| Interferon-gamma induces melanogenesis via post-translational regulation of tyrosinase. | Interferon-gamma induces melanogenesis via post-translational regulation of tyrosinase.
Mo X, Kazmi HR, Preston-Alp S, Zhou B, Zaidi MR., Free PMC Article | 04/30/2022 |
| Genetic modulators of IOP thus may be independently identified using the full array of BXD mice without concern for the presence of transillumination defect or mutations in Typr1 and/or Gpnmb. | Iris transillumination defect and its gene modulators do not correlate with intraocular pressure in the BXD family of mice.
Lu H, Lu L, Williams RW, Jablonski MM., Free PMC Article | 10/22/2016 |
| the results from the present study demonstrate that the MA extract increases melanogenesis through the upregulation of TRP-1 protein expression by post-transcriptional control in B16F10 cells | Melia azedarach extract stimulates melanogenesis through increase of tyrosinase-related protein 1 expression in B16F10 mouse melanoma cells.
Yao C, Jin CL, Oh IG, Park CH, Chung JH. | 01/30/2016 |
| Studied upregulation by Kaliziri extract of tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells. | Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells.
Tuerxuntayi A, Liu YQ, Tulake A, Kabas M, Eblimit A, Aisa HA., Free PMC Article | 11/22/2014 |
| The SNARE machinery composed of VAMP7 on Tyrp1-containing vesicles and syntaxin-3 and SNAP23 on melanosomes regulates Tyrp1 trafficking to the melanosome in melanocytes. | Syntaxin-3 is required for melanosomal localization of Tyrp1 in melanocytes.
Yatsu A, Ohbayashi N, Tamura K, Fukuda M. | 11/2/2013 |
| Addition of a TRP-1-directed monoclonal antibody to the treatment protocol for B16F10 skin melanoma mediates eradication of subcutaneous lesions. | Effective cooperation of monoclonal antibody and peptide vaccine for the treatment of mouse melanoma.
Ly LV, Sluijter M, van der Burg SH, Jager MJ, van Hall T. | 03/16/2013 |
| analysis of tyrosinase-related protein 1 in mouse melanocytes at early embryonic stage | Tyrosinase-related protein1 in mouse melanocytes at early embryonic stage.
Kawakami T, Soma Y. | 12/22/2012 |
| GILT-deficient mice have an increase in TRP1-specific regulatory T (Treg) cells compared with TRP1-deficient mice, and depletion of Treg cells partially restores the ability of GILT-deficient TRP1-specific CD4(+) T cells to induce vitiligo. | GILT modulates CD4+ T-cell tolerance to the melanocyte differentiation antigen tyrosinase-related protein 1.
Rausch MP, Hastings KT., Free PMC Article | 02/11/2012 |
| The Tyrp1b mutation modifies the pathways and gene networks in which Tyrp1 functions. | Complex interactions of Tyrp1 in the eye.
Lu H, Li L, Watson ER, Williams RW, Geisert EE, Jablonski MM, Lu L., Free PMC Article | 01/28/2012 |
| DNA vaccination with a melanoma-shared antigen Trp1, combined with systemic TGF-beta blockade during the perioperative period of primary tumor resection, confers protection against B16 melanoma. | Development of tumor-infiltrating CD8+ T cell memory precursor effector cells and antimelanoma memory responses are the result of vaccination and TGF-β blockade during the perioperative period of tumor resection.
Bellavance EC, Kohlhapp FJ, Zloza A, O'Sullivan JA, McCracken J, Jagoda MC, Lacek AT, Posner MC, Guevara-Patino JA., Free PMC Article | 05/28/2011 |
| both the Rab32/38 binding activity and VAMP7 binding activity of Varp are essential for trafficking of Tyrp1 in melanocytes but activation of Rab21 by the VPS9 domain is not necessary for Tyrp1 trafficking | Structure-function analysis of VPS9-ankyrin-repeat protein (Varp) in the trafficking of tyrosinase-related protein 1 in melanocytes.
Tamura K, Ohbayashi N, Ishibashi K, Fukuda M., Free PMC Article | 05/7/2011 |
| Tyrosinase-related protein 1 (Tyrp1) displayed enriched expression in the dorsal root ganglia, an inactivating mutation in the A/J mouse strain, and a null mutant found to be more resistant to thermal nociception compared to its wild-type counterpart. | Positional cloning of a quantitative trait locus contributing to pain sensitivity: possible mediation by Tyrp1.
