| Release of SMP30 in Extracellular Vesicles under Conditions of Ascorbic Acid Deficiency Is Involved with Acute Phase Response in ODS Rat. | Release of SMP30 in Extracellular Vesicles under Conditions of Ascorbic Acid Deficiency Is Involved with Acute Phase Response in ODS Rat.
Arakawa K, Inoue H, Ishigami A, Sato A, Takino Y, Tanaka M, Morimoto H, Takahashi N, Uehara M. | 01/10/2024 |
| Expression of Regucalcin, a calcium-binding protein is regulated by hypoxia-inducible factor-1alpha. | Expression of Regucalcin, a calcium-binding protein is regulated by hypoxia-inducible factor-1α.
Singh T, Banerjee P, Uditi, Kumari S, Chopra A, Singh N, Qamar I. | 02/12/2022 |
| Extracellular regucalcin suppresses colony formation and growth independent of tumor suppressor p53 in human mammary epithelial cells. | Extracellular regucalcin suppresses colony formation and growth independent of tumor suppressor p53 in human mammary epithelial cells.
Yamaguchi M, Murata T. | 08/7/2021 |
| The renal SMP30 expression levels positively correlated with plasma testosterone levels in the kidney. | Induction of renal senescence marker protein-30 (SMP30) expression by testosterone and its contribution to urinary calcium absorption in male rats.
Lin PH, Jian CY, Chou JC, Chen CW, Chen CC, Soong C, Hu S, Lieu FK, Wang PS, Wang SW., Free PMC Article | 08/25/2018 |
| Melatonin may produce a neuroprotective effect through its antioxidant action and by increasing hippocampal expression of SMP30 and osteopontin. | Melatonin ameliorates brain oxidative stress and upregulates senescence marker protein-30 and osteopontin in a rat model of vascular dementia.
Bin-Jaliah I, Sakr HF. | 08/4/2018 |
| n. These results showed the effect of RGN in inhibiting the glycolytic metabolism in rat prostate, which was underpinned by a reduced cell proliferation index. The present findings also suggest that the loss of RGN may predispose to a hyper glycolytic profile and fostered proliferation of prostate cells | Suppressed glycolytic metabolism in the prostate of transgenic rats overexpressing calcium-binding protein regucalcin underpins reduced cell proliferation.
Vaz CV, Marques R, Cardoso HJ, Maia CJ, Socorro S. | 12/17/2016 |
| results highlighted the importance of RGN as a regulatory protein in Ca2+-dependent signaling pathways and its deregulation of RGN expression by Ca2+o may contribute for onset and progression of PCa. | Effect of extracellular calcium on regucalcin expression and cell viability in neoplastic and non-neoplastic human prostate cells.
Vaz CV, Rodrigues DB, Socorro S, Maia CJ. | 12/5/2015 |
| RGN overexpression protects germ cell from apoptosis induced by noxious stimuli, which could be a relevant mechanism for fertility preservation in situations of oncological treatments. | Transgenic overexpression of regucalcin leads to suppression of thapsigargin- and actinomycin D-induced apoptosis in the testis by modulation of apoptotic pathways.
Correia S, Alves MG, Oliveira PF, Alves MR, van Pelt AM, Cavaco JE, Socorro S. | 12/6/2014 |
| A diminished influx of Ca2+ in epididymal tissues of RGN-overexpressing rats resulted in compromised sperm motility. | Sperm parameters and epididymis function in transgenic rats overexpressing the Ca2+-binding protein regucalcin: a hidden role for Ca2+ in sperm maturation?
Correia S, Oliveira PF, Guerreiro PM, Lopes G, Alves MG, Canário AV, Cavaco JE, Socorro S. | 03/8/2014 |
| Regucalcin may play a pivotal role in the regulation of Ca(2+) signaling which is stimulated through a neurotransmitter in the brain neurons with aging | Role of regucalcin in brain calcium signaling: involvement in aging.
Yamaguchi M. | 12/22/2012 |
| existence of multiple forms of SMP30 | Senescence marker protein 30 (SMP30) expression in eukaryotic cells: existence of multiple species and membrane localization.
Arun P, Aleti V, Parikh K, Manne V, Chilukuri N., Free PMC Article | 04/7/2012 |
| Rgn is a novel androgen-target gene in rat testis and may have a role in male reproductive function, particularly in the control of spermatogenesis. | Regucalcin is broadly expressed in male reproductive tissues and is a new androgen-target gene in mammalian testis.
