| MiRNA-1 promotes pyroptosis of cardiomyocytes and release of inflammatory factors by downregulating the expression level of PIK3R1 through the FoxO3a pathway. | MiRNA-1 promotes pyroptosis of cardiomyocytes and release of inflammatory factors by downregulating the expression level of PIK3R1 through the FoxO3a pathway.
Yao RD, Li HL, Liu Y, Sun LT. | 07/3/2021 |
| Its downregulation may be involved in the development of sex hormone disorder and calcium loss. | Exogenous leptin administered intramuscularly induces sex hormone disorder and Ca loss via downregulation of Gnrh and PI3K expression.
Wu L, Liu W, Bayaer N, Gu W, Song J., Free PMC Article | 05/16/2015 |
| glucose induces apoptosis and inhibits proliferation of glial cells, which may be mediated by the phosphorylation of tuberin, down regulation of 8-oxoG-DNA glycosylase and 8-hydroxydeoxyguanosine accumulation via activation of Akt and ERK1/2MAPK pathways. | Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells.
Kumar P, Rao GN, Pal BB, Pal A. | 04/4/2015 |
| Phosphorylation of PI3K is inhibited during brain development following BIG1 depletion. | BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein regulates neurite development via PI3K-AKT and ERK signaling pathways.
Zhou C, Li C, Li D, Wang Y, Shao W, You Y, Peng J, Zhang X, Lu L, Shen X. | 02/28/2015 |
| PI3K activity is required for gastric mucosal inflammatory responses to Helicobacter pylori. | Role of ghrelin-induced phosphatidylinositol 3-kinase activation in modulation of gastric mucosal inflammatory responses to Helicobacter pylori.
Slomiany BL, Slomiany A. | 01/31/2015 |
| Phosphatidylinositol 3'-kinase is increased in heart tissue following exercise training in experimental diabetes. | Exercise training enhances cardiac IGFI-R/PI3K/Akt and Bcl-2 family associated pro-survival pathways in streptozotocin-induced diabetic rats.
Cheng SM, Ho TJ, Yang AL, Chen IJ, Kao CL, Wu FN, Lin JA, Kuo CH, Ou HC, Huang CY, Lee SD. | 03/1/2014 |
| Significant increases in IR b-subunit, IRS-1 and PTP1B protein contents were seen in the hearts of low protein diet group, also GLUT4 and PI3-kinase protein levels were markedly increased. | Adverse cardiac remodeling due to maternal low protein diet is associated with alterations in expression of genes regulating glucose metabolism.
Tappia PS, Guzman C, Dunn L, Aroutiounova N. | 08/31/2013 |
| Data suggest that NRG-1beta could prevents Ca(2+) overload and apoptosis by activating PI3K/Akt pathway of primary cultured DRG neurons with excitotoxicity induced by glutamate. | Neuregulin-1β prevents Ca(2+) overloading and apoptosis through PI3K/Akt activation in cultured dorsal root ganglion neurons with excitotoxicity induced by glutamate.
Liu Z, Li H, Zhang W, Li Y, Liu H, Li Z. | 05/19/2012 |
| Results show that ANGPT1 alters steroidogenesis, reduces ovarian apoptosis, and stimulates cell proliferation in antral follicles, and may exert these roles through the PI3K/AKT pathway. | Angiopoietin 1 reduces rat follicular atresia mediated by apoptosis through the PI3K/Akt pathway.
Parborell F, Abramovich D, Irusta G, Tesone M. | 03/3/2012 |
| the PI3K-Akt and MEK-ERK signalling cascades have distinct roles in the up-regulation of P2X(4)R expression in microglia at transcriptional and post-transcriptional levels | Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways.
Tsuda M, Toyomitsu E, Kometani M, Tozaki-Saitoh H, Inoue K., Free PMC Article | 12/24/2011 |
| Expression of PI-3K-P85alpha decreased in rats given alcohol and a high-fat diet. | [Effects of alcohol and high-fat diet on the expression of phosphatidylinositol 3-kinase in rat adipose tissue].
Yu D, Peng X, Zhao L, Tian L. | 12/11/2010 |
| Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis via the PI3K/Akt and ERK1/2 pathways | Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis via the PI3K/Akt and ERK1/2 pathways.
