| Study determined the effects of troxerutin on cognitive deficits and glutamate cysteine ligase subunits (GCLM and GCLC) in the hippocampus of streptozotocin-induced type 1 diabetes mellitus rat: troxerutin alleviates oxidative stress and promotes learning potential in STZ-induced diabetic rats likely through GCL mechanisms, especially that of GCLC. | Effects of troxerutin on cognitive deficits and glutamate cysteine ligase subunits in the hippocampus of streptozotocin-induced type 1 diabetes mellitus rats.
Zhang S, Li H, Zhang L, Li J, Wang R, Wang M. | 08/12/2017 |
| in diabetic retinopathy, histone methylation at Gclc-ARE4 plays an important role in regulating the Nrf2-Gclc-GSH cascade. | Epigenetic modifications of Nrf2-mediated glutamate-cysteine ligase: implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression.
Mishra M, Zhong Q, Kowluru RA., Free PMC Article | 06/20/2015 |
| Increased GCLC protein expression in the lungs were observed in the rats exposed to biomass smoke and cigarette smoke. | Development and systematic oxidative stress of a rat model of chronic bronchitis and emphysema induced by biomass smoke.
Hu G, Zhou Y, Hong W, Tian J, Hu J, Peng G, Cui J, Li B, Ran P. | 11/16/2013 |
| sumoylation of Nrf2 and MafG enhances heterodimerization and increases GCLC expression, which keeps HSCs in a quiescent state. | Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis.
Ramani K, Tomasi ML, Yang H, Ko K, Lu SC., Free PMC Article | 12/29/2012 |
| After exposure to 95% oxygen accumulation of nuclear ATF4 protein in whole lung extracts coincided with induction of glutamate-cysteine ligase catalytic subunit, an intregrated stress response gene. | Hyperoxia-induced activation of the integrated stress response in the newborn rat lung.
Konsavage WM, Zhang L, Wu Y, Shenberger JS. | 02/25/2012 |
| Data show that activation of the PPARgamma/PGC-1alpha pathway may protect against COPD progression by upregulating gamma-GCS and relieving oxidative stress. | Positive correlation between PPARgamma/PGC-1alpha and gamma-GCS in lungs of rats and patients with chronic obstructive pulmonary disease.
Li J, Dai A, Hu R, Zhu L, Tan S. | 02/12/2011 |
| The protection exerted by sulforaphane(SFN) on mitochondrial alterations and NQO1 and gammaGCL enzymes may be involved in the renoprotection of SFN against cisplatin. | Protective effect of sulforaphane against cisplatin-induced mitochondrial alterations and impairment in the activity of NAD(P)H: quinone oxidoreductase 1 and γ glutamyl cysteine ligase: studies in mitochondria isolated from rat kidney and in LLC-PK1 cells.
Guerrero-Beltrán CE, Calderón-Oliver M, Martínez-Abundis E, Tapia E, Zarco-Márquez G, Zazueta C, Pedraza-Chaverri J. | 10/23/2010 |
| Allitidum may increase the antioxidative ability of CCL-149 cells by increasing the expression of gamma-GCS protein and the content of glutathione. | [Effect of allitridum on expression of the gamma-glutamyl-cysteine synthetase in rat lung epithelial L2 cells].
Xiong LH, Yu L, Li B, Ran PX. | 09/13/2010 |
| After a single dose of deltamethrin, GCSh mRNA relative levels in cerebral cortex in rats were significantly decreased. | [Time course of gene expression of gamma-glutamylcysteine synthetase subunit and Nrf2 in brain tissues of rats exposed by deltamethrin].
Li HY, Shi N, Zhong YF, Dai ZH. | 08/2/2010 |
| Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress. | Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress.
Chen CN, Brown-Borg HM, Rakoczy SG, Ferrington DA, Thompson LV., Free PMC Article | 02/1/2010 |
| Results show that Nrf2 regulates the constitutive expression of rat Gclc through a distal antioxidant response element present in its 5'-flanking region. | Transcriptional regulation of rat gamma-glutamate cysteine ligase catalytic subunit gene is mediated through a distal antioxidant response element.
