| Wnt11 in regulation of physiological and pathological cardiac growth. | Wnt11 in regulation of physiological and pathological cardiac growth.
Halmetoja E, Nagy I, Szabo Z, Alakoski T, Yrjölä R, Vainio L, Viitavaara E, Lin R, Rahtu-Korpela L, Vainio S, Kerkelä R, Magga J. | 10/1/2022 |
| WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion. | WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion.
Rodriguez-Hernandez I, Maiques O, Kohlhammer L, Cantelli G, Perdrix-Rosell A, Monger J, Fanshawe B, Bridgeman VL, Karagiannis SN, Penin RM, Marcolval J, Marti RM, Matias-Guiu X, Fruhwirth GO, Orgaz JL, Malanchi I, Sanz-Moreno V., Free PMC Article | 11/28/2020 |
| Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment. | Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment.
O'Brien LL, Combes AN, Short KM, Lindström NO, Whitney PH, Cullen-McEwen LA, Ju A, Abdelhalim A, Michos O, Bertram JF, Smyth IM, Little MH, McMahon AP., Free PMC Article | 03/16/2019 |
| Study utilizing mouse kidney cultures and time-lapse imaging provided quantitative experimental support that a ligand-receptor-based Turing mechanism, implemented via GDNF-RET signaling, specifies the areas of outgrowth during kidney branching morphogenesis. The positive feedback between GDNF and WNT11 enables the dense packing of the ureteric buds. | Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback.
Menshykau D, Michos O, Lang C, Conrad L, McMahon AP, Iber D., Free PMC Article | 02/23/2019 |
| These studies revealed a previously unappreciated role for WNT11 for dorsal mesenchymal protrusion (DMP) formation and distinct tissue-specific requirements for WNT11 in outflow tract and DMP development. | Tissue specific requirements for WNT11 in developing outflow tract and dorsal mesenchymal protrusion.
van Vliet PP, Lin L, Boogerd CJ, Martin JF, Andelfinger G, Grossfeld PD, Evans SM., Free PMC Article | 10/14/2017 |
| Wnt4 and Wnt11 cooperatively contribute to mammalian neuromuscular junction formation. | Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways.
Messéant J, Ezan J, Delers P, Glebov K, Marchiol C, Lager F, Renault G, Tissir F, Montcouquiol M, Sans N, Legay C, Strochlic L. | 09/16/2017 |
| Results provide evidence that Wnt11 is involved in the organization of kidney tubules through the planar cell polarity pathway taking part in fine-tuning of nephrogenesis. | Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis.
Nagy II, Xu Q, Naillat F, Ali N, Miinalainen I, Samoylenko A, Vainio SJ., Free PMC Article | 09/9/2017 |
| under tensile stress, miR-154-5p negatively regulates ADSCs osteogenic differentiation through the Wnt/PCP pathway by directly targeting Wnt11 | MiR-154-5p regulates osteogenic differentiation of adipose-derived mesenchymal stem cells under tensile stress through the Wnt/PCP pathway by targeting Wnt11.
Li J, Hu C, Han L, Liu L, Jing W, Tang W, Tian W, Long J. | 04/9/2016 |
| a mechanistic link between E-cadherin loss and subsequent control of Rho-driven anoikis resistance through p120- and Kaiso-dependent expression of Wnt11, is reported. | Nuclear p120-catenin regulates the anoikis resistance of mouse lobular breast cancer cells through Kaiso-dependent Wnt11 expression.
van de Ven RA, Tenhagen M, Meuleman W, van Riel JJ, Schackmann RC, Derksen PW., Free PMC Article | 02/27/2016 |
| Studied groups of embryoid bodies (EBs) with different starting numbers of ESCs & found differential gene expression patterns for Wnt5a & Wnt11. Wnt11 inc'd the percentage of beating EBs by upregulating expression of cardiac-specific genes. | Enrichment of cardiac differentiation by a large starting number of embryonic stem cells in embryoid bodies is mediated by the Wnt11-JNK pathway.
Chen M, Qian C, Bi LL, Zhao F, Zhang GY, Wang ZQ, Gan XD, Wang YG. | 12/5/2015 |
| Data show that Wnt5a and Wnt11 are required for proper patterning of the neural tube and somites by regulating notochord formation. | Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation.
Andre P, Song H, Kim W, Kispert A, Yang Y., Free PMC Article | 07/25/2015 |
| These results provide formal genetic proof that the majority of the endocardium and myocardium diverge by mid-gastrulation in the mouse, and suggest a tight spatial and temporal control of Wnt11 expression in the myocardial lineage. | Mapping the dynamic expression of Wnt11 and the lineage contribution of Wnt11-expressing cells during early mouse development.
