| The microwave radiation led to shrinkage and even loss of dendritic spines in hippocampus by SNK-SPAR pathway, resulting in the cognitive impairments. | Microwave radiation leading to shrinkage of dendritic spines in hippocampal neurons mediated by SNK-SPAR pathway.
Zhi WJ, Peng RY, Li HJ, Zou Y, Yao BW, Wang CZ, Liu ZH, Gao XH, Xu XP, Dong J, Zhao L, Zhou HM, Wang LF, Hu XJ. | 08/11/2018 |
| Prenatal stress increased spar in thr hippocampus of the offspring at adulthood in rats | Prenatal stress increased Snk Polo-like kinase 2, SCF β-TrCP ubiquitin ligase and ubiquitination of SPAR in the hippocampus of the offspring at adulthood.
Chutabhakdikul N, Surakul P. | 06/28/2014 |
| Long-term potentiation triggers downregulation of SPAR requiring ubiquitin proteasome system and NMDA receptor activation but not cyclin-dependent kinase (CDK)5. | Hippocampal LTP triggers proteasome-mediated SPAR degradation in CA1 neurons.
Chen Y, Yuanxiang P, Knöpfel T, Thomas U, Behnisch T. | 08/25/2012 |
| the SNK-SPAR pathway may possibly play a crucial role in Amyloid beta-induced excitotoxic damage in the central nervous system by regulating synaptic stability. | Role of the SNK-SPAR pathway in the development of Alzheimer's disease.
Gong X, Lu X, Zhan L, Sui H, Qi X, Ji Z, Niu X, Liu L. | 06/28/2010 |
| the multiple SPAR functional domains have been expressed in E. coli in quantities suitable for biophysical and biochemical studies, allowing us to investigate the role of the PDZ domain in SPAR function . | Heterologous high-level E. coli expression, purification and biophysical characterization of the spine-associated RapGAP (SPAR) PDZ domain.
Brown BL, Hadley M, Page R. | 01/21/2010 |
| postsynaptic RapGAP SPAR is regulated by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons | Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons.
Ang XL, Seeburg DP, Sheng M, Harper JW., Free PMC Article | 01/21/2010 |
| serum-inducible kinase bound to and phosphorylated spine-associated Rap guanosine triphosphatase activating protein (SPAR), a postsynaptic actin regulatory protein, leading to degradation of SPAR | Targeted protein degradation and synapse remodeling by an inducible protein kinase.
Pak DT, Sheng M. | 01/21/2010 |
| findings suggest that SPAL may be involved in the NMDA-mediated organization of cytoskeletal networks and signal transduction | SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus.
Roy BC, Kohu K, Matsuura K, Yanai H, Akiyama T. | 01/21/2010 |
| PSD-Zip70 in collaboration with SPAR is critically involved in spine maturity, especially in the mature spine formation and the maintenance of spine maturity. | Collaboration of PSD-Zip70 with its binding partner, SPAR, in dendritic spine maturity.
Maruoka H, Konno D, Hori K, Sobue K., Free PMC Article | 01/21/2010 |
| SPA-1 directly binds to AQP2 and regulates at least in part AQP2 trafficking | Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1.
Noda Y, Horikawa S, Furukawa T, Hirai K, Katayama Y, Asai T, Kuwahara M, Katagiri K, Kinashi T, Hattori M, Minato N, Sasaki S. | 01/21/2010 |
| A novel binding partner for the PDZ domain of SPAR and Shank3 proteins, ProSAPiP1, is reported and characterized. | ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3.
Wendholt D, Spilker C, Schmitt A, Dolnik A, Smalla KH, Proepper C, Bockmann J, Sobue K, Gundelfinger ED, Kreutz MR, Boeckers TM. | 01/21/2010 |