| Hnrnpk protects against osteoarthritis through targeting WWC1 mRNA and inhibiting Hippo signaling pathway. | Hnrnpk protects against osteoarthritis through targeting WWC1 mRNA and inhibiting Hippo signaling pathway.
Zhang S, Zhang B, Liao Z, Chen Y, Guo W, Wu J, Liu H, Weng R, Su D, Chen G, Zhang Z, Li C, Long J, Xiao Y, Ma Y, Zhou T, Xu C, Su P., | 05/23/2024 |
| KIBRA single nucleotide polymorphism is associated with hippocampal subfield volumes and cognition across development. | KIBRA single nucleotide polymorphism is associated with hippocampal subfield volumes and cognition across development.
Homayouni R, Daugherty AM, Yu Q, Raz N, Ofen N. | 02/7/2024 |
| KIBRA upregulation increases susceptibility to podocyte injury and glomerular disease progression. | KIBRA upregulation increases susceptibility to podocyte injury and glomerular disease progression.
Meliambro K, Yang Y, de Cos M, Rodriguez Ballestas E, Malkin C, Haydak J, Lee JR, Salem F, Mariani LH, Gordon RE, Basgen JM, Wen HH, Fu J, Azeloglu EU, He JC, Wong JS, Campbell KN., Free PMC Article | 04/12/2023 |
| Thalamic gray matter volume mediates the association between KIBRA polymorphism and olfactory function among older adults: a population-based study. | Thalamic gray matter volume mediates the association between KIBRA polymorphism and olfactory function among older adults: a population-based study.
Song L, Han X, Li Y, Han X, Zhao M, Li C, Wang P, Wang J, Dong Y, Cong L, Han X, Hou T, Liu K, Wang Y, Qiu C, Du Y., Free PMC Article | 04/4/2023 |
| Associations of WWC1 variants with Alzheimer's disease and vascular dementia among rural older adults in China: A population-based study. | Associations of WWC1 variants with Alzheimer's disease and vascular dementia among rural older adults in China: A population-based study.
Wang C, Han X, Dong Y, Liu C, Wang X, Hou T, Tan Q, Wang Y, Du Y, Qiu C. | 03/31/2023 |
| KIBRA Gene Variant Is Associated with Ability in Chess and Science. | KIBRA Gene Variant Is Associated with Ability in Chess and Science.
Ahmetov II, Valeeva EV, Yerdenova MB, Datkhabayeva GK, Bouzid A, Bhamidimarri PM, Sharafetdinova LM, Egorova ES, Semenova EA, Gabdrakhmanova LJ, Yusupov RA, Larin AK, Kulemin NA, Generozov EV, Hamoudi R, Kustubayeva AM, Rees T., Free PMC Article | 02/14/2023 |
| BDNF and KIBRA Polymorphisms Are Related to Altered Resting State Network Connectivity in Middle Age. | BDNF and KIBRA Polymorphisms Are Related to Altered Resting State Network Connectivity in Middle Age.
Blujus JK, Korthauer LE, Awe E, Frahmand M, Driscoll I. | 07/9/2022 |
| Pathological Significance and Prognostic Role of WWC1 in Upper Urinary Tract Urothelial Cancer. | Pathological Significance and Prognostic Role of WWC1 in Upper Urinary Tract Urothelial Cancer.
Kurata H, Mitsunari K, Kondo T, Masato M, Ito H, Mukae Y, Nakamura Y, Matsuo T, Ohba K, Mochizuki Y, Sakai H, Miyata Y. | 05/14/2022 |
| KIBRA connects Hippo signaling and cancer. | KIBRA connects Hippo signaling and cancer.
Swaroop B SS, Kanumuri R, Ezhil I, Naidu Sampangi JK, Kremerskothen J, Rayala SK, Venkatraman G. | 09/25/2021 |
| Low KIBRA Expression Is Associated with Poor Prognosis in Patients with Triple-Negative Breast Cancer. | Low KIBRA Expression Is Associated with Poor Prognosis in Patients with Triple-Negative Breast Cancer.
