| Transthyretin-Regulated Diabetic Retinopathy Through the VEGFA/PI3K/AKT Pathway. | Transthyretin-Regulated Diabetic Retinopathy Through the VEGFA/PI3K/AKT Pathway.
Liu L, Gao Y, Yao S., Free PMC Article | 01/31/2024 |
| Transthyretin knockdown recapitulates the insulin-sensitizing effects of exercise and promotes skeletal muscle adaptation to exercise endurance. | Transthyretin knockdown recapitulates the insulin-sensitizing effects of exercise and promotes skeletal muscle adaptation to exercise endurance.
Wu B, Qiu R, Wang S, He Y, Wang J, Xu Z, Lin X, Li H, Zheng F. | 07/19/2023 |
| Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models. | Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models.
Saito-Takatsuji H, Yoshitomi Y, Yamamoto R, Furuyama T, Ishigaki Y, Kato N, Yonekura H, Ikeda T., Free PMC Article | 03/23/2023 |
| Early life stressful experiences escalate aggressive behavior in adulthood via changes in transthyretin expression and function. | Early life stressful experiences escalate aggressive behavior in adulthood via changes in transthyretin expression and function.
Rawat RS, Bhambri A, Pal M, Roy A, Jain S, Pillai B, Konar A., Free PMC Article | 11/12/2022 |
| Evidence From Human Placenta, Endoplasmic Reticulum-Stressed Trophoblasts, and Transgenic Mice Links Transthyretin Proteinopathy to Preeclampsia. | Evidence From Human Placenta, Endoplasmic Reticulum-Stressed Trophoblasts, and Transgenic Mice Links Transthyretin Proteinopathy to Preeclampsia.
Cheng S, Huang Z, Banerjee S, Jash S, Buxbaum JN, Sharma S., Free PMC Article | 07/30/2022 |
| Transthyretin contributes to insulin resistance and diminishes exercise-induced insulin sensitivity in obese mice by inhibiting AMPK activity in skeletal muscle. | Transthyretin contributes to insulin resistance and diminishes exercise-induced insulin sensitivity in obese mice by inhibiting AMPK activity in skeletal muscle.
He Y, Qiu R, Wu B, Gui W, Lin X, Li H, Zheng F. | 05/29/2021 |
| Gender-specific effects of transthyretin on neural stem cell fate in the subventricular zone of the adult mouse. | Gender-specific effects of transthyretin on neural stem cell fate in the subventricular zone of the adult mouse.
Vancamp P, Gothié JD, Luongo C, Sébillot A, Le Blay K, Butruille L, Pagnin M, Richardson SJ, Demeneix BA, Remaud S., Free PMC Article | 11/21/2020 |
| in the diabetic retinopathy environment, TTR might affect the lncRNA MEG3/miR-223-3p axis by the direct binding with PABPC1, and finally repress retinal vessel proliferation. | Transthyretin Upregulates Long Non-Coding RNA MEG3 by Affecting PABPC1 in Diabetic Retinopathy.
Fan G, Gu Y, Zhang J, Xin Y, Shao J, Giampieri F, Battino M., Free PMC Article | 05/2/2020 |
| TTR is not synthesized in brain resident cells in the ischemic infarct core and adjacent peri-infarct area. | Transthyretin expression in the postischemic brain.
Talhada D, Gonçalves I, Gomes JC, Saraiva MJ, Reis Santos C, Ruscher K., Free PMC Article | 03/21/2020 |
| Knockdown of Ttr in cultured cerebellar granule neurons significantly decreased the delta receptor expression; whereas overexpressing Ttr in cortical neurons increased the delta receptor expression. In vivo analysis of Ttr-/- mice revealed a significant decrease of the surface expression of the delta-GABAA-Rs in cerebellar granule neurons. Together, studies identified Ttr as a novel regulator of the delta-GABAA-Rs. | Identification of transthyretin as a novel interacting partner for the δ subunit of GABAA receptors.
Zhou L, Tang X, Li X, Bai Y, Buxbaum JN, Chen G., Free PMC Article | 10/5/2019 |
| results point to a new TTR role through the IGF-I axis, mediated through TTR-IGF-IR interactions. | Evidence for synergistic action of transthyretin and IGF-I over the IGF-I receptor.
Vieira M, Leal SS, Gomes CM, Saraiva MJ. | 03/30/2019 |
| Effects in the heart of a transthyretin V30M transgenic mouse model of transthyretin amyloidosis with doxycycline-tauroursodeoxycholic acid treatment have been reported. | Doxycycline-tauroursodeoxycholic acid treatment: effects in the heart of a transthyretin V30M transgenic mouse model.
Teixeira C, Costelha S, Martins HS, Teixeira A, Saraiva MJ. | 03/16/2019 |
| A C57BL/6 mouse line carrying the transthyretin (TTR) Gly83Arg gene mutation was successfully established. This strain of mice can be used for the study of hereditary vitreous amyloidosis. | A mouse model of a novel missense mutation (Gly83Arg) in a Chinese kindred manifesting vitreous amyloidosis only.
