| RCOR1 improves neurobehaviors and neuron injury in rat cerebral palsy by Endothelin-1 targeting-induced Akt/GSK-3beta pathway upregulation. | RCOR1 improves neurobehaviors and neuron injury in rat cerebral palsy by Endothelin-1 targeting-induced Akt/GSK-3β pathway upregulation.
Xu H, Yu X, Xie R, Wang Y, Li C. | 01/8/2024 |
| CEBPB/POU2F2 modulates endothelin 1 expression in prehypertensive SHR vascular smooth muscle cells. | CEBPB/POU2F2 modulates endothelin 1 expression in prehypertensive SHR vascular smooth muscle cells.
Yang TC, Lu MH, Wang WJ, Chen JY., Free PMC Article | 05/5/2023 |
| The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats. | The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats.
Costello HM, Juffre A, Cheng KY, Bratanatawira P, Crislip GR, Zietara A, Spires DR, Staruschenko A, Douma LG, Gumz ML., Free PMC Article | 03/6/2023 |
| Indoxyl sulfate enhances endothelin-1-induced contraction via impairment of NO/cGMP signaling in rat aorta. | Indoxyl sulfate enhances endothelin-1-induced contraction via impairment of NO/cGMP signaling in rat aorta.
Matsumoto T, Takayanagi K, Kojima M, Taguchi K, Kobayashi T. | 02/5/2022 |
| Fever Induced by Zymosan A and Polyinosinic-Polycytidylic Acid in Female Rats: Influence of Sex Hormones and the Participation of Endothelin-1. | Fever Induced by Zymosan A and Polyinosinic-Polycytidylic Acid in Female Rats: Influence of Sex Hormones and the Participation of Endothelin-1.
Coelho LCM, Cruz JV, Maba IK, Zampronio AR. | 10/9/2021 |
| Diabetes-related sex differences in the brain endothelin system following ischemia in vivo and in human brain endothelial cells in vitro. | Diabetes-related sex differences in the brain endothelin system following ischemia in vivo and in human brain endothelial cells in vitro.
Abdul Y, Li W, Vargas JD, Grant E, He L, Jamil S, Ergul A., Free PMC Article | 07/10/2021 |
| Role of Orai1 and L-type CaV1.2 channels in Endothelin-1 mediated coronary contraction under ischemia and reperfusion. | Role of Orai1 and L-type Ca(V)1.2 channels in Endothelin-1 mediated coronary contraction under ischemia and reperfusion.
Calderón-Sánchez EM, Ávila-Medina J, Callejo-García P, Fernández-Velasco M, Ordóñez A, Smani T. | 06/5/2021 |
| Endothelin-1 decreases the expression of Ephrin-A and B subtypes in cultured rat astrocytes through ETB receptors. | Endothelin-1 decreases the expression of Ephrin-A and B subtypes in cultured rat astrocytes through ET(B) receptors.
Koyama Y, Tsuboi S, Mizogui F. | 05/8/2021 |
| Effects and safety of Psilocybe cubensis and Panaeolus cyanescens magic mushroom extracts on endothelin-1-induced hypertrophy and cell injury in cardiomyocytes. | Effects and safety of Psilocybe cubensis and Panaeolus cyanescens magic mushroom extracts on endothelin-1-induced hypertrophy and cell injury in cardiomyocytes.
Nkadimeng SM, Steinmann CML, Eloff JN., Free PMC Article | 05/1/2021 |
| Effects of ET-1 and TNF-alpha levels on the cardiac function and prognosis in rats with chronic heart failure. | Effects of ET-1 and TNF-α levels on the cardiac function and prognosis in rats with chronic heart failure.
Tang J, Xie Q, Ma D, Wang W. | 12/19/2020 |
| Endothelin-1 Mediated Decrease in Mitochondrial Gene Expression and Bioenergetics Contribute to Neurodegeneration of Retinal Ganglion Cells. | Endothelin-1 Mediated Decrease in Mitochondrial Gene Expression and Bioenergetics Contribute to Neurodegeneration of Retinal Ganglion Cells.
Chaphalkar RM, Stankowska DL, He S, Kodati B, Phillips N, Prah J, Yang S, Krishnamoorthy RR., Free PMC Article | 12/12/2020 |
| These results indicate that endogenous ET-1 induced by hypoxia promotes hypoxia-induced ANP secretion by activation of COX2-L-PGDS-PPARgamma signaling in beating rat atria | Endogenous ET-1 promotes ANP secretion through activation of COX2-L-PGDS-PPARγ signaling in hypoxic beating rat atria.
Li X, Han ZN, Liu Y, Hong L, Cui BR, Cui X. | 07/4/2020 |
| endothelin-1 may play opposing roles in the lungs vs pulmonary artery in monocrotaline-induced pulmonary hypertension. | Opposite alterations of endothelin-1 in lung and pulmonary artery mirror gene expression of bone morphogenetic protein receptor 2 in experimental pulmonary hypertension.