Kim SW, Chu J, Do SI, Na K., Free PMC Article | 09/11/2021 |
| Interaction of COMT and KIBRA modulates the association between hippocampal structure and episodic memory performance in healthy young adults. | Interaction of COMT and KIBRA modulates the association between hippocampal structure and episodic memory performance in healthy young adults.
Wang J, Wu S, Sun Y, Fang Y, Wu R, Lu J, Qing Z, Liang X, Wang Z, Zhang W, Chen Q, Cao P, Zhang B. | 05/22/2021 |
| KIBRA polymorphism modulates gray matter volume to influence cognitive ability in the elderly. | KIBRA polymorphism modulates gray matter volume to influence cognitive ability in the elderly.
Li R, Wan W, Li J. | 05/8/2021 |
| SOX2 antagonizes WWC1 to drive YAP1 activation in esophageal squamous cell carcinoma. | SOX2 antagonizes WWC1 to drive YAP1 activation in esophageal squamous cell carcinoma.
Chai Y, Li Q, Zhao H, Zhang Z, Yu X, Pang L, Liu Z, Zhao J, Wang L, Li F., Free PMC Article | 09/26/2020 |
| The Influence of Hippocampal Dopamine D2 Receptors on Episodic Memory Is Modulated by BDNF and KIBRA Polymorphisms. | The Influence of Hippocampal Dopamine D2 Receptors on Episodic Memory Is Modulated by BDNF and KIBRA Polymorphisms.
Papenberg G, Karalija N, Salami A, Andersson M, Axelsson J, Riklund K, Lindenberger U, Nyberg L, Bäckman L. | 08/15/2020 |
| We show that recombinant human KIBRA WW2 domain is primarily disordered, binds SYNPO with relatively weak affinity and remains largely disordered in the complex. | Intrinsic disorder and amino acid specificity modulate binding of the WW2 domain in kidney and brain protein (KIBRA) to synaptopodin.
Kwok E, Rodriguez DJ, Kremerskothen J, Nyarko A., Free PMC Article | 06/13/2020 |
| Our results confirm a role of the KIBRA T allele on progression of cognitive decline | KIBRA T allele influences memory performance and progression of cognitive decline: a 7-year follow-up study in subjective cognitive decline and mild cognitive impairment.
Mazzeo S, Bessi V, Padiglioni S, Bagnoli S, Bracco L, Sorbi S, Nacmias B. | 01/18/2020 |
| theses results reveal crosstalk between H3K27me3 inhibition catalyzed by EZH2 and CpG island methylation mediated by DNMT1 within the wwc1 promoter, which synergistically silence wwc1 gene expression in triple negative breast cancer. | The EZH2- H3K27me3-DNMT1 complex orchestrates epigenetic silencing of the wwc1 gene, a Hippo/YAP pathway upstream effector, in breast cancer epithelial cells.
Liu X, Li C, Zhang R, Xiao W, Niu X, Ye X, Li Z, Guo Y, Tan J, Li Y. | 11/30/2019 |
| KIBRA functions co-operatively with the protein tyrosine phosphatase PTPN14 to trigger mechanotransduction-regulated signals that inhibit the nuclear localization of oncogenic transcriptional co-activators YAP/TAZ. Our results argue that the selective advantage produced by 5q loss involves reduced dosage of KIBRA, promoting oncogenic functioning of YAP/TAZ in TNBC. | KIBRA (WWC1) Is a Metastasis Suppressor Gene Affected by Chromosome 5q Loss in Triple-Negative Breast Cancer.
Knight JF, Sung VYC, Kuzmin E, Couzens AL, de Verteuil DA, Ratcliffe CDH, Coelho PP, Johnson RM, Samavarchi-Tehrani P, Gruosso T, Smith HW, Lee W, Saleh SM, Zuo D, Zhao H, Guiot MC, Davis RR, Gregg JP, Moraes C, Gingras AC, Park M., Free PMC Article | 09/21/2019 |
| Epistasis between variants of WWC1 and TLN2 in association to Alzheimer's. | Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease.
