| CLEC16A-An Emerging Master Regulator of Autoimmunity and Neurodegeneration. | CLEC16A-An Emerging Master Regulator of Autoimmunity and Neurodegeneration.
Pandey R, Bakay M, Hakonarson H., Free PMC Article | 05/22/2023 |
| CTLA4, SH2B3, and CLEC16A diversely affect the progression of early islet autoimmunity in relatives of Type 1 diabetes patients. | CTLA4, SH2B3, and CLEC16A diversely affect the progression of early islet autoimmunity in relatives of Type 1 diabetes patients.
Vandewalle J, Desouter AK, Van der Auwera BJ, Tenoutasse S, Gillard P, De Block C, Keymeulen B, Gorus FK, Van de Casteele M, Belgian Diabetes Registry., Free PMC Article | 03/29/2023 |
| CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment. | CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.
Smits DJ, Dekker J, Schot R, Tabarki B, Alhashem A, Demmers JAA, Dekkers DHW, Romito A, van der Spek PJ, van Ham TJ, Bertoli-Avella AM, Mancini GMS., Free PMC Article | 02/27/2023 |
| An intrinsically disordered protein region encoded by the human disease gene CLEC16A regulates mitophagy. | An intrinsically disordered protein region encoded by the human disease gene CLEC16A regulates mitophagy.
Gingerich MA, Liu X, Chai B, Pearson GL, Vincent MP, Stromer T, Zhu J, Sidarala V, Renberg A, Sahu D, Klionsky DJ, Schnell S, Soleimanpour SA., Free PMC Article | 01/28/2023 |
| Exploring the role of the multiple sclerosis susceptibility gene CLEC16A in T cells. | Exploring the role of the multiple sclerosis susceptibility gene CLEC16A in T cells.
Eriksson AM, Leikfoss IS, Abrahamsen G, Sundvold V, Isom MM, Keshari PK, Rognes T, Landsverk OJB, Bos SD, Harbo HF, Spurkland A, Berge T. | 10/30/2021 |
| Mitophagy protects beta cells from inflammatory damage in diabetes. | Mitophagy protects β cells from inflammatory damage in diabetes.
Sidarala V, Pearson GL, Parekh VS, Thompson B, Christen L, Gingerich MA, Zhu J, Stromer T, Ren J, Reck EC, Chai B, Corbett JA, Mandrup-Poulsen T, Satin LS, Soleimanpour SA., Free PMC Article | 05/29/2021 |
| The Role of Autoimmunity-Related Gene CLEC16A in the B Cell Receptor-Mediated HLA Class II Pathway. | The Role of Autoimmunity-Related Gene CLEC16A in the B Cell Receptor-Mediated HLA Class II Pathway.
Rijvers L, Melief MJ, van Langelaar J, van der Vuurst de Vries RM, Wierenga-Wolf AF, Koetzier SC, Priatel JJ, Jorritsma T, van Ham SM, Hintzen RQ, van Luijn MM. | 03/27/2021 |
| CLEC16A rs12708716 is associated with insulin-triggered type 1 diabetes. | Variants in the BACH2 and CLEC16A gene might be associated with susceptibility to insulin-triggered type 1 diabetes.
Onuma H, Kawamura R, Tabara Y, Yamashita M, Ohashi J, Kawasaki E, Imagawa A, Yamada Y, Chujo D, Takahashi K, Suehiro T, Takata Y, Osawa H, Makino H., Free PMC Article | 04/18/2020 |
| CLEC16A restrains secretory functions including cytokine release and cytotoxicity, and a delicate balance of CLEC16A is needed for NK cell function and homeostasis. | The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice.
Pandey R, Bakay M, Hain HS, Strenkowski B, Yermakova A, Kushner JA, Orange JS, Hakonarson H., Free PMC Article | 01/11/2020 |
| The genotypes of IL-4 (rs2243250)*C/C and CLEC16A (rs6498169)*G/G were associated with primary progressive multiple sclerosis in Russians. The association between the HLA-DRB1*15 and PPMS found out in other populations was confirmed in Russians. | [Polymorphic variants of the immune response genes as risk factors for primary progressive multiple sclerosis].
