| Role of integrin alpha8 in murine model of lung fibrosis | Role of integrin alpha8 in murine model of lung fibrosis.
Hung CF, Wilson CL, Chow YH, Schnapp LM., Free PMC Article | 12/1/2018 |
| Itga8-/- renal mesangial cells showed reduced phagocytosis of matrix-coated beads and apoptotic cells compared to WT renal mesangial cells. | Expression of the Alpha8 Integrin Chain Facilitates Phagocytosis by Renal Mesangial Cells.
Marek I, Becker R, Fahlbusch FB, Menendez-Castro C, Rascher W, Daniel C, Volkert G, Hartner A. | 06/23/2018 |
| alpha8 Integrin is expressed in functional placental compartments among its ligands, OPN and/or FN, across species. Although this may point to a regulatory role in trophoblast function, our data from alpha8 integrin-deficient mice indicated only mild placental pathology. | Integrin α8 Is Abundant in Human, Rat, and Mouse Trophoblasts.
Herdl S, Huebner H, Volkert G, Marek I, Menendez-Castro C, Noegel SC, Ruebner M, Rascher W, Hartner A, Fahlbusch FB. | 05/26/2018 |
| Study observed that in the Apoe-deficient model of atherosclerosis, the female sex is a risk factor to develop more severe atherosclerotic lesions, although serum fat levels are not higher in females than in males. In contrast, female mice are protected from renal damage induced by the concomitant deficiency of Apoe and Itga8 | Sex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8.
Marek I, Canu M, Cordasic N, Rauh M, Volkert G, Fahlbusch FB, Rascher W, Hilgers KF, Hartner A, Menendez-Castro C., Free PMC Article | 05/5/2018 |
| Mechanistically, ligation of alpha8beta1 by the milk protein Mfge8 reduces antral smooth muscle contractile force by preventing RhoA activation through a PTEN-dependent mechanism. | α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism.
Khalifeh-Soltani A, Ha A, Podolsky MJ, McCarthy DA, McKleroy W, Azary S, Sakuma S, Tharp KM, Wu N, Yokosaki Y, Hart D, Stahl A, Atabai K., Free PMC Article | 12/2/2017 |
| Itga8 seems to attenuate tubulointerstitial fibrosis in unilateral ureteral obstruction not via regulation of cell turnover, but via regulation of TGF-beta signalling, fibroblast activation and/or immune cell infiltration | Alpha8 Integrin (Itga8) Signalling Attenuates Chronic Renal Interstitial Fibrosis by Reducing Fibroblast Activation, Not by Interfering with Regulation of Cell Turnover.
Marek I, Lichtneger T, Cordasic N, Hilgers KF, Volkert G, Fahlbusch F, Rascher W, Hartner A, Menendez-Castro C., Free PMC Article | 07/30/2016 |
| Fibrillin-1 and alpha8 integrin interact, and thus, regulate mesangial cell adhesion and migration. | Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells.
Marek I, Volkert G, Hilgers KF, Bieritz B, Rascher W, Reinhardt DP, Hartner A., Free PMC Article | 08/8/2015 |
| Alpha 8 integrin expression is strongly induced in a mouse model of renal fibrosis. | Tubulointerstitial de novo expression of the α8 integrin chain in a rodent model of renal fibrosis--a potential target for anti-fibrotic therapy?
Hartner A, Menendez-Castro C, Cordasic N, Marek I, Volkert G, Klanke B, Rascher W, Hilgers KF., Free PMC Article | 04/27/2013 |
| The findings indicate that QBRICK facilitates the integrin alpha8beta1-dependent interactions of cells with basement membranes by regulating the basement membrane assembly of nephronectin and explain why renal defects occur in Fraser syndrome. | Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.
Kiyozumi D, Takeichi M, Nakano I, Sato Y, Fukuda T, Sekiguchi K., Free PMC Article | 08/25/2012 |
| Lack of alpha8 integrin leads to morphological changes in renal mesangial cells, but not in vascular smooth muscle cells. | Lack of α8 integrin leads to morphological changes in renal mesangial cells, but not in vascular smooth muscle cells.