Laurentino SS, Correia S, Cavaco JE, Oliveira PF, Rato L, Sousa M, Barros A, Socorro S. | 12/24/2011 |
| Studies indicate that regucalcin plays an important role as a regulatory protein in cell signaling system, and it is proposed to play a pivotal role in keep of cell homeostasis and function. | Regucalcin and cell regulation: role as a suppressor protein in signal transduction.
Yamaguchi M. | 10/22/2011 |
| SMP30 protein levels were not altered in cortex and cerebellum of young (6 months) and old (21 months) rats. | Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis.
Son TG, Park HR, Kim SJ, Kim K, Kim MS, Ishigami A, Handa S, Maruyama N, Chung HY, Lee J. | 01/21/2010 |
| regucalcin has a role in the regulation of Ca(2+)-ATPase activity in the brain mitochondria of rats | Regucalcin increases Ca2+-ATPase activity in the mitochondria of brain tissues of normal and transgenic rats.
Yamaguchi M, Takakura Y, Nakagawa T. | 01/21/2010 |
| These studies provide novel insights into the mechanism that regulate SMP30 gene expression. | Molecular characterization of senescence marker protein-30 gene promoter: identification of repressor elements and functional nuclear factor binding sites.
Rath B, Pandey RS, Debata PR, Maruyama N, Supakar PC., Free PMC Article | 01/21/2010 |
| Data show that regucalcin mRNA and protein are present in rat mammary gland that estradiol down-regulates regucalcin expression. | Regucalcin is expressed in rat mammary gland and prostate and down-regulated by 17beta-estradiol.
Maia CJ, Santos CR, Schmitt F, Socorro S. | 01/21/2010 |
| This study demonstrates that overexpression of regucalcin suppresses the enhancing effect of insulin or glucose on the gene expression of insulin signaling-related proteins in the cloned rat hepatoma H4-II-E cells. | Overexpression of regucalcin suppresses gene expression of insulin signaling-related proteins in cloned rat hepatoma H4-II-E cells: involvement of insulin resistance.
Nakashima C, Yamaguchi M. | 01/21/2010 |
| Leptin mRNA expression in the adipose or liver tissues was significantly decreased in 50-week-old regucalcin transgenic rats. | Change in lipid components in the adipose and liver tissues of regucalcin transgenic rats with increasing age: suppression of leptin and adiponectin gene expression.
Yamaguchi M, Nakagawa T. | 01/21/2010 |
| Endogenous regucalcin has an inhibitory effect on NO synthase activity in the brain cytosol of young and aged rats | Inhibitory role of regucalcin in the regulation of nitric oxide synthase activity in rat brain cytosol: involvement of aging.
Tobisawa M, Yamaguchi M. | 01/21/2010 |
| This study demonstrates that overexpression of regucalcin caused a remarkable increase in its nuclear localization, and that it has suppressive effects on the gene expression of L-type Ca(2+) channel or CaR. | Overexpression of regucalcin enhances its nuclear localization and suppresses L-type Ca2+ channel and calcium-sensing receptor mRNA expressions in cloned normal rat kidney proximal tubular epithelial NRK52E cells.
Nakagawa T, Yamaguchi M. | 01/21/2010 |
| Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate in the liver | Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate in the liver.
Kondo Y, Ishigami A, Kubo S, Handa S, Gomi K, Hirokawa K, Kajiyama N, Chiba T, Shimokado K, Maruyama N. | 01/21/2010 |
| This study demonstrates that overexpression of RGPR-p117 enhances the expression of regucalcin mRNA and its protein level in NRK52E cells. RGPR-p117 may play a role as a transcriptional factor. | Overexpression of RGPR-p117 enhances regucalcin gene expression in cloned normal rat kidney proximal tubular epithelial cells.
Sawada N, Yamaguchi M. | 01/21/2010 |
| The effect of regucalcin in increasing superoxide dismutase (SOD) activity may not involve the sulfhydryl group of SOD. | Regucalcin increases superoxide dismutase activity in rat liver cytosol.
Fukaya Y, Yamaguchi M. | 01/21/2010 |
| effect of regucalcin, a regulatory protein of Ca2+ signaling, on guanosine-5'-triphosphatase (GTPase) activity in isolated rat liver plasma membranes was investigated; GTPase activity was significantly increased by the addition of Ca2+ | Activatory effect of regucalcin on GTPase activity in rat liver plasma membranes.
Takahashi H, Yamaguchi M. | 01/21/2010 |