Popova EV, Kiselev IS, Boyko AN, Sivertseva SA, Malkova NA, Korobko DS, Spirin NN, Kasatkin DS, Karaeva AV, Turova EL, Spirina NN, Volkova LI, Baulina NM, Bashinskaya VV, Kulakova OG, Favorova OO. | 04/13/2019 |
| Data (including data from studies using knockout and transgenic mice/cells) suggest that CLEC16A, NRDP1, and USP8 form tripartite complex; CLEC16A-NRDP1-USP8 complex appears to rely on ubiquitin signals to promote mitophagy and maintain mitochondrial function necessary for beta-cell function. (CLEC16A = C-type lectin domain family 16 member A; NRDP1 = ubiquitin-protein ligase NRDP1; USP8 = ubiquitin specific peptidase 8) | Clec16a, Nrdp1, and USP8 Form a Ubiquitin-Dependent Tripartite Complex That Regulates β-Cell Mitophagy.
Pearson G, Chai B, Vozheiko T, Liu X, Kandarpa M, Piper RC, Soleimanpour SA., Free PMC Article | 05/26/2018 |
| Golgi-associated CLEC16A negatively regulates autophagy via modulation of mTOR activity. | Human CLEC16A regulates autophagy through modulating mTOR activity.
Tam RC, Li MW, Gao YP, Pang YT, Yan S, Ge W, Lau CS, Chan VS. | 05/27/2017 |
| Study provides evidence that Clec16a plays a key role in the survival of Purkinje cells and in the degradative function or clearance of autolysosomes. | Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival.
Redmann V, Lamb CA, Hwang S, Orchard RC, Kim S, Razi M, Milam A, Park S, Yokoyama CC, Kambal A, Kreamalmeyer D, Bosch MK, Xiao M, Green K, Kim J, Pruett-Miller SM, Ornitz DM, Allen PM, Beatty WL, Schmidt RE, DiAntonio A, Tooze SA, Virgin HW., Free PMC Article | 01/28/2017 |
| A possible regulatory role for the multiple sclerosis-associated rs12927355 in CLEC16A. | Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells.
Leikfoss IS, Keshari PK, Gustavsen MW, Bjølgerud A, Brorson IS, Celius EG, Spurkland A, Bos SD, Harbo HF, Berge T., Free PMC Article | 05/21/2016 |
| CLEC16A was found to be a susceptibility factor for SLE, with possible contribution to the development of the disease. | Systemic Lupus Erythematosus Patients Exhibit Reduced Expression of CLEC16A Isoforms in Peripheral Leukocytes.
Tam RC, Lee AL, Yang W, Lau CS, Chan VS., Free PMC Article | 04/2/2016 |
| Clec16a knockdown mice showed reduced number of B cells and elevated IgM levels compared with controls. | Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells.
Li J, Jørgensen SF, Maggadottir SM, Bakay M, Warnatz K, Glessner J, Pandey R, Salzer U, Schmidt RE, Perez E, Resnick E, Goldacker S, Buchta M, Witte T, Padyukov L, Videm V, Folseraas T, Atschekzei F, Elder JT, Nair RP, Winkelmann J, Gieger C, Nöthen MM, Büning C, Brand S, Sullivan KE, Orange JS, Fevang B, Schreiber S, Lieb W, Aukrust P, Chapel H, Cunningham-Rundles C, Franke A, Karlsen TH, Grimbacher B, Hakonarson H, Hammarström L, Ellinghaus E., Free PMC Article | 03/5/2016 |
| identify CLEC16A as a pivotal gene in multiple sclerosis that serves as a direct regulator of the human leukocyte antigen class II pathway in antigen-presenting cells. | Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis.
van Luijn MM, Kreft KL, Jongsma ML, Mes SW, Wierenga-Wolf AF, van Meurs M, Melief MJ, der Kant Rv, Janssen L, Janssen H, Tan R, Priatel JJ, Neefjes J, Laman JD, Hintzen RQ., Free PMC Article | 08/8/2015 |
| data suggests that two polymorphisms of the CLEC16A gene play an important role in the developing of ACS in men. | Association of the C-type lectin-like domain family-16A (CLEC16A) gene polymorphisms with acute coronary syndrome in Mexican patients.
