| Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome. | Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome.
Pandey A, Shen C, Feng S, Enosi Tuipulotu D, Ngo C, Liu C, Kurera M, Mathur A, Venkataraman S, Zhang J, Talaulikar D, Song R, Wong JJ, Teoh N, Kaakoush NO, Man SM., Free PMC Article | 02/4/2024 |
| Nuclear expression of Ku70/80 is associated with CHEK2 germline mutations in breast cancer. | Nuclear expression of Ku70/80 is associated with CHEK2 germline mutations in breast cancer.
Jakub R, Filip M, Daniel B, Jolanta H, Tomasz H, Cezary C, Jan L, Wenancjusz D, Domagała P. | 09/22/2023 |
| Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage. | Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage.
Abbasi S, Bayat L, Schild-Poulter C., Free PMC Article | 05/5/2023 |
| TEX10 Promotes the Tumorigenesis and Radiotherapy Resistance of Urinary Bladder Carcinoma by Stabilizing XRCC6. | TEX10 Promotes the Tumorigenesis and Radiotherapy Resistance of Urinary Bladder Carcinoma by Stabilizing XRCC6.
Luo S, Wang W, Feng J, Li R., Free PMC Article | 03/26/2022 |
| The Large Nonstructural Protein (NS1) of Human Bocavirus 1 Directly Interacts with Ku70, Which Plays an Important Role in Virus Replication in Human Airway Epithelia. | The Large Nonstructural Protein (NS1) of Human Bocavirus 1 Directly Interacts with Ku70, Which Plays an Important Role in Virus Replication in Human Airway Epithelia.
Shao L, Ning K, Wang J, Cheng F, Wang S, Qiu J., Free PMC Article | 03/5/2022 |
| Down-regulation of GP130 signaling sensitizes bladder cancer to cisplatin by impairing Ku70 DNA repair signaling and promoting apoptosis. | Down-regulation of GP130 signaling sensitizes bladder cancer to cisplatin by impairing Ku70 DNA repair signaling and promoting apoptosis.
He S, Li G, Schätzlein AG, Humphrey PA, Weiss RM, Uchegbu IF, Martin DT. | 01/22/2022 |
| Phospho-Ku70 induced by DNA damage interacts with RNA Pol II and promotes the formation of phospho-53BP1 foci to ensure optimal cNHEJ. | Phospho-Ku70 induced by DNA damage interacts with RNA Pol II and promotes the formation of phospho-53BP1 foci to ensure optimal cNHEJ.
Schellenbauer A, Guilly MN, Grall R, Le Bars R, Paget V, Kortulewski T, Sutcu H, Mathé C, Hullo M, Biard D, Leteurtre F, Barroca V, Corre Y, Irbah L, Rass E, Theze B, Bertrand P, Demmers JAA, Guirouilh-Barbat J, Lopez BS, Chevillard S, Delic J., Free PMC Article | 01/1/2022 |
| The Role of Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond. | The Role of Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond.
Sui H, Hao M, Chang W, Imamichi T., Free PMC Article | 12/11/2021 |
| Ku70 suppresses alternative end joining in G1-arrested progenitor B cells. | Ku70 suppresses alternative end joining in G1-arrested progenitor B cells.
Liang Z, Kumar V, Le Bouteiller M, Zurita J, Kenrick J, Lin SG, Lou J, Hu J, Ye AY, Boboila C, Alt FW, Frock RL., Free PMC Article | 12/4/2021 |
| A uniform expression library for the exploration of FOX transcription factor biology. | A uniform expression library for the exploration of FOX transcription factor biology.
Moparthi L, Koch S. | 08/14/2021 |
| XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi-center study. | XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi-center study.
Yu LX, Liu LY, Xiang YJ, Wang F, Zhou F, Huang SY, Zheng C, Ye CM, Zhou WZ, Yin GS, Zhang JL, Cui SD, Tian FG, Fan ZM, Geng CZ, Cao XC, Yang ZL, Wang X, Liang H, Wang S, Jiang HC, Duan XN, Wang HB, Li GL, Wang QT, Zhang JG, Jin F, Tang JH, Li L, Zhu SG, Zuo WS, Ma ZB, Yu ZG., Free PMC Article | 07/31/2021 |
| Skp2 regulates DNA damage repair and apoptosis via interaction with Ku70. | Skp2 regulates DNA damage repair and apoptosis via interaction with Ku70.
Jia J, Yan D, Wang Y, Liu M, Jia Z, Luo L, Ren J, Fang J, Yuan H, Zhao Y, Song Y, He Y, Wang X. | 05/1/2021 |
| Assessment of DNA damage by 53PB1 and pKu70 detection in peripheral blood lymphocytes by immunofluorescence and high-resolution transmission electron microscopy. | Assessment of DNA damage by 53PB1 and pKu70 detection in peripheral blood lymphocytes by immunofluorescence and high-resolution transmission electron microscopy.
