| Impact of allele-selective silencing of von Willebrand factor in mice based on a single nucleotide allelic difference in von Willebrand factor. | Impact of allele-selective silencing of von Willebrand factor in mice based on a single nucleotide allelic difference in von Willebrand factor.
Jongejan YK, Linthorst NA, Schrader Echeverri E, Laan SNJ, Dirven RJ, Dahlman JE, van Vlijmen BJM, Denis CV, Eikenboom JCJ. | 04/4/2024 |
| Regulation of von Willebrand factor by ADAMTS13 ameliorates lipopolysaccharide-induced lung injury in mice. | Regulation of von Willebrand factor by ADAMTS13 ameliorates lipopolysaccharide-induced lung injury in mice.
Onodera Y, Mitani S, Hosoda C, Takabayashi Y, Sakata A, Kawasaki R, Mori R, Ohshima C, Nishio K, Sugimoto M, Soejima K, Mackman N, Shima M, Tatsumi K. | 11/30/2023 |
| von Willebrand factor modulates immune complexes and the recall response against factor VIII in a murine hemophilia A model. | von Willebrand factor modulates immune complexes and the recall response against factor VIII in a murine hemophilia A model.
Oleshko O, Vollack-Hesse N, Tiede A, Hegermann J, Curth U, Werwitzke S., Free PMC Article | 11/8/2023 |
| von Willebrand Factor: A Central Regulator of Arteriovenous Fistula Maturation Through Smooth Muscle Cell Proliferation and Outward Remodeling. | von Willebrand Factor: A Central Regulator of Arteriovenous Fistula Maturation Through Smooth Muscle Cell Proliferation and Outward Remodeling.
Laboyrie SL, de Vries MR, de Jong A, de Boer HC, Lalai RA, Martinez L, Vazquez-Padron RI, Rotmans JI., Free PMC Article | 08/27/2022 |
| Dual Targeting of Angipoietin-1 and von Willebrand Factor by microRNA-671-5p Attenuates Liver Angiogenesis and Fibrosis. | Dual Targeting of Angipoietin-1 and von Willebrand Factor by microRNA-671-5p Attenuates Liver Angiogenesis and Fibrosis.
Yang L, Yue W, Zhang H, Zhang Z, Xue R, Dong C, Liu F, Chang N, Yang L, Li L., Free PMC Article | 06/11/2022 |
| Von Willebrand factor exerts hepatoprotective effects in acute but not chronic cholestatic liver injury in mice. | Von Willebrand factor exerts hepatoprotective effects in acute but not chronic cholestatic liver injury in mice.
Poole LG, Fournier AK, Cline-Fedewa HM, Kopec AK, Luyendyk JP, Groeneveld DJ., Free PMC Article | 01/1/2022 |
| Involvement of von Willebrand factor and botrocetin in the thrombocytopenia induced by Bothrops jararaca snake venom. | Involvement of von Willebrand factor and botrocetin in the thrombocytopenia induced by Bothrops jararaca snake venom.
Thomazini CM, Sachetto ATA, de Albuquerque CZ, de Moura Mattaraia VG, de Oliveira AK, Serrano SMT, Lebrun I, Barbaro KC, Santoro ML., Free PMC Article | 12/18/2021 |
| Acrolein Induces Systemic Coagulopathy via Autophagy-dependent Secretion of von Willebrand Factor in Mice after Traumatic Brain Injury. | Acrolein Induces Systemic Coagulopathy via Autophagy-dependent Secretion of von Willebrand Factor in Mice after Traumatic Brain Injury.
Cui W, Wu X, Feng D, Luo J, Shi Y, Guo W, Liu H, Wang Q, Wang L, Ge S, Qu Y., Free PMC Article | 09/11/2021 |
| von Willebrand factor variant D1472H has no effect in mice with humanized VWF-platelet interactions. | von Willebrand factor variant D1472H has no effect in mice with humanized VWF-platelet interactions.
