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    FGFR3 fibroblast growth factor receptor 3 [ Homo sapiens (human) ]

    Gene ID: 2261, updated on 20-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    [Clinical characteristics and prognosis of newly diagnosed multiple myeloma patients with FGFR3 gene mutations].

    [Clinical characteristics and prognosis of newly diagnosed multiple myeloma patients with FGFR3 gene mutations].
    Shen N, Zhang J, Xia Y, Shen XX, Wang J, Jin YY, Zhang R, Li JY, Chen LJ., Free PMC Article

    03/21/2024
    Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts.

    Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts.
    Bahlinger V, Branz A, Strissel PL, Strick R, Lange F, Geppert CI, Klümper N, Hölzel M, Wach S, Taubert H, Sikic D, Wullich B, Angeloni M, Ferrazzi F, Diehl L, Kovalenko M, Elboudwarej E, Jürgensmeier JM, Hartmann A, Eckstein M.

    03/6/2024
    Exploring FGFR3 Mutations in the Male Germline: Implications for Clonal Germline Expansions and Paternal Age-Related Dysplasias.

    Exploring FGFR3 Mutations in the Male Germline: Implications for Clonal Germline Expansions and Paternal Age-Related Dysplasias.
    Moura S, Hartl I, Brumovska V, Calabrese PP, Yasari A, Striedner Y, Bishara M, Mair T, Ebner T, Schütz GJ, Sevcsik E, Tiemann-Boege I., Free PMC Article

    02/28/2024
    N-glycan on N262 of FGFR3 regulates the intracellular localization and phosphorylation of the receptor.

    N-glycan on N262 of FGFR3 regulates the intracellular localization and phosphorylation of the receptor.
    Hashimoto U, Fujitani N, Uehara Y, Okamoto H, Saitou A, Ito F, Ariki S, Shiratsuchi A, Hasegawa Y, Takahashi M.

    02/24/2024
    Non-Small Cell Lung Carcinoma With Clear Cell Features and FGFR3::TACC3 Gene Rearrangement : Clinicopathologic and Next Generation Sequencing Study of 7 Cases.

    Non-Small Cell Lung Carcinoma With Clear Cell Features and FGFR3::TACC3 Gene Rearrangement : Clinicopathologic and Next Generation Sequencing Study of 7 Cases.
    Suster D, Mackinnon AC, Ronen N, Mejbel HA, Harada S, Suster S.

    02/22/2024
    FGFR3 Alterations in Bladder Cancer Stimulate Serine Synthesis to Induce Immune-Inert Macrophages That Suppress T-cell Recruitment and Activation.

    FGFR3 Alterations in Bladder Cancer Stimulate Serine Synthesis to Induce Immune-Inert Macrophages That Suppress T-cell Recruitment and Activation.
    Ouyang Y, Ou Z, Zhong W, Yang J, Fu S, Ouyang N, Chen J, Xu L, Wu D, Qian J, Lin Y, Lin T, Huang J., Free PMC Article

    01/3/2024
    Unravelling the pathogenesis of foramen magnum stenosis in patients with severe achondroplasia: a CT-based comparison with age-matched controls and FGFR3 craniosynostosis syndromes.

    Unravelling the pathogenesis of foramen magnum stenosis in patients with severe achondroplasia: a CT-based comparison with age-matched controls and FGFR3 craniosynostosis syndromes.
    Zhang CH, D'Arco F, Borghi A, Picariello S, Cheung M, Irving M, Thompson D.

    12/1/2023
    Genome-wide open reading frame profiling identifies fibroblast growth factor signaling as a driver of PD-L1 expression in head and neck squamous cell carcinoma.

    Genome-wide open reading frame profiling identifies fibroblast growth factor signaling as a driver of PD-L1 expression in head and neck squamous cell carcinoma.
    Mann JE, Smith JD, Kulkarni A, Foltin SK, Scheftz EB, Murray IR, Gensterblum-Miller E, Brummel CV, Bhangale A, Hoesli RC, Brenner JC.