Gao F, Hu XY, Xie XJ, Xu QY, Wang YP, Liu XB, Xiang MX, Sun Y, Wang JA., Free PMC Article | 11/27/2010 |
| Receptor interacting protein 3 suppresses vascular smooth muscle cell growth by inhibition of the phosphoinositide 3-kinase-Akt axis | Receptor interacting protein 3 suppresses vascular smooth muscle cell growth by inhibition of the phosphoinositide 3-kinase-Akt axis.
Li Q, Li G, Lan X, Zheng M, Chen KH, Cao CM, Xiao RP., Free PMC Article | 05/3/2010 |
| Fetal exposure to dexamethasone was associated with decreased insulin signaling at the level of p85 binding to IRS-1. | Effect of fetal dexamethasone exposure on the development of adult insulin sensitivity in a rat model.
O'Brien K, Sekimoto H, Boney C, Malee M. | 01/21/2010 |
| Phosphatidylinositol 3-kinase is a major factor in the expression of central sensitization after noxious inflammatory stimuli. | Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions.
Pezet S, Marchand F, D'Mello R, Grist J, Clark AK, Malcangio M, Dickenson AH, Williams RJ, McMahon SB., Free PMC Article | 01/21/2010 |
| Link the class IA PI3K-Akt pathway to Na(+)-K(+)-ATPase in ouabain-induced myocyte hypertrophy. | Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes.
Liu L, Zhao X, Pierre SV, Askari A. | 01/21/2010 |
| p70 PDGFR-beta functions as an adapter that recruits PI3K to the membrane upon AT1 receptor stimulation by angiotensin II | Angiotensin II stimulates phosphorylation of an ectodomain-truncated platelet-derived growth factor receptor-beta and its binding to class IA PI3K in vascular smooth muscle cells.
Gao BB, Hansen H, Chen HC, Feener EP., Free PMC Article | 01/21/2010 |
| JAK2 functions as an upstream mediator of the phosphatidylinositol 3 (PI 3)-kinase activity in gastrin signaling | Involvement of JAK2 upstream of the PI 3-kinase in cell-cell adhesion regulation by gastrin.
Ferrand A, Kowalski-Chauvel A, Bertrand C, Pradayrol L, Fourmy D, Dufresne M, Seva C. | 01/21/2010 |
| in cells transformed by the v-crk oncogene, the adapter protein Cas forms a stable complex with the p85 regulatory subunit of phosphatidylinositol 3'-kinase (PI3K) coincident with the appearance of Cas-associated PI3K activity | Src-dependent association of Cas and p85 phosphatidylinositol 3'-kinase in v-crk-transformed cells.
Riggins RB, DeBerry RM, Toosarvandani MD, Bouton AH. | 01/21/2010 |
| PI3-K/Akt is critically involved in mechanotransduction of VSMC in vitro and within the vasculature in vivo. Furthermore, caveolin-1 is essential for the integrin-mediated activation of PI3-K/Akt. | Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo.
Sedding DG, Hermsen J, Seay U, Eickelberg O, Kummer W, Schwencke C, Strasser RH, Tillmanns H, Braun-Dullaeus RC. | 01/21/2010 |
| acidosis accelerates protein degradation by impairing insulin signaling through PI3K in muscle cells. | Acidosis impairs insulin receptor substrate-1-associated phosphoinositide 3-kinase signaling in muscle cells: consequences on proteolysis.
Franch HA, Raissi S, Wang X, Zheng B, Bailey JL, Price SR. | 01/21/2010 |
| rab3 and PI3K positively and coordinately regulate NE uptake in PC12 neuroendocrine cells at least in part by stimulating the secretory vesicle uptake step. | Coordinate regulation of catecholamine uptake by rab3 and phosphoinositide 3-kinase.
Francis SC, Sunshine C, Kirk KL. | 01/21/2010 |
| inhibition of MMP9 expression by PDGF-PI3k pathway | Induced expression of MMP-9 in C6 glioma cells is inhibited by PDGF via a PI 3-kinase-dependent pathway.
Estève PO, Robledo O, Potworowski EF, St-Pierre Y. | 01/21/2010 |
| Data suggest that ketone bodies promote insulin resistance through decreased activation of the PI3-K/PKB signaling cascade, and that vanadate can bypass insulin resistance and stimulate glucose uptake in OHB-treated cardiomyocytes. | Chronic exposure to ketone bodies impairs glucose uptake in adult cardiomyocytes in response to insulin but not vanadate: the role of PI3-K.
Pelletier A, Tardif A, Gingras MH, Chiasson JL, Coderre L. | 01/21/2010 |