| EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression. | EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression.
Lin ZS, Chung CC, Liu YC, Chang CH, Liu HC, Liang YY, Huang TL, Chen TM, Lee CH, Tang CH, Hung MC, Chen YH., Free PMC Article | 01/14/2023 |
| Rs3802278 in 3'-UTR of SULF1 associated with platinum resistance and survival in Chinese epithelial ovarian cancer patients. | Rs3802278 in 3'-UTR of SULF1 associated with platinum resistance and survival in Chinese epithelial ovarian cancer patients.
Zeng F, Liu Y, Ouyang Q, Sun Z, Zhang K, Li X, Liu Y. | 02/5/2022 |
| LncRNA NEAT1 regulated cell proliferation, invasion, migration and apoptosis by targeting has-miR-376b-3p/SULF1 axis in non-small cell lung cancer. | LncRNA NEAT1 regulated cell proliferation, invasion, migration and apoptosis by targeting has-miR-376b-3p/SULF1 axis in non-small cell lung cancer.
Chen LM, Niu YD, Xiao M, Li XJ, Lin H. | 04/3/2021 |
| HSulf1 and palbociclib exert synergistic antitumor effects on RBpositive triplenegative breast cancer. | HSulf‑1 and palbociclib exert synergistic antitumor effects on RB‑positive triple‑negative breast cancer.
Chen F, Zhang Z, Yu Y, Liu Q, Pu F., Free PMC Article | 03/13/2021 |
| Upregulated sulfatase and downregulated MMP-3 in thoracic aortic aneurysm. | Upregulated sulfatase and downregulated MMP-3 in thoracic aortic aneurysm.
Matusiewicz M, Rachwalik M, Krzystek-Korpacka M, Bielicki G, Berdowska I, Nowicki R, Gamian A, Jasiński M. | 10/10/2020 |
| our study highlights that upregulation of SULF-1 in SKOV3 cells inhibits cell proliferation, migration, and invasion in vitro and decreases lymph node metastasis in vivo. | Upregulation of sulfatase-1 decreases metastatic potential of SKOV3 human ovarian cancer cells in vitro and in vivo.
Mahmoud SA, Mohammed MI, Mahmoud MA, Munkaila A, Yabasin IB. | 05/30/2020 |
| Sulf-1 might play a critical role from development to maintenance of intervertebral disc homeostasis by regulating collagen expression | Role of heparan sulfate 6-0 endosulfatases in intervertebral disc homeostasis.
Otsuki S, Alvarez-Garcia O, Lotz MK, Neo M., Free PMC Article | 02/22/2020 |
| SULF1 is highly expressed and positively correlated with poor prognosis in colon cancer. | [Bioinformatical analysis of correlation between sulfatase-1 (SULF1) and prognosis of colon cancer and underlying mechanisms].
Gong W, Li T. | 01/18/2020 |
| the catch bond interaction between the hydrophilic domain of the human cell surface sulfatase 1 (Sulf1HD) and its physiological substrate heparan sulfate, was investigated. | Exploring the Sulfatase 1 Catch Bond Free Energy Landscape using Jarzynski's Equality.
Walhorn V, Möller AK, Bartz C, Dierks T, Anselmetti D., Free PMC Article | 12/7/2019 |
| Sulf1 is a potential up-regulatory factor in anti-hypertensive actions of CCL5 via AT2 R pathway on Ang II-induced hypertensive effects in SHR VSMCs. | Sulfatase 1 mediates the attenuation of Ang II-induced hypertensive effects by CCL5 in vascular smooth muscle cells from spontaneously hypertensive rats.
Cha HJ, Kim HY, Kim HS. | 10/26/2019 |
| High SULF1 expression is associated with glioma. | Multi-tasking Sulf1/Sulf2 enzymes do not only facilitate extracellular cell signalling but also participate in cell cycle related nuclear events.
Krishnakumar K, Chakravorty I, Foy W, Allen S, Justo T, Mukherjee A, Dhoot GK. | 12/22/2018 |
| These findings suggested that SULF1 could be an indicator of the clinicopathological features and prognosis of pancreatic cancer. | Sulfatase 1 expression in pancreatic cancer and its correlation with clinicopathological features and postoperative prognosis.
Lyu Y, Cheng Y, Wang B, Chen L, Zhao S. | 11/10/2018 |
| Defective autophagy is associated with loss of HSulf-1 in ovarian cancer. | Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer.
Roy D, Mondal S, Khurana A, Jung DB, Hoffmann R, He X, Kalogera E, Dierks T, Hammond E, Dredge K, Shridhar V., Free PMC Article | 10/27/2018 |
| our study found that increased SULF1 expression is significantly predictive of more advanced tumor stage and poorer metastasis-free survival and disease-specific survival in patients with both UTUC and UBUC. | Sulfatase-1 overexpression indicates poor prognosis in urothelial carcinoma of the urinary bladder and upper tract.
