| Expression levels of ICER and BDNF were increased remarkably but the GABAA R alpha1 subunit decreased significantly in the drug-resistant epileptic rats. However, the expression levels of ICER, BDNF were decreased and the expression of the GABAA R alpha1 subunit increased significantly in the drug-resistant epileptic rats after two weeks of Hip-LFS. | Influence of hippocampal low-frequency stimulation on GABA(A) R α1, ICER and BNDF expression level in brain tissues of amygdala-kindled drug-resistant temporal lobe epileptic rats.
Xu K, Liu Z, Wang L, Wu G, Liu T. | 11/9/2019 |
| Using an ADHD rat model, we demonstrate that impulsive animals are neurochemically and behaviorally more sensitive to heroin and exhibit reduced Crem expression in the nucleus accumbens core. | Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability.
Miller ML, Ren Y, Szutorisz H, Warren NA, Tessereau C, Egervari G, Mlodnicka A, Kapoor M, Chaarani B, Morris CV, Schumann G, Garavan H, Goate AM, Bannon MJ, IMAGEN Consortium, Halperin JM, Hurd YL., Free PMC Article | 03/30/2019 |
| These data suggest that fluoride can impair male reproduction by affecting expression of P450, CREM, and ACT in the testes. | Effects of Fluoride on Expression of P450, CREM and ACT Proteins in Rat Testes.
Zhang J, Zhu Y, Liang C, Qie M, Niu R, Sun Z, Wang J, Wang J. | 01/28/2017 |
| The ERK1/2 and ICER-mediated feed forward loop is the hidden design principle underlying the switching role of beta-adrenergic receptor signaling in cell survival or death decision of cardiomyocytes. | The switching role of β-adrenergic receptor signalling in cell survival or death decision of cardiomyocytes.
Shin SY, Kim T, Lee HS, Kang JH, Lee JY, Cho KH, Kim DH., Free PMC Article | 10/3/2015 |
| CREM/ICER is a negative regulator of endothelial function | Upregulation of CREM/ICER suppresses wound endothelial CRE-HIF-1α-VEGF-dependent signaling and impairs angiogenesis in type 2 diabetes.
Bitar MS, Al-Mulla F., Free PMC Article | 10/3/2015 |
| Hyperglycemia downregulates Connexin36 in pancreatic islets via the upregulation of ICER-1/ICER-1gamma. | Hyperglycemia downregulates Connexin36 in pancreatic islets via the upregulation of ICER-1/ICER-1γ.
Haefliger JA, Rohner-Jeanrenaud F, Caille D, Charollais A, Meda P, Allagnat F. | 01/11/2014 |
| CREM-1 may play an important role in regulating neuronal death after traumatic brain injury by interacting with cyclic AMP response element-binding protein (CREB). | Cyclic AMP response element modulator-1 (CREM-1) involves in neuronal apoptosis after traumatic brain injury.
Wu X, Jin W, Liu X, Fu H, Gong P, Xu J, Cui G, Ni Y, Ke K, Gao Z, Gao Y. | 03/30/2013 |
| The induction of ICER in GSNO-treated RPaSMC highlights a novel cross-talk mechanism between cGMP and cAMP signaling pathways. | Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene.
Steinbicker AU, Liu H, Jiramongkolchai K, Malhotra R, Choe EY, Busch CJ, Graveline AR, Kao SM, Nagasaka Y, Ichinose F, Buys ES, Brouckaert P, Zapol WM, Bloch KD., Free PMC Article | 06/30/2012 |
| we have found that silencing of ICERs enhances the CRE-driven transcription and exerts a mild, although significant, neuroprotective effect | Silencing of ICERs (Inducible cAMP Early Repressors) results in partial protection of neurons from programmed cell death.
Bieganska K, Figiel I, Gierej D, Kaczmarek L, Klejman A. | 05/19/2012 |
| Induction of ICER links oxidative stress to beta cell failure caused by oxidised LDL, and it can be effectively abrogated by antioxidant treatment. | Role for inducible cAMP early repressor in promoting pancreatic beta cell dysfunction evoked by oxidative stress in human and rat islets.
Favre D, Niederhauser G, Fahmi D, Plaisance V, Brajkovic S, Beeler N, Allagnat F, Haefliger JA, Regazzi R, Waeber G, Abderrahmani A., Free PMC Article | 03/10/2012 |
| Reduction in testicular CREMtau expression may be one of the mechanisms responsible for impairment of spermatogenesis in ipsilateral testes after unilateral testicular torsion-detorsion. | Role of cAMP-responsive element modulator-tau (CREMtau) in ipsilateral testicular injury after unilateral testicular torsion-detorsion.
Wei SM, Yan ZZ, Zhou J. | 12/9/2011 |
| Data identified ICER as a novel CHIP substrate and that the ERK5-CHIP complex plays an obligatory role in inhibition of ICER expression, cardiomyocyte apoptosis, and cardiac dysfunction. | Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor.
