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    Cpe carboxypeptidase E [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25669, updated on 24-Jul-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The neuroprotective effect of CPE-DeltaN against neuronal glutamate neurotoxicity was mediated by secreted FGF2.

    carboxypeptidase E-ΔN, a neuroprotein transiently expressed during development protects embryonic neurons against glutamate neurotoxicity.
    Qin XY, Cheng Y, Murthy SR, Selvaraj P, Loh YP., Free PMC Article

    Data indicate that secreted carboxypeptidase E (CPE) promotes PC12 cell survival under metabolic stress.

    Carboxypeptidase E promotes cancer cell survival, but inhibits migration and invasion.
    Murthy SRK, Dupart E, Al-Sweel N, Chen A, Cawley NX, Loh YP., Free PMC Article

    These results reveal a novel role for CPE in the regulation of DAT trafficking and DAT-mediated dopamine uptake.

    Regulation of dopamine transporter activity by carboxypeptidase E.
    Zhang H, Li S, Wang M, Vukusic B, Pristupa ZB, Liu F., Free PMC Article

    CPE mediates the effects of NOS1AP on dendrite morphology.

    NOS1AP regulates dendrite patterning of hippocampal neurons through a carboxypeptidase E-mediated pathway.
    Carrel D, Du Y, Komlos D, Hadzimichalis NM, Kwon M, Wang B, Brzustowicz LM, Firestein BL., Free PMC Article

    CPE expression levels were compared among mature retina tissue, RGC-5 cells and its differentiated cells; more CPE and preproNPY protein expression in the tumor cells or tumor tissue were observed

    PC2/CPE-mediated pro-protein processing in tumor cells and its differentiated cells or tissues.
    Tang SS, Zhang JH, Liu HX, Li HZ., Free PMC Article

    Data show that the carboxypeptidase E cytoplasmic tail binds dynactin that recruits kinesins or dynein for driving bi-directional transport of BDNF vesicles to maintain vesicle homeostasis and secretion in hippocampal neurons.

    A bi-directional carboxypeptidase E-driven transport mechanism controls BDNF vesicle homeostasis in hippocampal neurons.
    Park JJ, Cawley NX, Loh YP., Free PMC Article

    our data anticipate the possibility that carboxypeptidase-E, prohormone convertase 1, and prohormone convertase 2 might be potential target for the maturation of somatostatin

    Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain.
    Billova S, Galanopoulou AS, Seidah NG, Qiu X, Kumar U.

    Data suggest that ischemia has an adverse impact on the neuropeptide-processing system in the brain and that the lack of an active carboxypeptidase E neuropeptide-processing enzyme exacerbates ischemic brain injury.

    Altered biosynthesis of neuropeptide processing enzyme carboxypeptidase E after brain ischemia: molecular mechanism and implication.
    Zhou A, Minami M, Zhu X, Bae S, Minthorne J, Lan J, Xiong ZG, Simon RP.

    Carboxypeptidase E (CPE) is key enzyme for pro-GnRH processing. Reproductive deficits in Cpe(fat/fat) males appear to be due primarily to abnormal sexual behavior.

    Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice.
    Srinivasan S, Bunch DO, Feng Y, Rodriguiz RM, Li M, Ravenell RL, Luo GX, Arimura A, Fricker LD, Eddy EM, Wetsel WC.

    SgIII and CPE form the separate functional sorting complex by anchoring to cholesterol-rich SG membranes, and POMC-derived peptides are transferred from CPE to SgIII, and subsequently to CgA.

    Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules.
    Hosaka M, Watanabe T, Sakai Y, Kato T, Takeuchi T.

    The carboxypeptidase E (CPE) is involved in gut hormone processing and is not presence in gut endocrine cells.

    Carboxypeptidase E in rat antropyloric mucosa: distribution in progenitor and mature endocrine cell types.
    Hougaard DM, Larsson LI.

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