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    FGF1 fibroblast growth factor 1 [ Homo sapiens (human) ]

    Gene ID: 2246, updated on 11-Sep-2019

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The study examines the effect of size and sulfation pattern of heparan sulfate (HS) upon FGF1 oligomerization, binding stoichiometry and conformational stability, through a combination of ion mobility (IM) and theoretical modeling approaches. Ion mobility-mass spectrometry (IMMS) of FGF1 in the presence of several HS fragments ranging from tetrasaccharide (dp4) to dodecasaccharide (dp12) in length was performed.

    Gas-Phase Analysis of the Complex of Fibroblast GrowthFactor 1 with Heparan Sulfate: A Traveling Wave Ion Mobility Spectrometry (TWIMS) and Molecular Modeling Study.
    Zhao Y, Singh A, Xu Y, Zong C, Zhang F, Boons GJ, Liu J, Linhardt RJ, Woods RJ, Amster IJ., Free PMC Article

    Gas5 regulated proliferation and apoptosis in growth plate by controlling FGF1 expression via miR-21 regulation.

    Long non-coding RNA Gas5 regulates proliferation and apoptosis in HCS-2/8 cells and growth plate chondrocytes by controlling FGF1 expression via miR-21 regulation.
    Liu X, She Y, Wu H, Zhong D, Zhang J., Free PMC Article

    Modification of the heparin-binding region of FGF1 significantly improves the cardioprotective efficacy, even in the presence of heparin, identifying a novel FGF ligand available for therapeutic use in ischemic heart disease.

    A novel fibroblast growth factor-1 ligand with reduced heparin binding protects the heart against ischemia-reperfusion injury in the presence of heparin co-administration.
    Huang C, Liu Y, Beenken A, Jiang L, Gao X, Huang Z, Hsu A, Gross GJ, Wang YG, Mohammadi M, Schultz JEJ., Free PMC Article

    FGF1 protects neuroblastoma cells from p53-dependent apoptosis through an intracrine pathway regulated by FGF1 phosphorylation.

    FGF1 protects neuroblastoma SH-SY5Y cells from p53-dependent apoptosis through an intracrine pathway regulated by FGF1 phosphorylation.
    Pirou C, Montazer-Torbati F, Jah N, Delmas E, Lasbleiz C, Mignotte B, Renaud F., Free PMC Article

    Specific heparin derivatives molecular recognition patterns by FGF1 have been reported.

    Computational drill down on FGF1-heparin interactions through methodological evaluation.
    Babik S, Samsonov SA, Pisabarro MT., Free PMC Article

    Multiple stepwise linear regression analysis found serum level of FGF1 was dependent on anti-diabetic drugs, hemoglobin A1C, body mass index and sex. Serum level of FGF1 is associated with the decreased risk of obesity in human.

    Serum Fibroblast Growth Factor 1 is Associated with the Decreased Risk of Obesity in Human.
    Zhu J, Wang Y, Zhu K, Gao J, Wan X, Pang X, Fei S.

    Our study suggests that the genetic variants of FGF1 rs34011, more so than FGF2 rs2922979, may play a role in PE pathogenesis in Tunisian women.

    FGF1 and FGF2 mutations in preeclampsia and related features.
    Marwa BA, Raguema N, Zitouni H, Feten HB, Olfa K, Elfeleh R, Almawi W, Mahjoub T.

    FGF1 and 2 strongly prevent the osteogenic commitment and differentiation of hBMSCs.

    Canonical FGFs Prevent Osteogenic Lineage Commitment and Differentiation of Human Bone Marrow Stromal Cells Via ERK1/2 Signaling.
    Simann M, Le Blanc S, Schneider V, Zehe V, Lüdemann M, Schütze N, Jakob F, Schilling T.

    Transfected FGF1 promotes angiogenic proliferation.

    Fibroblast Growth Factor 1-Transfected Adipose-Derived Mesenchymal Stem Cells Promote Angiogenic Proliferation.
    Hoseini SJ, Ghazavi H, Forouzanfar F, Mashkani B, Ghorbani A, Mahdipour E, Ghasemi F, Sadeghnia HR, Ghayour-Mobarhan M., Free PMC Article

    These observations suggest a crucial role for cancer-associated fibroblasts and fibroblast growth factor-1/fibroblast growth factor receptor 4 signaling in the progression of ovarian cancer. the expression level of Snail1 and MMP3 was reduced, while the expression level of E-cadherin increased

    Cancer-associated fibroblasts secrete FGF-1 to promote ovarian proliferation, migration, and invasion through the activation of FGF-1/FGFR4 signaling.
    Sun Y, Fan X, Zhang Q, Shi X, Xu G, Zou C.

    Enzyme-linked immunosorbent assay was used to detect the levels of chemokine (C-X-C motif) ligand 12, chemokine (C-X-C motif) ligand 7, hepatocyte growth factor, and fibroblast growth factor 1 in the supernatants of the laryngeal squamous cell carcinoma and control cells.

    The primary growth of laryngeal squamous cell carcinoma cells in vitro is effectively supported by paired cancer-associated fibroblasts alone.
    Wang M, Wu C, Guo Y, Cao X, Zheng W, Fan GK.

    fibroblast growth factor 1 (FGF1) to be synergistically induced by heat shock and wounding.