Fortin A, Diez E, Ritchie J, Sotocinal SG, Dube MP, Gagne M, Paquette O, Skamene E, Mogil JS. | 03/5/2011 |
| this study suggests that DHICA monomers are required to incorporate into the DHI polymer backbone of eumelanin, which highlights the important role of Dct in the regulation of DHICA-mediated antioxidation. | Regulation of DHICA-mediated antioxidation by dopachrome tautomerase: implication for skin photoprotection against UVA radiation.
Jiang S, Liu XM, Dai X, Zhou Q, Lei TC, Beermann F, Wakamatsu K, Xu SZ. | 06/28/2010 |
| NZG/Kgm mouse has two recessive pigmentation variant genes (oca2(p) and tyrp-1(b)) and that the tyrp-1(b) gene locus associates with large body size. | New Zealand Ginger mouse: novel model that associates the tyrp1b pigmentation gene locus with regulation of lean body mass.
Duchesnes CE, Naggert JK, Tatnell MA, Beckman N, Marnane RN, Rodrigues JA, Halim A, Pontré B, Stewart AW, Wolff GL, Elliott R, Mountjoy KG., Free PMC Article | 01/21/2010 |
| Data demonstrate that endogenous tyrosinase-related protein-1 expression alters the functionality of the autoreactive T cell repertoire. | High-avidity autoreactive CD4+ T cells induce host CTL, overcome T(regs) and mediate tumor destruction.
Brandmaier AG, Leitner WW, Ha SP, Sidney J, Restifo NP, Touloukian CE., Free PMC Article | 01/21/2010 |
| Varp functions as the Rab32/38 effector that controls trafficking of Tyrp1 in melanocytes. | Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes.
Tamura K, Ohbayashi N, Maruta Y, Kanno E, Itoh T, Fukuda M., Free PMC Article | 01/21/2010 |
| these data demonstrate that Tyrp1 interacts directly with Tyrosinase in vivo, which may regulate the stability and trafficking of melanogenic enzymes and thus pigment synthesis. | Direct interaction of tyrosinase with Tyrp1 to form heterodimeric complexes in vivo.
Kobayashi T, Hearing VJ. | 01/21/2010 |
| used sequence polymorphisms to finely map the deletion breakpoints and identify strong candidate genes for the known phenotypes | Genomic anatomy of the Tyrp1 (brown) deletion complex.
Smyth IM, Wilming L, Lee AW, Taylor MS, Gautier P, Barlow K, Wallis J, Martin S, Glithero R, Phillimore B, Pelan S, Andrew R, Holt K, Taylor R, McLaren S, Burton J, Bailey J, Sims S, Squares J, Plumb B, Joy A, Gibson R, Gilbert J, Hart E, Laird G, Loveland J, Mudge J, Steward C, Swarbreck D, Harrow J, North P, Leaves N, Greystrong J, Coppola M, Manjunath S, Campbell M, Smith M, Strachan G, Tofts C, Boal E, Cobley V, Hunter G, Kimberley C, Thomas D, Cave-Berry L, Weston P, Botcherby MR, White S, Edgar R, Cross SH, Irvani M, Hummerich H, Simpson EH, Johnson D, Hunsicker PR, Little PF, Hubbard T, Campbell RD, Rogers J, Jackson IJ., Free PMC Article | 01/21/2010 |
| The presence of a distal Tyrp1 regulatory element, which specifies melanocyte-specific expression, supports the idea that separate regulatory sequences can mediate differential gene expression in melanocytes and RPE. | A conserved transcriptional enhancer that specifies Tyrp1 expression to melanocytes.
Murisier F, Guichard S, Beermann F. | 01/21/2010 |
| We found that ionophore monensin (Mon) and the quaternary amine chloroquine (CQ) discriminate between the traffic routes of TRP-2 and TRP-1 | Tyrosinase-related protein-2 and -1 are trafficked on distinct routes in B16 melanoma cells.
Negroiu G, Dwek RA, Petrescu SM. | 01/21/2010 |
| the role of Tyrp1 mechanisms involved in the subsequent IOP elevation and optic nerve degeneration remain unclear | Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1.
Howell GR, Libby RT, Marchant JK, Wilson LA, Cosma IM, Smith RS, Anderson MG, John SW., Free PMC Article | 01/21/2010 |