| Induction of Siglec-F[hi]CD101[hi] eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection. | Induction of Siglec-F(hi)CD101(hi) eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection.
Chetty A, Darby MG, Pillaye J, Taliep A, Cunningham AF, O'Shea MK, Katawa G, Layland LE, Ritter M, Horsnell WGC., Free PMC Article | 06/3/2023 |
| Siglec-F-expressing neutrophils are essential for creating a profibrotic microenvironment in renal fibrosis. | Siglec-F-expressing neutrophils are essential for creating a profibrotic microenvironment in renal fibrosis.
Ryu S, Shin JW, Kwon S, Lee J, Kim YC, Bae YS, Bae YS, Kim DK, Kim YS, Yang SH, Kim HY., Free PMC Article | 06/18/2022 |
| IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F(+) neutrophils. | IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F(+) neutrophils.
Borkner L, Curham LM, Wilk MM, Moran B, Mills KHG., Free PMC Article | 01/22/2022 |
| Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration. | Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration.
Morshed N, Ralvenius WT, Nott A, Watson LA, Rodriguez FH, Akay LA, Joughin BA, Pao PC, Penney J, LaRocque L, Mastroeni D, Tsai LH, White FM., Free PMC Article | 08/28/2021 |
| A novel Siglec-F(+) neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model. | A novel Siglec-F(+) neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model.
Matsui M, Nagakubo D, Satooka H, Hirata T. | 12/5/2020 |
| the knockdown of Siglec-F enhanced GM-CSF-induced STAT5 phosphorylation and reduced the STAT6 phosphorylation and expression of arginase-1 in interleukin-4-stimulated macrophages | Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages.
Tateyama H, Murase Y, Higuchi H, Inasaka Y, Kaneoka H, Iijima S, Nishijima KI., Free PMC Article | 02/22/2020 |
| Immunohistochemical analysis of the Peyer's patches (PPs) tissue sections shows that Siglec-F is expressed on the surface of the Intestinal microfold (M) cell membrane exposed to the intestinal lumen. | Siglec-F is a novel intestinal M cell marker.
Gicheva N, Macauley MS, Arlian BM, Paulson JC, Kawasaki N., Free PMC Article | 06/24/2017 |
| These data identify a previously unrecognized endogenous anti-inflammatory property of airway mucins by which their glycans can control lung eosinophilia through engagement of Siglec-F. | Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.
Kiwamoto T, Katoh T, Evans CM, Janssen WJ, Brummet ME, Hudson SA, Zhu Z, Tiemeyer M, Bochner BS., Free PMC Article | 07/25/2015 |
| depending on the nature of the allergy model used, the negative regulatory role of siglec-F on eosinophilia may be overridden. | Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model.
McMillan SJ, Richards HE, Crocker PR., Free PMC Article | 01/10/2015 |
| Engagement of Siglec-F induced mouse eosinophil apoptosis that was modest in magnitude and dependent on caspase activity. | Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen.
Mao H, Kano G, Hudson SA, Brummet M, Zimmermann N, Zhu Z, Bochner BS., Free PMC Article | 04/26/2014 |
| Sialic acid-binding Ig-like lectin-F (Siglec-F) in mice and its functional paralog Siglec-8 in humans are transmembrane receptors that play a role in the apoptosis of eosinophils. | Antiallergic effect of anti-Siglec-F through reduction of eosinophilic inflammation in murine allergic rhinitis.
Kim YH, Park CS, Lim DH, Son BK, Kim JH, Ahn SH, Bochner BS, Na K, Jang TY. | 01/4/2014 |
| neither KSGal6ST nor C6ST-1 is required for Siglec-F ligand synthesis in leukocytes or lung tissue | Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue.
Patnode ML, Cheng CW, Chou CC, Singer MS, Elin MS, Uchimura K, Crocker PR, Khoo KH, Rosen SD., Free PMC Article | 12/21/2013 |
| these studies demonstrate that ST3Gal-III plays an important role in Siglec-F ligand formation and eosinophil apoptosis with resultant effects on eosinophilic inflammation in the lung. | Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice.
Suzukawa M, Miller M, Rosenthal P, Cho JY, Doherty TA, Varki A, Broide D., Free PMC Article | 08/31/2013 |
| Overall, this study demonstrates an important role for Siglec-F in modulating levels of chronic eosinophilic airway inflammation, peribronchial fibrosis. | Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13.
Cho JY, Song DJ, Pham A, Rosenthal P, Miller M, Dayan S, Doherty TA, Varki A, Broide DH., Free PMC Article | 03/26/2011 |
| alpha2,3-linked sialic acid-containing glycoprotein Siglec-F ligands and the enzymes required for their synthesis are constitutively expressed in lungs, especially by airway epithelium. | Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs.
Guo JP, Brummet ME, Myers AC, Na HJ, Rowland E, Schnaar RL, Zheng T, Zhu Z, Bochner BS., Free PMC Article | 03/19/2011 |
| REVIEW: Murine experiments in normal, Siglec-F-deficient mice and hypereosinophilic mice have resulted in similar conclusions that Siglec-F, like Siglec-8, plays a distinctive and important role in regulating eosinophil accumulation and survival in vivo. | Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors.
Bochner BS., Free PMC Article | 01/21/2010 |
| are a family of sialic acid receptor proteins expressed in immune cells, recognize their ligands and play a role in the signal transduction. | [Functions and molecular evolution of Siglecs, a family of sialic acid receptor proteins].
Angata T. | 01/21/2010 |
| The results suggest that these two siglec proteins have evolved distinct endocytic mechanisms consistent with roles in cell signaling and innate immunity. | Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity.
Tateno H, Li H, Schur MJ, Bovin N, Crocker PR, Wakarchuk WW, Paulson JC., Free PMC Article | 01/21/2010 |
| Negative feedback role for Siglec-F in regulating the pathogenesis of human eosinophil-mediated disorders. | Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils.
Zhang M, Angata T, Cho JY, Miller M, Broide DH, Varki A., Free PMC Article | 01/21/2010 |
| We detected expression of mSiglec-5 (or -F), -10, and -E mRNA in purified mouse eosinophils | Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G).
Aizawa H, Zimmermann N, Carrigan PE, Lee JJ, Rothenberg ME, Bochner BS. | 01/21/2010 |