| RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS. | RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS.
Shimizu M, Shiraishi N, Tada S, Sasaki T, Beck G, Nagano S, Kinoshita M, Sumi H, Sugimoto T, Ishida Y, Koda T, Ishikura T, Sugiyama Y, Kihara K, Kanakura M, Nakajima T, Takeda S, Takahashi MP, Yamashita T, Okuno T, Mochizuki H., Free PMC Article | 11/27/2023 |
| RGMa promotes dedifferentiation of vascular smooth muscle cells into a macrophage-like phenotype in vivo and in vitro. | RGMa promotes dedifferentiation of vascular smooth muscle cells into a macrophage-like phenotype in vivo and in vitro.
Yuan X, Xiao H, Hu Q, Shen G, Qin X., Free PMC Article | 10/29/2022 |
| RGMa regulates CCL5 expression via the BMP receptor in experimental autoimmune encephalomyelitis mice and endothelial cells. | RGMa regulates CCL5 expression via the BMP receptor in experimental autoimmune encephalomyelitis mice and endothelial cells.
Tang S, Su B, Tao T, Yan W, Zhang R, Qin X, Feng J., Free PMC Article | 04/2/2022 |
| Aberrant promoter hypermethylation inhibits RGMA expression and contributes to tumor progression in breast cancer. | Aberrant promoter hypermethylation inhibits RGMA expression and contributes to tumor progression in breast cancer.
Li Y, Liu HT, Chen X, Wang YW, Tian YR, Ma RR, Song L, Zou YX, Gao P. | 02/19/2022 |
| RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway. | RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway.
do Carmo Costa A, Copola AGL, Carvalho E Souza C, Nogueira JM, Silva GAB, Jorge EC. | 12/4/2021 |
| Repulsive Guidance Molecule A Suppresses Adult Neurogenesis. | Repulsive Guidance Molecule A Suppresses Adult Neurogenesis.
Isaksen TJ, Fujita Y, Yamashita T., Free PMC Article | 02/6/2021 |
| Inhibiting Rgma suppresses secondary progression in a mouse model of multiple sclerosis. | Inhibiting repulsive guidance molecule-a suppresses secondary progression in mouse models of multiple sclerosis.
Tanabe S, Fujita Y, Ikuma K, Yamashita T., Free PMC Article | 12/14/2019 |
| After chronic morphine injection, Rgma was upregulated in C57BL/6J striatum. | Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans.
Cheng Z, Zhou H, Sherva R, Farrer LA, Kranzler HR, Gelernter J., Free PMC Article | 10/19/2019 |
| Study focused on the RGMa and RGMb expression in cerebral cortex and hippocampus of newborn mice with maternal lead exposure. RGMa and RGMb expression in hippocampus were upregulated in lead exposed groups, and the RGMa and RGMb expression in cerebral cortex were also higher. | Effects of maternal lead exposure on RGMa and RGMb expression in the hippocampus and cerebral cortex of mouse pups.
Li N, Qiao M, Zhao Q, Zhang P, Song L, Li L, Cui C. | 11/18/2017 |
| promotes dendritic cell maturation | A novel role for RGMa in modulation of bone marrow-derived dendritic cells maturation induced by lipopolysaccharide.
Xu X, Gao Y, Shan F, Feng J. | 12/17/2016 |
| RGMa is involved in Th17-cell-mediated neurodegeneration. | Repulsive guidance molecule-a is involved in Th17-cell-induced neurodegeneration in autoimmune encephalomyelitis.
Tanabe S, Yamashita T. | 07/25/2015 |
| repulsive RGMa-Neogenin interactions drive interneurons into the migratory corridor | RGMa regulates cortical interneuron migration and differentiation.
O'Leary C, Cole SJ, Langford M, Hewage J, White A, Cooper HM., Free PMC Article | 12/20/2014 |
| Postnatal spiral ganglion neurons retain capacity to send out processes that respond to signals for synaptogenesis, but postnatal RGMa expression appears to be detrimental to regeneration of afferent hair cell innervation and antagonizes synaptogenesis | Inhibition of repulsive guidance molecule, RGMa, increases afferent synapse formation with auditory hair cells.