Lohmeier HK, Slobodianuk TL, Kanaji S, Haberichter SL, Montgomery RR, Flood VH., Free PMC Article | 07/10/2021 |
| Von Willebrand factor delays liver repair after acetaminophen-induced acute liver injury in mice. | Von Willebrand factor delays liver repair after acetaminophen-induced acute liver injury in mice.
Groeneveld D, Cline-Fedewa H, Baker KS, Williams KJ, Roth RA, Mittermeier K, Lisman T, Palumbo JS, Luyendyk JP., Free PMC Article | 06/5/2021 |
| Conformation-dependent blockage of activated VWF improves outcomes of traumatic brain injury in mice. | Conformation-dependent blockage of activated VWF improves outcomes of traumatic brain injury in mice.
Xu X, Wang C, Wu Y, Houck K, Hilton T, Zhou A, Wu X, Han C, Yang M, Yang W, Shi FD, Stolla M, Cruz MA, Li M, Zhang J, Dong JF., Free PMC Article | 05/29/2021 |
| The Commensal Microbiota Enhances ADP-Triggered Integrin alphaIIbbeta3 Activation and von Willebrand Factor-Mediated Platelet Deposition to Type I Collagen. | The Commensal Microbiota Enhances ADP-Triggered Integrin α(IIb)β(3) Activation and von Willebrand Factor-Mediated Platelet Deposition to Type I Collagen.
Kiouptsi K, Jäckel S, Wilms E, Pontarollo G, Winterstein J, Karwot C, Groß K, Jurk K, Reinhardt C., Free PMC Article | 02/27/2021 |
| Endothelial CD40 Mediates Microvascular von Willebrand Factor-Dependent Platelet Adhesion Inducing Inflammatory Venothrombosis in ADAMTS13 Knockout Mice. | Endothelial CD40 Mediates Microvascular von Willebrand Factor-Dependent Platelet Adhesion Inducing Inflammatory Venothrombosis in ADAMTS13 Knockout Mice.
Tahir S, Wagner AH, Dietzel S, Mannell H, Pircher J, Weckbach LT, Hecker M, Pohl U. | 12/26/2020 |
| von Willebrand Factor Is a Critical Mediator of Deep Vein Thrombosis in a Mouse Model of Diet-Induced Obesity. | von Willebrand Factor Is a Critical Mediator of Deep Vein Thrombosis in a Mouse Model of Diet-Induced Obesity.
Michels A, Dwyer CN, Mewburn J, Nesbitt K, Kawecki C, Lenting P, Swystun LL, Lillicrap D. | 12/19/2020 |
| Hemophilia A and B mice, but not VWF(-/-)mice, display bone defects in congenital development and remodeling after injury. | Hemophilia A and B mice, but not VWF(-/-)mice, display bone defects in congenital development and remodeling after injury.
Taves S, Sun J, Livingston EW, Chen X, Amiaud J, Brion R, Hannah WB, Bateman TA, Heymann D, Monahan PE., Free PMC Article | 11/21/2020 |
| Functional regulation of von Willebrand factor ameliorates acute ischemia-reperfusion kidney injury in mice. | Functional regulation of von Willebrand factor ameliorates acute ischemia-reperfusion kidney injury in mice.
Ono S, Matsui H, Noda M, Kasuda S, Yada N, Yoshimoto K, Akiyama M, Miyata T, Sugimoto M, Nishio K., Free PMC Article | 10/31/2020 |
| Synergic effect of GPIBA and von Willebrand factor in pathogenesis of deep vein thrombosis. | Synergic effect of GPIBA and von Willebrand factor in pathogenesis of deep vein thrombosis.
Li D, Zhang X, Zhang H, Li X. | 09/19/2020 |
| VWF deficiency is associated with elevated reticulocyte production following malaria infection, which leads to an increase in parasite load and malaria-associated acute respiratory distress syndrome. | von Willebrand factor in experimental malaria-associated acute respiratory distress syndrome.