    11/3/2023
    Fibroblast growth factor receptor 3 mutation attenuates response to immune checkpoint blockade in metastatic urothelial carcinoma by driving immunosuppressive microenvironment.

    Fibroblast growth factor receptor 3 mutation attenuates response to immune checkpoint blockade in metastatic urothelial carcinoma by driving immunosuppressive microenvironment.
    Song Y, Peng Y, Qin C, Wang Y, Yang W, Du Y, Xu T., Free PMC Article

    10/10/2023
    The Association of P53, CK29, and FGFR3 Overexpression with the Characteristics of Urothelial Cell Carcinoma of the Bladder.

    P53, CK20, and FGFR3 Overexpression is Associated with the Characteristics of Urothelial Cell Carcinoma of the Bladder.
    Asgari M, Firouzi F, Abolhasani M, Bahadoram M, Barahman M, Madjd Z, Mehrazam M, Hassanzadeh S, Akade E., Free PMC Article

    10/5/2023
    KLF2 regulates stemness of human mesenchymal stem cells by targeting FGFR3.

    KLF2 regulates stemness of human mesenchymal stem cells by targeting FGFR3.
    Gong Z, Shu Z, Zhou Y, Chen Y, Zhu H.

    09/29/2023
    FGFR3 mutation characterization identifies prognostic and immune-related gene signatures in bladder cancer.

    FGFR3 mutation characterization identifies prognostic and immune-related gene signatures in bladder cancer.
    Xu PH, Chen S, Wang Y, Jin S, Wang J, Ye D, Zhu X, Shen Y.

    08/28/2023
    Frequent Telomerase Reverse Transcriptase Promoter and Fibroblast Growth Factor Receptor 3 Mutations Support the Precursor Nature of Papillary Urothelial Hyperplasia of the Urinary Bladder.

    Frequent Telomerase Reverse Transcriptase Promoter and Fibroblast Growth Factor Receptor 3 Mutations Support the Precursor Nature of Papillary Urothelial Hyperplasia of the Urinary Bladder.
    Cheng L, Lopez-Beltran A, Wang M, Whaley RD, De Souza A, Au S, Ge R, Cimadamore A, Amin A, Golijanin B, MacLennan GT, Osunkoya AO, Montironi R, Zhang S.

    07/31/2023
    Promotion effect of FGF23 on osteopenia in congenital scoliosis through FGFr3/TNAP/OPN pathway.

    Promotion effect of FGF23 on osteopenia in congenital scoliosis through FGFr3/TNAP/OPN pathway.
    Zhang H, Xiang G, Li J, He S, Wang Y, Deng A, Wang Y, Guo C., Free PMC Article

    06/23/2023
    Autoantibodies Against Trisulfated Heparin Disaccharide and Fibroblast Growth Factor Receptor-3 May Play a Role in the Pathogenesis of Neuropathic Corneal Pain.

    Autoantibodies Against Trisulfated Heparin Disaccharide and Fibroblast Growth Factor Receptor-3 May Play a Role in the Pathogenesis of Neuropathic Corneal Pain.
    Bayraktutar BN, Atocha V, Farhad K, Soto O, Hamrah P.,

    06/13/2023
    Familial isolated acanthosis nigricans as a result of a recurrent FGFR3 truncating mutation.

    Familial isolated acanthosis nigricans as a result of a recurrent FGFR3 truncating mutation.
    Pesqué D, March-Rodriguez Á, Abreu-Rodríguez I, Pérez-Jurado LA, Pujol RM.

    06/8/2023
    [Investigation of the mutational status of the FGFR3 gene in urothelial bladder carcinoma].

    [Investigation of the mutational status of the FGFR3 gene in urothelial bladder carcinoma].
    Oliushina EM, Zavalishina LE, Alekseenok EY, Oskina NA, Andreeva YY, Kuznetsova OA, Filipenko ML, Frank GA.

    04/17/2023
    P4HA2-mediated HIF-1alpha stabilization promotes erdafitinib-resistance in FGFR3-alteration bladder cancer.

    P4HA2-mediated HIF-1α stabilization promotes erdafitinib-resistance in FGFR3-alteration bladder cancer.
    Li X, Li Y, Liu B, Chen L, Lyu F, Zhang P, He Q, Cheng L, Liu C, Song Y, Xing Y.