Sinha T, Lin L, Li D, Davis J, Evans S, Wynshaw-Boris A, Wang J., Free PMC Article | 04/11/2015 |
| Wnt5a/Wnt11 inhibit beta-catenin to promote SHF development through Caspase-dependent Akt degradation | Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT.
Bisson JA, Mills B, Paul Helt JC, Zwaka TP, Cohen ED. | 03/21/2015 |
| Notch1-induced WISP-1 expression appeared to be Wnt11-dependent, but Wnt1-independent | Inhibition of fibroblast growth by Notch1 signaling is mediated by induction of Wnt11-dependent WISP-1.
Liu ZJ, Li Y, Tan Y, Xiao M, Zhang J, Radtke F, Velazquez OC., Free PMC Article | 02/14/2015 |
| The apical and basolateral secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by different mechanisms. | The apical and basolateral secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by different mechanisms.
Yamamoto H, Awada C, Hanaki H, Sakane H, Tsujimoto I, Takahashi Y, Takao T, Kikuchi A. | 01/18/2014 |
| demonstrates that the combination of Wnt11 and BMP-2 effectively promotes cardiomyogenic differentiation of BM-MSCs in vitro. The synergistic effect of Wnt11 and BMP-2 on the cardiomyogenic differentiation of BM-MSCs is further enhanced in myocardium | Efficient cardiomyogenic differentiation of bone marrow mesenchymal stromal cells by combination of Wnt11 and bone morphogenetic protein 2.
Zhang Z, Li H, Ma Z, Feng J, Gao P, Dong H, Zhang Z. | 10/27/2012 |
| all the TGF-beta, Wnt11, and JNK targets were activated in a unilateral ureteral obstruction (UUO) model of renal fibrosis in vivo. | Activation of Wnt11 by transforming growth factor-β drives mesenchymal gene expression through non-canonical Wnt protein signaling in renal epithelial cells.
Zhang P, Cai Y, Soofi A, Dressler GR., Free PMC Article | 08/25/2012 |
| Transplantation of MSC(Wnt11) improved cardiac function. The release of Wnt11 and other factors from transplanted MSC(Wnt11) is more likely responsible for protection of native CM at risk. | Paracrine effect of Wnt11-overexpressing mesenchymal stem cells on ischemic injury.
Zuo S, Jones WK, Li H, He Z, Pasha Z, Yang Y, Wang Y, Fan GC, Ashraf M, Xu M., Free PMC Article | 06/16/2012 |
| Wnt11 is involved in the protection of the host intestinal cells by blocking the invasion of pathogenic bacteria, suppressing inflammation, and inhibiting apoptosis. | Wingless homolog Wnt11 suppresses bacterial invasion and inflammation in intestinal epithelial cells.
Liu X, Wu S, Xia Y, Li XE, Xia Y, Zhou ZD, Sun J., Free PMC Article | 01/28/2012 |
| noncanonical Wnt (Wnt11) enhanced cardiomyocyte differentiation while preventing stabilization of the beta-catenin protein, suggesting active repression of canonical Wnt signals | Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals.
Abdul-Ghani M, Dufort D, Stiles R, De Repentigny Y, Kothary R, Megeney LA., Free PMC Article | 01/29/2011 |
| GLI3 repressor controls nephron number by regulating ureteric tip cell expression of Wnt11 and Ret | GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells.
Cain JE, Islam E, Haxho F, Chen L, Bridgewater D, Nieuwenhuis E, Hui CC, Rosenblum ND., Free PMC Article | 03/15/2010 |
| Wnt-11 signalling serves as a critical cell adhesion cue for the organization of the cardiomyocytes in the developing ventricular wall, which is essential for the establishment of a functional heart. | Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and beta-catenin expression.
Nagy II, Railo A, Rapila R, Hast T, Sormunen R, Tavi P, Räsänen J, Vainio SJ. | 02/22/2010 |
| Data show that the higher expression of WNT5a in smaller EBs enhanced endothelial cell differentiation, and in contrast, the increased expression of WNT11 enhanced cardiogenesis. | Microwell-mediated control of embryoid body size regulates embryonic stem cell fate via differential expression of WNT5a and WNT11.
Hwang YS, Chung BG, Ortmann D, Hattori N, Moeller HC, Khademhosseini A., Free PMC Article | 01/21/2010 |
| Within fetal liver kinase (Flk)1-positive cells, Wnt11 may play a critical role in Flk1-positive cell fate determination, at least partially by modulating canonical Wnt/beta-catenin signalling. | Differential expression of the Wnt and Frizzled genes in Flk1+ cells derived from mouse ES cells.
Kim DJ, Park CS, Yoon JK, Song WK. | 01/21/2010 |
| Wnt11 signals through beta-catenin, activating Rspo2 expression, which is then required for Wnt11-mediated osteoblast maturation. | Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2.
Friedman MS, Oyserman SM, Hankenson KD., Free PMC Article | 01/21/2010 |