| A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network. | A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.
Broman MT, Nadadur RD, Perez-Cervantes C, Burnicka-Turek O, Lazarevic S, Gams A, Laforest B, Steimle JD, Iddir S, Wang Z, Smith L, Mazurek SR, Olivey HE, Zhou P, Gadek M, Shen KM, Khan Z, Theisen JWM, Yang XH, Ikegami K, Efimov IR, Pu WT, Weber CR, McNally EM, Svensson EC, Moskowitz IP. | 04/16/2024 |
| Long noncoding RNA CCDC26 as a modulator of transcriptional switching between fetal and embryonic globins. | Long noncoding RNA CCDC26 as a modulator of transcriptional switching between fetal and embryonic globins.
Hirano T, Tsuruda T, Tanaka Y, Harada H, Yamazaki T, Ishida A. | 07/17/2021 |
| LncRNA ZFPM2-AS1 promotes lung adenocarcinoma progression by interacting with UPF1 to destabilize ZFPM2. | LncRNA ZFPM2-AS1 promotes lung adenocarcinoma progression by interacting with UPF1 to destabilize ZFPM2.
Han S, Cao D, Sha J, Zhu X, Chen D., Free PMC Article | 05/15/2021 |
| EphA3 promotes the proliferation of NPC cells through negatively regulating the ability of FOG2. | EphA3 promotes the proliferation of NPC cells through negatively regulating the ability of FOG2.
Song Z, Gao S, Liu YM, Wang Y, Sun ZX, Bao D, Liu C. | 04/17/2021 |
| Analysis of variants in GATA4 and FOG2/ZFPM2 demonstrates benign contribution to 46,XY disorders of sex development. | Analysis of variants in GATA4 and FOG2/ZFPM2 demonstrates benign contribution to 46,XY disorders of sex development.
van den Bergen JA, Robevska G, Eggers S, Riedl S, Grover SR, Bergman PB, Kimber C, Jiwane A, Khan S, Krausz C, Raza J, Atta I, Davis SR, Ono M, Harley V, Faradz SMH, Sinclair AH, Ayers KL., Free PMC Article | 04/3/2021 |
| The single nucleotide polymorphisms (SNPs) of NKX2.5, GATA4, and TBX5 are highly associated with congenital heart diseases in the Chinese population, but not significant in the SNPs of FOG2. | [Association of single nucleotide polymorphisms of transcription factors with congenital heart diseases in the Chinese population: a Meta analysis].
Chen LT, Yang TB, Wang TT, Zheng Z, Zhao LJ, Ye ZW, Zhang SM, Qin JB., Free PMC Article | 12/22/2018 |
| when ZFPM2R698Q was co-transfected with GATA4, BNP promoter activity increased significantly, whereas co-transfection with ZFPM2R736L and GATA4 did not significantly increase BNP promoter activity. This suggests that the R698Q mutation may affect the ability of ZFPM2 to bind GATA4. | Identification of ZFPM2 mutations in sporadic conotruncal heart defect patients.
Pu T, Liu Y, Xu R, Li F, Chen S, Sun K. | 02/17/2018 |
| Aberrant methylation status at the promoter CpG island shore of ZFPM2 gene may be associated with its gene transcription regulation in the tetralogy of fallot patients | CpG island shore methylation of ZFPM2 is identified in tetralogy of fallot samples.
Sheng W, Chen L, Wang H, Ma X, Ma D, Huang G. | 05/27/2017 |
| Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor. | Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor.
Klarin D, Emdin CA, Natarajan P, Conrad MF, INVENT Consortium, Kathiresan S., Free PMC Article | 05/6/2017 |
| ZFPM2 is a glioma susceptibility gene, its genotype and expression showing associations with incidence and severity. The balancing selection acting on ZFPM2 may relate to its roles in multiple organ development or associated disease etiology. | Glioma Association and Balancing Selection of ZFPM2.
Tsang SY, Mei L, Wan W, Li J, Li Y, Zhao C, Ding X, Pun FW, Hu X, Wang J, Zhang J, Luo R, Cheung ST, Leung GK, Poon WS, Ng HK, Zhang L, Xue H., Free PMC Article | 05/7/2016 |
| Isolated congenital diaphragmatic hernia was the predominant phenotype observed in our ZFPM2 mutation patients. | Prevalence and penetrance of ZFPM2 mutations and deletions causing congenital diaphragmatic hernia.
Longoni M, Russell MK, High FA, Darvishi K, Maalouf FI, Kashani A, Tracy AA, Coletti CM, Loscertales M, Lage K, Ackerman KG, Woods SA, Ward-Melver C, Andrews D, Lee C, Pober BR, Donahoe PK., Free PMC Article | 12/19/2015 |
| screened a larger CTD population, which comprised 145 tetralogy of Fallot (TOF), 37 double-outlet ventricle outflow (DORV), and 18 transposition of the great artery (TGA), to investigate exon mutations as well as copy number variations in ZFPM2/FOG2 | Novel missense variants of ZFPM2/FOG2 identified in conotruncal heart defect patients do not impair interaction with GATA4.
