| Identify Dyrk1a as a novel negative regulator of D-cyclin-mediated Rb1/E2f-signalling. As dysregulation of this pathway with impaired cardiomyocyte proliferation leads to cardiomyopathy. | Dyrk1a regulates the cardiomyocyte cell cycle via D-cyclin-dependent Rb/E2f-signalling.
Hille S, Dierck F, Kühl C, Sosna J, Adam-Klages S, Adam D, Lüllmann-Rauch R, Frey N, Kuhn C. | 02/18/2017 |
| Inflammation disrupts LDLr feedback regulation through the activation of the mTOR pathway, increasing mTORC1 activity and up-regulating SREBP-2-mediated cholesterol uptake through Rb phosphorylation. | Activation of mTOR modulates SREBP-2 to induce foam cell formation through increased retinoblastoma protein phosphorylation.
Ma KL, Liu J, Wang CX, Ni J, Zhang Y, Wu Y, Lv LL, Ruan XZ, Liu BC. | 07/5/2014 |
| Phosphorylated retinoblastoma protein (p-Rb) is involved in neuronal apoptosis after traumatic brain injury in adult rats. | Phosphorylated retinoblastoma protein (p-Rb) is involved in neuronal apoptosis after traumatic brain injury in adult rats.
Liu W, Liu X, Yang H, Zhu X, Yi H, Zhu X, Zhang J. | 11/16/2013 |
| a role for Rb protein in directing oncogenic cell growth | Loss of Rb cooperates with Ras to drive oncogenic growth in mammalian cells.
Collins MJ, Napoli I, Ribeiro S, Roberts S, Lloyd AC. | 05/4/2013 |
| Rb pathway may only be involved in early neuronal apoptosis and may be not an apoptotic signal in the late stages of transient cerebral ischemia. | The involvement of upregulation and translocation of phospho-Rb in early neuronal apoptosis following focal cerebral ischemia in rats.
Yu Y, Luo X, Ren QG, Yi CJ, Yu ZY, Xie XW, Wang W. | 12/14/2011 |
| Results indicate that HIV-infection in the brain is associated with site-specific hyperphosphorylation of pRb at serine795, and that this phosphorylation contributes to neuronal death in this disease. | Site-specific hyperphosphorylation of pRb in HIV-induced neurotoxicity.
Akay C, Lindl KA, Wang Y, White MG, Isaacman-Beck J, Kolson DL, Jordan-Sciutto KL., Free PMC Article | 10/8/2011 |
| Data show that proliferaton and nuclear expression of cyclin D1 and p-Rb coincide with the early phase of cyst growth, suggesting that there might be a therapeutic window in which cyclin-dependent kinase inhibitors are most effective in ARPKD. | Early cyst growth is associated with the increased nuclear expression of cyclin D1/Rb protein in an autosomal-recessive polycystic kidney disease rat model.
Schwensen KG, Burgess JS, Graf NS, Alexander SI, Harris DC, Phillips JK, Rangan GK. | 07/23/2011 |
| JC virus tAg contributes significantly to viral DNA replication in vivo; binds Rb proteins and PP2A. | JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activity.
Bollag B, Hofstetter CA, Reviriego-Mendoza MM, Frisque RJ., Free PMC Article | 09/13/2010 |
| proliferative lesions activate the cell cycle machinery following tumor promotion via a regulatory mechanism involving inactivation of GSK3beta and retinoblastoma protein | Involvement of glycogen synthase kinase-3beta signaling and aberrant nucleocytoplasmic localization of retinoblastoma protein in tumor promotion in a rat two-stage thyroid carcinogenesis model.
Ago K, Saegusa Y, Nishimura J, Dewa Y, Kemmochi S, Kawai M, Harada T, Mitsumori K, Shibutani M. | 08/16/2010 |
| These data demonstrate how a new molecular network on ATM regulates the cell cycle through the control of pRb phosphorylation. | ATM is involved in cell-cycle control through the regulation of retinoblastoma protein phosphorylation.
Pizarro JG, Folch J, de la Torre AV, Junyent F, Verdaguer E, Jordan J, Pallas M, Camins A. | 07/26/2010 |
| Expression of Rb is closely event-related to malignant transformation and conversion of the oral mucosa, and is a reliable biomarker linked to oral cancer pathogenesis. | Imbalance of tumor suppression genes expression following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Ribeiro DA, Fracalossi AC, Uatari SA, Oshima CT, Salvadori DM. | 03/15/2010 |
| Ink4a/Cdk4/Rb1 pathway deregulation, more than Arf/Mdm2/Tp53 pathway, has a major role in the development of these tumors through p16(Ink4a) deregulation. | Molecular analysis of the Ink4a/Rb1-Arf/Tp53 pathways in radon-induced rat lung tumors.
