| alpha-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation. | α-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation.
Fan JK, Wang MC, Yang HM, Zhang JN, Gu L, Zhang H. | 06/16/2023 |
| Antagonization of OX1 Receptor Potentiates CB2 Receptor Function in Microglia from APPSw/Ind Mice Model. | Antagonization of OX(1) Receptor Potentiates CB(2) Receptor Function in Microglia from APP(Sw/Ind) Mice Model.
Raïch I, Rebassa JB, Lillo J, Cordomi A, Rivas-Santisteban R, Lillo A, Reyes-Resina I, Franco R, Navarro G., Free PMC Article | 11/19/2022 |
| The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors. | The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors.
Cook C, Nunn N, Worth AA, Bechtold DA, Suter T, Gackeheimer S, Foltz L, Emmerson PJ, Statnick MA, Luckman SM., Free PMC Article | 10/22/2022 |
| Orexin 1 Receptor Antagonism in the Basolateral Amygdala Shifts the Balance From Pro- to Antistress Signaling and Behavior. | Orexin 1 Receptor Antagonism in the Basolateral Amygdala Shifts the Balance From Pro- to Antistress Signaling and Behavior.
Yaeger JDW, Krupp KT, Jacobs BM, Onserio BO, Meyerink BL, Cain JT, Ronan PJ, Renner KJ, DiLeone RJ, Summers CH., Free PMC Article | 05/7/2022 |
| Decreased Orexin Receptor 1 mRNA Expression in the Locus Coeruleus in Both Tau Transgenic rTg4510 and Tau Knockout Mice and Accompanying Ascending Arousal System Tau Invasion in rTg4510. | Decreased Orexin Receptor 1 mRNA Expression in the Locus Coeruleus in Both Tau Transgenic rTg4510 and Tau Knockout Mice and Accompanying Ascending Arousal System Tau Invasion in rTg4510.
Keenan RJ, Oberrauch S, Bron R, Nowell CJ, Challis LM, Hoyer D, Jacobson LH. | 09/18/2021 |
| Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. | Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity.
Xiao X, Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan DA, Wunderlich FT, Rahmouni K, Kong D, Scammell TE, Lowell BB, Kloppenburg P, Brüning JC, Hausen AC., Free PMC Article | 09/18/2021 |
| Nucleus accumbens shell Orexin-1 receptors are not needed for single-bottle limited daily access alcohol intake in C57BL/6 mice. | Nucleus accumbens shell Orexin-1 receptors are not needed for single-bottle limited daily access alcohol intake in C57BL/6 mice.
Lei K, Kwok C, Hopf FW., Free PMC Article | 09/18/2021 |
| Differential importance of nucleus accumbens Ox1Rs and AMPARs for female and male mouse binge alcohol drinking. | Differential importance of nucleus accumbens Ox1Rs and AMPARs for female and male mouse binge alcohol drinking.
Kwok C, Lei K, Pedrozo V, Anderson L, Ghotra S, Walsh M, Li L, Yu J, Hopf FW., Free PMC Article | 08/14/2021 |
| Orexin 1 and 2 Receptors in the Prelimbic Cortex Modulate Threat Valuation. | Orexin 1 and 2 Receptors in the Prelimbic Cortex Modulate Threat Valuation.
Soares VPMN, de Andrade TGCS, Canteras NS, Coimbra NC, Wotjak CT, Almada RC. | 07/31/2021 |
| Involvement of descending pain control system regulated by orexin receptor signaling in the induction of central post-stroke pain in mice. | Involvement of descending pain control system regulated by orexin receptor signaling in the induction of central post-stroke pain in mice.
Matsuura W, Nakamoto K, Tokuyama S. | 12/5/2020 |
| Hcrt excitatory input to cingulate cortex deep layer cells is mediated through HCRTR1 but is unlikely to be involved in the putative role of cortical nNOS/NK1R neurons in sleep homeostasis. | Excitation of Cortical nNOS/NK1R Neurons by Hypocretin 1 is Independent of Sleep Homeostasis.
Williams RH, Black SW, Thomas AM, Piquet J, Cauli B, Kilduff TS., Free PMC Article | 05/16/2020 |
| Under enforced wakefulness (EW), or after cage change (CC), Hcrtr1 knockout mice exhibited a weakened ability to lower infra-theta; frequencies (1-7 Hz), and mount a robust, narrow-bandwidth, high-frequency theta; rhythm (~8.5 Hz). A fast-gamma (55-80 Hz) response, whose dynamics closely parallelled theta;, also diminished, while beta/slow-gamma activity (15-45 Hz) increased. | Bidirectional and context-dependent changes in theta and gamma oscillatory brain activity in noradrenergic cell-specific Hypocretin/Orexin receptor 1-KO mice.
Li S, Franken P, Vassalli A., Free PMC Article | 10/26/2019 |
| OX1R expression is associated with a strong specific immunomodulatory effect of orexin-A via OX1R and down-regulation of the pro-inflammatory cytokine production and secretion, as shown in two murine models recapitulating either the acute or chronic phase of ulcerative colitis. | Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A.
