| Adipose tissue peroxisomal lipid synthesis orchestrates obesity and insulin resistance through LXR-dependent lipogenesis. | Adipose tissue peroxisomal lipid synthesis orchestrates obesity and insulin resistance through LXR-dependent lipogenesis.
Kleiboeker B, He A, Tan M, Lu D, Hu D, Liu X, Goodarzi P, Hsu FF, Razani B, Semenkovich CF, Lodhi IJ., Free PMC Article | 04/4/2024 |
| Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages. | Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages.
Zhang R, Dong Y, Liu Y, Moezzi D, Ghorbani S, Mirzaei R, Lozinski BM, Dunn JF, Yong VW, Xue M., Free PMC Article | 01/3/2024 |
| Activation of NR1H3 signaling pathways by psoralidin attenuates septic myocardial injury. | Activation of NR1H3 signaling pathways by psoralidin attenuates septic myocardial injury.
Yang Y, Lei W, Qian L, Zhang S, Yang W, Lu C, Song Y, Liang Z, Deng C, Chen Y, Tian Y, Zhao H. | 06/15/2023 |
| Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages. | Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages.
van Wouw SAE, van den Berg M, El Ouraoui M, Meurs A, Kingma J, Ottenhoff R, Loix M, Hoeksema MA, Prange K, Pasterkamp G, Hendriks JJA, Bogie JFJ, van Klinken JB, Vaz FM, Jongejan A, de Winther MPJ, Zelcer N., Free PMC Article | 02/28/2023 |
| Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1. | Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1.
Kim J, Lee H, Lee JE, Choi G, Chung H, Kim D, Park MJ, Gye YS, Shin KS, Kang CY, Kwok SK, Chung Y., Free PMC Article | 02/23/2023 |
| Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRalpha. | Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRα.
Kain J, Wei X, Reddy NA, Price AJ, Woods C, Bochkis IM., Free PMC Article | 03/26/2022 |
| Liver X receptors regulate natural killer T cell population and antitumor activity in the liver of mice. | Liver X receptors regulate natural killer T cell population and antitumor activity in the liver of mice.
Endo-Umeda K, Nakashima H, Uno S, Toyoshima S, Umeda N, Komine-Aizawa S, Seki S, Makishima M., Free PMC Article | 03/12/2022 |
| Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner. | Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner.
Bogie JFJ, Vanmierlo T, Vanmol J, Timmermans S, Mailleux J, Nelissen K, Wijnands E, Wouters K, Stinissen P, Gustafsson JÅ, Steffensen KR, Mulder M, Zelcer N, Hendriks JJA. | 03/12/2022 |
| Hepatic lysosomal acid lipase drives the autophagy-lysosomal response and alleviates cholesterol metabolic disorder in ApoE deficient mice. | Hepatic lysosomal acid lipase drives the autophagy-lysosomal response and alleviates cholesterol metabolic disorder in ApoE deficient mice.
Li F, Zhao X, Li H, Liu Y, Zhang Y, Huang X, Cao J, Du F, Wu D, Yu H. | 01/8/2022 |
| SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1. | SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1.
Zhu C, Huang M, Kim HG, Chowdhury K, Gao J, Liu S, Wan J, Wei L, Dong XC., Free PMC Article | 01/1/2022 |
| Myeloid-Derived Suppressive Cells Deficient in Liver X Receptor alpha Protected From Autoimmune Hepatitis. | Myeloid-Derived Suppressive Cells Deficient in Liver X Receptor α Protected From Autoimmune Hepatitis.
Li B, Lian M, Li Y, Qian Q, Zhang J, Liu Q, Tang R, Ma X., Free PMC Article | 12/25/2021 |
| Crosstalk Between LXR and Caveolin-1 Signaling Supports Cholesterol Efflux and Anti-Inflammatory Pathways in Macrophages. | Crosstalk Between LXR and Caveolin-1 Signaling Supports Cholesterol Efflux and Anti-Inflammatory Pathways in Macrophages.
Ramírez CM, Torrecilla-Parra M, Pardo-Marqués V, de-Frutos MF, Pérez-García A, Tabraue C, de la Rosa JV, Martín-Rodriguez P, Díaz-Sarmiento M, Nuñez U, Orizaola MC, Través PG, Camps M, Boscá L, Castrillo A., Free PMC Article | 12/25/2021 |
| Liver X Receptor Alpha Activation Inhibits Autophagy and Lipophagy in Hepatocytes by Dysregulating Autophagy-Related 4B Cysteine Peptidase and Rab-8B, Reducing Mitochondrial Fuel Oxidation. | Liver X Receptor Alpha Activation Inhibits Autophagy and Lipophagy in Hepatocytes by Dysregulating Autophagy-Related 4B Cysteine Peptidase and Rab-8B, Reducing Mitochondrial Fuel Oxidation.
Kim YS, Nam HJ, Han CY, Joo MS, Jang K, Jun DW, Kim SG. | 10/16/2021 |
| Differential Role of Liver X Receptor (LXR) alpha and LXRbeta in the Regulation of UDP-Glucuronosyltransferase 1A1 in Humanized UGT1 Mice. | Differential Role of Liver X Receptor (LXR) α and LXRβ in the Regulation of UDP-Glucuronosyltransferase 1A1 in Humanized UGT1 Mice.
