| PDGFRalpha[+]ITGA11[+] fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay. | PDGFRα(+)ITGA11(+) fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay.
Zheng H, An M, Luo Y, Diao X, Zhong W, Pang M, Lin Y, Chen J, Li Y, Kong Y, Zhao Y, Yin Y, Ai L, Huang J, Chen C, Lin T. | 04/16/2024 |
| Osteosarcoma Cells Secrete CXCL14 That Activates Integrin alpha11beta1 on Fibroblasts to Form a Lung Metastatic Niche. | Osteosarcoma Cells Secrete CXCL14 That Activates Integrin α11β1 on Fibroblasts to Form a Lung Metastatic Niche.
Xu Y, Deng C, Chen H, Song Y, Xu H, Song G, Wang X, Luo T, Chen W, Ma J, Zeng A, Huang S, Chen Z, Fu J, Gong M, Tai Y, Huang A, Feng H, Hu J, Zhu X, Tang Q, Lu J, Wang J. | 04/8/2024 |
| Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin alpha11 expression. | Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin α11 expression.
Iwai M, Tulafu M, Togo S, Kawaji H, Kadoya K, Namba Y, Jin J, Watanabe J, Okabe T, Hidayat M, Sumiyoshi I, Itoh M, Koyama Y, Ito Y, Orimo A, Takamochi K, Oh S, Suzuki K, Hayashizaki Y, Yoshida K, Takahashi K., Free PMC Article | 04/2/2022 |
| Inhibition of integrin subunit alpha 11 restrains gastric cancer progression through phosphatidylinositol 3-kinase/Akt pathway. | Inhibition of integrin subunit alpha 11 restrains gastric cancer progression through phosphatidylinositol 3-kinase/Akt pathway.
Zhang H, Zhang L, Lu M., Free PMC Article | 02/19/2022 |
| Long noncoding RNA FEZF1AS1 facilitates nonsmall cell lung cancer progression via the ITGA11/miR516b5p axis. | Long non‑coding RNA FEZF1‑AS1 facilitates non‑small cell lung cancer progression via the ITGA11/miR‑516b‑5p axis.
Song H, Li H, Ding X, Li M, Shen H, Li Y, Zhang X, Xing L., Free PMC Article | 08/7/2021 |
| p75NTR optimizes the osteogenic potential of human periodontal ligament stem cells by up-regulating alpha1 integrin expression. | p75NTR optimizes the osteogenic potential of human periodontal ligament stem cells by up-regulating α1 integrin expression.
Li J, Zhao M, Wang Y, Shen M, Wang S, Tang M, Li M, Luo Y, Yang K, Wen X., Free PMC Article | 05/1/2021 |
| Integrin alpha11 cytoplasmic tail is required for FAK activation to initiate 3D cell invasion and ERK-mediated cell proliferation. | Integrin α11 cytoplasmic tail is required for FAK activation to initiate 3D cell invasion and ERK-mediated cell proliferation.
Erusappan P, Alam J, Lu N, Zeltz C, Gullberg D., Free PMC Article | 11/21/2020 |
| integrin alpha11 pro-invasive activity relies on its ability to interact with PDGFRbeta in a ligand-dependent manner and to promote its downstream JNK activation, leading to the production of tenascin C, a pro-invasive matricellular protein. | Stromal integrin α11 regulates PDGFR-β signaling and promotes breast cancer progression.
Primac I, Maquoi E, Blacher S, Heljasvaara R, Van Deun J, Smeland HY, Canale A, Louis T, Stuhr L, Sounni NE, Cataldo D, Pihlajaniemi T, Pequeux C, De Wever O, Gullberg D, Noel A., Free PMC Article | 06/20/2020 |
| this study presents ITGA11 as an interesting stromal therapeutic target that plays a crucial role in the regulation of the differentiation of Pancreatic stellate cells into cancer-associated fibroblasts and paracrine effects. | Integrin α11 in pancreatic stellate cells regulates tumor stroma interaction in pancreatic cancer.
Schnittert J, Bansal R, Mardhian DF, van Baarlen J, Östman A, Prakash J. | 05/16/2020 |
| Data show that integrin alpha-11 (integrin alpha11) is a physiologically important receptor for Osteolectin, mediating its effect on osteogenesis. | Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass.
Shen B, Vardy K, Hughes P, Tasdogan A, Zhao Z, Yue R, Crane GM, Morrison SJ., Free PMC Article | 04/25/2020 |
| ITGA11 expression may be a predictor of poor prognosis in patients with surgically resected NSCLC. | Integrin α11 in non-small cell lung cancer is associated with tumor progression and postoperative recurrence.
Ando T, Kage H, Matsumoto Y, Zokumasu K, Yotsumoto T, Maemura K, Amano Y, Watanabe K, Nakajima J, Nagase T, Takai D., Free PMC Article | 01/18/2020 |
| ITGA11 is a highly promising target that is selectively overexpressed in myofibroblasts during fibrotic diseases and regulates myofibroblast differentiation and key phenotypic characteristics. | Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases.
