| Melanocortin-4 receptor signaling in the central amygdala mediates chronic inflammatory pain effects on nociception. | Melanocortin-4 receptor signaling in the central amygdala mediates chronic inflammatory pain effects on nociception.
Sharfman NM, Kelley LK, Secci ME, Gilpin NW., Free PMC Article | 04/16/2022 |
| Nicotine-induced Brain Stimulation Reward is Modulated by Melanocortin-4 Receptors in Ovariectomized Rats. | Nicotine-induced Brain Stimulation Reward is Modulated by Melanocortin-4 Receptors in Ovariectomized Rats.
Upadhya MA, Upadhya HM, Borkar CD, Choudhary AG, Singh U, Chavan P, Sakharkar A, Singru P, Subhedar NK, Kokare DM. | 06/26/2021 |
| Activation of the Melanocortin-4 Receptor Prevents Oxidative Damage and Mitochondrial Dysfunction in Cultured Hippocampal Neurons Exposed to Ethanol. | Activation of the Melanocortin-4 Receptor Prevents Oxidative Damage and Mitochondrial Dysfunction in Cultured Hippocampal Neurons Exposed to Ethanol.
Quintanilla RA, Pérez MJ, Aranguiz A, Tapia-Monsalves C, Mendez G. | 06/19/2021 |
| The increase in hypothalamic nesfatin-1 participates in regulating feeding behavior through the MC3/4R-ERK signaling especially after SG and RYGB. | Hypothalamic nesfatin-1 mediates feeding behavior via MC3/4R-ERK signaling pathway after weight loss in obese Sprague-Dawley rats.
Zhang T, Wang M, Liu L, He B, Hu J, Wang Y. | 05/23/2020 |
| deficiency was associated with impaired ventilatory responses to hypercapnia independently of obesity | Role of melanocortin 4 receptor in hypertension induced by chronic intermittent hypoxia.
do Carmo JM, da Silva AA, Moak SP, da Silva FS, Spradley FT, Hall JE., Free PMC Article | 04/25/2020 |
| findings suggest that alpha-MSH suppresses I A by activating MC4R, which is coupled sequentially to the Gbetagamma complex of the Gi/o-protein and downstream class I PI3K-dependent p38alpha signaling, thereby increasing TG neuronal excitability and mechanical pain sensitivity in rats. | Melanocortin type 4 receptor-mediated inhibition of A-type K(+) current enhances sensory neuronal excitability and mechanical pain sensitivity in rats.
Zhang Y, Jiang D, Li H, Sun Y, Jiang X, Gong S, Qian Z, Tao J., Free PMC Article | 10/19/2019 |
| MC3R deficiency caused a reduction of food intake and body weight, whereas at the same time exhibited additive effects on top of MC4R deficiency on lipid and glucose metabolism. | Effects of Melanocortin 3 and 4 Receptor Deficiency on Energy Homeostasis in Rats.
You P, Hu H, Chen Y, Zhao Y, Yang Y, Wang T, Xing R, Shao Y, Zhang W, Li D, Chen H, Liu M., Free PMC Article | 06/30/2018 |
| Thus study demonstrated that Adolescent Alcohol Exposure-Induced Changes in melanocortin 4 receptor. | Adolescent Alcohol Exposure-Induced Changes in Alpha-Melanocyte Stimulating Hormone and Neuropeptide Y Pathways via Histone Acetylation in the Brain During Adulthood.
Kokare DM, Kyzar EJ, Zhang H, Sakharkar AJ, Pandey SC., Free PMC Article | 05/19/2018 |
| results revealed that MC4R activation was able to attenuate oxidative stress and mitochondrial dysfunction in skeletal muscle induced by diabetes partially through activating the AMPK-SIRT1-PGC-1alpha signaling pathway. | Melanocortin 4 Receptor Activation Attenuates Mitochondrial Dysfunction in Skeletal Muscle of Diabetic Rats.
Zhang HH, Liu J, Qin GJ, Li XL, Du PJ, Hao X, Zhao D, Tian T, Wu J, Yun M, Bai YH. | 01/6/2018 |
| Although MC4R obese pregnant rats had elevated blood pressure associated with reduced total NOS activity and expression, they had enhanced NOS-mediated attenuation of vasoconstriction, with no evidence of alterations in NOS-mediated regulation of blood pressure. | Nitric oxide synthase-mediated blood pressure regulation in obese melanocortin-4 receptor-deficient pregnant rats.
Spradley FT, Sasser JM, Musall JB, Sullivan JC, Granger JP., Free PMC Article | 07/1/2017 |
| MC4R is predominantly expressed in hepatocytes and upregulated during rat liver regeneration after hepatectomy. | Upregulation of hepatic melanocortin 4 receptor during rat liver regeneration.
Xu M, Alwahsh SM, Ramadori G, Kollmar O, Slotta JE. | 06/24/2017 |
| Data show that selective activation of melanocortin 4 receptor (MC4R) decreased levels of TLR4, HMGB1 and caspase-3 mRNA in liver tissues, and significantly downregulated positive rate of NF-kappaB p65 in hepatocytes. | [Selectively activating melanocortin 4 receptor acts against rat sepsis-induced acute liver injury via HMGB1/TLR4/NF-κB signaling pathway].
Li H, Qiu D, Gao Q, Wang H, Sun M. | 01/14/2017 |
| A synthetic peptide corresponding to cytoplasmic loop 1 of MC4R suppresses basal adenylate cyclase activity and basal level of GppNHp binding of heterotrimeric G proteins produced by THIQ and alpha-MSH in synaptosomal membranes of rat brain. | Regulation of the Melanocortin-Sensitive Adenylate Cyclase System by N-Acylated Peptide 71-82 of Type 4 Melanocortin Receptor.
