| Knockdown of Smox protects the integrity of the blood-brain barrier through antioxidant effect and Nrf2 pathway activation in stroke. | Knockdown of Smox protects the integrity of the blood-brain barrier through antioxidant effect and Nrf2 pathway activation in stroke.
Wang G, Li Z, Lin P, Zhang H, Wang Y, Zhang T, Wang H, Li H, Lin L, Zhao Y, Jia L, Chen Y, Ji H, Zhao W, Fu Z, Zhong Z. | 01/4/2024 |
| Protective Role of Spermidine in Colitis and Colon Carcinogenesis. | Protective Role of Spermidine in Colitis and Colon Carcinogenesis.
Gobert AP, Latour YL, Asim M, Barry DP, Allaman MM, Finley JL, Smith TM, McNamara KM, Singh K, Sierra JC, Delgado AG, Luis PB, Schneider C, Washington MK, Piazuelo MB, Zhao S, Coburn LA, Wilson KT., Free PMC Article | 03/12/2022 |
| Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia. | Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia.
Zahedi K, Brooks M, Barone S, Rahmati N, Murray Stewart T, Dunworth M, Destefano-Shields C, Dasgupta N, Davidson S, Lindquist DM, Fuller CE, Smith RD, Cleveland JL, Casero RA Jr, Soleimani M., Free PMC Article | 08/21/2021 |
| Emerging Role for Linear and Circular Spermine Oxidase RNAs in Skeletal Muscle Physiopathology. | Emerging Role for Linear and Circular Spermine Oxidase RNAs in Skeletal Muscle Physiopathology.
Reinoso-Sánchez JF, Baroli G, Duranti G, Scaricamazza S, Sabatini S, Valle C, Morlando M, Casero RA Jr, Bozzoni I, Mariottini P, Ceci R, Cervelli M., Free PMC Article | 03/13/2021 |
| Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling. | Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling.
Sierra JC, Piazuelo MB, Luis PB, Barry DP, Allaman MM, Asim M, Sebrell TA, Finley JL, Rose KL, Hill S, Holshouser SL, Casero RA, Cleveland JL, Woster PM, Schey KL, Bimczok D, Schneider C, Gobert AP, Wilson KT., Free PMC Article | 12/5/2020 |
| Epileptic seizures and oxidative stress in a mouse model over-expressing spermine oxidase. | Epileptic seizures and oxidative stress in a mouse model over-expressing spermine oxidase.
Leonetti A, Baroli G, Fratini E, Pietropaoli S, Marcoli M, Mariottini P, Cervelli M. | 11/21/2020 |
| High SMOX expression is associated with neuroblastoma. | Link between spermine oxidase and apoptosis antagonizing transcription factor: A new pathway in neuroblastoma.
Fratini E, Cervelli M, Mariottini P, Kanamori Y, Amendola R, Agostinelli E. | 03/14/2020 |
| Our studies indicate that SMOX has immunomodulatory effects in experimental colitis via polyamine flux. Thus, SMOX contributes to the immunopathogenesis of C. rodentium infection, but is protective in DSS colitis, indicating the divergent effects of spermidine. | Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection.
Gobert AP, Al-Greene NT, Singh K, Coburn LA, Sierra JC, Verriere TG, Luis PB, Schneider C, Asim M, Allaman MM, Barry DP, Cleveland JL, Destefano Shields CE, Casero RA Jr, Washington MK, Piazuelo MB, Wilson KT., Free PMC Article | 08/17/2019 |
| Dach-SMOX transgenic mouse can be considered as a suitable in vivo genetic model to study the involvement of spermine oxidase in excitotoxicity. | Glutamate Excitotoxicity Linked to Spermine Oxidase Overexpression.
Pietropaoli S, Leonetti A, Cervetto C, Venturini A, Mastrantonio R, Baroli G, Persichini T, Colasanti M, Maura G, Marcoli M, Mariottini P, Cervelli M. | 02/9/2019 |
| Novel evidences of the complex and critical functions carried out by spermine oxidase and spermine in the mammalian brain. | A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury.
Cervelli M, Bellavia G, D'Amelio M, Cavallucci V, Moreno S, Berger J, Nardacci R, Marcoli M, Maura G, Piacentini M, Amendola R, Cecconi F, Mariottini P., Free PMC Article | 11/4/2017 |
| Spermine oxidase is an important regulator of muscle gene expression and fiber size. | Spermine oxidase maintains basal skeletal muscle gene expression and fiber size and is strongly repressed by conditions that cause skeletal muscle atrophy.
Bongers KS, Fox DK, Kunkel SD, Stebounova LV, Murry DJ, Pufall MA, Ebert SM, Dyle MC, Bullard SA, Dierdorff JM, Adams CM., Free PMC Article | 04/18/2015 |
| Data (including data from studies using recombinant mutant proteins) suggest that Glu216-Ser218 is a hot spot responsible for Smox substrate specificity; Smox with mutation E216L/S218A exhibits specificity for N'-acetylspermine rather than spermine. | The Glu²¹⁶/Ser²¹⁸ pocket is a major determinant of spermine oxidase substrate specificity.
Cervelli M, Angelucci E, Stano P, Leboffe L, Federico R, Antonini G, Mariottini P, Polticelli F. | 09/27/2014 |
| ROS overexposure by mSMOX delivers an earlier adaptive response to radiation | Reactive oxygen species spermine metabolites generated from amine oxidases and radiation represent a therapeutic gain in cancer treatments.
Amendola R, Cervelli M, Fratini E, Sallustio DE, Tempera G, Ueshima T, Mariottini P, Agostinelli E. | 04/12/2014 |
| Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. | Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA.
Chaturvedi R, Asim M, Romero-Gallo J, Barry DP, Hoge S, de Sablet T, Delgado AG, Wroblewski LE, Piazuelo MB, Yan F, Israel DA, Casero RA Jr, Correa P, Gobert AP, Polk DB, Peek RM Jr, Wilson KT., Free PMC Article | 01/21/2012 |
| Spermine oxidase binds spermine in a similar conformation as that observed in the yeast polyamine oxidase FMS1-spermine complex and demonstrate a major role for residues His82 and Lys367 in substrate binding and catalysis. | Probing mammalian spermine oxidase enzyme-substrate complex through molecular modeling, site-directed mutagenesis and biochemical characterization.
Tavladoraki P, Cervelli M, Antonangeli F, Minervini G, Stano P, Federico R, Mariottini P, Polticelli F. | 08/6/2011 |
| expression and characterization of mouse spermine oxidase | Heterologous expression and characterization of mouse spermine oxidase.
Cervelli M, Polticelli F, Federico R, Mariottini P. | 01/21/2010 |
| we identified a second domain that is necessary for nuclear localization of the spermine oxidase splice variant | Two short protein domains are responsible for the nuclear localization of the mouse spermine oxidase mu isoform.
Bianchi M, Amendola R, Federico R, Polticelli F, Mariottini P. | 01/21/2010 |