| RS 2247911 polymorphism of GPRC6A gene and serum undercarboxylated-osteocalcin are associated with testis function. | RS 2247911 polymorphism of GPRC6A gene and serum undercarboxylated-osteocalcin are associated with testis function.
Jawich K, Rocca MS, Al Fahoum S, Alhalabi M, Di Nisio A, Foresta C, Ferlin A, De Toni L. | 08/20/2022 |
| Explaining Divergent Observations Regarding Osteocalcin/GPRC6A Endocrine Signaling. | Explaining Divergent Observations Regarding Osteocalcin/GPRC6A Endocrine Signaling.
Pi M, Nishimoto SK, Darryl Quarles L., Free PMC Article | 10/23/2021 |
| Analysis of GPRC6A variants in different pancreatitis etiologies. | Analysis of GPRC6A variants in different pancreatitis etiologies.
Kaune T, Ruffert C, Hesselbarth N, Damm M, Krug S, Cardinal von Widdern J, Masson E, Chen JM, Rebours V, Buscail L, Férec C, Grützmann R, Te Morsche RHM, Drenth JP, Cavestro GM, Zuppardo RA, Saftoiu A, Malecka-Panas E, Głuszek S, Bugert P, Lerch MM, Sendler M, Weiss FU, Zou WB, Deng SJ, Liao Z, Scholz M, Kirsten H, Hegyi P, Witt H, Michl P, Griesmann H, Rosendahl J. | 09/18/2021 |
| Humanized GPRC6A(KGKY) is a gain-of-function polymorphism in mice. | Humanized GPRC6A(KGKY) is a gain-of-function polymorphism in mice.
Pi M, Xu F, Ye R, Nishimoto SK, Kesterson RA, Williams RW, Lu L, Quarles LD., Free PMC Article | 12/12/2020 |
| SHBG141-161 Domain-Peptide Stimulates GPRC6A-Mediated Response in Leydig and beta-Langerhans cell lines. | SHBG141-161 Domain-Peptide Stimulates GPRC6A-Mediated Response in Leydig and β-Langerhans cell lines.
De Toni L, Guidolin D, De Filippis V, Peterle D, Rocca MS, Di Nisio A, De Rocco Ponce M, Foresta C., Free PMC Article | 11/21/2020 |
| rs2274911 polymorphism in GPRC6A associated with serum E2 and PSA in a Southern Chinese male population. | rs2274911 polymorphism in GPRC6A associated with serum E2 and PSA in a Southern Chinese male population.
Qi N, Chen Y, Zeng Y, Bao M, Long X, Guo Y, Tan A, Gao Y, Zhang H, Yang X, Hu Y, Mo Z, Jiang Y. | 10/24/2020 |
| Human GPRC6A is required for mediating the effects of testosterone on cell proliferation and autophagy. | Human GPRC6A Mediates Testosterone-Induced Mitogen-Activated Protein Kinases and mTORC1 Signaling in Prostate Cancer Cells.
Ye R, Pi M, Nooh MM, Bahout SW, Quarles LD., Free PMC Article | 06/22/2019 |
| The G protein-coupled receptor family C group 6 member A (GPRC6A) and zinc transporter member 9 (ZIP9) have also been portrayed as mARs, related to the extranuclear action of androgens. | Membrane androgen receptors (OXER1, GPRC6A AND ZIP9) in prostate and breast cancer: A comparative study of their expression.
Kalyvianaki K, Panagiotopoulos AA, Malamos P, Moustou E, Tzardi M, Stathopoulos EN, Ioannidis GS, Marias K, Notas G, Theodoropoulos PA, Castanas E, Kampa M. | 06/8/2019 |
| If the regulatory functions of GPRC6A identified in mice translate to humans, and polymorphisms in GPRC6A are found to predict racial disparities in human diseases, GPRC6A may be a new gene target to predict, prevent, and treat MetS, PCa, and other disorders impacted by GPRC6A. | GPRC6A: Jack of all metabolism (or master of none).
Pi M, Nishimoto SK, Quarles LD., Free PMC Article | 10/20/2018 |
| Human GPRC6A is a functional osteocalcin and testosterone sensing receptor that promotes prostate cancer progression. | CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model.
Ye R, Pi M, Cox JV, Nishimoto SK, Quarles LD., Free PMC Article | 04/7/2018 |
| he nonrare polymorphism rs2274911 in the GPRC6A gene was associated with insulin resistance features, independently of the metabolic phenotype and osteocalcin levels. | The rs2274911 polymorphism in GPRC6A gene is associated with insulin resistance in normal weight and obese subjects.
Di Nisio A, Rocca MS, Fadini GP, De Toni L, Marcuzzo G, Marescotti MC, Sanna M, Plebani M, Vettor R, Avogaro A, Foresta C. | 09/23/2017 |
| Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function | Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function.
