| IKZF3 polymorphisms contribute to the increased risk of acute lymphoblastic leukemia in children. | IKZF3 polymorphisms contribute to the increased risk of acute lymphoblastic leukemia in children.
Yang X, Yang L, Luo A, Liu S, Zhang X, Liu X, Liu X, Luo A, Cai M, Yan Y, Wu X, Huang K, Xu L, Jiang H. | 02/26/2024 |
| Disease-associated AIOLOS variants lead to immune deficiency/dysregulation by haploinsufficiency and redefine AIOLOS functional domains. | Disease-associated AIOLOS variants lead to immune deficiency/dysregulation by haploinsufficiency and redefine AIOLOS functional domains.
Kuehn HS, Sakovich IS, Niemela JE, Gil Silva AA, Stoddard JL, Polyakova EA, Esteve Sole A, Aleshkevich SN, Uglova TA, Belevtsev MV, Vertelko VR, Shman TV, Kupchinskaya AN, Walter JE, Fleisher TA, Notarangelo LD, Peng XP, Delmonte OM, Sharapova SO, Rosenzweig SD., Free PMC Article | 02/9/2024 |
| Genetic variations in IKZF3, LET7-a2, and CDKN2B-AS1: Exploring associations with metabolic syndrome susceptibility and clinical manifestations. | Genetic variations in IKZF3, LET7-a2, and CDKN2B-AS1: Exploring associations with metabolic syndrome susceptibility and clinical manifestations.
Paniri A, Hosseini MM, Fattahi S, Amiribozorgi G, Asouri M, Maadi M, Motamed N, Zamani F, Akhavan-Niaki H., Free PMC Article | 02/8/2024 |
| IKZF3 is a novel prognostic biomarker for head and neck squamous cell carcinoma: A study based on bioinformatics analysis. | IKZF3 is a novel prognostic biomarker for head and neck squamous cell carcinoma: A study based on bioinformatics analysis.
Li H, Ye M, Hu Z, Lu H, Zheng D, Wu M, Ge T, Xu S, Ge Z, Zhang S, Xu G, Chen H., Free PMC Article | 04/19/2023 |
| IKZF3 amplification frequently occurs in HER2-positive breast cancer and is a potential therapeutic target. | IKZF3 amplification frequently occurs in HER2-positive breast cancer and is a potential therapeutic target.
Lin CY, Yu CJ, Shen CI, Liu CY, Chao TC, Huang CC, Tseng LM, Lai JI. | 10/8/2022 |
| AIOLOS Variants Causing Immunodeficiency in Human and Mice. | AIOLOS Variants Causing Immunodeficiency in Human and Mice.
Yamashita M, Morio T., Free PMC Article | 04/30/2022 |
| Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity. | Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity.
Qiu J, Zhang J, Ji Y, Sun H, Gu Z, Sun Q, Bai M, Gong J, Tang J, Zhang Y, Li S, Shao Z, Li J, Sheng H, Shen L, Qiu J., Free PMC Article | 03/19/2022 |
| Aiolos regulates eosinophil migration into tissues. | Aiolos regulates eosinophil migration into tissues.
Felton JM, Bouffi C, Schwartz JT, Schollaert KL, Malik A, Vallabh S, Wronowski B, Magier AZ, Merlin L, Barski A, Weirauch MT, Fulkerson PC, Rothenberg ME., Free PMC Article | 03/19/2022 |
| IKZF3 deficiency potentiates chimeric antigen receptor T cells targeting solid tumors. | IKZF3 deficiency potentiates chimeric antigen receptor T cells targeting solid tumors.
Zou Y, Liu B, Li L, Yin Q, Tang J, Jing Z, Huang X, Zhu X, Chi T. | 01/8/2022 |
| T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients. | T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients.
Kuehn HS, Chang J, Yamashita M, Niemela JE, Zou C, Okuyama K, Harada J, Stoddard JL, Nunes-Santos CJ, Boast B, Baxter RM, Hsieh EWY, Garofalo M, Fleisher TA, Morio T, Taniuchi I, Dutmer CM, Rosenzweig SD., Free PMC Article | 01/1/2022 |
| A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation. | A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation.
Lazarian G, Yin S, Ten Hacken E, Sewastianik T, Uduman M, Font-Tello A, Gohil SH, Li S, Kim E, Joyal H, Billington L, Witten E, Zheng M, Huang T, Severgnini M, Lefebvre V, Rassenti LZ, Gutierrez C, Georgopoulos K, Ott CJ, Wang L, Kipps TJ, Burger JA, Livak KJ, Neuberg DS, Baran-Marszak F, Cymbalista F, Carrasco RD, Wu CJ., Free PMC Article | 10/2/2021 |
| A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS. | A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS.
Yamashita M, Kuehn HS, Okuyama K, Okada S, Inoue Y, Mitsuiki N, Imai K, Takagi M, Kanegane H, Takeuchi M, Shimojo N, Tsumura M, Padhi AK, Zhang KYJ, Boisson B, Casanova JL, Ohara O, Rosenzweig SD, Taniuchi I, Morio T., Free PMC Article | 08/28/2021 |
| [Relationship between IKZF3 Gene Single Nucleotide Polymorphisms and Childhood Acute Lymphoblastic Leukemia]. | [Relationship between IKZF3 Gene Single Nucleotide Polymorphisms and Childhood Acute Lymphoblastic Leukemia].
Hong Y, Wang Q, Song YL, Liu GM, Yang X, Yan MX. | 07/3/2021 |
| Role of Aiolos and Ikaros in the Antitumor and Immunomodulatory Activity of IMiDs in Multiple Myeloma: Better to Lose Than to Find Them. | Role of Aiolos and Ikaros in the Antitumor and Immunomodulatory Activity of IMiDs in Multiple Myeloma: Better to Lose Than to Find Them.