Kraisin S, Verhenne S, Pham TT, Martinod K, Tersteeg C, Vandeputte N, Deckmyn H, Vanhoorelbeke K, Van den Steen PE, De Meyer SF., Free PMC Article | 07/18/2020 |
| The findings identify Tspan18 as a novel regulator of endothelial cell Orai1/Ca2+ signaling and von Willebrand factor release in response to inflammatory stimuli. | Tspan18 is a novel regulator of the Ca(2+) channel Orai1 and von Willebrand factor release in endothelial cells.
Noy PJ, Gavin RL, Colombo D, Haining EJ, Reyat JS, Payne H, Thielmann I, Lokman AB, Neag G, Yang J, Lloyd T, Harrison N, Heath VL, Gardiner C, Whitworth KM, Robinson J, Koo CZ, Di Maio A, Harrison P, Lee SP, Michelangeli F, Kalia N, Rainger GE, Nieswandt B, Brill A, Watson SP, Tomlinson MG., Free PMC Article | 06/20/2020 |
| Heart and lung endothelial cells demonstrate VWF upregulation in response to hypoxia, using distinct mechanisms, while this response is lacking in kidney endothelial cells | Endothelial cells of different organs exhibit heterogeneity in von Willebrand factor expression in response to hypoxia.
Mojiri A, Alavi P, Lorenzana Carrillo MA, Nakhaei-Nejad M, Sergi CM, Thebaud B, Aird WC, Jahroudi N. | 05/16/2020 |
| Developed a murine model of defective VWF-collagen IV interactions with VWF variant p.R1399H with decreased binding to collagen IV and increased bleeding times. | Defective collagen binding and increased bleeding in a murine model of von Willebrand disease affecting collagen IV binding.
Slobodianuk TL, Kochelek C, Foeckler J, Kalloway S, Weiler H, Flood VH., Free PMC Article | 04/18/2020 |
| the heparin-binding domain within the VWF A1 domain can function as a growth factor reservoir, leading to effective angiogenesis and tissue regeneration. | The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing.
Ishihara J, Ishihara A, Starke RD, Peghaire CR, Smith KE, McKinnon TAJ, Tabata Y, Sasaki K, White MJV, Fukunaga K, Laffan MA, Lutolf MP, Randi AM, Hubbell JA., Free PMC Article | 01/11/2020 |
| VWF is involved in the pathogenesis of early brain injury following subarachnoid hemorrhage. | Role of von Willebrand factor and ADAMTS-13 in early brain injury after experimental subarachnoid hemorrhage.
Wan H, Wang Y, Ai J, Brathwaite S, Ni H, Macdonald RL, Hol EM, Meijers JCM, Vergouwen MDI., Free PMC Article | 09/21/2019 |
| VWF promotes neutrophil recruitment in ischaemic mouse liver | Von Willebrand Factor Aggravates Hepatic Ischemia-Reperfusion Injury by Promoting Neutrophil Recruitment in Mice.
Urisono Y, Sakata A, Matsui H, Kasuda S, Ono S, Yoshimoto K, Nishio K, Sho M, Akiyama M, Miyata T, Okuchi K, Nishimura S, Sugimoto M. | 08/3/2019 |
| This study uncovers a novel synergistic action between VWF and cellular microvesicles in TBI-induced vascular leakage and coagulopathy and demonstrates protective effects of rADAMTS-13. | von Willebrand factor enhances microvesicle-induced vascular leakage and coagulopathy in mice with traumatic brain injury.
Wu Y, Liu W, Zhou Y, Hilton T, Zhao Z, Liu W, Wang M, Yeon J, Houck K, Thiagarajan P, Zhang F, Shi FD, Wu X, Li M, Dong JF, Zhang J., Free PMC Article | 07/20/2019 |