Bastide K, Guilly MN, Bernaudin JF, Joubert C, Lectard B, Levalois C, Malfoy B, Chevillard S. | 01/21/2010 |
| Cdk2 signaling pathways are critical regulators of cardiac I/R injury in vivo and support a cardioprotective role for Rb | Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury.
Liem DA, Zhao P, Angelis E, Chan SS, Zhang J, Wang G, Berthet C, Kaldis P, Ping P, MacLellan WR., Free PMC Article | 01/21/2010 |
| Results suggest that proper CXCR4 stimulation by CXCL12 in the mature CNS can prevent impairment of the Rb-E2F pathway and support neuronal survival. | The chemokine CXCL12 promotes survival of postmitotic neurons by regulating Rb protein.
Khan MZ, Brandimarti R, Shimizu S, Nicolai J, Crowe E, Meucci O., Free PMC Article | 01/21/2010 |
| These results indicate that cyclin D-cdk4/6-dependent phosphorylation of pRb and activation of E2F is necessary for hypertrophic growth in cardiomyocytes. | Phosphorylation of pRb by cyclin D kinase is necessary for development of cardiac hypertrophy.
Hinrichsen R, Hansen AH, Haunsø S, Busk PK., Free PMC Article | 01/21/2010 |
| Results suggest that phosphorylation of the cell cycle regulator, Rb, contributes to death in oxygen-glucose deprivation in septal neurons but Cdk5 can have a protective role. | Overexpression of Cdk5 or non-phosphorylatable retinoblastoma protein protects septal neurons from oxygen-glucose deprivation.
Panickar KS, Nonner D, White MG, Barrett JN. | 01/21/2010 |
| Results suggest that Bin1 gene suppression caused by oncogenic E1A via Rb/E2F1 inactivation is an essential step in cell cycle progression promoted by c-Myc, and subsequently, E1A transformation. | Adenovirus E1A oncoprotein liberates c-Myc activity to promote cell proliferation through abating Bin1 expression via an Rb/E2F1-dependent mechanism.
Kinney EL, Tanida S, Rodrigue AA, Johnson JK, Tompkins VS, Sakamuro D. | 01/21/2010 |
| Results show that the Rb-E2F pathway functions as a bistable switch to convert graded serum inputs into all-or-none E2F responses. | A bistable Rb-E2F switch underlies the restriction point.
Yao G, Lee TJ, Mori S, Nevins JR, You L. | 01/21/2010 |
| Caspase-9 antagonizes p53-induced apoptosis by generating a p76(Rb) truncated form of Rb | Caspase-9 can antagonize p53-induced apoptosis by generating a p76(Rb) truncated form of Rb.
Lemaire C, Godefroy N, Costina-Parvu I, Rincheval V, Renaud F, Trotot P, Bouleau S, Mignotte B, Vayssière JL. | 01/21/2010 |
| MyoD may function in myonuclei in response to denervation to protect against denervation-induced apoptosis via perhaps the activation of p21 and Rb | In vivo expression patterns of MyoD, p21, and Rb proteins in myonuclei and satellite cells of denervated rat skeletal muscle.
Ishido M, Kami K, Masuhara M. | 01/21/2010 |
| the derepression of Rb-E2F-regulated genes leads to apoptosis through inactivation of focal adhesion kinase and activation of caspase-8 | Loss of Rb-E2F repression results in caspase-8-mediated apoptosis through inactivation of focal adhesion kinase.
Lieman JH, Worley LA, Harbour JW. | 01/21/2010 |
| ERK1/2 mediates EGF-induced rapid Rb phosphorylation at Ser780 and Ser795 | Epidermal growth factor-induced rapid retinoblastoma phosphorylation at Ser780 and Ser795 is mediated by ERK1/2 in small intestine epithelial cells.
Guo J, Sheng G, Warner BW. | 01/21/2010 |
| deregulation of p16-cyclin D1/Cdk4-Rb pathway, but not oncogenic activation of ras, plays a crucial role in bladder tumorigenesis induced by bladder calculi | Deregulation of the p16-cyclin D1/cyclin-dependent kinase 4-retinoblastoma pathway involved in the rat bladder carcinogenesis induced by terephthalic acid-calculi.
Cui L, Shi Y, Qian J, Dai G, Wang Y, Xia Y, Chen J, Song L, Wang S, Wang X. | 01/21/2010 |
| Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation | Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation.
Garnovskaya MN, Mukhin YV, Vlasova TM, Grewal JS, Ullian ME, Tholanikunnel BG, Raymond JR. | 01/21/2010 |
| employs both canonical cyclin-dependent kinase/cyclin regulation and metabolic regulation as a means to limit proliferation, underscoring its potency in tumor suppression | Retinoblastoma tumor suppressor targets dNTP metabolism to regulate DNA replication.
Angus SP, Wheeler LJ, Ranmal SA, Zhang X, Markey MP, Mathews CK, Knudsen ES. | 01/21/2010 |