Shpakov AO, Derkach KV, Shpakova EA. | 10/1/2016 |
| Results suggest that the anti-inflammatory effects of MC4 receptor agonists may not be sufficient to prevent tinnitus. | The anti-inflammatory selective melanocortin receptor subtype 4 agonist, RO27-3225, fails to prevent acoustic trauma-induced tinnitus in rats.
Zheng Y, McPherson K, Reid P, Smith PF. | 05/21/2016 |
| These results suggest that although hindbrain MC4R activity contributes to appetite and heart rate regulation, it does not play a major role in mediating the elevated blood pressue in spontaneously hypertensive rats. | Role of hindbrain melanocortin-4 receptor activity in controlling cardiovascular and metabolic functions in spontaneously hypertensive rats.
do Carmo JM, da Silva AA, Hall JE., Free PMC Article | 03/12/2016 |
| Nesfatin-1 suppresses L-type Ca2+ channels via the MC4-R that couples sequentially to the betagamma subunits of Gi/o-protein and the novel PKC theta isoform in adult ventricular myocytes. | Nesfatin-1 Suppresses Cardiac L-type Ca²⁺ Channels Through Melanocortin Type 4 Receptor and the Novel Protein Kinase C Theta Isoform Pathway.
Ying J, Zhang Y, Gong S, Chang Z, Zhou X, Li H, Tao J, Zhang G. | 02/27/2016 |
| in rats immunized with M4R and M3R peptides the sensitivity of ACSS thyrocytes to TSH were decreased, whereas in rats iimunized with 5-HT1BR peptide the deficit of thyroid hormones was associated with decreased level of TSH | [THE THYROID STATUS OF RATS IMMUNIZED WITH PEPTIDES DERIVED FROM THE EXTRACELLULAR REGIONS OF THE TYPES 3 AND 4 MELANOCORTIN RECEPTORS AND THE 1B-SUBTYPE 5-HYDROXYTRYPTAMINE RECEPTOR].
Derkach KV, Moyseuk IV, Shpakova EA, Sphakov AO. | 12/19/2015 |
| MC4 receptors play a critical role in stress-induced reinstatement of nicotine seeking, but these receptors may not play a role in the dysphoria associated with acute nicotine withdrawal. | A critical role for the melanocortin 4 receptor in stress-induced relapse to nicotine seeking in rats.
Qi X, Yamada H, Corrie LW, Ji Y, Bauzo RM, Alexander JC, Bruijnzeel AW. | 10/24/2015 |
| The alpha-MSH-MC4R system in the posterior ventral tegmental area might be a part of the neuroadaptive mechanism underlying ethanol addiction. | Alpha-melanocyte stimulating hormone modulates ethanol self-administration in posterior ventral tegmental area through melanocortin-4 receptors.
Shelkar GP, Kale AD, Singh U, Singru PS, Subhedar NK, Kokare DM. | 10/24/2015 |
| proopiomelanocortin derivatives acting via the central MC4 receptor participate in the resuscitative effects of 8-OH-DPAT | Proopiomelanocortin but not vasopressin or renin-angiotensin system induces resuscitative effects of central 5-HT1A activation in haemorrhagic shock in rats.
Sowa P, Adamczyk-Sowa M, Zwirska-Korczala K, Pierzchala K, Adamczyk D, Paluch Z, Misiolek M. | 07/4/2015 |
| These data suggest that increases in arterial pressure with chronic hyperandrogenemia in female rats are due, in part, to activation of the sympathetic nervous system, renal nerves, and MC4R. | Roles for the sympathetic nervous system, renal nerves, and CNS melanocortin-4 receptor in the elevated blood pressure in hyperandrogenemic female rats.
Maranon R, Lima R, Spradley FT, do Carmo JM, Zhang H, Smith AD, Bui E, Thomas RL, Moulana M, Hall JE, Granger JP, Reckelhoff JF., Free PMC Article | 06/20/2015 |
| These results support the hypothesis that endogenous MC4R signaling contributes to the HPA axis response to stress. | Loss of melanocortin-4 receptor function attenuates HPA responses to psychological stress.
Ryan KK, Mul JD, Clemmensen C, Egan AE, Begg DP, Halcomb K, Seeley RJ, Herman JP, Ulrich-Lai YM., Free PMC Article | 11/8/2014 |
| The data of this study demonstrated that MC4R signaling is not required for weight loss following treatment with an Angiotensin-converting enzyme inhibitor. | Angiotensin-converting enzyme inhibition reduces food intake and weight gain and improves glucose tolerance in melanocortin-4 receptor deficient female rats.
Mul JD, Seeley RJ, Woods SC, Begg DP., Free PMC Article | 06/28/2014 |
| We showed that the melanocortin-3/4 receptor antagonist SHU 9119 attenuates the food intake-suppressive effect of aminoprocalcitonin. | Aminoprocalcitonin-mediated suppression of feeding involves the hypothalamic melanocortin system.
Tavares E, Maldonado R, Miñano FJ. | 11/30/2013 |
| These results indicated that activation of MC4Rs in the right IML elicited tachycardia and one of the sources of melanocortins in the IML is the ARCN. | Activation of melanocortin receptors in the intermediolateral cell column of the upper thoracic cord elicits tachycardia in the rat.
Iwasa M, Kawabe K, Sapru HN., Free PMC Article | 11/16/2013 |