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    Slc34a1 solute carrier family 34 member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25548, updated on 22-Aug-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion.

    Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion.
    Clerin V, Saito H, Filipski KJ, Nguyen AH, Garren J, Kisucka J, Reyes M, Jüppner H., Free PMC Article

    multiprotein kinase cascade involving G protein-coupled receptor kinase 6A controls the Ser(290) phosphorylation status of NHERF1 and regulates PTH-sensitive, NPT2A-mediated phosphate uptake

    Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport.
    Zhang Q, Xiao K, Paredes JM, Mamonova T, Sneddon WB, Liu H, Wang D, Li S, McGarvey JC, Uehling D, Al-Awar R, Joseph B, Jean-Alphonse F, Orte A, Friedman PA., Free PMC Article

    Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membranes in a vitamin B12 deficiency suggests that vitamin B12 plays an important role in Pi homeostasis

    Vitamin B₁₂ deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a.
    Shiga T, Kimira Y, Mano H, Kawata T, Tadokoro T, Suzuki T, Yamamoto Y.

    NaPi-IIa mRNA expression is affected by hyperphosphatemia.

    Effect of hyperphosphatemia on gene expression of the Na-Pi cotransporter in rats.
    Zhang C, Shi LM, Li Y, Zhu QG, Jin CL, Wang HP, Zhou L, Hu XP, Zhang L, Wang H, Yuan GJ, Xu L, Zhao YK, Chou Y.

    Estrogen induces phosphaturia by directly and specifically targeting NaPi-IIa in the proximal tubule cells.

    Estrogen directly and specifically downregulates NaPi-IIa through the activation of both estrogen receptor isoforms (ERα and ERβ) in rat kidney proximal tubule.
    Burris D, Webster R, Sheriff S, Faroqui R, Levi M, Hawse JR, Amlal H., Free PMC Article

    Magnesium deficiency induces downregulation of 1alpha(OH)ase and type IIa and IIc Na/Pi cotransporters, and upregulation of 24(OH)ase in the kidney.

    Magnesium deficiency regulates vitamin D metabolizing enzymes and type II sodium-phosphate cotransporter mRNA expression in rats.
    Matsuzaki H, Katsumata S, Kajita Y, Miwa M.

    Downregulation of renal Npt2a expression through induction of plasma iPTH levels alters Pi homeostasis during LPS-induced acute inflammation.

    Downregulation of renal type IIa sodium-dependent phosphate cotransporter during lipopolysaccharide-induced acute inflammation.
    Ikeda S, Yamamoto H, Masuda M, Takei Y, Nakahashi O, Kozai M, Tanaka S, Nakao M, Taketani Y, Segawa H, Iwano M, Miyamoto K, Takeda E.

    NaPi-2a transporter expression in the trans-Golgi network and its interaction with PIST in the proximal tubule is modulated by inorganic phosphate

    Inorganic phosphate modulates the expression of the NaPi-2a transporter in the trans-Golgi network and the interaction with PIST in the proximal tubule.
    Lanaspa MA, Caldas YA, Breusegem SY, Andrés-Hernando A, Cicerchi C, Levi M, Sorribas V., Free PMC Article

    We demonstrated a progressive decrease in brush-border membrane (BBM) expression of Npt2a from rats treated with PTH for 6 h or 4 days.

    Parathyroid hormone (PTH) decreases sodium-phosphate cotransporter type IIa (NpT2a) mRNA stability.
    Murray RD, Holthouser K, Clark BJ, Salyer SA, Barati MT, Khundmiri SJ, Lederer ED.

    PFA decreased iPTH level but had no effect on NaPi-2 mRNA expression. Renagel decreased serum P and iPTH levels, but upregulated renal NaPi-2 mRNA expression.

    Effects of phosphonoformic acid and renagel on renal type IIa sodium-dependent phosphate cotransporter mRNA expression in hyperphosphatemia rats.
    Zeng M, Wang X, Wang X, Zhao X.

    NaPi-IIa can form some different complexes on the apical plasma membrane of renal proximal tubular cells.

    Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis.
    Tanimura A, Yamada F, Saito A, Ito M, Kimura T, Anzai N, Horie D, Yamamoto H, Miyamoto K, Taketani Y, Takeda E.

    Shank2 is positioned to coordinate the regulated endocytic retrieval and downregulation of NaPiIIa in rat renal proximal tubule cells.

    Shank2 redistributes with NaPilla during regulated endocytosis.
    Dobrinskikh E, Giral H, Caldas YA, Levi M, Doctor RB., Free PMC Article

    expression in renal brush border reduced by parathyroid hormone

    Acute parathyroid hormone differentially regulates renal brush border membrane phosphate cotransporters.
    Picard N, Capuano P, Stange G, Mihailova M, Kaissling B, Murer H, Biber J, Wagner CA.

