| Lymphedema as first clinical presentation of Cantu Syndrome: reversed phenotyping after identification of gain-of-function variant in ABCC9. | Lymphedema as first clinical presentation of Cantu Syndrome: reversed phenotyping after identification of gain-of-function variant in ABCC9.
Gao J, McClenaghan C, Christiaans I, Alders M, van Duinen K, van Haelst MM, van Haaften G, Nichols CG., Free PMC Article | 02/13/2023 |
| Cardiac dysfunction in spontaneously hypertensive old rats is associated with a significant decrease of SUR2 expression. | Cardiac dysfunction in spontaneously hypertensive old rats is associated with a significant decrease of SUR2 expression.
Strutynskyi RB, Goncharov SV, Tumanovska LV, Nagibin VS, Dosenko VE. | 02/19/2022 |
| Up-regulation of the KATP channel accelerates repolarization and shortens action potential duration during stress and exercise. | Effects of regular exercise on ventricular myocyte biomechanics and K(ATP) channel function.
Wang X, Fitts RH. | 09/7/2019 |
| D207E of Sue2 increases KATP channel activity by increasing intrinsic stability of the open state, whereas the cluster of Y981S/G985E/M1056I substitutions, as well as R1150Q/R1150W, augmented Mg-nucleotide activation. | Cantu syndrome-associated SUR2 (ABCC9) mutations in distinct structural domains result in K(ATP) channel gain-of-function by differential mechanisms.
McClenaghan C, Hanson A, Sala-Rabanal M, Roessler HI, Josifova D, Grange DK, van Haaften G, Nichols CG., Free PMC Article | 02/16/2019 |
| In vascular smooth muscle KATP channel subunits Kir6.1 and SUR2B contribute to modify the functionality of this channel in hypertension with age. | Altered KATP Channel Subunits Expression and Vascular Reactivity in Spontaneously Hypertensive Rats With Age.
Liu X, Duan P, Hu X, Li R, Zhu Q., Free PMC Article | 11/4/2017 |
| These data provide insights into the molecular basis by which phosphorylation of SUR2B NBD1 activates KATP channels. | Phosphorylation-dependent changes in nucleotide binding, conformation, and dynamics of the first nucleotide binding domain (NBD1) of the sulfonylurea receptor 2B (SUR2B).
de Araujo ED, Alvarez CP, López-Alonso JP, Sooklal CR, Stagljar M, Kanelis V., Free PMC Article | 12/5/2015 |
| Electrophysiological studies employing SUR2A/Kir6.2-expressing HEK cells showed that increasing endogenous or exogenous Phosphatidylinositol 4,5-bisphosphate diminished the inhibitory effect of Syn-1A on KATP currents. | Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels.
Xie L, Liang T, Kang Y, Lin X, Sobbi R, Xie H, Chao C, Backx P, Feng ZP, Shyng SL, Gaisano HY. | 05/23/2015 |
| Suggest that the increase in KATP channel subunits, SUR2 and Kir6.1, in the rostral ventrolateral medulla may be responsible for the greater sympathetic outflow and pressor effect of hydroxylamine in Ad-cystathionine beta-synthetase injected rats. | Gene transfer of cystathionine β-synthase into RVLM increases hydrogen sulfide-mediated suppression of sympathetic outflow via KATP channel in normotensive rats.
Duan XC, Guo R, Liu SY, Xiao L, Xue HM, Guo Q, Jin S, Wu YM. | 05/16/2015 |
| Results demonstrate differential and highly localized expression pattern of sulphonylurea receptor proteins SUR2A and 2B (SUR1) in rat kidney. | Localization of sulphonylurea receptor proteins SUR2A and SUR2B and/or SUR1 in rat kidney.
Qureshi IZ, Beesley AH, White SJ. | 12/21/2013 |
| Testosterone protect female embryonic heart H9c2 cells against severe metabolic stress by its conversion into metabolites that activate estrogen receptors and up-regulate IES SUR2B. | Testosterone protects female embryonic heart H9c2 cells against severe metabolic stress by activating estrogen receptors and up-regulating IES SUR2B.
Ballantyne T, Du Q, Jovanović S, Neemo A, Holmes R, Sinha S, Jovanović A., Free PMC Article | 07/6/2013 |
| mRNA & protein of SUR2A & SUR2B are expressed in whole rat brain extracts & selected regions. SUR2B to be localized in astrocytes and oligodendrocytes, while SUR2A is only localized in oligodendrocytes. | Localization of the ATP-sensitive K(+) channel regulatory subunits SUR2A and SUR2B in the rat brain.
Zhou M, He HJ, Tanaka O, Sekiguchi M, Kawahara K, Abe H. | 05/4/2013 |
| Electron microscopy revealed that SUR2B assmbles as a tetramer of four subunits surrounding a central hole. | Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles.
Fotinou C, Aittoniemi J, de Wet H, Polidori A, Pucci B, Sansom MS, Vénien-Bryan C, Ashcroft FM., Free PMC Article | 04/13/2013 |
| SUR2 helped to regulate the proliferation and differentiation of preadipocytes. Glibenclamide inhibited the expression of SUR2 mRNA in preadipocytes. | Involvement of ATP-sensitive potassium channels in proliferation and differentiation of rat preadipocytes.