Woo CH, Le NT, Shishido T, Chang E, Lee H, Heo KS, Mickelsen DM, Lu Y, McClain C, Spangenberg T, Yan C, Molina CA, Yang J, Patterson C, Abe J., Free PMC Article | 01/8/2011 |
| The data provide evidence that endogenous ICER formation is required for termination of CRH transcription. | Cyclic AMP inducible early repressor mediates the termination of corticotropin releasing hormone transcription in hypothalamic neurons.
Liu Y, Aguilera G., Free PMC Article | 02/22/2010 |
| BDNF- and seizure-dependent phosphorylation of STAT3 cause the adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB) family member ICER (inducible cAMP early repressor) to bind with phosphorylated CREB at the Gabra1:CRE site. | BDNF selectively regulates GABAA receptor transcription by activation of the JAK/STAT pathway.
Lund IV, Hu Y, Raol YH, Benham RS, Faris R, Russek SJ, Brooks-Kayal AR., Free PMC Article | 01/21/2010 |
| Decrease of alpha1 is dependent upon the inducible cAMP early repressor (ICER) | Surface expression of GABAA receptors is transcriptionally controlled by the interplay of cAMP-response element-binding protein and its binding partner inducible cAMP early repressor.
Hu Y, Lund IV, Gravielle MC, Farb DH, Brooks-Kayal AR, Russek SJ., Free PMC Article | 01/21/2010 |
| chronic exposure to palmitate inhibits the Cx36 expression through PKA-mediated ICER-1gamma overexpression | ICER-1gamma overexpression drives palmitate-mediated connexin36 down-regulation in insulin-secreting cells.
Allagnat F, Alonso F, Martin D, Abderrahmani A, Waeber G, Haefliger JA. | 01/21/2010 |
| Yukmijihwang-tang restored CREM at both the mRNA and protein levels following treatment with cyclophosphamide. | Yukmijihwang-tang protects against cyclophosphamide-induced reproductive toxicity.
Oh MS, Chang MS, Park W, Kim DR, Bae H, Huh Y, Park SK. | 01/21/2010 |
| CREB functional antagonist Crem/ICER may have a specific function in programmed cell death of neurons, probably by silencing the expression of anti-apoptotic genes | Inducible cAMP early repressor, an endogenous antagonist of cAMP responsive element-binding protein, evokes neuronal apoptosis in vitro.
Jaworski J, Mioduszewska B, Sánchez-Capelo A, Figiel I, Habas A, Gozdz A, Proszynski T, Hetman M, Mallet J, Kaczmarek L., Free PMC Article | 01/21/2010 |
| Our results suggest that the expression of CREB depends on the cell type and the age of the animal. | CREB expression in cardiac fibroblasts and CREM expression in ventricular myocytes.
Husse B, Isenberg G. | 01/21/2010 |
| upon whisker stimulation by exploration of a novel, enriched environment, in the barrel cortex ICER protein (CREM), is differentially regulated in the temporal domain | Expression of c-Fos, ICER, Krox-24 and JunB in the whisker-to-barrel pathway of rats: time course of induction upon whisker stimulation by tactile exploration of an enriched environment.
Bisler S, Schleicher A, Gass P, Stehle JH, Zilles K, Staiger JF. | 01/21/2010 |
| Distinct distribution of ICER- immunoreactivity throughout the rat brain and pituitary forms the basis to better understand the mandatory role of this inhhibitory transcription factor within cyclic AMP signaling. | Distribution of transcription factor inducible cyclicAMP early repressor (ICER) in rodent brain and pituitary.
Kell CA, Dehghani F, Wicht H, Molina CA, Korf HW, Stehle JH. | 01/21/2010 |
| ICER has a key regulatory role in the PKA enhancement of VDR transcription and therefore in the cross-talk between the PKA signaling pathway and the vitamin D endocrine system | Evidence for a regulatory role of inducible cAMP early repressor in protein kinase a-mediated enhancement of vitamin D receptor expression and modulation of hormone action.
Huening M, Yehia G, Molina CA, Christakos S. | 01/21/2010 |
| As a CREB antagonist, ICER appears to be of pivotal importance in neuronal plasticity and programmed cell death. | Inducible cAMP early repressor (ICER) in the nervous system--a transcriptional regulator of neuronal plasticity and programmed cell death.
Mioduszewska B, Jaworski J, Kaczmarek L. | 01/21/2010 |
| HNF4alpha, CREM, HNF1alpha, and C/EBPalpha have roles in transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine | Transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine. Role of HNF4alpha, CREM, HNF1alpha, and C/EBPalpha.
Gautier-Stein A, Zitoun C, Lalli E, Mithieux G, Rajas F. | 01/21/2010 |
| ICER plays an important role in molecular mechanisms governing gastrin-mediated growth by modulating gastrin's transcriptional activation of growth-related genes. | Inducible cAMP early repressor suppresses gastrin-mediated activation of cyclin D1 and c-fos gene expression.
Steigedal TS, Bruland T, Misund K, Thommesen L, Laegreid A. | 01/21/2010 |