Messal N, Fernandez N, Dayot S, Gratio V, Nicole P, Prochasson C, Chantret I, LeGuilloux G, Jarry A, Couvelard A, Tréton X, Voisin T, Ogier-Denis E, Couvineau A. | 12/22/2018 |
| Investigated the role of orexin receptors in compulsive-like alcohol drinking, found that systemic administration of the selective OX1R blocker SB-334867 reduced compulsive-like consumption. Results suggest that OX1R signaling is particularly important for promoting compulsive-like alcohol drinking, and that OX1Rs might represent a novel therapy to counteract compulsive aspects of human alcohol use disorders. | Orexin-1 receptor blockade suppresses compulsive-like alcohol drinking in mice.
Lei K, Wegner SA, Yu JH, Hopf FW., Free PMC Article | 02/24/2018 |
| OXA and OX1R are expressed in the testis and that they may help in proliferation and development of germ cells, Leydig cells and Sertoli cells, and in the spermatogenic process and steroidogenesis. | Localization and expression of Orexin A and its receptor in mouse testis during different stages of postnatal development.
Joshi D, Singh SK. | 09/9/2017 |
| Results thus suggest that type 1 diabetes mellitus impairs testicular steroidogenesis and glucose homeostasis through inhibition of orexin A/OX1R signaling cascade due to decreased OX1R expression in adult mice, thereby affecting germ cell survival and their proliferation in the testis. | Decreased expression of orexin 1 receptor in adult mice testes during alloxan-induced diabetes mellitus perturbs testicular steroidogenesis and glucose homeostasis.
Joshi D, Sarkar D, Singh SK. | 08/12/2017 |
| Binding of OXA to OX1R is important for the development of the testis. | Localization, expression and role of Orexin A and its receptor in testes of neonatal mice.
Joshi D, Singh SK. | 08/5/2017 |
| Study demonstrated that activation of the OX1 receptor in the ventrolateral periaqueductal gray of mice can initiate an endocannabinoid-CB1 receptor-mediated analgesia. Activation of the OX2 receptor in the ventrolateral periaqueductal gray was also antinociceptive but this antinociceptive effect is CB1 receptor-independent. | Stress induces analgesia via orexin 1 receptor-initiated endocannabinoid/CB1 signaling in the mouse periaqueductal gray.
Lee HJ, Chang LY, Ho YC, Teng SF, Hwang LL, Mackie K, Chiou LC., Free PMC Article | 06/24/2017 |
| Elevation levels of OX1R and OX2R following experimental autoimmune encephalomyelitis induction suggest that alteration in orexinergic system may involve in pathogenesis of multiple sclerosis. | Increase in mRNA Level of Orexin1 and 2 Receptors Following Induction of Experimental Autoimmune Encephalomyelitis in Mice.
Fatemi I, Shamsizadeh A, Roohbakhsh A, Ayoobi F, Sanati MH, Motevalian M. | 01/28/2017 |
| Study provides pharmacological and molecular evidence indicating, respectively, a role for OXR1 signaling in ethanol and saccharin binge-like drinking | Orexin receptor 1 signaling contributes to ethanol binge-like drinking: Pharmacological and molecular evidence.
Carvajal F, Alcaraz-Iborra M, Lerma-Cabrera JM, Valor LM, de la Fuente L, Sanchez-Amate Mdel C, Cubero I. | 01/23/2016 |
| orexin activation of OX1R in the bone locally suppresses bone formation and enhances bone resorption by lowering osseous ghrelin expression. | Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action.
Wei W, Motoike T, Krzeszinski JY, Jin Z, Xie XJ, Dechow PC, Yanagisawa M, Wan Y., Free PMC Article | 06/20/2015 |
| findings demonstrate that Hcrtr-1 modulates the reinforcing properties of cannabinoids. | The hypocretin/orexin receptor-1 as a novel target to modulate cannabinoid reward.
Flores Á, Maldonado R, Berrendero F. | 01/24/2015 |
| The transcripts for the Orx1 and Orx2 receptors diverged in the basolateral amygdala with Orx1 increasing and Orx2 decreasing in animals that were susceptible to the chronic defeat. | Anxiolytic function of the orexin 2/hypocretin A receptor in the basolateral amygdala.
Arendt DH, Hassell J, Li H, Achua JK, Guarnieri DJ, Dileone RJ, Ronan PJ, Summers CH., Free PMC Article | 10/11/2014 |
| more severe depressive behavior was associated with reduced hippocampal orexin expression, contrasted with increased orexin plus Orx1 receptor mRNA expression in the amygdala. | Depressive behavior and activation of the orexin/hypocretin system.
Arendt DH, Ronan PJ, Oliver KD, Callahan LB, Summers TR, Summers CH. | 07/27/2013 |
| data demonstrate that hypocretin signaling acting on Hcrtr-1 in the PVN plays a crucial role in the expression of nicotine withdrawal. | Hypocretin/orexin signaling in the hypothalamic paraventricular nucleus is essential for the expression of nicotine withdrawal.
Plaza-Zabala A, Flores Á, Maldonado R, Berrendero F. | 05/19/2012 |