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    Igha immunoglobulin heavy constant alpha [ Mus musculus (house mouse) ]

    Gene ID: 238447, updated on 20-Jul-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA.

    Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA.
    Satoh-Takayama N, Kato T, Motomura Y, Kageyama T, Taguchi-Atarashi N, Kinoshita-Daitoku R, Kuroda E, Di Santo JP, Mimuro H, Moro K, Ohno H.

    In transgenic mice, IgAN pathogenesis involves impaired clearance of abnormal IgA via CD89, primarily by the Kupffer cells. Conditional IgAN progression in CD89 transgenic mice thus reveals important aspects of IgAN pathogenesis.

    Critical Role of Kupffer Cell CD89 Expression in Experimental IgA Nephropathy.
    Xu L, Li B, Huang M, Xie K, Li D, Li Y, Gu H, Fang J., Free PMC Article

    Increased production of IL-5 from Peyer's patch cells and the restored Th1-type immune response might cause the production of abnormal IgA and might induce the glomerular deposition of IgA in IGA nephropathy.

    Release from Th1-type immune tolerance in spleen and enhanced production of IL-5 in Peyer's patch by cholera toxin B induce the glomerular deposition of IgA.
    Yamanaka T, Tamauchi H, Suzuki Y, Suzuki H, Horikoshi S, Terashima M, Iwabuchi K, Habu S, Okumura K, Tomino Y.

    pIgR/SIgA deficiency in the airways leads to persistent activation of innate immune responses to resident lung microbiota, driving progressive small airway remodelling and emphysema.

    Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.
    Richmond BW, Brucker RM, Han W, Du RH, Zhang Y, Cheng DS, Gleaves L, Abdolrasulnia R, Polosukhina D, Clark PE, Bordenstein SR, Blackwell TS, Polosukhin VV., Free PMC Article

    The differential and synergistic effect of retinoic acid and TGF-beta on switching of different B cell subpopulations to IgA, is reported.

    An intrinsic propensity of murine peritoneal B1b cells to switch to IgA in presence of TGF-β and retinoic acid.
    Roy B, Brennecke AM, Agarwal S, Krey M, Düber S, Weiss S., Free PMC Article

    Our data suggest a critical role of O-linked glycans attached to the hinge region in the development of IgA nephropathy-like disease induced by 6-19 IgA rheumatoid factor in mice.

    O-linked glycosylation determines the nephritogenic potential of IgA rheumatoid factor.
    Kihara M, Ito K, Nakata J, Otani M, Tran NL, Morito N, Takahashi S, Wada Y, Izui S., Free PMC Article

    Data indicate the importance of the mucosal IgA response in defense against HIV/AIDS.

    Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice.
    Hur EM, Patel SN, Shimizu S, Rao DS, Gnanapragasam PN, An DS, Yang L, Baltimore D., Free PMC Article

    Glycosylation of the CH2/CH3 interface inhibits interaction with the pathogen IgA binding protein SSL7, while maintaining binding of pIgR, essential to the biosynthesis and transport of SIgA.

    Interaction of human, rat, and mouse immunoglobulin A (IgA) with Staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor.
    Wines BD, Ramsland PA, Trist HM, Gardam S, Brink R, Fraser JD, Hogarth PM., Free PMC Article

    Caloric restriction reduces IgA levels and modifies cytokine mRNA expression in mouse small intestine

    Caloric restriction reduces IgA levels and modifies cytokine mRNA expression in mouse small intestine.
    Lara-Padilla E, Campos-Rodríguez R, Jarillo-Luna A, Reyna-Garfias H, Rivera-Aguilar V, Miliar A, Berral de la Rosa FJ, Navas P, López-Lluch G.

    Aberrant glycosylation of immunoglobulin A causes IGA nephropathy. (review)

    [Aberrant glycosylation of immunoglobulin A and renal disease].
    Asano M.

    CD37 protects against glomerular IgA deposition and renal pathology

    The tetraspanin CD37 protects against glomerular IgA deposition and renal pathology.
    Rops AL, Figdor CG, van der Schaaf A, Tamboer WP, Bakker MA, Berden JH, Dijkman HB, Steenbergen EJ, van der Vlag J, van Spriel AB., Free PMC Article

    IgA of the Igh-2(a) allotype was found to be unique in its total lack of a covalent bond between alpha and L: -chains, formation of which apparently depends on the presence of an "extra" Cys in the hinges of all of the other five allotypes.

    Structural correlates of mouse IgA allotypes.
    Phillips-Quagliata JM.

    The variable regions associated with IgA of peritoneal B1b cells displayed extensive variation due to somatic hypermutation.

    Somatic hypermutation in peritoneal B1b cells.
    Roy B, Shukla S, Łyszkiewicz M, Krey M, Viegas N, Düber S, Weiss S.

    tetraspanin protein CD37 inhibits IgA responses and regulates the anti-fungal immune response.

    The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity.
    van Spriel AB, Sofi M, Gartlan KH, van der Schaaf A, Verschueren I, Torensma R, Raymakers RA, Loveland BE, Netea MG, Adema GJ, Wright MD, Figdor CG., Free PMC Article

    Results suggest that mesenteric lymph nodes may play a complementary role in secretory IgA production in aged animals.

    Role of mesenteric lymph nodes and aging in secretory IgA production in mice.
    Santiago AF, Fernandes RM, Santos BP, Assis FA, Oliveira RP, Carvalho CR, Faria AM.

    These results suggest that activin A induces IgA isotype switching via Smad3/4-mediated germ line alpha transcription.

    Activin A stimulates IgA expression in mouse B cells.
    Lee HJ, Seo GY, Kim HA, Kim PH.

    Mouse IgA allotypes have major differences in their hinge regions.

    Mouse IgA allotypes have major differences in their hinge regions.
    Phillips-Quagliata JM.

    secretions of IgAs rather than innate defense peptides are critical to regulation of commensal bacterial flora and that the segmented filamentous bacteria antigens are strong stimuli of the mucosal immune system

    Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut.
    Suzuki K, Meek B, Doi Y, Muramatsu M, Chiba T, Honjo T, Fagarasan S., Free PMC Article

    ligation of CD40 on B cells, without the addition of other B cell activators or cytokines, results in germline transcription and switch recombination that are largely restricted to the gamma2a gene.

    Induced expression of murine gamma2a by CD40 ligation independently of IFN-gamma.
    Collins JT, Shi J, Burrell BE, Bishop DK, Dunnick WA.

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