    Chronic estrogen treatment is associated with an inhibitory, parathyroid hormone-independent effect on the expression of NaPiIIa in the kidney, leading to sex-related differences in phosphate balance.

    Evidence of a parathyroid hormone-independent chronic effect of estrogen on renal phosphate handling and sodium-dependent phosphate cotransporter type IIa expression.
    Guttmann-Rubinstein L, Lichtstein D, Ilani A, Gal-Moscovici A, Scherzer P, Rubinger D.

    Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency.

    Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency.
    Breusegem SY, Takahashi H, Giral-Arnal H, Wang X, Jiang T, Verlander JW, Wilson P, Miyazaki-Anzai S, Sutherland E, Caldas Y, Blaine JT, Segawa H, Miyamoto K, Barry NP, Levi M., Free PMC Article

    Under a high-Mg2+ diet, NaPi-IIa expression is dependent on PTH levels, whereas NaPi-IIc expression seems to be independent of PTH levels

    Magnesium stimulates renal phosphate reabsorption.
    Thumfart J, Jung S, Amasheh S, Krämer S, Peters H, Sommer K, Biber J, Murer H, Meij I, Querfeld U, Wagner CA, Müller D.

    These results suggest that downregulation of Npt2 protein (aka Slc34a1) may contribute to the decreased tubular reabsorption of phosphate in acute ischemic renal failure and hyperphosphatemia.

    Regulation of the renal sodium-dependent phosphate cotransporter NaPi2 (Npt2) in acute renal failure due to ischemia and reperfusion.
    Rubinger D, Wald H, Gimelreich D, Halaihel N, Rogers T, Levi M, Popovtzer MM.

    A model of rat sodium phosphate cotransporter type IIa (NaPi-IIa) comprising 12 transmembrane domain (TMD)s, with both N- and C-termini orientated intracellularly and a large hydrophilic extracellular loop between the fifth and sixth TMDs, is proposed.

    Topology of the type IIa Na+/P(i) cotransporter.
    Radanovic T, Gisler SM, Biber J, Murer H.

    urinary excretion of cAMP and PTH/PTH-related peptide (PTHrP) receptor and type II sodium-dependent phosphate transporter (NaPi-2) mRNA in the kidney were both decreased in rats fed the high P diets containing 1.2% or greater P

    Decreased mRNA expression of the PTH/PTHrP receptor and type II sodium-dependent phosphate transporter in the kidney of rats fed a high phosphorus diet accompanied with a decrease in serum calcium concentration.
    Katsumata S, Masuyama R, Uehara M, Suzuki K.

    the diurnal changes in urinary phosphate excretion appear to be mainly related to changes in serum phosphate and tubular threshold but not to NaPi-IIa expression

    Unchanged expression of the sodium-dependent phosphate cotransporter NaPi-IIa despite diurnal changes in renal phosphate excretion.
    Bielesz B, Bacic D, Honegger K, Biber J, Murer H, Wagner CA.

    FGF23 mutant thus blunts the signalling of Pi deprivation to the renal type-II Na/Pi cotransporter, suggesting that the FGF23 pathway could be involved in the signalling of dietary Pi.

    Effect of hydrolysis-resistant FGF23-R179Q on dietary phosphate regulation of the renal type-II Na/Pi transporter.
    Segawa H, Kawakami E, Kaneko I, Kuwahata M, Ito M, Kusano K, Saito H, Fukushima N, Miyamoto K.

    NaPi protein diffusion, clustering, and activity is mediated by partitioning of NaPi cotransporter in cholesterol-, sphingomyelin-and glycosphingolipid-enriched membrane domains

    Partitioning of NaPi cotransporter in cholesterol-, sphingomyelin-, and glycosphingolipid-enriched membrane domains modulates NaPi protein diffusion, clustering, and activity.
    Inoue M, Digman MA, Cheng M, Breusegem SY, Halaihel N, Sorribas V, Mantulin WW, Gratton E, Barry NP, Levi M.

    Signals for mRNA encoding Slc17a2 are found in the inferior olivary complex and in most brainstem precerebellar nuclei sending mossy fibers, such as the pontine, pontine tegmental reticular, lateral reticular and external cuneate nuclei.

    Differential distribution of vesicular glutamate transporters in the rat cerebellar cortex.
    Hioki H, Fujiyama F, Taki K, Tomioka R, Furuta T, Tamamaki N, Kaneko T.

    The expression of NaPi-IIa and NaPi-IIb seem regulated by phosphate in a manner consistent with their playing a role in transcellular P(i) flux during mineralization.

    Type II Na+-Pi cotransporters in osteoblast mineral formation: regulation by inorganic phosphate.
    Lundquist P, Murer H, Biber J.

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