| Hepatocyte-Derived Igkappa Exerts a Protective Effect against ConA-Induced Acute Liver Injury. | Hepatocyte-Derived Igκ Exerts a Protective Effect against ConA-Induced Acute Liver Injury.
Yin S, Shi Q, Shao W, Zhang C, Zhang Y, Qiu X, Huang J., Free PMC Article | 03/6/2021 |
| data suggest that Dnmt3a and Dnmt3b are critical to regulate the onset of Igkappa light chain rearrangement during early B-cell development | De novo DNA Methyltransferases Dnmt3a and Dnmt3b regulate the onset of Igκ light chain rearrangement during early B-cell development.
Manoharan A, Du Roure C, Rolink AG, Matthias P. | 10/31/2015 |
| ATM kinases activated by RAG DSBs during Igkappa recombination transduce transient H2AX/MDC1-independent signals that suppress initiation of further Igkappa rearrangements to control Igkappa allelic exclusion. | The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements.
Steinel NC, Lee BS, Tubbs AT, Bednarski JJ, Schulte E, Yang-Iott KS, Schatz DG, Sleckman BP, Bassing CH., Free PMC Article | 04/13/2013 |
| using mouse immunoglobulin-kappa (Igkappa) as a model system, we demonstrate that although individual haematopoietic stem cells are characterized by allelic plasticity, early lymphoid lineage cells become committed to the choice of a single allele, and this decision is then stably maintained in a clonal manner that predetermines monoallelic rearrangement in B cells | Clonal allelic predetermination of immunoglobulin-κ rearrangement.
Farago M, Rosenbluh C, Tevlin M, Fraenkel S, Schlesinger S, Masika H, Gouzman M, Teng G, Schatz D, Rais Y, Hanna JH, Mildner A, Jung S, Mostoslavsky G, Cedar H, Bergman Y. | 12/22/2012 |
| Igkappa rearrangements play an important role in receptor editing, a role that may explain why Igkappa recombination clearly fails to approach an equal rearrangement frequency for each variable (V) gene that might be considered optimal for diversity. | Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.
Aoki-Ota M, Torkamani A, Ota T, Schork N, Nemazee D., Free PMC Article | 06/2/2012 |
| We conclude that the HS10, E3', and Ed differentially regulate Igkappa gene dynamics. | A new hypersensitive site, HS10, and the enhancers, E3' and Ed, differentially regulate Igκ gene expression.
Zhou X, Xiang Y, Ding X, Garrard WT., Free PMC Article | 04/21/2012 |
| Sis(-/-) mice exhibit a skewed Igkappa repertoire with markedly decreased distal and enhanced proximal Vkappa gene usage for primary rearrangement | A multifunctional element in the mouse Igκ locus that specifies repertoire and Ig loci subnuclear location.
Xiang Y, Zhou X, Hewitt SL, Skok JA, Garrard WT., Free PMC Article | 07/9/2011 |
| The Igkappa gene enhancers, E3' and Ed, are essential for triggering transcription. | The Igκ gene enhancers, E3' and Ed, are essential for triggering transcription.
Zhou X, Xiang Y, Garrard WT., Free PMC Article | 01/8/2011 |
| Non-allergen-mediated hypersensitivity responses in the colon and ileum are associated with increases in Ig kappa chain production in a murine model of mast cell-dependent colitis. | Ig-free light chains play a crucial role in murine mast cell-dependent colitis and are associated with human inflammatory bowel diseases.
Rijnierse A, Redegeld FA, Blokhuis BR, Van der Heijden MW, Te Velde AA, Pronk I, Hommes DW, Nijkamp FP, Koster AS, Kraneveld AD. | 09/6/2010 |
| Splicing inhibition, nonsense-mediated decay and nonsense-altered splicing each has an individual partial effect that together associate into an efficient surveillance machinery, downregulating nonfunctional immunoglobulin kappa mRNA. | Multiple RNA surveillance mechanisms cooperate to reduce the amount of nonfunctional Ig kappa transcripts.
Chemin G, Tinguely A, Sirac C, Lechouane F, Duchez S, Cogné M, Delpy L. | 07/5/2010 |
| V kappa-V kappa structures arise via RAG-mediated, intrachromosomal recombination. | Violations of the 12/23 rule at the mouse immunoglobulin kappa locus, including V kappa-V kappa rearrangement.