Brugeaud A, Tong M, Luo L, Edge AS., Free PMC Article | 11/8/2014 |
| RGMa inhibits axon growth by phosphorylating CRMP-2 via both Rho-kinase and GSK-3beta signaling pathways. | CRMP-2 is involved in axon growth inhibition induced by RGMa in vitro and in vivo.
Wang T, Wu X, Yin C, Klebe D, Zhang JH, Qin X. | 11/16/2013 |
| Strong expression of RGMa, RGMb and Neogenin protein was found on several major axon tracts such as the primary olfactory projections, anterior commissure and fasciculus retroflexus. | Spatiotemporal expression of repulsive guidance molecules (RGMs) and their receptor neogenin in the mouse brain.
van den Heuvel DM, Hellemons AJ, Pasterkamp RJ., Free PMC Article | 08/31/2013 |
| RGMa enhances CD4+ T cell activation facilitating central nervous system intervention in an animal model of multiple sclerosis presented in this review. | Repulsive guidance molecule-a and demyelination: implications for multiple sclerosis.
Kubo T, Tokita S, Yamashita T. | 04/13/2013 |
| Loss-of-function analysis in mice revealed that RGMa may play a more important role in neural tube morphogenesis. | Repulsive guidance molecule A (RGMa): a molecule for all seasons.
Key B, Lah GJ., Free PMC Article | 12/8/2012 |
| identification of neogenin-binding site on the repulsive guidance molecule A | Identification of the neogenin-binding site on the repulsive guidance molecule A.
Itokazu T, Fujita Y, Takahashi R, Yamashita T., Free PMC Article | 07/28/2012 |
| activated microglia play a major role in inhibiting axon regeneration via RGMa | Activated microglia inhibit axonal growth through RGMa.
Kitayama M, Ueno M, Itakura T, Yamashita T., Free PMC Article | 02/4/2012 |
| RGM-A is a unique endogenous inhibitor of leukocyte chemotaxis that limits inflammatory leukocyte traffic | Repulsive guidance molecule-A (RGM-A) inhibits leukocyte migration and mitigates inflammation.
Mirakaj V, Brown S, Laucher S, Steinl C, Klein G, Köhler D, Skutella T, Meisel C, Brommer B, Rosenberger P, Schwab JM., Free PMC Article | 06/18/2011 |
| Neutralizing antibodies to RGMa attenuated clinical symptoms of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and reduced invasion of inflammatory cells into the CNS. | RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis.
Muramatsu R, Kubo T, Mori M, Nakamura Y, Fujita Y, Akutsu T, Okuno T, Taniguchi J, Kumanogoh A, Yoshida M, Mochizuki H, Kuwabara S, Yamashita T. | 06/4/2011 |
| RGMa may negatively regulate neuronal network formation in cortical neurons. | Inhibition of branching and spine maturation by repulsive guidance molecule in cultured cortical neurons.
Yoshida J, Kubo T, Yamashita T. | 01/21/2010 |
| a higher expression of RGMa, RGMb and neogenin was found in the retinas of all glaucoma-affected mice; a higher RGMa and RGMb expression were detected in the optic nerves of glaucoma-affected DBA/2J-mice older than 11M | Gene expression of the repulsive guidance molecules/neogenin in the developing and mature mouse visual system: C57BL/6J vs. the glaucoma model DBA/2J.
Schnichels S, Conrad S, Warstat K, Henke-Fahle S, Skutella T, Schraermeyer U, Julien S. | 01/21/2010 |
| RGMa-mediated neogenin signal transduction pathway involved in axonal guidance. | Neogenin-RGMa signaling at the growth cone is bone morphogenetic protein-independent and involves RhoA, ROCK, and PKC.
Conrad S, Genth H, Hofmann F, Just I, Skutella T. | 01/21/2010 |
| May be involved in cell migration, differentiation, and apoptosis with similar cellular mechanisms as described in the central nervous system. | Gene expression of the repulsive guidance molecules during development of the mouse intestine.
Metzger M, Conrad S, Alvarez-Bolado G, Skutella T, Just L. | 01/21/2010 |