Lee HY, Yeh BW, Chan TC, Yang KF, Li WM, Huang CN, Ke HL, Li CC, Yeh HC, Liang PI, Shiue YL, Wu WJ, Li CF., Free PMC Article | 04/28/2018 |
| Data show that sulfatase 1 (hSulf-1) overexpression in melanoma cells can inhibit cell proliferation and induce cell cycle arrest and apoptosis by decreasing the protein kinase B (AKT) phosphorylation and limiting cyclin dependent kinase 4 (CDK4) nuclear import. | Human sulfatase 1 exerts anti-tumor activity by inhibiting the AKT/ CDK4 signaling pathway in melanoma.
Lou X, Sun B, Song J, Wang Y, Jiang J, Xu Y, Ren Z, Su C., Free PMC Article | 03/10/2018 |
| Sulf-1 is responsive to TNF-alpha stimulation and may function as an autocrine regulator of fibroblast expansion in the course of an inflammatory response | Tumour-necrosis factor-α induces heparan sulfate 6-O-endosulfatase 1 (Sulf-1) expression in fibroblasts.
Sikora AS, Hellec C, Carpentier M, Martinez P, Delos M, Denys A, Allain F. | 11/11/2017 |
| The short variants of Sulf1 promoted FGF2-induced MDA-MB231 and MCF7 in vitro growth while full-length Sulf1 inhibited growth supporting in vivo mammary tumour cell signalling patterns of growth. | Short SULF1/SULF2 splice variants predominate in mammary tumours with a potential to facilitate receptor tyrosine kinase-mediated cell signalling.
Gill RM, Mehra V, Milford E, Dhoot GK. | 07/8/2017 |
| The SULF1/SULF2 activation thus does not only promote regulated foetal growth and injury-induced liver regeneration but also dysregulated tumour growth. | SULF1/SULF2 reactivation during liver damage and tumour growth.
Graham K, Murphy JI, Dhoot GK. | 05/13/2017 |
| Results show that SULF1 or SULF2 overexpression contributes to colorectal cancer cell proliferation, migration, and invasion. | Enhanced tumorigenic potential of colorectal cancer cells by extracellular sulfatases.
Vicente CM, Lima MA, Yates EA, Nader HB, Toma L. | 02/6/2016 |
| Data suggest that Sulfatase 1 (hSulf-1) may be a suitable target for cancer therapy. | Sulfatase 1 (hSulf-1) reverses basic fibroblast growth factor-stimulated signaling and inhibits growth of hepatocellular carcinoma in animal model.
Xu G, Ji W, Su Y, Xu Y, Yan Y, Shen S, Li X, Sun B, Qian H, Chen L, Fu X, Wu M, Su C., Free PMC Article | 05/16/2015 |
| findings show an upregulation of SULF1 in degenerative discs for the first time, and suggest that there is a link between SULF1 and disc degeneration | Increased sulfatase 1 gene expression in degenerative intervertebral disc cells.
Tsai TT, Ho NY, Fang HC, Lai PL, Niu CC, Chen LH, Chen WJ, Pang JH. | 05/2/2015 |
| rs6990375 polymorphism of SULF1 gene could be one of the factors related to recurrent miscarriage in Iranian women. | The association of arylendosulfatase 1 (SULF1) gene polymorphism with recurrent miscarriage.
Zahraei M, Sheikhha MH, Kalantar SM, Ghasemi N, Jahaninejad T, Rajabi S, Mohammadpour H., Free PMC Article | 10/25/2014 |
| Loss of HSulf-1 expression promotes tumorigenicity in ovarian cancer through regulating Bim expression. | Loss of HSulf-1 expression enhances tumorigenicity by inhibiting Bim expression in ovarian cancer.
He X, Khurana A, Roy D, Kaufmann S, Shridhar V., Free PMC Article | 10/4/2014 |
| identification of markers including SULF1 may improve detection of this disease at its earliest stages improving patient treatment and prognosis | Association of the SNP rs2623047 in the HSPG modification enzyme SULF1 with an Australian Caucasian breast cancer cohort.
Okolicsanyi RK, Faure M, Jacinto JM, Chacon-Cortes D, Chambers S, Youl PH, Haupt LM, Griffiths LR. | 08/30/2014 |
| SULF1/SULF2 splice variants regulate pancreatic tumor progression. | SULF1/SULF2 splice variants differentially regulate pancreatic tumour growth progression.
Gill RM, Michael A, Westley L, Kocher HM, Murphy JI, Dhoot GK. | 07/12/2014 |