    03/27/2023
    PRMT5/FGFR3/AKT Signaling Axis Facilitates Lung Cancer Cell Metastasis.

    PRMT5/FGFR3/AKT Signaling Axis Facilitates Lung Cancer Cell Metastasis.
    Zheng Y, Lu J, Hu X, Hu X, Gao X, Zhou J., Free PMC Article

    03/20/2023
    FGFR3 Mutation Status and FGFR3 Expression in a Large Bladder Cancer Cohort Treated by Radical Cystectomy: Implications for Anti-FGFR3 Treatment?

    FGFR3 Mutation Status and FGFR3 Expression in a Large Bladder Cancer Cohort Treated by Radical Cystectomy: Implications for Anti-FGFR3 Treatment?(†).
    van Rhijn BWG, Mertens LS, Mayr R, Bostrom PJ, Real FX, Zwarthoff EC, Boormans JL, Abas C, van Leenders GJLH, Götz S, Hippe K, Bertz S, Neuzillet Y, Sanders J, Broeks A, van der Heijden MS, Jewett MAS, Marquez M, Stoehr R, Zlotta AR, Eckstein M, Soorojebally Y, Roshani H, Burger M, Otto W, Radvanyi F, Sirab N, Pouessel D, Wullich B, van der Kwast TH, Malats N, Hartmann A, Allory Y, Zuiverloon TCM.

    02/22/2023
    Oncogenic driver FGFR3-TACC3 requires five coiled-coil heptads for activation and disulfide bond formation for stability.

    Oncogenic driver FGFR3-TACC3 requires five coiled-coil heptads for activation and disulfide bond formation for stability.
    Wang CG, Peiris MN, Meyer AN, Nelson KN, Donoghue DJ., Free PMC Article

    02/16/2023
    Infiltrating gliomas with FGFR alterations: Histologic features, genetic alterations, and potential clinical implications.

    Infiltrating gliomas with FGFR alterations: Histologic features, genetic alterations, and potential clinical implications.
    Dono A, El Achi H, Bundrant BE, Goli PS, Zhu P, Ozkizilkaya HI, Esquenazi Y, Ballester LY.

    02/15/2023
    Genetic Interference of FGFR3 Impedes Invasion of Upper Tract Urothelial Carcinoma Cells by Alleviating RAS/MAPK Signal Activity.

    Genetic Interference of FGFR3 Impedes Invasion of Upper Tract Urothelial Carcinoma Cells by Alleviating RAS/MAPK Signal Activity.
    Huang GK, Huang CC, Kang CH, Cheng YT, Tsai PC, Kao YH, Chung YH., Free PMC Article

    01/28/2023
    Evaluation of Volumetric Bone Mineral Density, Bone Microarchitecture, and Bone Strength in Patients with Achondroplasia Caused by FGFR3 c.1138G > A Mutation.

    Evaluation of Volumetric Bone Mineral Density, Bone Microarchitecture, and Bone Strength in Patients with Achondroplasia Caused by FGFR3 c.1138G > A Mutation.
    Liang H, Qi W, Jin C, Pang Q, Liu W, Jiang Y, Wang O, Li M, Xing X, Pan H, Xia W.

    01/21/2023
    FGFR3 Mutational Activation Can Induce Luminal-like Papillary Bladder Tumor Formation and Favors a Male Sex Bias.

    FGFR3 Mutational Activation Can Induce Luminal-like Papillary Bladder Tumor Formation and Favors a Male Sex Bias.
    Shi MJ, Fontugne J, Moreno-Vega A, Meng XY, Groeneveld C, Dufour F, Kamoun A, Viborg Lindskrog S, Cabel L, Krucker C, Rapinat A, Dunois-Larde C, Lepage ML, Chapeaublanc E, Levrel O, Dixon V, Lebret T, Almeida A, De Reynies A, Rochel N, Dyrskjøt L, Allory Y, Radvanyi F, Bernard-Pierrot I.

    01/11/2023
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