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    Dpysl3 dihydropyrimidinase-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 22240, updated on 5-Sep-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Collapsin Response Mediator Protein 4 (CRMP4) Facilitates Wallerian Degeneration and Axon Regeneration following Sciatic Nerve Injury.

    Collapsin Response Mediator Protein 4 (CRMP4) Facilitates Wallerian Degeneration and Axon Regeneration following Sciatic Nerve Injury.
    Girouard MP, Simas T, Hua L, Morquette B, Khazaei MR, Unsain N, Johnstone AD, Rambaldi I, Sanz RL, Di Raddo ME, Gamage KK, Yong Y, Willis DE, Verge VMK, Barker PA, Deppmann C, Fournier AE., Free PMC Article

    08/7/2021
    Loss of Collapsin Response Mediator Protein 4 Attenuates 6-Hydroxydopamine-Induced Impairments in a Mouse Model of Parkinson's Disease.

    Loss of Collapsin Response Mediator Protein 4 Attenuates 6-Hydroxydopamine-Induced Impairments in a Mouse Model of Parkinson's Disease.
    Li W, Goshima Y, Ohshima T.

    06/5/2021
    Results found that Crmp4-KO mice have abnormalities that are relevant to some phenotypes of human autism spectrum disorders (ASD). Accumulating evidence suggests that a disturbance in the regulatory function of CRMP4 in forming neuronal networks is an important aspect underlying some characteristics of ASD, including sexual differences. These findings provide CRMP4 as a novel candidate gene contributing to ASD.

    Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism.
    Tsutiya A, Nakano Y, Hansen-Kiss E, Kelly B, Nishihara M, Goshima Y, Corsmeier D, White P, Herman GE, Ohtani-Kaneko R., Free PMC Article

    07/20/2019
    Knockdown of DPYSL3 promoted the metastatic ability of Lewis lung carcinoma cells.

    Inhibition of cell-adhesion protein DPYSL3 promotes metastasis of lung cancer.
    Yang Y, Jiang Y, Xie D, Liu M, Song N, Zhu J, Fan J, Zhu C., Free PMC Article

    11/17/2018
    findings identify CRMP4 as a novel negative regulator of osteoblast differentiation.

    CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling.
    Abdallah BM, Figeac F, Larsen KH, Ditzel N, Keshari P, Isa A, Jafari A, Andersen TL, Delaisse JM, Goshima Y, Ohshima T, Kassem M.

    02/17/2018
    Crmp4 deletion promotes axonal growth and nociceptive recovery after spinal cord injury.

    Deletion of Crmp4 attenuates CSPG-induced inhibition of axonal growth and induces nociceptive recovery after spinal cord injury.
    Nagai J, Takaya R, Piao W, Goshima Y, Ohshima T.

    01/13/2018
    Results indicate that CRMP1 and CRMP4 regulate proper orientation of the basal dendrites of layer V neurons in the cerebral cortex during development.

    CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain.
    Takaya R, Nagai J, Piao W, Niisato E, Nakabayashi T, Yamazaki Y, Nakamura F, Yamashita N, Kolattukudy P, Goshima Y, Ohshima T.

    08/12/2017
    CRMP4-deficient mice show reduced inflammation and suppressed dopaminergic neuronal death in a model of Parkinson's disease.

    Loss of collapsin response mediator protein 4 suppresses dopaminergic neuron death in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease.
    Tonouchi A, Nagai J, Togashi K, Goshima Y, Ohshima T.

    06/10/2017
    our data suggest that disruption of CRMP4 produces a temporary alteration in the thickness of the external of the olfactory bulb, which is constituted mainly of mitral cell apical dendrites, through the enhanced growth of these dendrites

    Deletion of collapsin response mediator protein 4 results in abnormal layer thickness and elongation of mitral cell apical dendrites in the neonatal olfactory bulb.
    Tsutiya A, Watanabe H, Nakano Y, Nishihara M, Goshima Y, Ohtani-Kaneko R., Free PMC Article

    01/14/2017
    These results suggest that deletion of CRMP4 is a unique therapeutic strategy that overcomes two obstacles to CNS repair after SCI.

    Crmp4 deletion promotes recovery from spinal cord injury by neuroprotection and limited scar formation.
    Nagai J, Kitamura Y, Owada K, Yamashita N, Takei K, Goshima Y, Ohshima T., Free PMC Article

    11/28/2015
    CRMP4 inhibits prostate cancer cells growth in the nude mouse bone microenvironment.

    Upregulation of CRMP4, a new prostate cancer metastasis suppressor gene, inhibits tumor growth in a nude mouse intratibial injection model.
    Zhou W, Xie P, Pang M, Yang B, Fang Y, Shu T, Liu C, Wang X, Zhang L, Li S, Rong L.

    08/15/2015
    This study identified a dual role for CRMP4 in regulating the actin and microtubule growth cone cytoskeleton.

    Collapsin response mediator protein 4 regulates growth cone dynamics through the actin and microtubule cytoskeleton.
    Khazaei MR, Girouard MP, Alchini R, Ong Tone S, Shimada T, Bechstedt S, Cowan M, Guillet D, Wiseman PW, Brouhard G, Cloutier JF, Fournier AE., Free PMC Article

    02/14/2015
    In the human ortholog of Dpysl3, the association between the rs147541241 variant and amyotrophic lateral sclerosis was limited to the French population.

    A rare motor neuron deleterious missense mutation in the DPYSL3 (CRMP4) gene is associated with ALS.
    Blasco H, Bernard-Marissal N, Vourc'h P, Guettard YO, Sunyach C, Augereau O, Khederchah J, Mouzat K, Antar C, Gordon PH, Veyrat-Durebex C, Besson G, Andersen PM, Salachas F, Meininger V, Camu W, Pettmann B, Andres CR, Corcia P, French ALS Study Group..

    04/15/2014
    CRMP4 regulates the number of tyrosine hydroxylase immunoreactive neurons in the female anteroventral periventricular nucleus.

    Collapsin response mediator protein 4 affects the number of tyrosine hydroxylase-immunoreactive neurons in the sexually dimorphic nucleus in female mice.
    Iwakura T, Sakoh M, Tsutiya A, Yamashita N, Ohtani A, Tsuda MC, Ogawa S, Tsukahara S, Nishihara M, Shiga T, Goshima Y, Kato T, Ohtani-Kaneko R.

    02/1/2014
    Results suggest that CRMP4 suppresses apical dendrite bifurcation of CA1 pyramidal neurons in the mouse hippocampus and that this is partly dependent on Sema3A signaling.

    CRMP4 suppresses apical dendrite bifurcation of CA1 pyramidal neurons in the mouse hippocampus.
    Niisato E, Nagai J, Yamashita N, Abe T, Kiyonari H, Goshima Y, Ohshima T.

    04/13/2013
    MAG-mediated axon protection against VNC is suppressed in CRMP4-/- DRG neurons.

    CRMP4 mediates MAG-induced inhibition of axonal outgrowth and protection against Vincristine-induced axonal degeneration.
    Nagai J, Goshima Y, Ohshima T.

    11/3/2012
    Hypoxia-ischemia (HI)induces dephosphorylation of CRMPs (CRMP1, 2, and 5) in neonatal brain. Hypophosphorylated CRMPs might be implicated in the pathogenesis of HI-related neurological disorders.

    Proteomic analysis of neonatal mouse brain: evidence for hypoxia- and ischemia-induced dephosphorylation of collapsin response mediator proteins.
    Zhou Y, Bhatia I, Cai Z, He QY, Cheung PT, Chiu JF.

    01/21/2010
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