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    Cpe carboxypeptidase E [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25669, updated on 24-Jul-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The neuroprotective effect of CPE-DeltaN against neuronal glutamate neurotoxicity was mediated by secreted FGF2.

    carboxypeptidase E-ΔN, a neuroprotein transiently expressed during development protects embryonic neurons against glutamate neurotoxicity.
    Qin XY, Cheng Y, Murthy SR, Selvaraj P, Loh YP., Free PMC Article

    07/25/2015
    Data indicate that secreted carboxypeptidase E (CPE) promotes PC12 cell survival under metabolic stress.

    Carboxypeptidase E promotes cancer cell survival, but inhibits migration and invasion.
    Murthy SRK, Dupart E, Al-Sweel N, Chen A, Cawley NX, Loh YP., Free PMC Article

    01/18/2014
    These results reveal a novel role for CPE in the regulation of DAT trafficking and DAT-mediated dopamine uptake.

    Regulation of dopamine transporter activity by carboxypeptidase E.
    Zhang H, Li S, Wang M, Vukusic B, Pristupa ZB, Liu F., Free PMC Article

    05/7/2011
    CPE mediates the effects of NOS1AP on dendrite morphology.

    NOS1AP regulates dendrite patterning of hippocampal neurons through a carboxypeptidase E-mediated pathway.
    Carrel D, Du Y, Komlos D, Hadzimichalis NM, Kwon M, Wang B, Brzustowicz LM, Firestein BL., Free PMC Article

    01/21/2010
    CPE expression levels were compared among mature retina tissue, RGC-5 cells and its differentiated cells; more CPE and preproNPY protein expression in the tumor cells or tumor tissue were observed

    PC2/CPE-mediated pro-protein processing in tumor cells and its differentiated cells or tissues.
    Tang SS, Zhang JH, Liu HX, Li HZ., Free PMC Article

    01/21/2010
    Data show that the carboxypeptidase E cytoplasmic tail binds dynactin that recruits kinesins or dynein for driving bi-directional transport of BDNF vesicles to maintain vesicle homeostasis and secretion in hippocampal neurons.

    A bi-directional carboxypeptidase E-driven transport mechanism controls BDNF vesicle homeostasis in hippocampal neurons.
    Park JJ, Cawley NX, Loh YP., Free PMC Article

    01/21/2010
    our data anticipate the possibility that carboxypeptidase-E, prohormone convertase 1, and prohormone convertase 2 might be potential target for the maturation of somatostatin

    Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain.
    Billova S, Galanopoulou AS, Seidah NG, Qiu X, Kumar U.

    01/21/2010
    Data suggest that ischemia has an adverse impact on the neuropeptide-processing system in the brain and that the lack of an active carboxypeptidase E neuropeptide-processing enzyme exacerbates ischemic brain injury.

    Altered biosynthesis of neuropeptide processing enzyme carboxypeptidase E after brain ischemia: molecular mechanism and implication.
    Zhou A, Minami M, Zhu X, Bae S, Minthorne J, Lan J, Xiong ZG, Simon RP.

    01/21/2010
    Carboxypeptidase E (CPE) is key enzyme for pro-GnRH processing. Reproductive deficits in Cpe(fat/fat) males appear to be due primarily to abnormal sexual behavior.

    Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice.
    Srinivasan S, Bunch DO, Feng Y, Rodriguiz RM, Li M, Ravenell RL, Luo GX, Arimura A, Fricker LD, Eddy EM, Wetsel WC.

    01/21/2010
    SgIII and CPE form the separate functional sorting complex by anchoring to cholesterol-rich SG membranes, and POMC-derived peptides are transferred from CPE to SgIII, and subsequently to CgA.

    Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules.
    Hosaka M, Watanabe T, Sakai Y, Kato T, Takeuchi T.

    01/21/2010
    The carboxypeptidase E (CPE) is involved in gut hormone processing and is not presence in gut endocrine cells.

    Carboxypeptidase E in rat antropyloric mucosa: distribution in progenitor and mature endocrine cell types.
    Hougaard DM, Larsson LI.

    01/21/2010
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