| PES1 is a biomarker of head and neck squamous cell carcinoma and is associated with the tumor microenvironment. | PES1 is a biomarker of head and neck squamous cell carcinoma and is associated with the tumor microenvironment.
He Y, Xiang J, Li Y, Huang W, Gu F, Wang Y, Chen R., Free PMC Article | 06/26/2023 |
| Overexpression of hepatic pescadillo 1 in obesity induces lipid dysregulation by inhibiting autophagy. | Overexpression of hepatic pescadillo 1 in obesity induces lipid dysregulation by inhibiting autophagy.
Zhou J, Lu Y, Lin Y, Li C, Liu J, Jiang Z, Chen K. | 06/21/2023 |
| Pescadillo ribosomal biogenesis factor 1 reduction suppresses tumour growth and renders chemosensitivity of head and neck squamous cell carcinoma. | Pescadillo ribosomal biogenesis factor 1 reduction suppresses tumour growth and renders chemosensitivity of head and neck squamous cell carcinoma.
Li D, Yao C, Ding Z, Liu P, Chen X, Liu W, Yi F, Jiang C, Li H, Liu Y, Wu J., Free PMC Article | 03/24/2023 |
| microRNA-1271 impedes the development of prostate cancer by downregulating PES1 and upregulating ERbeta. | microRNA-1271 impedes the development of prostate cancer by downregulating PES1 and upregulating ERβ.
Jiang Z, Zhang Y, Chen X, Wang Y, Wu P, Wu C, Chen D., Free PMC Article | 06/19/2021 |
| PES1 promotes the occurrence and development of papillary thyroid cancer by upregulating the ERalpha/ERbeta protein ratio. | PES1 promotes the occurrence and development of papillary thyroid cancer by upregulating the ERα/ERβ protein ratio.
Qiu YB, Liao LY, Jiang R, Xu M, Xu LW, Chen GG, Liu ZM., Free PMC Article | 08/22/2020 |
| CD44 regulates PES1 in liver cancer stem cells via miR-105-5p to promote cell growth | PES1 is regulated by CD44 in liver cancer stem cells via miR-105-5p.
Wei S, Liu K, He Q, Gao Y, Shen L. | 06/20/2020 |
| PES1 facilitates telomerase assembly by promoting direct interaction between TERT and TR without affecting TERT and TR levels | PES1 is a critical component of telomerase assembly and regulates cellular senescence.
Cheng L, Yuan B, Ying S, Niu C, Mai H, Guan X, Yang X, Teng Y, Lin J, Huang J, Jin R, Wu J, Liu B, Chang S, Wang E, Zhang C, Hou N, Cheng X, Xu D, Yang X, Gao S, Ye Q., Free PMC Article | 06/6/2020 |
| Authors showed that PES1 interacted with BRD4 to enhance c-Myc expression, which is the primary cause of cancer cell resistance to BET inhibitors in pancreatic cancer. | PES1 promotes BET inhibitors resistance and cells proliferation through increasing c-Myc expression in pancreatic cancer.
Jin X, Fang R, Fan P, Zeng L, Zhang B, Lu X, Liu T., Free PMC Article | 05/16/2020 |
| PES1 is transcriptionally regulated by BRD4 and promotes cell proliferation and glycolysis in hepatocellular carcinoma | PES1 is transcriptionally regulated by BRD4 and promotes cell proliferation and glycolysis in hepatocellular carcinoma.
Fan P, Wang B, Meng Z, Zhao J, Jin X. | 05/18/2019 |
| upregulated in hepatocellular carcinoma tissues and cells, potentially representing a novel prognostic marker for overall survival | PES1 enhances proliferation and tumorigenesis in hepatocellular carcinoma via the PI3K/AKT pathway.
Wang J, Sun J, Zhang N, Yang R, Li H, Zhang Y, Chen K, Kong D. | 03/2/2019 |
| posttranslational modification of PES1 by SUMOylation may serve as a key factor that regulates the function of PES1 in vivo | SUMOylation of PES1 upregulates its stability and function via inhibiting its ubiquitination.