Veteskova J, Kmecova Z, Malikova E, Doka G, Radik M, Vavrinec P, Krenek P, Klimas J. | 06/20/2020 |
| Results suggest that both endothelin 1 (ET-1) and transforming growth factor-beta 1 (TGF-beta1), by specifically binding to their receptors, might be involved in the myocardial synthesis of brain natriuretic peptide (BNP) during ventricular arrhythmia (VA) in vivo. | The Expression of BNP, ET-1, and TGF-β1 in Myocardium of Rats with Ventricular Arrhythmias.
Tian M, Xiao Y, Xue J, Zhang Y, Jia Y, Luo X, Wang T, Zhu B, Cao Z., Free PMC Article | 04/25/2020 |
| These findings suggest that Sulf2 is an up-regulatory factor in the additive action of CXCL8 via the AT1 R pathway on Ang II-induced ET-1 expression in vascular smooth muscle cells under hypertension environment. | Sulfatase 2 mediates, partially, the expression of endothelin-1 and the additive effect of Ang II-induced endothelin-1 expression by CXCL8 in vascular smooth muscle cells from spontaneously hypertensive rats.
Kim HY, Jeong DW, Kim HS. | 03/28/2020 |
| Endothelin-1 protein and mRNA expression in the alveolar macrophages during hypoxia. | Decreased Ambient Oxygen Tension Alters the Expression of Endothelin-1, iNOS and cGMP in Rat Alveolar Macrophages.
Chen IC, Lin YT, Huang JS, Wu BN, Hsu JH, Tan MS, Dai ZK., Free PMC Article | 07/27/2019 |
| Study shoes that endothelin-A receptor mediates endothelin-1-induced carotid sinus nerve activity increase through PLC, PKC and p38 MAPK signalling pathways in chronic intermittent hypoxia. | Endothelin-1 enhanced carotid body chemosensory activity in chronic intermittent hypoxia through PLC, PKC and p38MAPK signaling pathways.
Li J, Yang S, Yu F, Ji E, Woodrow Weiss J. | 04/20/2019 |
| Results suggest that increases in central ET-1 activity could possibly play a role in chronic estradiol-17beta-induced increase in blood pressure. | Chronic exposure to low doses of estradiol-17ß increases blood pressure in young female rats: A possible role for central Endothelin-1.
Subramanian M, MohanKumar SM, Balasubramanian P, Northcott CA, Garver H, Fink GD, MohanKumar PS., Free PMC Article | 09/8/2018 |
| liraglutide suppresses ET-1 and enhances eNOS/sGC/PKG pathways in treatment of monocrotaline-induced pulmonary arterial hypertension | Liraglutide prevents and reverses monocrotaline-induced pulmonary arterial hypertension by suppressing ET-1 and enhancing eNOS/sGC/PKG pathways.
Lee MY, Tsai KB, Hsu JH, Shin SJ, Wu JR, Yeh JL., Free PMC Article | 07/7/2018 |
| In heart irradiation groups, 3-fold up-regulation of both ET-1 and COX-2 was observed. In pelvis irradiation groups, 3-fold up-regulation of ET-1 was seen, but not significant changes in COX-2 gene expression have observed at distant heart tissues after pelvis irradiation. | Radiation-induced non-targeted effect in vivo: Evaluation of cyclooygenase-2 and endothelin-1 gene expression in rat heart tissues.
Fardid R, Najafi M, Salajegheh A, Kazemi E, Rezaeyan A. | 02/24/2018 |
| the mRNA expression of prepro-endothelin-1 (ppET-1), as well as that of the ETA and ETB receptors, were quantified by real-time PCR in these veins... exercise training mobilizes endothelin-1 (ET-1) to reinforce the Ang II-induced responses mainly through ETA activation | Prostanoids counterbalance the synergism between endothelin-1 and angiotensin II in mesenteric veins of trained rats.
Chies AB, de Oliveira PB, Rossignoli PS, Baptista RFF, de Lábio RW, Payão SLM. | 12/2/2017 |
| tonus of the remodeled spiral artery determined by the endovascular trophoblast response to the ET1 and NO systems | Vasoactivity of the rat endovascular trophoblast.
Ariel I, Skarzinski G, Belzer V, Abu Ahmad W, Abassi Z, Bursztyn M. | 10/14/2017 |
| EDN-1 overexpressed bone marrow-derived mesenchymal stem cells showed increased proliferation and significantly increased osteogenesis potential ability than vector transfected control | In vivo and in vitro study of osteogenic potency of endothelin-1 on bone marrow-derived mesenchymal stem cells.
Hu LW, Wang X, Jiang XQ, Xu LQ, Pan HY. | 10/7/2017 |
| Activation of renal medullary P2Y2/P2Y4 receptors promotes ET-1-dependent natriuresis in ovariectomized rats. | Ovariectomy uncovers purinergic receptor activation of endothelin-dependent natriuresis.
Gohar EY, Kasztan M, Becker BK, Speed JS, Pollock DM., Free PMC Article | 09/23/2017 |
| The results of this study indicated that ET1 signaling is critical in maintaining the excitability of glutamatergic neurons in the hippocampus and, thus, in modulating anxiety-like behaviors. | Hippocampal Endothelin-1 decreases excitability of pyramidal neurons and produces anxiolytic effects.
Chen M, Shu S, Yan HH, Pei L, Wang ZF, Wan Q, Bi LL. | 09/9/2017 |