Marek I, Volkert G, Jahn A, Fahlbusch F, Zürn C, Ozcan Z, Goppelt-Struebe M, Hilgers KF, Rascher W, Hartner A., Free PMC Article | 04/16/2011 |
| Mice mutant for alpha8-integrin exhibit a specific impairment of long-term potentiation at synapses of Schaffer collateral-CA1 field of the hippocampus. | α8-integrins are required for hippocampal long-term potentiation but not for hippocampal-dependent learning.
Chan CS, Chen H, Bradley A, Dragatsis I, Rosenmund C, Davis RL., Free PMC Article | 02/26/2011 |
| alpha8-integrin is protective for the structure and function of the glomerulus and maintains podocyte integrity during the development of diabetic nephropathy | Lack of {alpha}8-integrin aggravates podocyte injury in experimental diabetic nephropathy.
Hartner A, Cordasic N, Menendez-Castro C, Volkert G, Yabu JM, Kupraszewicz-Hutzler M, Rascher W, Hilgers KF. | 12/4/2010 |
| we propose that integrin alpha8beta1 plays a critical role in lung morphogenesis by regulating mesenchymal cell adhesion and migration | The role of integrin alpha8beta1 in fetal lung morphogenesis and injury.
Benjamin JT, Gaston DC, Halloran BA, Schnapp LM, Zent R, Prince LS., Free PMC Article | 01/21/2010 |
| The induction of -integrin in -smooth muscle actin (-SMA) positive myofibroblasts of the liver and heart suggests that -integrin might modulate the function of activated myofibroblasts, cells contributing to fibrotic remodeling. | Deletion of the alpha-8 integrin gene does not protect mice from myocardial fibrosis in DOCA hypertension.
Lijnen PJ. | 01/21/2010 |
| Lack of alpha8 integrin does not reduce fibrotic changes in the hearts of DOCA-salt hypertensive mice. | Deletion of the alpha8 integrin gene does not protect mice from myocardial fibrosis in DOCA hypertension.
Hartner A, Cordasic N, Rascher W, Hilgers KF. | 01/21/2010 |
| Interactions between alpha(8)-integrin and the mesangial matrix may contribute to healing of glomerular injury by influencing cell proliferation and apoptosis | Glomerular regeneration is delayed in nephritic alpha 8-integrin-deficient mice: contribution of alpha 8-integrin to the regulation of mesangial cell apoptosis.
Hartner A, Marek I, Cordasic N, Haas C, Schocklmann H, Hulsmann-Volkert G, Plasa I, Rascher W, Hilgers KF, Amann K. | 01/21/2010 |
| results thus place nephronectin and alpha8beta1 integrin in a pathway that regulates Gdnf expression and is essential for kidney development | The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression.
Linton JM, Martin GR, Reichardt LF., Free PMC Article | 01/21/2010 |
| Lack of alpha8 causes unilateral or bilateral renal agenesis, significantly reduced renal mass, and higher blood pressure. Many alpha8-deficient mice had malformations of the kidney with collapse or atrophy of tubuli and interstitial cell infiltrates. | Aspects of the renal phenotype of adult alpha8 integrin-deficient mice.
Hartner A, Haas C, Amann K, Sterzel RB. | 01/21/2010 |
| Role in regulation of mesangial cell phenotype. Seems to promote adhesion, but inhibit migration and proliferation of mesangial cells. Alpha8 integrin could play important role in maintaining tissue integrity in glomerulus during glomerular injury. | Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation.
Bieritz B, Spessotto P, Colombatti A, Jahn A, Prols F, Hartner A. | 01/21/2010 |
| Integrin alpha8beta1-fibronectin-mediated survival appears to be mediated by the PI3 kinase pathway | Integrin alpha8beta1-fibronectin interactions promote cell survival via PI3 kinase pathway.
Farias E, Lu M, Li X, Schnapp LM. | 01/21/2010 |