| Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages. | Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages.
Masui O, Corbel C, Nagao K, Endo TA, Kezuka F, Diabangouaya P, Nakayama M, Kumon M, Koseki Y, Obuse C, Koseki H, Heard E. | 02/4/2023 |
| PRC1 is a critical regulator for anaphase spindle midzone assembly and cytokinesis in mouse oocyte meiosis. | PRC1 is a critical regulator for anaphase spindle midzone assembly and cytokinesis in mouse oocyte meiosis.
Li XH, Ju JQ, Pan ZN, Wang HH, Wan X, Pan MH, Xu Y, Sun MH, Sun SC. | 07/24/2021 |
| Cdk1 negatively regulates the spindle localization of Prc1 in mouse oocytes. | Cdk1 negatively regulates the spindle localization of Prc1 in mouse oocytes.
Nishiyama S, Yoshida S, Kitajima TS. | 06/12/2021 |
| Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes. | Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes.
Yoshida S, Nishiyama S, Lister L, Hashimoto S, Mishina T, Courtois A, Kyogoku H, Abe T, Shiraishi A, Choudhary M, Nakaoka Y, Herbert M, Kitajima TS., Free PMC Article | 08/22/2020 |
| The results suggest that histone H1-dependent chromatin compaction plays a critical role in the stable propagation of H2AK119ub1 by RYBP/YAF2-PRC1 during cell division. | RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division.
Zhao J, Wang M, Chang L, Yu J, Song A, Liu C, Huang W, Zhang T, Wu X, Shen X, Zhu B, Li G. | 04/25/2020 |
| Results indicate that Ub-independent mode of repression by PRC1 plays a key role in mammalian development during cell fate restriction. | Ubiquitination-Independent Repression of PRC1 Targets during Neuronal Fate Restriction in the Developing Mouse Neocortex.
Tsuboi M, Kishi Y, Yokozeki W, Koseki H, Hirabayashi Y, Gotoh Y. | 05/25/2019 |
| Authors analyzed whether elevated levels of the polycomb repressor complex 1 (PRC1) components Bmi1 and Ring1b and their catalyzed histone modification H2AK119ub in ADMs and tumor cells, are responsible for the mediation of acinar gene silencing. | Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells.
Benitz S, Regel I, Reinhard T, Popp A, Schäffer I, Raulefs S, Kong B, Esposito I, Michalski CW, Kleeff J., Free PMC Article | 12/2/2017 |
| Here, the authors discover that the histone H2AK119 E3 ubiquitin ligase activity of Polycomb repressive complex 1 (PRC1) is defined by the composition of its catalytic subunits and is highly regulated by RYBP/YAF2-dependent stimulation. | RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes.
Rose NR, King HW, Blackledge NP, Fursova NA, Ember KJ, Fischer R, Kessler BM, Klose RJ., Free PMC Article | 11/4/2017 |
| Here, by combining live-cell single-molecule tracking (SMT) and genetic engineering, the authors reveal that H3K27me3 contributes significantly to the targeting of Cbx7-PRC1 complex to chromatin. | Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin.
Zhen CY, Tatavosian R, Huynh TN, Duc HN, Das R, Kokotovic M, Grimm JB, Lavis LD, Lee J, Mejia FJ, Li Y, Yao T, Ren X., Free PMC Article | 11/4/2017 |
| Pcgf6 is essential for recruitment of PRC1.6 to chromatin. Our results reveal a previously uncharacterized, H2AK119ub1-independent chromatin assembly associated with PRC1.6 complex | Essential Role for Polycomb Group Protein Pcgf6 in Embryonic Stem Cell Maintenance and a Noncanonical Polycomb Repressive Complex 1 (PRC1) Integrity.
Zhao W, Tong H, Huang Y, Yan Y, Teng H, Xia Y, Jiang Q, Qin J., Free PMC Article | 07/8/2017 |
| The data reveal how the interplay between PRC1, ncRNA and Mediator complexes controls pluripotency and cellular differentiation. | Dual role of Med12 in PRC1-dependent gene repression and ncRNA-mediated transcriptional activation.
Papadopoulou T, Kaymak A, Sayols S, Richly H., Free PMC Article | 05/20/2017 |
| our findings show that PRC1 mediates gene repression by combining multiple and different effector mechanisms, of which H2A ubiquitination is a major contributor | Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity.
Endoh M, Endo TA, Endoh T, Isono K, Sharif J, Ohara O, Toyoda T, Ito T, Eskeland R, Bickmore WA, Vidal M, Bernstein BE, Koseki H., Free PMC Article | 01/5/2013 |