Lorat Y, Fleckenstein J, Görlinger P, Rübe C, Rübe CE., Free PMC Article | 12/12/2020 |
| Inhibition of DNA Repair Protein Ku70 in High-Glucose Environment Aggravates the Neurotoxicity Induced by Bupivacaine in SH-SY5Y Cells. | Inhibition of DNA Repair Protein Ku70 in High-Glucose Environment Aggravates the Neurotoxicity Induced by Bupivacaine in SH-SY5Y Cells.
Ji ZH, Zhou Y, Wang H, Li S, Liang GQ, Mao J., Free PMC Article | 12/5/2020 |
| Exome sequencing identifies de novo splicing variant in XRCC6 in sporadic case of autism. | Exome sequencing identifies de novo splicing variant in XRCC6 in sporadic case of autism.
Sjaarda CP, Wood S, McNaughton AJM, Taylor S, Hudson ML, Liu X, Guerin A, Ayub M. | 10/10/2020 |
| RNF8 has both KU-dependent and independent roles in chromosomal break repair. | RNF8 has both KU-dependent and independent roles in chromosomal break repair.
Tsai LJ, Lopezcolorado FW, Bhargava R, Mendez-Dorantes C, Jahanshir E, Stark JM., Free PMC Article | 09/12/2020 |
| Using a combination of biotin identification and affinity purification coupled to mass spectrometry, this is the first report that comprehensively characterizes the Ku protein interaction landscape, revealing new cellular processes and protein complexes involving the Ku complexcomposed of( Ku70 and Ku80). | Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.
Abbasi S, Schild-Poulter C. | 05/9/2020 |
| The opposing changes in mRNA expression levels of Ku-70 in patients with hypothyroidism indicate its potential as a prognostic marker for hypothyroidism induced by (131)I treatment. | Radiosensitivity-related postirradiation hypothyroidism in Graves' disease patients.
Jia X, Guo K, Gao R, Yu Y, Yang A. | 03/28/2020 |
| Our data clearly indicate the importance of interactions between HIV-1 Integrase and Ku70 in HIV-1 replication at the post-integrational repair step. | NHEJ pathway is involved in post-integrational DNA repair due to Ku70 binding to HIV-1 integrase.
Knyazhanskaya E, Anisenko A, Shadrina O, Kalinina A, Zatsepin T, Zalevsky A, Mazurov D, Gottikh M., Free PMC Article | 03/14/2020 |
| XRCC6 showed significantly low expression in de novo myelodysplastic syndrome comparing to controls and for patients who presented chromosomal abnormalities. | Can synthetic lethality approach be used with DNA repair genes for primary and secondary MDS?
Junior HLR, de Oliveira RTG, de Paula Borges D, Costa MB, Farias IR, Dos Santos AWA, Magalhães SMM, Pinheiro RF. | 03/7/2020 |
| Data suggest that Fusobacterium nucleatum infection promoted the proliferation ability of Tca8113 oral squamous cell carcinoma by causing DNA damage via the Ku autoantigen, 70 kDa (Ku70)/tumor supressor p53 (p53) pathway. | Fusobacterium nucleatum Caused DNA Damage and Promoted Cell Proliferation by the Ku70/p53 Pathway in Oral Cancer Cells.
Geng F, Zhang Y, Lu Z, Zhang S, Pan Y., Free PMC Article | 02/8/2020 |
| Our research revealed XRCC6 C1310G and LIG4 T9I polymorphisms are associated with diminished risk of colorectal cancer. However, to confirm obtained results, a further investigations should be carried out. | Association of XRCC6 C1310G and LIG4 T9I polymorphisms of NHEJ DNA repair pathway with risk of colorectal cancer in the Polish population.
Balinska K, Wilk D, Filipek B, Mik M, Zelga P, Skubel P, Dziki Ł, Dziki A, Mucha B, Kabziński J, Majsterek I. | 01/4/2020 |
| dynamic equilibrium of acetylation/deacetylation of Ku70 lysine residues K317, K331 and K338 is critical for optimal repair of radiation-induced DNA-double strand breaks | Ku70 N-terminal lysines acetylation/deacetylation is required for radiation-induced DNA-double strand breaks repair.
Al Emam A, Arbon D, Jeeves M, Kysela B. | 07/6/2019 |
| The deoxyribose phosphate lyase of DNA polymerase beta suppresses a processive DNA synthesis to prevent trinucleotide repeat instability. | The deoxyribose phosphate lyase of DNA polymerase β suppresses a processive DNA synthesis to prevent trinucleotide repeat instability.
Lai Y, Weizmann Y, Liu Y., Free PMC Article | 06/29/2019 |
| These data first uncovered potentially pathogenic miR-379-5p and two novel targets PARP1 and XRCC6 in biochemical premature ovarian insufficiency. | MicroRNA-379-5p is associate with biochemical premature ovarian insufficiency through PARP1 and XRCC6.
Dang Y, Wang X, Hao Y, Zhang X, Zhao S, Ma J, Qin Y, Chen ZJ., Free PMC Article | 06/15/2019 |