Vargas-Alarcon G, Ramirez-Bello J, Angeles-Martinez J, Rodriguez-Perez JM, Perez-Hernandez N, Posadas-Romero C, Jorge-Galarza E, Ocampo-Arcos WA, Obil-Chavarria C, Fragoso JM. | 08/1/2015 |
| This study demonstrated that the Polymorphism, Single Nucleotide of CLEC16A is associated with multiple sclerosis in Russia. | GWAS-identified multiple sclerosis risk loci involved in immune response: validation in Russians.
Bashinskaya VV, Kulakova OG, Kiselev IS, Baulina NM, Favorov AV, Boyko AN, Tsareva EY, Favorova OO. | 07/4/2015 |
| The study suggested that a CLEC16A polymorphism may be protective against Vogt-Koyanagi-Harada syndrome syndrome in a Chinese Han population. | A variant of CLEC16A gene confers protection for Vogt-Koyanagi-Harada syndrome but not for Behcet's disease in a Chinese Han population.
Li K, Hou S, Qi J, Kijlstra A, Yang P. | 05/9/2015 |
| Our results suggest that polymorphisms rs6498169 of CLEC16A gene confers susceptibility to AITDs. We therefore disclose for the first time the association of rs6498169 SNP with AITDs. | Polymorphisms of CLEC16A region and autoimmune thyroid diseases.
Muhali FS, Cai TT, Zhu JL, Qin Q, Xu J, He ST, Shi XH, Jiang WJ, Xiao L, Li DF, Zhang JA., Free PMC Article | 01/24/2015 |
| Forty-eight SNPs, all located in CLEC16A, provided a statistically significant association with type 1 diabetes mellitus, with rs34306440 being most significantly associated. The mechanisim is likely through reduced expression of DEXI transcripts. | Fine mapping and functional studies of risk variants for type 1 diabetes at chromosome 16p13.13.
Tomlinson MJ 4th, Pitsillides A, Pickin R, Mika M, Keene KL, Hou X, Mychaleckyj J, Chen WM, Concannon P, Onengut-Gumuscu S., Free PMC Article | 01/17/2015 |
| Study demonstrates that a diabetogenic SNP in the CLEC16A locus correlates with islet CLEC16A expression, beta cell function, and glycemic control in human subjects. Clec16a controls beta cell function and prevents diabetes by controlling mitophagy. | The diabetes susceptibility gene Clec16a regulates mitophagy.
Soleimanpour SA, Gupta A, Bakay M, Ferrari AM, Groff DN, Fadista J, Spruce LA, Kushner JA, Groop L, Seeholzer SH, Kaufman BA, Hakonarson H, Stoffers DA., Free PMC Article | 09/6/2014 |
| The data indicates a possible regulatory role for multiple sclerosis-associated non-coding CLEC16A SNPs and a common control mechanism for the expression of CLEC16A, SOCS1 and DEXI. | Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus.
Leikfoss IS, Mero IL, Dahle MK, Lie BA, Harbo HF, Spurkland A, Berge T. | 06/29/2013 |
| Polymorphisms in the inflammatory genes CIITA, CLEC16A and IFNG influence BMD, bone loss and fracture in elderly women | Polymorphisms in the inflammatory genes CIITA, CLEC16A and IFNG influence BMD, bone loss and fracture in elderly women.
Swanberg M, McGuigan FE, Ivaska KK, Gerdhem P, Åkesson K., Free PMC Article | 05/11/2013 |