Wang YH, Zheng HY, Qin NL, Yu SB, Liu SY. | 08/25/2012 |
| Both mRNA and protein expression of cardiac K-ATP (SUR2A/Kir6.2) channels are decreased in diabetic rats. | Increase of ATP-sensitive potassium (K(ATP)) channels in the heart of type-1 diabetic rats.
Chen ZC, Cheng YZ, Chen LJ, Cheng KC, Li Y, Cheng J., Free PMC Article | 06/9/2012 |
| K(ATP) channel subunits Kir6.1, Kir6.2, SUR1 and SUR2B were identified in the trigeminal ganglia and trigeminal nucleus caudalis. | K(ATP) channel openers in the trigeminovascular system.
Ploug KB, Amrutkar DV, Baun M, Ramachandran R, Iversen A, Lund TM, Gupta S, Hay-Schmidt A, Olesen J, Jansen-Olesen I. | 05/26/2012 |
| The paper identified a protein kinase A phosphorylation site on SUR2B subunit (Ser1387) and suggests it is required for Kir6.1/SUR2B channel activation by beta-adrenergic receptors. | PKA phosphorylation of SUR2B subunit underscores vascular KATP channel activation by beta-adrenergic receptors.
Shi Y, Wu Z, Cui N, Shi W, Yang Y, Zhang X, Rojas A, Ha BT, Jiang C., Free PMC Article | 03/22/2012 |
| Guanxinkang injection significantly increased mRNA and protein expressions of Kir6.1, Kir6.2, SUR2A and SUR2B in ischemic myocytes but with no significant difference compared to pinacidil. | [Effects of Guanxinkang on expressions of ATP-sensitive potassium channel subunits Kir6.1, Kir6.2, SUR2A and SUR2B in ischemic myocytes of rats].
Chen FR, Zhang N, Liu P, Zhang YY, Han XH, Cai JF. | 03/10/2012 |
| Both SUR1 and SUR2 subunits of KATP channel are involved in uterine contraction/relaxation and myometrial response to either oxytocin or tocolytic agents. | Ontogeny of sulfonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometrium.
Lovasz N, Ducza E, Gaspar R, Falkay G. | 12/10/2011 |
| The boundaries of the first nucleotide-binding domain of SUR2A have been determined from samples of folded and functional protein that provide a platform for insight into the role of SUR2A in regulating KATP channel activity. | The first nucleotide binding domain of the sulfonylurea receptor 2A contains regulatory elements and is folded and functions as an independent module.
de Araujo ED, Ikeda LK, Tzvetkova S, Kanelis V. | 11/26/2011 |
| The novel cGMP/PKG/ROS/calmodulin/CaMKII signaling pathway may regulate cardiomyocyte excitability by opening K(ATP) channels and contribute to cardiac protection against ischemia-reperfusion injury. | Activation of cGMP-dependent protein kinase stimulates cardiac ATP-sensitive potassium channels via a ROS/calmodulin/CaMKII signaling cascade.
Chai Y, Zhang DM, Lin YF., Free PMC Article | 07/30/2011 |
| ATP-sensitive potassium channels might be involved in the proliferation and differentiation of rat preadipocytes by changing the expression of P21, P27 and leptin. | Effects of ATP-sensitive potassium channels on the expression of P21, P27 and leptin.
Wang Y, Zheng H, Liu S. | 02/5/2011 |
| ATP-sensitive potassium channels containing different SUR2 isoforms are differentially modulated by MgATP, with Kir6.2/SUR2B being activated more than Kir6.2/SUR2A. Purified SUR2B has a lower ATPase activity and a 10-fold lower K(m) for MgATP than SUR2A. | The ATPase activities of sulfonylurea receptor 2A and sulfonylurea receptor 2B are influenced by the C-terminal 42 amino acids.
de Wet H, Fotinou C, Amad N, Dreger M, Ashcroft FM., Free PMC Article | 07/12/2010 |
| SUR2A is important for coupling cardiac K(ATP) channels to caveolin-3, possibly through the caveolin-3 scaffolding domain. | Role for SUR2A in coupling cardiac K(ATP) channels to caveolin-3.
Sun W, Hu K. | 06/28/2010 |
| Data suggest that AV-SUR2A increases resistance to metabolic stress in H9C2 cells by increasing the number of sarcolemmal K(ATP) channels and subsarcolemmal ATP. | Infection with AV-SUR2A protects H9C2 cells against metabolic stress: a mechanism of SUR2A-mediated cytoprotection independent from the K(ATP) channel activity.
Du Q, Jovanović S, Sukhodub A, Jovanović A., Free PMC Article | 05/31/2010 |
| M-LDH physically associated with Kir6.2/SUR2A regulates the activity of sarcolemmal K(ATP) channels as well as an intracellular ATP production during metabolic stress, both of which are important for cell survival. | M-LDH physically associated with sarcolemmal K ATP channels mediates cytoprotection in heart embryonic H9C2 cells.
Jovanović S, Du Q, Sukhodub A, Jovanović A., Free PMC Article | 01/21/2010 |