Shenvi SV, Smith EJ, Hagen TM., Free PMC Article | 01/21/2010 |
| The rat GCLC-antioxidant response element is an Nrf2-mediated element to which binding has been demonstrated in nuclear extracts and induced by tert-butylhydroquinone. | Identification and characterization of an Nrf2-mediated ARE upstream of the rat glutamate cysteine ligase catalytic subunit gene (GCLC).
Li M, Chiu JF, Kelsen A, Lu SC, Fukagawa NK. | 01/21/2010 |
| Gclc was significantly reduced in methionine and choline-deficient rat liver but not in high-fat diet livers. | Genes of the antioxidant response undergo upregulation in a rodent model of nonalcoholic steatohepatitis.
Lickteig AJ, Fisher CD, Augustine LM, Cherrington NJ. | 01/21/2010 |
| CO produced by HO-1 rescues PC12 cells from nitrosative stress through induction of GCLC, which is mediated by activation of phosphatidylinositol 3-kinase/Akt and subsequently Nrf2 signaling. | Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling.
Li MH, Jang JH, Na HK, Cha YN, Surh YJ. | 01/21/2010 |
| gonadotropins regulate follicular GCL expression in a follicle stage-dependent manner and in a GCL subunit-dependent manner | Gonadotropin regulation of glutamate cysteine ligase catalytic and modifier subunit expression in rat ovary is subunit and follicle stage specific.
Tsai-Turton M, Luderer U. | 01/21/2010 |
| the catalytic efficiency of rat GCL is increased by holoenzyme formation and the first demonstration of differential up-regulation of the GCL subunits in response to cysteine deprivation | Differential regulation of glutamate-cysteine ligase subunit expression and increased holoenzyme formation in response to cysteine deprivation.
Lee JI, Kang J, Stipanuk MH., Free PMC Article | 01/21/2010 |
| Nrf1 and Nrf2 regulate the GCLC promoter by modulating the expression of key AP-1 and NF-kappaB family members. | Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1.
Yang H, Magilnick N, Lee C, Kalmaz D, Ou X, Chan JY, Lu SC., Free PMC Article | 01/21/2010 |
| role of AP-1 in induction by tert-butylhydroquinone | Role of AP-1 in the coordinate induction of rat glutamate-cysteine ligase and glutathione synthetase by tert-butylhydroquinone.
Yang H, Zeng Y, Lee TD, Yang Y, Ou X, Chen L, Haque M, Rippe R, Lu SC. | 01/21/2010 |
| Graafian follicular apoptosis may be associated with down-regulation of Gclm and Gclc transcription in granulosa cells and oocytes. | Localization of glutamate cysteine ligase subunit mRNA within the rat ovary and relationship to follicular apoptosis.
Luderer U, Diaz D, Faustman EM, Kavanagh TJ. | 01/21/2010 |
| Buthionine sulfoximine inhibited Gclc. | Regulation of glutathione in cardiac myocytes.
Li S, Li X, Rozanski GJ. | 01/21/2010 |
| specific and independent disruption of each subunit of GCL in neurons can be said to cause a primary decrease in glutathione that is sufficient to promote neurodegeneration | Knockdown of glutamate-cysteine ligase by small hairpin RNA reveals that both catalytic and modulatory subunits are essential for the survival of primary neurons.
Diaz-Hernandez JI, Almeida A, Delgado-Esteban M, Fernandez E, Bolaños JP. | 01/21/2010 |
| E-box is an important transcriptional suppressor element in the GCLC promoter. | Identification of an E-box motif as a transcriptional repressor element in the proximal promoter region of the GCLC gene in rat lung epithelial L2 cells.
Cheng LL, Li B, Luo JD, Tu HB, Liu QC, Ran P. | 01/21/2010 |