Quan F, Liu L, Yang J.

    09/18/2021
    Loss of FBP1 promotes proliferation, migration, and invasion by regulating fatty acid metabolism in esophageal squamous cell carcinoma.

    Loss of FBP1 promotes proliferation, migration, and invasion by regulating fatty acid metabolism in esophageal squamous cell carcinoma.
    He Y, Hua R, Li B, Gu H, Sun Y, Li Z., Free PMC Article

    08/7/2021
    Genetic Analysis of Tyrosinemia Type 1 and Fructose-1, 6 Bisphosphatase Deficiency Affected in Pakistani Cohorts.

    Genetic Analysis of Tyrosinemia Type 1 and Fructose-1, 6 Bisphosphatase Deficiency Affected in Pakistani Cohorts.
    Yasir Zahoor M, Cheema HA, Ijaz S, Fayyaz Z.

    06/26/2021
    Fructose-1, 6-bisphosphatase 1 interacts with NF-kappaB p65 to regulate breast tumorigenesis via PIM2 induced phosphorylation.

    Fructose-1, 6-bisphosphatase 1 interacts with NF-κB p65 to regulate breast tumorigenesis via PIM2 induced phosphorylation.
    Lu C, Ren C, Yang T, Sun Y, Qiao P, Han X, Yu Z., Free PMC Article

    05/22/2021
    Fructose-1,6-bisphosphatase loss modulates STAT3-dependent expression of PD-L1 and cancer immunity.

    Fructose-1,6-bisphosphatase loss modulates STAT3-dependent expression of PD-L1 and cancer immunity.
    Wang B, Zhou Y, Zhang J, Jin X, Wu H, Huang H., Free PMC Article

    04/13/2021
    A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.

    A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.
    Lu C, Ren C, Yang T, Sun Y, Qiao P, Wang D, Lv S, Yu Z.

    03/6/2021
    CELF6 modulates triple-negative breast cancer progression by regulating the stability of FBP1 mRNA.

    CELF6 modulates triple-negative breast cancer progression by regulating the stability of FBP1 mRNA.
    Yang X, Zhao L, Pei J, Wang Z, Zhang J, Wang B.

    02/13/2021
    Knockdown of FBP1 enhances radiosensitivity in prostate cancer cells by activating autophagy.

    Knockdown of FBP1 enhances radiosensitivity in prostate cancer cells by activating autophagy.
    Li XR, Zhou KQ, Yin Z, Gao YL, Yang X.

    12/19/2020
    The involvement of FBP1 in prostate cancer cell epithelial mesenchymal transition, invasion and metastasis by regulating the MAPK signaling pathway.

    The involvement of FBP1 in prostate cancer cell epithelial mesenchymal transition, invasion and metastasis by regulating the MAPK signaling pathway.
    Zhang YP, Liu KL, Yang Z, Lu BS, Qi JC, Han ZW, Yin YW, Zhang M, Chen DM, Wang XW, Li W, Xin H., Free PMC Article

    09/12/2020
    Exon 2 deletion (previously termed exon 1) was found to be the most common mutation in Turkish fructose-1,6-biphosphatase deficiency patients.

    Exon 2 deletion represents a common mutation in Turkish patients with fructose-1,6-bisphosphatase deficiency.
    Kılıç M, Kasapkara ÇS, Yılmaz DY, Özgül RK.

    05/2/2020
    We propose that the reduced FBP1 level reprogrammed the metabolic state of glioblastoma (GBM) cells, and thus, FBP1 is a potential therapeutic target regulating GBM metabolism following radiotherapy.

    Decreased FBP1 expression rewires metabolic processes affecting aggressiveness of glioblastoma.
    Son B, Lee S, Kim H, Kang H, Jeon J, Jo S, Seong KM, Lee SJ, Youn H, Youn B.

    04/25/2020
    Restoration of FBP1 suppressed Snail-induced epithelial to mesenchymal transition in hepatocellular carcinoma.

    Restoration of FBP1 suppressed Snail-induced epithelial to mesenchymal transition in hepatocellular carcinoma.
    Liu GM, Li Q, Zhang PF, Shen SL, Xie WX, Chen B, Wu J, Hu WJ, Huang XY, Peng BG., Free PMC Article

    12/14/2019
    FBP1 inhibited the autophagy and proliferation in liver cancer cells

    [Fructose-1, 6-bisphosphatase inhibits autophagy and proliferation in liver cancer cells].
    Pan XM, Zhang GJ, Chen XM, Liang L, Tang N, Wang K.

    10/26/2019
    Identification of a frequent variant (E281K) in Indian patients with fructose-1,6-bisphosphatase deficiency

    Clinical and molecular characterization of Indian patients with fructose-1, 6-bisphosphatase deficiency: Identification of a frequent variant (E281K).
    Bhai P, Bijarnia-Mahay S, Puri RD, Saxena R, Gupta D, Kotecha U, Sachdev A, Gupta D, Vyas V, Agarwal D, Jain V, Bansal RK, Kumar TG, Verma IC.