Cippitelli M, Stabile H, Kosta A, Petillo S, Gismondi A, Santoni A, Fionda C., Free PMC Article | 05/29/2021 |
| IKZF1/3 and CRL4(CRBN) E3 ubiquitin ligase mutations and resistance to immunomodulatory drugs in multiple myeloma. | IKZF1/3 and CRL4(CRBN) E3 ubiquitin ligase mutations and resistance to immunomodulatory drugs in multiple myeloma.
Barrio S, Munawar U, Zhu YX, Giesen N, Shi CX, Viá MD, Sanchez R, Bruins L, Demler T, Müller N, Haertle L, Garitano A, Steinbrunn T, Danhof S, Cuenca I, Barrio-Garcia C, Braggio E, Rosenwald A, Martinez-Lopez J, Rasche L, Raab MS, Stewart AK, Einsele H, Stühmer T, Kortüm KM., Free PMC Article | 05/8/2021 |
| Trans-Ancestral Fine-Mapping and Epigenetic Annotation as Tools to Delineate Functionally Relevant Risk Alleles at IKZF1 and IKZF3 in Systemic Lupus Erythematosus. | Trans-Ancestral Fine-Mapping and Epigenetic Annotation as Tools to Delineate Functionally Relevant Risk Alleles at IKZF1 and IKZF3 in Systemic Lupus Erythematosus.
Vyse TJ, Cunninghame Graham DS., Free PMC Article | 03/6/2021 |
| Overexpression of Aiolos promotes epithelial-mesenchymal transition and cancer stem cell-like properties in lung cancer cells. | Overexpression of Aiolos promotes epithelial-mesenchymal transition and cancer stem cell-like properties in lung cancer cells.
Hung JJ, Kao YS, Huang CH, Hsu WH., Free PMC Article | 09/19/2020 |
| Selective degradation of Aiolos and Ikaros (IKZF1) by lenalidomide suppressed ILC1 and NK cell differentiation. | Suppression of Aiolos and Ikaros expression by lenalidomide reduces human ILC3-ILC1/NK cell transdifferentiation.
Mazzurana L, Forkel M, Rao A, Van Acker A, Kokkinou E, Ichiya T, Almer S, Höög C, Friberg D, Mjösberg J. | 05/30/2020 |
| we identified and characterised oncogenic fusion genes and their function in CRC, and implicated NAGLU-IKZF3 and RNF121-FOLR2 as novel molecular targets for personalised medicine development. | Integrative analysis of oncogenic fusion genes and their functional impact in colorectal cancer.
Choi Y, Kwon CH, Lee SJ, Park J, Shin JY, Park DY., Free PMC Article | 08/17/2019 |
| The minor alleles of rs2941522, rs907091, rs1453559, rs12150079 and rs2872507 were statistically associated with an increased risk in Graves' disease patients. | Polymorphisms of IKZF3 Gene and Autoimmune Thyroid Diseases: Associated with Graves' Disease but Not with Hashimoto's Thyroiditis.
Li L, Ding X, Wang X, Yao Q, Shao X, An X, Yan N, Jiang Y, Wang W, Shi L, Qin Q, Song R, Zhang JA, Sun P. | 05/19/2018 |
| Aiolos promotes the binding of Blimp-1 to target genes and thereby enhances Blimp-1-dependent transcriptional repression. | Aiolos collaborates with Blimp-1 to regulate the survival of multiple myeloma cells.
Hung KH, Su ST, Chen CY, Hsu PH, Huang SY, Wu WJ, Chen MJ, Chen HY, Wu PC, Lin FR, Tsai MD, Lin KI., Free PMC Article | 01/13/2018 |
| IKZF1 and IKZF3 expressions were associated with longer median progression free survival and overall survival in multiple myeloma patients | High IKZF1/3 protein expression is a favorable prognostic factor for survival of relapsed/refractory multiple myeloma patients treated with lenalidomide.
Pourabdollah M, Bahmanyar M, Atenafu EG, Reece D, Hou J, Chang H., Free PMC Article | 12/2/2017 |
| Inhibition of B cell plasmablast differentiation by reduction of Aiolos and Ikaros may have utility in the treatment of systemic lupus erythematosus , where elevated levels of BAFF and Aiolos may prime CD27(+) memory and double negative memory-like B cells to become Ab-producing plasmablasts in the presence of BAFF and proinflammatory cytokines. | Aiolos Overexpression in Systemic Lupus Erythematosus B Cell Subtypes and BAFF-Induced Memory B Cell Differentiation Are Reduced by CC-220 Modulation of Cereblon Activity.
Nakayama Y, Kosek J, Capone L, Hur EM, Schafer PH, Ringheim GE., Free PMC Article | 10/28/2017 |
| this study shows that Ikaros undergoes a transient increase in protein levels at the transitional single-positive CD8+ developmental stage before diverging in their expression patterns at later stages | Expression patterns of Ikaros family members during positive selection and lineage commitment of human thymocytes.
Mitchell JL, Seng A, Yankee TM., Free PMC Article | 05/20/2017 |
| Our data indicate a possible regulatory role for the multiple sclerosis-associated IKZF3 and IQGAP1 variants. | Allelic imbalance of multiple sclerosis susceptibility genes IKZF3 and IQGAP1 in human peripheral blood.
Keshari PK, Harbo HF, Myhr KM, Aarseth JH, Bos SD, Berge T., Free PMC Article | 10/22/2016 |