    Activation of heat shock response augments fibroblast growth factor-1 expression in wounded lung epithelium.
    Scheraga RG, Thompson C, Tulapurkar ME, Nagarsekar AC, Cowan M, Potla R, Sun J, Cai R, Logun C, Shelhamer J, Todd NW, Singh IS, Luzina IG, Atamas SP, Hasday JD., Free PMC Article

    The results indicate that suramin blocks the interaction between hFGF1 and FGFR2 D2.

    Suramin blocks interaction between human FGF1 and FGFR2 D2 domain and reduces downstream signaling activity.
    Wu ZS, Liu CF, Fu B, Chou RH, Yu C.

    activation of AurA kinase through FGF1/FGFR signaling axis sustains the stem cell characteristics of glioblastoma cells.

    Activation of Aurora A kinase through the FGF1/FGFR signaling axis sustains the stem cell characteristics of glioblastoma cells.
    Hsu YC, Kao CY, Chung YF, Lee DC, Liu JW, Chiu IM.

    Study showed that both aFGF and bFGF were highly expressed in cervical cancer tissues. In tumors of higher clinical stages, the expression of these factors was further enhanced, suggesting that they play a role in facilitating cervical cancer cell proliferation.

    Acidic and basic fibroblast growth factor expression levels in cervical cancer and their effects on tumor cell proliferation.
    Zhang QH, Xu P, Lu YX, Dou HT.

    FGF1 may play a role in the pathogenesis of T2 diabetes mellitus.

    Fibroblast growth factor 1 levels are elevated in newly diagnosed type 2 diabetes compared to normal glucose tolerance controls.
    Wang S, Yang Q, Yu S, Pan R, Jiang D, Liu Y, Hu H, Sun W, Hong X, Xue H, Qian W, Wang D, Zhou L, Mao C, Yuan G.

    anti-importin alpha1 antibody treatment suppressed the importin alpha1-FGF1 complex formation and ERK1/2 activation, resulting in decreased cell growth. This study provides novel evidence that functional importin alpha1 is located at the cell surface, where it accelerates the proliferation of cancer cells.

    Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling.
    Yamada K, Miyamoto Y, Tsujii A, Moriyama T, Ikuno Y, Shiromizu T, Serada S, Fujimoto M, Tomonaga T, Naka T, Yoneda Y, Oka M., Free PMC Article

    The mutational introduction of a novel Cys residue (Ala66Cys) that forms a stabilizing disulfide bond (i.e., cystine) with one of the extant Cys residues (Cys83) effectively eliminates one Cys while increasing overall stability.

    Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application.
    Xia X, Kumru OS, Blaber SI, Middaugh CR, Li L, Ornitz DM, Sutherland MA, Tenorio CA, Blaber M., Free PMC Article

    The role of intracellular FGF1 is to protect the cell against stress conditions by providing an additional signal for cell survival, independently of receptor-activated signaling cascades.

    Identification of new FGF1 binding partners-Implications for its intracellular function.
    Bober J, Olsnes S, Kostas M, Bogacz M, Zakrzewska M, Otlewski J., Free PMC Article

    Data suggest folding of FGF1 is critical for its nonclassical secretion via permeability of lipid bilayer; mutation of proline135 in C-terminus of FGF1 leads to partial unfolding/decrease in FGF1's ability to permeabilize phosphatidylserine bilayers.

    Folding of Fibroblast Growth Factor 1 Is Critical for Its Nonclassical Release.
    Prudovsky I, Kacer D, Davis J, Shah V, Jayanthi S, Huber I, Dakshinamurthy R, Ganter O, Soldi R, Neivandt D, Guvench O, Suresh Kumar TK., Free PMC Article

    The analysis identified a signaling axis between FGF signaling and the transcription factor Sox1, which is preferentially expressed in stem- and mesenchymal-like breast cancers.

    Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells.
    Dravis C, Spike BT, Harrell JC, Johns C, Trejo CL, Southard-Smith EM, Perou CM, Wahl GM., Free PMC Article

    FGF-1 synthesis and secretion by synovial fibroblasts were significantly increased in osteoarthritis.

    Upregulation of fibroblast growth factor 1 in the synovial membranes of patients with late stage osteoarthritis.
    Li R, Wang B, He CQ, Yang YQ, Guo H, Chen Y, Du TH.

    expression of human FGF1 solely in beta-cells in fgf1(-/-) animals prevented overnutrition induced compensatory beta-cell differentiation.

    FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation.
    Li M, Page-McCaw P, Chen W., Free PMC Article

    Results show that stress functionally associates FGF1 with AHNAK2 and both proteins with the cytoskeleton and their co-localization in the vicinity of the cell membrane. AHNAK2 seems to be an important element of the FGF1 export pathway.

    AHNAK2 Participates in the Stress-Induced Nonclassical FGF1 Secretion Pathway.
    Kirov A, Kacer D, Conley BA, Vary CP, Prudovsky I., Free PMC Article

    These findings suggest that the presence of FGF1 may serve as a prognostic indicator and a potential therapeutic target for non-small cell lung cancer patients, especially for lung squamous cell carcinoma.

    Clinicopathological significance of fibroblast growth factor 1 in non-small cell lung cancer.
    Li J, Wei Z, Li H, Dang Q, Zhang Z, Wang L, Gao W, Zhang P, Yang D, Liu J, Sun Y, Gao W.

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