| that activity-dependent regulation of ADAR2 proteostasis and GluK2 Q/R editing are key determinants of kainate receptors | ADAR2-mediated Q/R editing of GluK2 regulates kainate receptor upscaling in response to suppression of synaptic activity.
Gurung S, Evans AJ, Wilkinson KA, Henley JM., Free PMC Article | 11/2/2019 |
| lower levels of ADAR2 in the nucleus of immature neurons than in mature neurons. | Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA editing during neuronal development.
Behm M, Wahlstedt H, Widmark A, Eriksson M, Öhman M. | 08/12/2017 |
| The JNK1 pathway may be functionally linked to the nutrient-sensing actions of ADAR2-mediated RNA editing in professional secretory cells. | c-Jun amino-terminal kinase-1 mediates glucose-responsive upregulation of the RNA editing enzyme ADAR2 in pancreatic beta-cells.
Yang L, Huang P, Li F, Zhao L, Zhang Y, Li S, Gan Z, Lin A, Li W, Liu Y., Free PMC Article | 04/27/2013 |
| Cleaved ADAR2 leads to a decrease or loss of GluR2 editing, which will further result in high Ca2 influx and excitotoxic neuronal death. | Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing.
Mahajan SS, Thai KH, Chen K, Ziff E., Free PMC Article | 02/25/2012 |
| both sequence and structural elements are required to define adenosine moieties targeted for specific ADAR2-mediated deamination | Structure and sequence determinants required for the RNA editing of ADAR2 substrates.
Dawson TR, Sansam CL, Emeson RB. | 01/21/2010 |
| RNA structure-dependent recognition by the two double-stranded RNA binding motifs of rat ADAR2. | Structure and specific RNA binding of ADAR2 double-stranded RNA binding motifs.
Stefl R, Xu M, Skrisovska L, Emeson RB, Allain FH. | 01/21/2010 |
| results implicate the carboxy-terminal domain of the large subunit of RNA polymerase II in site-selective RNA editing by ADAR2 and in coordination of editing with alternative splicing. | RNA editing and alternative splicing: the importance of co-transcriptional coordination.
Laurencikiene J, Källman AM, Fong N, Bentley DL, Ohman M., Free PMC Article | 01/21/2010 |
| interaction with RNA transcripts containing selective and nonselective editing sites | Biochemical analysis and scanning force microscopy reveal productive and nonproductive ADAR2 binding to RNA substrates.
Klaue Y, Källman AM, Bonin M, Nellen W, Ohman M., Free PMC Article | 01/21/2010 |
| the nucleolar localization of ADAR2 represents an important mechanism by which RNA editing can be modulated by the sequestration of enzymatic activity from potential RNA substrates in the nucleoplasm | Modulation of RNA editing by functional nucleolar sequestration of ADAR2.
Sansam CL, Wells KS, Emeson RB., Free PMC Article | 01/21/2010 |
| RNA editing by ADAR2 in pancreatic islets and beta-cells is metabolically regulated by nutritional and energy status | RNA editing by ADAR2 is metabolically regulated in pancreatic islets and beta-cells.
Gan Z, Zhao L, Yang L, Huang P, Zhao F, Li W, Liu Y. | 01/21/2010 |
| ADAR2 double-stranded RNA binding motifs serve differential roles in RNA dimerization in RNA eduting. | Dimerization of ADAR2 is mediated by the double-stranded RNA binding domain.
Poulsen H, Jorgensen R, Heding A, Nielsen FC, Bonven B, Egebjerg J., Free PMC Article | 01/21/2010 |