Ran LX, Zheng ZY, Xie B, Nie XM, Chen XW, Su G, Cai SJ. | 11/17/2018 |
| Results indicate that TTR stability is important for its recently described functions in assisting Abeta transport at the BBB and at the liver and also in regulating LRP1 levels and activity. TTR stabilization can serve as an avenue to increase both Abeta elimination and LRP1 levels, which in turn will further participate in Abeta clearance. | Transthyretin stability is critical in assisting beta amyloid clearance- Relevance of transthyretin stabilization in Alzheimer's disease.
Alemi M, Silva SC, Santana I, Cardoso I., Free PMC Article | 07/21/2018 |
| This study reports a possible mechanism for Rhabdomyolysis-Induced Acute Kidney Injury and suggests that reductions in TTR could increase the generation of Reactive Oxygen Species and induce apoptosis. | Gene Microarray Integrated with High-Throughput Proteomics for the Discovery of Transthyretin in Rhabdomyolysis-Induced Acute Kidney Injury.
Li O, Geng X, Ma Q, Wang W, Liu R, Yin Z, Wang S, Cai G, Chen X, Hong Q. | 12/23/2017 |
| TTR neuritogenic activity is mediated by the megalin receptor and is lost in megalin-deficient neurons. | Transthyretin provides trophic support via megalin by promoting neurite outgrowth and neuroprotection in cerebral ischemia.
Gomes JR, Nogueira RS, Vieira M, Santos SD, Ferraz-Nogueira JP, Relvas JB, Saraiva MJ., Free PMC Article | 12/16/2017 |
| New insights into ghrelin cell physiology, and given the known functions of RBP4 and TTR, support an emerging role for the ghrelin cell in blood glucose handling and metabolism. | Expression of Serum Retinol Binding Protein and Transthyretin within Mouse Gastric Ghrelin Cells.
Walker AK, Gong Z, Park WM, Zigman JM, Sakata I., Free PMC Article | 11/4/2017 |
| Transthyretin (TTR) deposition in the peripheral nervous system is the hallmark of familial amyloidotic polyneuropathy (FAP). | Tissue remodeling after interference RNA mediated knockdown of transthyretin in a familial amyloidotic polyneuropathy mouse model.
Gonçalves NP, Gonçalves P, Magalhães J, Ventosa M, Coelho AV, Saraiva MJ. | 10/21/2017 |
| TTR mediated transport of thyroxine represents a survival mechanism necessary for the myogenic program. | Transthyretin: A Transporter Protein Essential for Proliferation of Myoblast in the Myogenic Program.
Lee EJ, Pokharel S, Jan AT, Huh S, Galope R, Lim JH, Lee DM, Choi SW, Nahm SS, Kim YW, Park SY, Choi I., Free PMC Article | 04/29/2017 |
| provide evidence of a new role of Transthyretin as a transcription inducer of insulin-like growth factor receptor I in central nervous system, unveiling a new role in neuroprotection | Transthyretin Induces Insulin-like Growth Factor I Nuclear Translocation Regulating Its Levels in the Hippocampus.
Vieira M, Gomes JR, Saraiva MJ., Free PMC Article | 03/12/2016 |
| data also indicate that it is unlikely that the behaviors seen in Ttr(-/-) mice are related to its function | Silencing of murine transthyretin and retinol binding protein genes has distinct and shared behavioral and neuropathologic effects.
Buxbaum JN, Roberts AJ, Adame A, Masliah E. | 10/17/2015 |
| Native transthyretin inhibits all preeclampsia-like features in the humanized mouse model. | Transthyretin is dysregulated in preeclampsia, and its native form prevents the onset of disease in a preclinical mouse model.
Kalkunte SS, Neubeck S, Norris WE, Cheng SB, Kostadinov S, Vu Hoang D, Ahmed A, von Eggeling F, Shaikh Z, Padbury J, Berg G, Olofsson A, Markert UR, Sharma S., Free PMC Article | 06/14/2014 |
| Transthyretin silencing (TTRkd) significantly reduced myogenin expression. | Transthyretin is a key regulator of myoblast differentiation.
Lee EJ, Bhat AR, Kamli MR, Pokharel S, Chun T, Lee YH, Nahm SS, Nam JH, Hong SK, Yang B, Chung KY, Kim SH, Choi I., Free PMC Article | 04/19/2014 |
| Amyloid fibrils formed by a mutant form of TTR, A25T, activate microglia, leading to the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and nitric oxide. | Activated microglia mediate synapse loss and short-term memory deficits in a mouse model of transthyretin-related oculoleptomeningeal amyloidosis.
Azevedo EP, Ledo JH, Barbosa G, Sobrinho M, Diniz L, Fonseca AC, Gomes F, Romão L, Lima FR, Palhano FL, Ferreira ST, Foguel D., Free PMC Article | 03/15/2014 |
| Hsf-1 affects podocyte markers NPHS1, NPHS2 and WT1 in a transgenic mouse model of TTRVal30Met-related amyloidosis. | Hsf-1 affects podocyte markers NPHS1, NPHS2 and WT1 in a transgenic mouse model of TTRVal30Met-related amyloidosis.
Petrakis I, Mavroeidi V, Stylianou K, Andronikidi E, Lioudaki E, Perakis K, Stratigis S, Vardaki E, Zafeiri M, Giannakakis K, Plaitakis A, Amoiridis G, Saraiva MJ, Daphnis E. | 03/1/2014 |