| the histaminergic afferent inputs in the striatum may modulate both dopamine D1 and D2 receptor-expressing medium spiny projection neurons by activation of postsynaptic histamine H1 and H2 receptors. | Histamine Excites Striatal Dopamine D1 and D2 Receptor-Expressing Neurons via Postsynaptic H1 and H2 Receptors.
Zhuang QX, Xu HT, Lu XJ, Li B, Yung WH, Wang JJ, Zhu JN. | 12/22/2018 |
| findings indicate that histamine H1, H2, and H3 receptors are present in rat olfactory epithelium and may play a physiological role in olfactory transmission. | Expression and localization of histamine H(1), H(2), and H(3) receptors in rat olfactory epithelium.
Yu C, Li L, Xia Q, Tang Y. | 10/28/2017 |
| Isolated rat mesenteric collecting lymphatics were treated with 1- to 100-muM histamine. Pharmacologic blockade of either H1 or H2 histamine receptors significantly inhibited the response to histamine. | Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics.
Kurtz KH, Moor AN, Souza-Smith FM, Breslin JW., Free PMC Article | 06/20/2015 |
| Na+-Ca2+ exchangers coupled to H1 receptors and hyperpolarization-activated cyclic nucleotide-gated channels linked to H2 receptors co-mediate the strong postsynaptic excitatory action of histamine on al vestibular nucleus neurons | Postsynaptic mechanisms underlying the excitatory action of histamine on medial vestibular nucleus neurons in rats.
Zhang XY, Yu L, Zhuang QX, Peng SY, Zhu JN, Wang JJ., Free PMC Article | 09/6/2014 |
| Histamine H2 receptors, unlike the H1 receptor type, do not mediate emotional memory consolidation impairment. | Emotional memory consolidation impairment induced by histamine is mediated by H1 but not H2 receptors.
Gianlorenço AC, Serafim KR, Canto-de-Souza A, Mattioli R. | 08/31/2013 |
| Data suggest histamine stimulates proliferation of Leydig tumor cells via activation of HRH2 and a transient increase in intracellular cAMP levels. Normal/immature Leydig cells and progenitor Leydig cells exhibit very low levels of HDC expression. | Proliferative effect of histamine on MA-10 Leydig tumor cells mediated through HRH2 activation, transient elevation in cAMP production, and increased extracellular signal-regulated kinase phosphorylation levels.
Pagotto RM, Monzón C, Moreno MB, Pignataro OP, Mondillo C. | 05/18/2013 |
| Data suggest that histamine facilitates consolidation of fear extinction through mechanism involving Hrh2-dependent phosphorylation of ERK1 in hippocampus. | Histamine facilitates consolidation of fear extinction.
Bonini JS, Da Silva WC, Da Silveira CK, Köhler CA, Izquierdo I, Cammarota M. | 01/28/2012 |
| at the level of the hippocampus, histamine through its H1 and H2 receptors, mediates orofacial region pain | Interaction between histamine and morphine at the level of the hippocampus in the formalin-induced orofacial pain in rats.
Tamaddonfard E, Erfanparast A, Farshid AA, Khalilzadeh E. | 09/17/2011 |
| Data show that famotidine, a H2 receptor antagonist, decreases the late phase of orthodontic tooth movement in rats. | Famotidine, a H2 receptor antagonist, decreases the late phase of orthodontic tooth movement in rats.
Sprogar S, Kriznar I, Drevensek M, Vaupotic T, Drevensek G. | 01/21/2010 |
| Postischemic iecrease in H(2) receptor binding densities in the caudate-putamen. | Postischemic regulation of central histamine receptors.
Lozada A, Munyao N, Sallmen T, Lintunen M, Leurs R, Lindsberg PJ, Panula P. | 01/21/2010 |
| H1, H2, and H3 histamine receptor mRNA detected in modiolus but not in lateral and medial portions of the cochlea. First evidence of H1, H2, and H3 histamine receptor mRNA in rat cochlea. | Expression of mRNA encoding the H1, H2, and H3 histamine receptors in the rat cochlea.
Azuma H, Sawada S, Takeuchi S, Higashiyama K, Kakigi A, Takeda T. | 01/21/2010 |
| endogenous histamine might be involved in the recruitment of neutrophils and protein leaks in LPS-induced acute lung injury via the H2 receptors | The role of endogenous histamine on the pathogenesis of the lipopolysaccharide (LPS)-induced, acute lung injury: a pilot study.
Kim TH, Yoon HJ, Lim CM, Kim EK, Kim MJ, Koh Y. | 01/21/2010 |