| Glypican-4 serum levels are associated with cognitive dysfunction and vascular risk factors in Parkinson's disease. | Glypican-4 serum levels are associated with cognitive dysfunction and vascular risk factors in Parkinson's disease.
Tatenhorst L, Maass F, Paul H, Dambeck V, Bähr M, Dono R, Lingor P., Free PMC Article | 03/5/2024 |
| Circulating glypican-4 is a new predictor of all-cause mortality in patients with heart failure. | Circulating glypican-4 is a new predictor of all-cause mortality in patients with heart failure.
Muendlein A, Heinzle C, Leiherer A, Brandtner EM, Geiger K, Gaenger S, Fraunberger P, Mader A, Saely CH, Drexel H. | 12/5/2023 |
| The Shear Stress-Regulated Expression of Glypican-4 in Endothelial Dysfunction In Vitro and Its Clinical Significance in Atherosclerosis. | The Shear Stress-Regulated Expression of Glypican-4 in Endothelial Dysfunction In Vitro and Its Clinical Significance in Atherosclerosis.
Urschel K, Hug KP, Zuo H, Büttner M, Furtmair R, Kuehn C, Stumpfe FM, Botos B, Achenbach S, Yuan Y, Dietel B, Tauchi M., Free PMC Article | 08/19/2023 |
| Serum glypican-4 is associated with the 10-year clinical outcome of patients with peripheral artery disease. | Serum glypican-4 is associated with the 10-year clinical outcome of patients with peripheral artery disease.
Muendlein A, Heinzle C, Leiherer A, Geiger K, Brandtner EM, Gaenger S, Fraunberger P, Saely CH, Drexel H. | 10/22/2022 |
| Serum glypican-4 is a marker of future vascular risk and mortality in coronary angiography patients. | Serum glypican-4 is a marker of future vascular risk and mortality in coronary angiography patients.
Muendlein A, Brandtner EM, Leiherer A, Geiger K, Heinzle C, Gaenger S, Fraunberger P, Mader A, Saely CH, Drexel H. | 03/26/2022 |
| Downregulation of glypican-4 facilitates breast cancer progression by inducing cell migration and proliferation. | Downregulation of glypican-4 facilitates breast cancer progression by inducing cell migration and proliferation.
Munir J, Van Ngu T, Na Ayudthaya PD, Ryu S. | 11/28/2020 |
| The GPC4 gene polymorphism is associated with susceptibility to EBV-positive NPC. The CC genotype of GPC4 may represent a risk factor for NPC in Northern China. | The Glypican-4 Gene Polymorphism rs1048369 and Susceptibility to Epstein-Barr Virus-Positive and -Negative Nasopharyngeal Carcinoma in Northern China.
Liu S, Liu W, Zhao D, Zhang Y, Zhao Z, Luo B. | 04/4/2020 |
| Pathogenic variants in GPC4 gene are associated with Keipert Syndrome. | Pathogenic Variants in GPC4 Cause Keipert Syndrome.
Amor DJ, Stephenson SEM, Mustapha M, Mensah MA, Ockeloen CW, Lee WS, Tankard RM, Phelan DG, Shinawi M, de Brouwer APM, Pfundt R, Dowling C, Toler TL, Sutton VR, Agolini E, Rinelli M, Capolino R, Martinelli D, Zampino G, Dumić M, Reardon W, Shaw-Smith C, Leventer RJ, Delatycki MB, Kleefstra T, Mundlos S, Mortier G, Bahlo M, Allen NJ, Lockhart PJ., Free PMC Article | 02/8/2020 |
| Results indicate a CD36-glypcian 4 (GPC4)-beta-catenin-c-myc signaling axis that regulates glycolysis in colorectal cancer (CRC) development and may provide an intervention strategy for CRC prevention. | CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis.
Fang Y, Shen ZY, Zhan YZ, Feng XC, Chen KL, Li YS, Deng HJ, Pan SM, Wu DH, Ding Y., Free PMC Article | 01/4/2020 |
| serum concentrations significantly increased in metabolic syndrome patients | Serum Glypican 4 Levels Are Associated with Metabolic Syndrome in a Han Population from Guizhou Province, China.
Ning DP, Xu K, Zhu HJ, Shan GL, Wang DM, Ping B, Yu YW, Pan H, Gong FY. | 08/10/2019 |
| The T allele of GPC4 may represent a risk factor for Epstein-Barr virus-associated gastric carcinoma. | Glypican-4 gene polymorphism (rs1048369) and susceptibility to Epstein-Barr virus-associated and -negative gastric carcinoma.
Zhao D, Liu S, Sun L, Zhao Z, Liu S, Kuang X, Shu J, Luo B. | 12/9/2017 |
| According to behavioral studies, downregulation of Gpc4 by Gpc4 siRNA decreased spontaneous seizure frequency, while upregulation of Gpc4 by recombinant Gpc4 overexpression led to a converse result. These findings support the hypothesis that increased expression of Gpc4 in the brain is associated with epileptic seizures. | Expression of Glypican-4 in the brains of epileptic patients and epileptic animals and its effects on epileptic seizures.
Xiong Y, Zhang Y, Zheng F, Yang Y, Xu X, Wang W, Zhu B, Wang X. | 05/27/2017 |
| serum level elevated in polycystic ovary syndrome and correlated with fat distribution and cardiovascular risk | Association of serum glypican-4 levels with cardiovascular risk predictors in women with polycystic ovary syndrome - a pilot study.
Jędrzejuk D, Lwow F, Kuliczkowska-Płaksej J, Hirnle L, Trzmiel-Bira A, Lenarcik-Kabza A, Kolackov K, Łaczmański Ł, Milewicz A. | 12/17/2016 |
| Data suggest gender difference in circulating GPC4 levels in nonalcoholic fatty liver disease; GPC4 levels in women appear to correlate with cardiometabolic risk factors (adiposity/body fat distribution, insulin resistance, and arterial stiffness). | Association of glypican-4 with body fat distribution, insulin resistance, and nonalcoholic fatty liver disease.
Yoo HJ, Hwang SY, Cho GJ, Hong HC, Choi HY, Hwang TG, Kim SM, Blüher M, Youn BS, Baik SH, Choi KM. | 10/19/2013 |
| new function of miR-125a by targeting gene glypican-4 in cell growth process | MicroRNA-125a inhibits cell growth by targeting glypican-4.
Feng C, Li J, Ruan J, Ding K. | 01/26/2013 |
| Findings establish that Gpc4 acts at the interface of extrinsic and intrinsic signal regulation to fine tune stem cell fate. | Modulating Glypican4 suppresses tumorigenicity of embryonic stem cells while preserving self-renewal and pluripotency.
Fico A, De Chevigny A, Egea J, Bösl MR, Cremer H, Maina F, Dono R. | 01/26/2013 |