Vinocur JM, Fesnak AD, Liu Y, Charan D, Prak ET., Free PMC Article | 01/21/2010 |
| Ig kappa chain locus and its 3' enhancer direct the immunoglobulin heavy chain locus to a repressive nuclear subcompartment and induce the Igh locus to decontract. | Association between the Igk and Igh immunoglobulin loci mediated by the 3' Igk enhancer induces 'decontraction' of the Igh locus in pre-B cells.
Hewitt SL, Farmer D, Marszalek K, Cadera E, Liang HE, Xu Y, Schlissel MS, Skok JA., Free PMC Article | 01/21/2010 |
| Before induction, the immunoglobulin (Ig) kappa locus is poised for recombination; both alleles are in a contracted state, and the enrichment of histone modifications and germline transcripts of specific Ig variable region kappa genes are observed. | Dynamic changes in accessibility, nuclear positioning, recombination, and transcription at the Ig kappa locus.
Fitzsimmons SP, Bernstein RM, Max EE, Skok JA, Shapiro MA. | 01/21/2010 |
| role for BLNK and perhaps BCR signaling, in the regulation of kappa light chain expression and continued immature B cell differentiation | Delayed cellular maturation and decreased immunoglobulin kappa light chain production in immature B lymphocytes lacking B cell linker protein.
Xu S, Lam KP., Free PMC Article | 01/21/2010 |
| Correlation of somatic hypermutation specificity and A-T base pair substitution errors by dna polymerase eta during copying of a mouse transgene | Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene.
Pavlov YI, Rogozin IB, Galkin AP, Aksenova AY, Hanaoka F, Rada C, Kunkel TA., Free PMC Article | 01/21/2010 |
| new transcriptional silencer and enhancer identified in Ig kappa gene | Chromatin structural analyses of the mouse Igkappa gene locus reveal new hypersensitive sites specifying a transcriptional silencer and enhancer.
Liu ZM, George-Raizen JB, Li S, Meyers KC, Chang MY, Garrard WT. | 01/21/2010 |
| Nomenclature and overview of the mouse (Mus musculus and Mus sp.) immunoglobulin kappa (IGK) genes. | Nomenclature and overview of the mouse (Mus musculus and Mus sp.) immunoglobulin kappa (IGK) genes.
Martinez-Jean C, Folch G, Lefranc MP. | 01/21/2010 |
| Differential accessibility at the locus plays a role in allelic exclusion | Differential accessibility at the kappa chain locus plays a role in allelic exclusion.
Goldmit M, Schlissel M, Cedar H, Bergman Y., Free PMC Article | 01/21/2010 |
| early B lymphoid epigenetic changes generate differential structures that serve as the basis for allelic exclusion of Igk | Epigenetic ontogeny of the Igk locus during B cell development.
Goldmit M, Ji Y, Skok J, Roldan E, Jung S, Cedar H, Bergman Y. | 01/21/2010 |
| conventional light chains(Ig kappa and Ig lambda), a hallmark of B cell differentiation, are necessary and sufficient to divert mu from a vesicular transport-independent to a vesicular transport-dependent degradative route | Immunoglobulin light chains dictate vesicular transport-dependent and -independent routes for IgM degradation by the ubiquitin-proteasome pathway.
Elkabetz Y, Kerem A, Tencer L, Winitz D, Kopito RR, Bar-Nun S. | 01/21/2010 |
| The kinetics of V-J joining of the mouse Ig kappa locus fit a constrained diffusion model of nuclear organization. | The kinetics of V-J joining throughout 3.5 megabases of the mouse Ig kappa locus fit a constrained diffusion model of nuclear organization.
Li S, Garrard WT. | 01/21/2010 |
| Immunoglobulin kappa chain deficiency allows heavy (H) chain retention in the cytoplasm, but prevents H chain release from the cell, and as a result secondary lymphoid organs are B cell depleted while T cell levels remain normal. | Block in development at the pre-B-II to immature B cell stage in mice without Ig kappa and Ig lambda light chain.
Zou X, Piper TA, Smith JA, Allen ND, Xian J, Brüggemann M. | 01/21/2010 |
| A kappa recombination signal sequence and its flanks support six- to nine-fold higher levels of recombination than a lambda counterpart. | The recombination difference between mouse kappa and lambda segments is mediated by a pair-wise regulation mechanism.
Larijani M, Chen S, Cunningham LA, Volpe JM, Cowell LG, Lewis SM, Wu GE. | 01/21/2010 |