Hansmann E, Mennillo E, Yoda E, Verreault M, Barbier O, Chen S, Tukey RH., Free PMC Article | 07/24/2021 |
| Purification, characterization and anti-atherosclerotic effects of the polysaccharides from the fruiting body of Cordyceps militaris. | Purification, characterization and anti-atherosclerotic effects of the polysaccharides from the fruiting body of Cordyceps militaris.
Yang X, Lin P, Wang J, Liu N, Yin F, Shen N, Guo S. | 07/24/2021 |
| Liver X receptors are required for thymic resilience and T cell output. | Liver X receptors are required for thymic resilience and T cell output.
Chan CT, Fenn AM, Harder NK, Mindur JE, McAlpine CS, Patel J, Valet C, Rattik S, Iwamoto Y, He S, Anzai A, Kahles F, Poller WC, Janssen H, Wong LP, Fernandez-Hernando C, Koolbergen DR, van der Laan AM, Yvan-Charvet L, Sadreyev RI, Nahrendorf M, Westerterp M, Tall AR, Gustafsson JA, Swirski FK., Free PMC Article | 03/13/2021 |
| Macrophage Lxralpha reduces atherosclerosis in Ldlr(-/-) mice independent of Arl7 transactivation. | Macrophage Lxrα reduces atherosclerosis in Ldlr(-/-) mice independent of Arl7 transactivation.
Yin Y, Zeng S, Li Y, Wu Z, Huang D, Gao P. | 02/27/2021 |
| LXRalpha Regulates ChREBPalpha Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction. | LXRα Regulates ChREBPα Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction.
Fan Q, Nørgaard RC, Grytten I, Ness CM, Lucas C, Vekterud K, Soedling H, Matthews J, Lemma RB, Gabrielsen OS, Bindesbøll C, Ulven SM, Nebb HI, Grønning-Wang LM, Sæther T., Free PMC Article | 02/27/2021 |
| Stigmasterol stimulates transintestinal cholesterol excretion independent of liver X receptor activation in the small intestine. | Stigmasterol stimulates transintestinal cholesterol excretion independent of liver X receptor activation in the small intestine.
Lifsey HC, Kaur R, Thompson BH, Bennett L, Temel RE, Graf GA., Free PMC Article | 02/13/2021 |
| Liver X Receptor Activation Impairs Neutrophil Functions and Aggravates Sepsis. | Liver X Receptor Activation Impairs Neutrophil Functions and Aggravates Sepsis.
Souto FO, Castanheira FVS, Trevelin SC, Lima BHF, Cebinelli GCM, Turato WM, Auxiliadora-Martins M, Basile-Filho A, Alves-Filho JC, Cunha FQ. | 02/6/2021 |
| LXR activation radiosensitizes non-small cell lung cancer by restricting myeloid-derived suppressor cells. | LXR activation radiosensitizes non-small cell lung cancer by restricting myeloid-derived suppressor cells.
Liang H, Shen X. | 01/16/2021 |
| Neuronal LXR Regulates Neuregulin 1 Expression and Sciatic Nerve-Associated Cell Signaling in Western Diet-fed Rodents. | Neuronal LXR Regulates Neuregulin 1 Expression and Sciatic Nerve-Associated Cell Signaling in Western Diet-fed Rodents.
Gavini CK, Bonomo R, Mansuy-Aubert V., Free PMC Article | 11/28/2020 |
| Identification of the fructose transporter GLUT5 (SLC2A5) as a novel target of nuclear receptor LXR. | Identification of the fructose transporter GLUT5 (SLC2A5) as a novel target of nuclear receptor LXR.
Zwarts I, van Zutphen T, Kruit JK, Liu W, Oosterveer MH, Verkade HJ, Uhlenhaut NH, Jonker JW., Free PMC Article | 10/31/2020 |
| Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function. | Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function.
Wouters E, de Wit NM, Vanmol J, van der Pol SMA, van Het Hof B, Sommer D, Loix M, Geerts D, Gustafsson JA, Steffensen KR, Vanmierlo T, Bogie JFJ, Hendriks JJA, de Vries HE., Free PMC Article | 10/3/2020 |
| impaired Ser196-LXRalpha phosphorylation acts as a novel nutritional molecular sensor that profoundly alters the hepatic H3K27 acetylome and transcriptome during NAFLD progression placing LXRalpha phosphorylation as an alternative anti-inflammatory or anti-fibrotic therapeutic target. | Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease.
Becares N, Gage MC, Voisin M, Shrestha E, Martin-Gutierrez L, Liang N, Louie R, Pourcet B, Pello OM, Luong TV, Goñi S, Pichardo-Almarza C, Røberg-Larsen H, Diaz-Zuccarini V, Steffensen KR, O'Brien A, Garabedian MJ, Rombouts K, Treuter E, Pineda-Torra I., Free PMC Article | 03/7/2020 |