Zhang W, Shen L, Deng Z, Ding Y, Mo X, Xu Z, Gao Q, Yi L., Free PMC Article | 12/5/2015 |
| Whole exome sequencing identified independent missense mutations in FOG2 in two patients with 46,XY gonadal dysgenesis. | Mutations in the FOG2/ZFPM2 gene are associated with anomalies of human testis determination.
Bashamboo A, Brauner R, Bignon-Topalovic J, Lortat-Jacob S, Karageorgou V, Lourenco D, Guffanti A, McElreavey K. | 02/14/2015 |
| Findings indicate that zinc finger protein, multitype 2 protein (ZFPM2) plays a role in diaphragm and cardiovascular development. | Exome sequencing identifies ZFPM2 as a cause of familial isolated congenital diaphragmatic hernia and possibly cardiovascular malformations.
Brady PD, Van Houdt J, Callewaert B, Deprest J, Devriendt K, Vermeesch JR. | 02/7/2015 |
| Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes. | Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes.
Carter DR, Buckle AD, Tanaka K, Perdomo J, Chong BH., Free PMC Article | 01/3/2015 |
| our results provide strong evidence regarding the susceptibility of the ZFPM2 gene to the development of non-syndromic TOF/DORV. | Identification of novel significant variants of ZFPM2/FOG2 in non-syndromic Tetralogy of Fallot and double outlet right ventricle in a Chinese Han population.
Huang X, Niu W, Zhang Z, Zhou C, Xu Z, Liu J, Su Z, Ding W, Zhang H. | 12/6/2014 |
| FOG1, FOG2 and GATA-6 modulate the transcriptional up-regulation of HAMP in hepatocytes during inflammation. | Friend of GATA and GATA-6 modulate the transcriptional up-regulation of hepcidin in hepatocytes during inflammation.
Bagu ET, Layoun A, Calvé A, Santos MM. | 06/14/2014 |
| Variants of the ZFPM2/FOG2 gene might be a common cause of Double outlet right ventricle. | Novel ZFPM2/FOG2 variants in patients with double outlet right ventricle.
Tan ZP, Huang C, Xu ZB, Yang JF, Yang YF. | 03/23/2013 |
| Sex Cord Stromal Tumors in childhood exhibited an embryonal gonadal phenotype, expressing a FOG-2/GATA-4 pattern in keeping with embryonal gonads. | GATA-4 and FOG-2 expression in pediatric ovarian sex cord-stromal tumors replicates embryonal gonadal phenotype: results from the TREP project.
Virgone C, Cecchetto G, Ferrari A, Bisogno G, Donofrio V, Boldrini R, Collini P, Dall'Igna P, Alaggio R., Free PMC Article | 03/2/2013 |
| association of the ZFPM2 SNP, rs12678719, with antipsychotic-induced parkinsonism | Association of the ZFPM2 gene with antipsychotic-induced parkinsonism in schizophrenia patients.
Greenbaum L, Smith RC, Lorberboym M, Alkelai A, Zozulinsky P, Lifschytz T, Kohn Y, Djaldetti R, Lerer B. | 09/1/2012 |
| New mutations in ZFPM2/FOG2 gene in tetralogy of Fallot and double outlet right ventricle | New mutations in ZFPM2/FOG2 gene in tetralogy of Fallot and double outlet right ventricle.
De Luca A, Sarkozy A, Ferese R, Consoli F, Lepri F, Dentici ML, Vergara P, De Zorzi A, Versacci P, Digilio MC, Marino B, Dallapiccola B. | 11/12/2011 |
| These results implicate FOG1 and 2 and CTBPs as partners of GATA proteins in the control of adipocyte proliferation and differentiation. | GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis.
Jack BH, Crossley M., Free PMC Article | 12/11/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Comparative analyses identify USH and its human homolog, FOG2, as the targets of fly miR-8 and human miR-200, respectively; USH/FOG2 inhibits PI3K activity, suppressing cell growth in both flies and humans. | Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K.
Hyun S, Lee JH, Jin H, Nam J, Namkoong B, Lee G, Chung J, Kim VN. | 01/21/2010 |
| SERCA2 is an important target of FOG-2 and that increased FOG-2 expression may contribute to a decline in cardiac function in end-stage heart failure by impaired T3 signaling | Increased FOG-2 in failing myocardium disrupts thyroid hormone-dependent SERCA2 gene transcription.
Rouf R, Greytak S, Wooten EC, Wu J, Boltax J, Picard M, Svensson EC, Dillmann WH, Patten RD, Huggins GS., Free PMC Article | 01/21/2010 |