| The hepatokine TSK maintains myofiber integrity and exercise endurance and contributes to muscle regeneration. | The hepatokine TSK maintains myofiber integrity and exercise endurance and contributes to muscle regeneration.
Wang Q, Qiu X, Liu T, Ahn C, Horowitz JF, Lin JD., Free PMC Article | 04/2/2022 |
| Deletion of the Feeding-Induced Hepatokine TSK Ameliorates the Melanocortin Obesity Syndrome. | Deletion of the Feeding-Induced Hepatokine TSK Ameliorates the Melanocortin Obesity Syndrome.
Wang Q, Zhang P, Cakir I, Mi L, Cone RD, Lin JD., Free PMC Article | 11/13/2021 |
| Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice. | Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice.
Ito N, Riyadh MA, Ahmad SAI, Hattori S, Kanemura Y, Kiyonari H, Abe T, Furuta Y, Shinmyo Y, Kaneko N, Hirota Y, Lupo G, Hatakeyama J, Abdulhaleem M FA, Anam MB, Yamaguchi M, Takeo T, Takebayashi H, Takebayashi M, Oike Y, Nakagata N, Shimamura K, Holtzman MJ, Takahashi Y, Guillemot F, Miyakawa T, Sawamoto K, Ohta K. | 07/24/2021 |
| Tsukushi is essential for the development of the inner ear. | Tsukushi is essential for the development of the inner ear.
Miwa T, Ohta K, Ito N, Hattori S, Miyakawa T, Takeo T, Nakagata N, Song WJ, Minoda R., Free PMC Article | 02/6/2021 |
| Tsukushi is essential for proper maintenance and terminal differentiation of mouse hippocampal neural stem cells. | Tsukushi is essential for proper maintenance and terminal differentiation of mouse hippocampal neural stem cells.
Ahmad SAI, Anam MB, Istiaq A, Ito N, Ohta K. | 12/26/2020 |
| The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis. | The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis.
Mouchiroud M, Camiré É, Aldow M, Caron A, Jubinville É, Turcotte L, Kaci I, Beaulieu MJ, Roy C, Labbé SM, Varin TV, Gélinas Y, Lamothe J, Trottier J, Mitchell PL, Guénard F, Festuccia WT, Joubert P, Rose CF, Karvellas CJ, Barbier O, Morissette MC, Marette A, Laplante M., Free PMC Article | 09/5/2020 |
| TSKU inactivation protects mice from diet-induced NASH and liver transcriptome remodeling. | Mapping the molecular signatures of diet-induced NASH and its regulation by the hepatokine Tsukushi.
Xiong X, Wang Q, Wang S, Zhang J, Liu T, Guo L, Yu Y, Lin JD., Free PMC Article | 11/30/2019 |
| The combinatorial guidance activities of draxin and Tsukushi are essential for forebrain commissure formation | The combinatorial guidance activities of draxin and Tsukushi are essential for forebrain commissure formation.
Hossain M, Ahmed G, Naser IB, Shinmyo Y, Ito A, Riyadh MA, Felemban A, Song X, Ohta K, Tanaka H. | 03/16/2013 |
| TSK controls the hair cycle by regulating TGF-beta1 signaling. | Tsukushi controls the hair cycle by regulating TGF-β1 signaling.
Niimori D, Kawano R, Felemban A, Niimori-Kita K, Tanaka H, Ihn H, Ohta K. | 03/2/2013 |
| targeted inactivation of the TSK gene in mice causes expansion of the ciliary body and up-regulation of Wnt2b and Fzd4 expression in the developing peripheral eye | Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4.
Ohta K, Ito A, Kuriyama S, Lupo G, Kosaka M, Ohnuma S, Nakagawa S, Tanaka H., Free PMC Article | 11/5/2011 |
| a crucial role for TSK for anterior commissure formation in the mouse brain was shown. | Tsukushi is required for anterior commissure formation in mouse brain.
Ito A, Shinmyo Y, Abe T, Oshima N, Tanaka H, Ohta K. | 01/15/2011 |