Jørgensen S, Have CT, Underwood CR, Johansen LD, Wellendorph P, Gjesing AP, Jørgensen CV, Quan S, Rui G, Inoue A, Linneberg A, Grarup N, Jun W, Pedersen O, Hansen T, Bräuner-Osborne H., Free PMC Article | 06/10/2017 |
| Osteocalcin and Sex Hormone Binding Globulin Compete on a Specific Binding Site of GPRC6A. | Osteocalcin and Sex Hormone Binding Globulin Compete on a Specific Binding Site of GPRC6A.
De Toni L, Guidolin D, De Filippis V, Tescari S, Strapazzon G, Santa Rocca M, Ferlin A, Plebani M, Foresta C. | 05/20/2017 |
| results suggest that G protein-coupled receptor class C group 6 member A(GPRC6A) inactivation or sub-function contributes to reduced exposure to androgens, leading to cryptorchidism during fetal life and/or low sperm production in adulthood | Polymorphism rs2274911 of GPRC6A as a Novel Risk Factor for Testis Failure.
De Toni L, Di Nisio A, Speltra E, Rocca MS, Ghezzi M, Zuccarello D, Turiaco N, Ferlin A, Foresta C. | 08/13/2016 |
| association of the THADA, FOXP4, GPRC6A/RFX6 and 8q24 genes with prostate cancer in Asian populations. | Association of THADA, FOXP4, GPRC6A/RFX6 genes and 8q24 risk alleles with prostate cancer in Northern Chinese men.
Li XH, Xu Y, Yang K, Shi JJ, Zhang X, Yang F, Yuan H, Zhu X, Zhang YH, Wang JY, Yang Z. | 01/16/2016 |
| The present experiments demonstrated a critical role for the GPRC6A-ERK1/2 and PI3K/Akt signaling pathway in arginine-mediated fibroblast survival. | L-arginine stimulates fibroblast proliferation through the GPRC6A-ERK1/2 and PI3K/Akt pathway.
Fujiwara T, Kanazawa S, Ichibori R, Tanigawa T, Magome T, Shingaki K, Miyata S, Tohyama M, Hosokawa K., Free PMC Article | 12/27/2014 |
| Duox1 activity is stimulated by testosterone through GPRC6A in skin keratinocytes | Testosterone stimulates Duox1 activity through GPRC6A in skin keratinocytes.
Ko E, Choi H, Kim B, Kim M, Park KN, Bae IH, Sung YK, Lee TR, Shin DW, Bae YS., Free PMC Article | 12/27/2014 |
| The F464Y substitution in GPRC6A may be a cause of primary testicular failure. | Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis.
Oury F, Ferron M, Huizhen W, Confavreux C, Xu L, Lacombe J, Srinivas P, Chamouni A, Lugani F, Lejeune H, Kumar TR, Plotton I, Karsenty G., Free PMC Article | 08/3/2013 |
| Extracellular Ca2+ activates the NLRP3 inflammasome via CaSR and GPRC6A. | Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors.
Rossol M, Pierer M, Raulien N, Quandt D, Meusch U, Rothe K, Schubert K, Schöneberg T, Schaefer M, Krügel U, Smajilovic S, Bräuner-Osborne H, Baerwald C, Wagner U., Free PMC Article | 06/8/2013 |
| the GPRC6A receptor functions as an amino acid sensor in GLUTag cells that promotes GLP-1 secretion | The G protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells.
Oya M, Kitaguchi T, Pais R, Reimann F, Gribble F, Tsuboi T., Free PMC Article | 05/4/2013 |
| Our results provide further support for association of the C2orf43, FOXP4, GPRC6A and RFX6 genes with prostate cancer in Eastern Asian populations | Replication and fine mapping for association of the C2orf43, FOXP4, GPRC6A and RFX6 genes with prostate cancer in the Chinese population.
Long QZ, Du YF, Ding XY, Li X, Song WB, Yang Y, Zhang P, Zhou JP, Liu XG., Free PMC Article | 12/22/2012 |
| GPRC6A is a novel molecular target for regulating prostate growth and cancer progression. | GPRC6A regulates prostate cancer progression.
Pi M, Quarles LD., Free PMC Article | 03/17/2012 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.
Takata R, Akamatsu S, Kubo M, Takahashi A, Hosono N, Kawaguchi T, Tsunoda T, Inazawa J, Kamatani N, Ogawa O, Fujioka T, Nakamura Y, Nakagawa H. | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density.
Giroux S, Elfassihi L, Clément V, Bussières J, Bureau A, Cole DE, Rousseau F. | 09/15/2010 |
| that GPRC6A gene polymorphisms were significantly associated with human spine BMD. | Impaired osteoblast function in GPRC6A null mice.
Pi M, Zhang L, Lei SF, Huang MZ, Zhu W, Zhang J, Shen H, Deng HW, Quarles LD., Free PMC Article | 09/6/2010 |