Bansal R, Nakagawa S, Yazdani S, van Baarlen J, Venkatesh A, Koh AP, Song WM, Goossens N, Watanabe H, Beasley MB, Powell CA, Storm G, Kaminski N, van Goor H, Friedman SL, Hoshida Y, Prakash J., Free PMC Article | 07/7/2018 |
| By employing co-immunoprecipitation and confocal microscopy analysis we showed that integrin alpha11beta1 and protein disulfide isomerase (PDI) create complexes bounded by disulfide bonds. Using surface plasmon resonance we provide biochemical evidence that PDI can interact directly with integrin subunit alpha11. | The role of Protein Disulfide Isomerase and thiol bonds modifications in activation of integrin subunit alpha11.
Popielarski M, Ponamarczuk H, Stasiak M, Michalec L, Bednarek R, Studzian M, Pulaski L, Swiatkowska M. | 02/24/2018 |
| Using MDR and RF, the overall best classifier of lung cancer status were SNPs rs1799732 (DRD2), rs5744256 (IL-18), rs2306022 (ITGA11) with training accuracy of 0.6592 and a testing accuracy of 0.6572 and a cross-validation consistency of 10/10 with permutation testing P<0.0001 | Incorporating epistasis interaction of genetic susceptibility single nucleotide polymorphisms in a lung cancer risk prediction model.
Marcus MW, Raji OY, Duffy SW, Young RP, Hopkins RJ, Field JK., Free PMC Article | 04/1/2017 |
| FGF2 may be redirecting fibroblasts towards an anti-fibrotic phenotype during wound healing by overriding TGFb1 mediated ITGA11 expression. | FGF2 Overrides TGFβ1-Driven Integrin ITGA11 Expression in Human Dermal Fibroblasts.
Grella A, Kole D, Holmes W, Dominko T. | 10/29/2016 |
| glycated collagen in the cardiac interstitium triggers an autocrine TGF-beta2 signaling pathway that stimulates alpha11 integrin expression through Smad2/3 binding elements in the alpha11 integrin promoter | Glycated Collagen Induces α11 Integrin Expression Through TGF-β2 and Smad3.
Talior-Volodarsky I, Arora PD, Wang Y, Zeltz C, Connelly KA, Gullberg D, McCulloch CA. | 10/24/2015 |
| Myometrium and uterine fibroids express ITGA11. | Collagen-binding α11 integrin expression in human myometrium and fibroids utilizing a novel RNA in situ probe.
Peavey M, Salleh N, Leppert P., Free PMC Article | 04/18/2015 |
| Interactions between alpha11 integrins and the Smad-dependent TGF-beta2 signalling may contribute to the formation of pro-fibrotic myofibroblasts and the development of a fibrotic interstitium in diabetic cardiomyopathy. | α11 integrin stimulates myofibroblast differentiation in diabetic cardiomyopathy.
Talior-Volodarsky I, Connelly KA, Arora PD, Gullberg D, McCulloch CA. | 03/23/2013 |
| The disturbance of alpha11beta1 mediated interactions to collagen I results in a tremendous reduction of hMSC numbers owing to mitochondrial leakage accompanied by Bcl-2-associated X protein upregulation. | Integrins α2β1 and α11β1 regulate the survival of mesenchymal stem cells on collagen I.
Popov C, Radic T, Haasters F, Prall WC, Aszodi A, Gullberg D, Schieker M, Docheva D., Free PMC Article | 12/3/2011 |
| Data show that the 3 kb alpha11 promoter contains most of the regulatory elements that direct ectomesenchymal and mesodermal fibroblast-specific expression. | The human alpha11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-beta1 in a Smad- and Sp1-dependent manner.
Lu N, Carracedo S, Ranta J, Heuchel R, Soininen R, Gullberg D. | 07/19/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) | A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.
Young RP, Hopkins RJ, Hay BA, Epton MJ, Mills GD, Black PN, Gardner HD, Sullivan R, Gamble GD. | 12/2/2009 |
| Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
Uhl GR, Liu QR, Drgon T, Johnson C, Walther D, Rose JE, David SP, Niaura R, Lerman C., Free PMC Article | 12/2/2009 |
| is a major collagen receptor on human periodontal ligament cells [and plays] a role in collagen lattice remodeling [ITGA11B1] | A role for alpha11beta1 integrin in the human periodontal ligament.
Barczyk MM, Olsen LH, da Franca P, Loos BG, Mustafa K, Gullberg D, Bolstad AI. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Lung cancer susceptibility model based on age, family history and genetic variants.
Young RP, Hopkins RJ, Hay BA, Epton MJ, Mills GD, Black PN, Gardner HD, Sullivan R, Gamble GD., Free PMC Article | 05/6/2009 |