| A genome-wide CRISPR screening uncovers that TOB1 acts as a key host factor for FMDV infection via both IFN and EGFR mediated pathways. | A genome-wide CRISPR screening uncovers that TOB1 acts as a key host factor for FMDV infection via both IFN and EGFR mediated pathways.
Peng G, Liu T, Qi X, Wang Y, Ren J, Peng J, Du X, Hu S, Wu S, Zhao Y, Li D, Zheng H., Free PMC Article | 04/5/2024 |
| TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells. | TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells.
Perez RC, Yang X, Familari M, Martinez G, Lovicu FJ, Hime GR, de Iongh RU. | 02/9/2024 |
| TOB1 Blocks Intestinal Mucosal Inflammation Through Inducing ID2-Mediated Suppression of Th1/Th17 Cell Immune Responses in IBD. | TOB1 Blocks Intestinal Mucosal Inflammation Through Inducing ID2-Mediated Suppression of Th1/Th17 Cell Immune Responses in IBD.
Lin R, Ma C, Fang L, Xu C, Zhang C, Wu X, Wu W, Zhu R, Cong Y, Liu Z., Free PMC Article | 04/30/2022 |
| Our findings provide important insights into a previously unrecognized oncogenic role of Tob1 in colon cancer and suggest that Tob1 is an adverse prognostic factor and therapeutic target for colon cancer. | High expression of Tob1 indicates poor survival outcome and promotes tumour progression via a Wnt positive feedback loop in colon cancer.
Li D, Xiao L, Ge Y, Fu Y, Zhang W, Cao H, Chen B, Wang H, Zhan YY, Hu T., Free PMC Article | 04/27/2019 |
| Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. | Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis.
Didonna A, Cekanaviciute E, Oksenberg JR, Baranzini SE., Free PMC Article | 05/5/2018 |
| Collectively, our data support a model of CNOT7, TOB1, CNOT1, and RNA-binding proteins collectively exerting post-transcriptional control on a metastasis suppressive transcriptional program to drive tumor cell metastasis | Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7.
Faraji F, Hu Y, Yang HH, Lee MP, Winkler GS, Hafner M, Hunter KW., Free PMC Article | 05/14/2016 |
| MiR-26a exerts its effect by directly targeting Tob1, the negative regulator of BMP/Smad signaling pathway by binding to the 3'-untranslated region and thus repressing Tob1 protein expression | MiR-26a Rescues Bone Regeneration Deficiency of Mesenchymal Stem Cells Derived From Osteoporotic Mice.
Li Y, Fan L, Hu J, Zhang L, Liao L, Liu S, Wu D, Yang P, Shen L, Chen J, Jin Y., Free PMC Article | 05/14/2016 |
| Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis. | Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.
May SL, Zhou Q, Lewellen M, Carter CM, Coffey D, Highfill SL, Bucher CM, Matise I, Morse HC 3rd, O'Sullivan MG, Schutten M, Johnson C, Bellgrau D, Blazar BR, Modiano JF., Free PMC Article | 10/24/2015 |
| Tob1(-/-), Tob2(-/-), and Tob1/2 double knockout (DKO, Tob1(-/-) & Tob2(-/-)) embryonic stem cells (ESCs) grew faster than wild type (WT) ESCs without losing pluripotency. | BTG/Tob family members Tob1 and Tob2 inhibit proliferation of mouse embryonic stem cells via Id3 mRNA degradation.
Chen Y, Wang C, Wu J, Li L. | 08/22/2015 |
| The expression of Tob1 was significantly increased at day 6 during C2C12 differentiation time, suggesting a possible role in skeletal muscle development. | Molecular characterization of Tob1 in muscle development in pigs.
Yuan J, Cao JY, Tang ZL, Wang N, Li K., Free PMC Article | 01/31/2015 |
| Experimental autoimmune encephalomyelitis in Tob1-eficient mice is associated with augmented central nervous system inflammation, increased infiltrating CD4+ and CD8+ T cell counts, and increased myelin-reactive Th1 and Th17 cells | Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity.
Schulze-Topphoff U, Casazza S, Varrin-Doyer M, Pekarek K, Sobel RA, Hauser SL, Oksenberg JR, Zamvil SS, Baranzini SE., Free PMC Article | 09/28/2013 |
| Tob1 is a crucial check point molecule that modulates the expression and activity of cell cycle proteins. | Tob1 is a constitutively expressed repressor of liver regeneration.
Ho KJ, Do NL, Otu HH, Dib MJ, Ren X, Enjyoji K, Robson SC, Terwilliger EF, Karp SJ., Free PMC Article | 06/28/2010 |
| KLF2 and TOB1 activate the mouse Dpp2 promoter. | Lymphocyte quiescence factor Dpp2 is transcriptionally activated by KLF2 and TOB1.
Bista P, Mele DA, Baez DV, Huber BT., Free PMC Article | 01/21/2010 |
| Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation | Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation.
Suzuki T, K-Tsuzuku J, Ajima R, Nakamura T, Yoshida Y, Yamamoto T., Free PMC Article | 01/21/2010 |
| deficiency prevents ovariectomy-induced bone loss through the superenhancement of osteoblastic activities in bone and that this results in further augmentation in the bone formation rate and the mineral apposition rate after ovariectomy in vivo | Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis.
Usui M, Yoshida Y, Tsuji K, Oikawa K, Miyazono K, Ishikawa I, Yamamoto T, Nifuji A, Noda M., Free PMC Article | 01/21/2010 |
| regulation of nuclear localization of Tob is important for its antiproliferative activity | Nuclear localization of Tob is important for regulation of its antiproliferative activity.
Kawamura-Tsuzuku J, Suzuki T, Yoshida Y, Yamamoto T. | 01/21/2010 |