Gusareva ES, Twizere JC, Sleegers K, Dourlen P, Abisambra JF, Meier S, Cloyd R, Weiss B, Dermaut B, Bessonov K, van der Lee SJ, Carrasquillo MM, Katsumata Y, Cherkaoui M, Asselbergh B, Ikram MA, Mayeux R, Farrer LA, Haines JL, Pericak-Vance MA, Schellenberg GD, Genetic and Environmental Risk in Alzheimer's Disease 1 consortium (GERAD1), Alzheimer's Disease Genetics Consortium (ADGC), European Alzheimer Disease Initiative Investigators (EADI1 Consortium), Sims R, Williams J, Amouyel P, van Duijn CM, Ertekin-Taner N, Van Broeckhoven C, Dequiedt F, Fardo DW, Lambert JC, Van Steen K., Free PMC Article | 09/21/2019 |
| MiR-21 suppressed the Hippo signaling pathway and promoted the progression of lung adenocarcinoma through targeting KIBRA. | Upregulated microRNA miR-21 promotes the progression of lung adenocarcinoma through inhibition of KIBRA and the Hippo signaling pathway.
An Y, Zhang Q, Li X, Wang Z, Li Y, Tang X. | 03/23/2019 |
| These results indicate that KIBRA C2 domain association with membranes is calcium-independent and involves distinctive C2 domain-membrane relative orientations. | Distinctive phosphoinositide- and Ca(2+)-binding properties of normal and cognitive performance-linked variant forms of KIBRA C2 domain.
Posner MG, Upadhyay A, Ishima R, Kalli AC, Harris G, Kremerskothen J, Sansom MSP, Crennell SJ, Bagby S., Free PMC Article | 01/26/2019 |
| Our findings suggest that the T-allele of KIBRA rs17070145 supports recollection based episodic memory retrieval and contributes to memory accuracy in a gender dependent manner. | The role of KIBRA in reconstructive episodic memory.
Zlomuzica A, Preusser F, Roberts S, Woud ML, Lester KJ, Dere E, Eley TC, Margraf J., Free PMC Article | 01/19/2019 |
| Overall low-KIBRA expression has an independent effect on the recurrence-free survival (RFS) and predicts the RFS outcome of luminal breast cancer patients who received endocrine therapy and breast cancer patients who received chemotherapy. | KIBRA; a novel biomarker predicting recurrence free survival of breast cancer patients receiving adjuvant therapy.
Mudduwa L, Peiris H, Gunasekara S, Abeysiriwardhana D, Liyanage N, Rayala SK, Liyanage T., Free PMC Article | 01/19/2019 |
| KIBRA rs17070145 is associated with accelerated cognitive decline in APOE epsilon4-positive cognitively normal adults with high Abeta-amyloid burden. | KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden.
Porter T, Burnham SC, Doré V, Savage G, Bourgeat P, Begemann K, Milicic L, Ames D, Bush AI, Maruff P, Masters CL, Rowe CC, Rainey-Smith S, Martins RN, Groth D, Verdile G, Villemagne VL, Laws SM., Free PMC Article | 12/1/2018 |
| Data (including data from studies in knockout mice) suggest that KIBRA plays important role in regulating HPO activity, YAP signaling, and actin cytoskeletal dynamics in podocytes; expression of KIBRA and YAP plus phosphorylation of YAP are up-regulated in glomeruli of patients with focal segmental glomerulosclerosis. (KIBRA = kidney/brain protein-KIBRA; HPO = hepatopoietin protein; YAP = Yes associated protein-1) | The Hippo pathway regulator KIBRA promotes podocyte injury by inhibiting YAP signaling and disrupting actin cytoskeletal dynamics.
Meliambro K, Wong JS, Ray J, Calizo RC, Towne S, Cole B, El Salem F, Gordon RE, Kaufman L, He JC, Azeloglu EU, Campbell KN., Free PMC Article | 11/17/2018 |