    07/27/2019
    The expansion of CB HSPCs by PPAR-gamma antagonism was completely suppressed by removal of glucose or inhibition of glycolysis. Moreover, knockdown of FBP1 expression promoted glycolysis and ex vivo expansion of long-term repopulating CB HSPCs, whereas overexpression of FBP1 suppressed the expansion of CB HSPCs that was induced by PPARG antagonism

    Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis.
    Guo B, Huang X, Lee MR, Lee SA, Broxmeyer HE., Free PMC Article

    05/11/2019
    FOXC1 bound directly to the promoter regions of the FBP1 gene and negatively regulated its transcriptional activity. Aberrant FBP1 expression contributed to colorectal cancer tumorigenicity. Decreased FBP1 expression coupled with increased FOXC1 expression provided better prognostic information than did FOXC1 expression alone. The FOXC1/FBP1 axis induces CRC cell proliferation and reprograms metabolism in CRCs.

    The FOXC1/FBP1 signaling axis promotes colorectal cancer proliferation by enhancing the Warburg effect.
    Li Q, Wei P, Wu J, Zhang M, Li G, Li Y, Xu Y, Li X, Xie D, Cai S, Xie K, Li D.

    05/11/2019
    overexpressed FBP1 may repress tumor growth, migration and glycolysis via targeting HIF-1alpha in breast cancer

    FBP1 modulates cell metabolism of breast cancer cells by inhibiting the expression of HIF-1α.
    Shi L, He C, Li Z, Wang Z, Zhang Q.

    04/27/2019
    FBP1 is highly expressed in human hypertrophic scars and increases fibroblast proliferation, apoptosis and collagen expression.

    FBP1 is highly expressed in human hypertrophic scars and increases fibroblast proliferation, apoptosis, and collagen expression.
    Zuo J, Chen Z, Zhong X, Lan W, Kuang Y, Huang D.

    04/6/2019
    findings implied the important roles of FBP1 expression in lung cancer development and progression

    Significance of Methylation of FBP1 Gene in Non-Small Cell Lung Cancer.
    Dong Y, Huaying S, Danying W, Chihong Z, Ruibin J, Xiaojiang S, Jianguo F., Free PMC Article

    01/19/2019
    FBP1 modulates the sensitivity of pancreatic cancer cells to BET inhibitors by decreasing the expression of c-Myc. These findings highlight FBP1 could be used as a therapeutic niche for patient-tailored therapies

    FBP1 loss contributes to BET inhibitors resistance by undermining c-Myc expression in pancreatic ductal adenocarcinoma.
    Wang B, Fan P, Zhao J, Wu H, Jin X, Wu H., Free PMC Article

    11/10/2018
    Low FBP1 expression is associated with metastasis in cholangiocarcinoma.

    Forced overexpression of FBP1 inhibits proliferation and metastasis in cholangiocarcinoma cells via Wnt/β-catenin pathway.
    Zhao W, Yang S, Chen J, Zhao J, Dong J.

    10/20/2018
    CBX3 serves as a positive regulator of aerobic glycolysis via suppressing of the FBP1 in pancreatic cancer cells.

    CBX3 promotes proliferation and regulates glycolysis via suppressing FBP1 in pancreatic cancer.
    Chen LY, Cheng CS, Qu C, Wang P, Chen H, Meng ZQ, Chen Z.

    09/15/2018
    Homozygous Alu element insertion in the FBP1 gene is associated with Fructose-1,6-bisphosphatase deficiency.

    Fructose-1,6-bisphosphatase deficiency caused by a novel homozygous Alu element insertion in the FBP1 gene and delayed diagnosis.
    Ramakrishna SH, Patil SJ, Jagadish AA, Sapare AK, Sagar H, Kannan S.

    09/8/2018
    decreased levels of FBP1 may be used as a predictor for poor prognosis of cervical cancer patients

    Fructose‑1,6‑bisphosphatase‑1 decrease may promote carcinogenesis and chemoresistance in cervical cancer.
    Li H, Li M, Pang Y, Liu F, Sheng D, Cheng X.

    07/21/2018
    Study identified for the first time that HNF4alpha and C/EBPalpha are important transcriptional regulators for FBP1 expression in human hepatoma HepG2 cells.

    CCAAT-enhancer binding protein-α (C/EBPα) and hepatocyte nuclear factor 4α (HNF4α) regulate expression of the human fructose-1,6-bisphosphatase 1 (FBP1) gene in human hepatocellular carcinoma HepG2 cells.
    Wattanavanitchakorn S, Rojvirat P, Chavalit T, MacDonald MJ, Jitrapakdee S., Free PMC Article

    07/7/2018
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