Li S, Wang M, Qu X, Xu Z, Yang Y, Su Q, Wu H., Free PMC Article | 01/27/2018 |
| PES1 may play an important role in development of gastric cancer. | Repression of PES1 expression inhibits growth of gastric cancer.
Li J, Zhou X, Lan X, Zeng G, Jiang X, Huang Z. | 02/18/2017 |
| The DDX27 can interact specifically with the Pes1 and Bop1 but fulfils critical function(s) for proper 3' end formation of 47S rRNA independently of the PeBoW-complex. | DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex.
Kellner M, Rohrmoser M, Forné I, Voss K, Burger K, Mühl B, Gruber-Eber A, Kremmer E, Imhof A, Eick D. | 08/15/2015 |
| PES1 may play important role in the progression of ovarian cancer by inversely regulating the ERalpha and ERbeta expression. | PES1 differentially regulates the expression of ERα and ERβ in ovarian cancer.
Li J, Zhuang Q, Lan X, Zeng G, Jiang X, Huang Z. | 08/16/2014 |
| these results uncover a potential role of PES1 in chemoresistance by regulating DNA damage response in colorectal cancer cells. | PES1 regulates sensitivity of colorectal cancer cells to anticancer drugs.
Xie W, Qu L, Meng L, Liu C, Wu J, Shou C. | 08/31/2013 |
| Upstream of c-Jun, it was revealed that c-Jun NH2-terminal kinases (JNK) is essential for controlling PES1 expression | Transcriptional regulation of PES1 expression by c-Jun in colon cancer.
Xie W, Feng Q, Su Y, Dong B, Wu J, Meng L, Qu L, Shou C., Free PMC Article | 01/26/2013 |
| expression of PES1 correlated positively with ERalpha expression and negatively with ERbeta expression and predicted good clinical outcome in breast cancer | PES1 promotes breast cancer by differentially regulating ERα and ERβ.
Cheng L, Li J, Han Y, Lin J, Niu C, Zhou Z, Yuan B, Huang K, Li J, Jiang K, Zhang H, Ding L, Xu X, Ye Q., Free PMC Article | 10/27/2012 |
| The physical interaction between B23 and PES1 implies that they may participate in ribosome biogenesis in a protein complex. | B23 interacts with PES1 and is involved in nucleolar localization of PES1.
Zhang J, Yang Y, Wu J. | 04/12/2010 |
| pescadillo might play a role in promoting the proliferation and carcinogenesis of human breast cancer, and thereby might be a potential target for human breast cancer treatment. | Down-regulation of pescadillo inhibits proliferation and tumorigenicity of breast cancer cells.
Li J, Yu L, Zhang H, Wu J, Yuan J, Li X, Li M. | 03/22/2010 |
| RRB1 interacts with YPH1 (yeast pescadillo homologue 1) and other members of the Yph1 complex | Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability.
Killian A, Le Meur N, Sesboüé R, Bourguignon J, Bougeard G, Gautherot J, Bastard C, Frébourg T, Flaman JM. | 01/21/2010 |
| Pes1 and Bop1 form a stable complex with a novel member, WDR12 (PeBoW complex). | Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation.
Hölzel M, Rohrmoser M, Schlee M, Grimm T, Harasim T, Malamoussi A, Gruber-Eber A, Kremmer E, Hiddemann W, Bornkamm GW, Eick D., Free PMC Article | 01/21/2010 |
| Mechanisms for the ability of Pes1 to transform cells, and its failure to immortalize them. | Role of pescadillo in the transformation and immortalization of mammalian cells.
Maiorana A, Tu X, Cheng G, Baserga R. | 01/21/2010 |
| Results describe the role of PeBoW-specific proteins Pes1, Bop1, and WDR12 in complex assembly and stability, nucleolar transport, and pre-ribosome association. | Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit.
Rohrmoser M, Hölzel M, Grimm T, Malamoussi A, Harasim T, Orban M, Pfisterer I, Gruber-Eber A, Kremmer E, Eick D., Free PMC Article | 01/21/2010 |