| HMGB1 Mediates Inflammation-Induced DMT1 Increase and Dopaminergic Neurodegeneration in the Early Stage of Parkinsonism. | HMGB1 Mediates Inflammation-Induced DMT1 Increase and Dopaminergic Neurodegeneration in the Early Stage of Parkinsonism.
Liang T, Yang SX, Qian C, Du LD, Qian ZM, Yung WH, Ke Y. | 04/1/2024 |
| The Endolysosomal Transporter DMT1 is Required for Morphine Regulation of Neuronal Ferritin Heavy Chain. | The Endolysosomal Transporter DMT1 is Required for Morphine Regulation of Neuronal Ferritin Heavy Chain.
Irollo E, Nash B, Luchetta J, Brandimarti R, Meucci O., Free PMC Article | 11/2/2023 |
| DMT1 mediates mitochondrial Fe2+ and Mn2+ acquisition. | A role for divalent metal transporter (DMT1) in mitochondrial uptake of iron and manganese.
Wolff NA, Garrick MD, Zhao L, Garrick LM, Ghio AJ, Thévenod F., Free PMC Article | 11/17/2018 |
| impaired intestinal expression of Dcyt-b and DMT-1 might be associated with the reduction of an iron uptake in CKD. Taken together, impaired these intestinal iron transporters may become a novel therapeutic target for cardio-renal anemia syndrome. | Altered expression of intestinal duodenal cytochrome b and divalent metal transporter 1 might be associated with cardio-renal anemia syndrome.
Naito Y, Sawada H, Oboshi M, Okuno K, Yasumura S, Okuhara Y, Eguchi A, Nishimura K, Soyama Y, Asakura M, Ishihara M, Tsujino T, Masuyama T. | 04/28/2018 |
| Mutations in the divalent metal transporter 1 (DMT1) decrease body iron status and up-regulate copper absorption | Loss of divalent metal transporter 1 function promotes brain copper accumulation and increases impulsivity.
Han M, Chang J, Kim J., Free PMC Article | 06/24/2017 |
| DMT1 and FPN1 are positively influenced by ferrous iron status in brain after intracerebral hemorrhage. DMT1 and FPN1 attenuate iron overload after ICH via increasing transmembrane iron export. | Changes of ferrous iron and its transporters after intracerebral hemorrhage in rats.
Wang G, Shao A, Hu W, Xue F, Zhao H, Jin X, Li G, Sun Z, Wang L., Free PMC Article | 10/1/2016 |
| work unveils the role of DMT1 in mediating the neuroregenerative action of iron. | DMT1 iron uptake in the PNS: bridging the gap between injury and regeneration.
Martinez-Vivot R, Copello G, Leal MC, Piñero G, Usach V, Rozenszajn M, Morelli L, Setton-Avruj CP. | 09/3/2016 |
| These results suggest that the genetic ablation of iPLA2b increased iron uptake in the brain through the activation of IRP2 and upregulation of DMT1, which may be associated with mitochondrial dysfunction. | Deficiency of Calcium-Independent Phospholipase A2 Beta Induces Brain Iron Accumulation through Upregulation of Divalent Metal Transporter 1.
Beck G, Shinzawa K, Hayakawa H, Baba K, Yasuda T, Sumi-Akamaru H, Tsujimoto Y, Mochizuki H., Free PMC Article | 06/28/2016 |
| the effects of hepcidin expression and hepcidin peptide on brain iron contents, iron transport across the brain-blood barrier, iron uptake and release, and also the expression of TfR1, DMT1, and Fpn, were investigated. | Hepcidin Suppresses Brain Iron Accumulation by Downregulating Iron Transport Proteins in Iron-Overloaded Rats.
Du F, Qian ZM, Luo Q, Yung WH, Ke Y. | 05/21/2016 |
| DMT1 expression was enhanced in the bone tissue of type 2 diabetic rats, and plays an important role in the pathological process of diabetic osteoporosis. | Regulation of DMT1 on Bone Microstructure in Type 2 Diabetes.
Zhang WL, Meng HZ, Yang MW., Free PMC Article | 02/20/2016 |
| Goat milk consumption potentiates liver DMT1 expression, enhancing Fe metabolism and storage. | Goat milk consumption modulates liver divalent metal transporter 1 (DMT1) expression and serum hepcidin during Fe repletion in Fe-deficiency anemia.
Díaz-Castro J, Pulido M, Alférez MJ, Ochoa JJ, Rivas E, Hijano S, López-Aliaga I. | 10/10/2015 |
| Hepcidin or enterocyte iron levels may be involved in the regulation of the age-dependent expression in the duodenum. | Age-dependent expression of duodenal cytochrome b, divalent metal transporter 1, ferroportin 1, and hephaestin in the duodenum of rats.
Kong WN, Wu Q, Shen D, Zhao SE, Guo P, Duan XL, Chang YZ. | 09/26/2015 |
| Spinal peroxynitrite activates DMT1-iron responsive element, leading to abnormal iron accumulation in postoperative hyperalgesia. | Spinal peroxynitrite contributes to remifentanil-induced postoperative hyperalgesia via enhancement of divalent metal transporter 1 without iron-responsive element-mediated iron accumulation in rats.
Shu RC, Zhang LL, Wang CY, Li N, Wang HY, Xie KL, Yu YH, Wang GL. | 06/27/2015 |
| Data suggest that expression of Dmt1/Slc11a2 in intestinal mucosa can be regulated by dietary factors; here, expression of Dmt1/Slc11a2 in mucosa of cecum is up-regulated by prebiotic supplement, inulin, in iron-deficiency anemia. | Effects of prebiotic supplementation on the expression of proteins regulating iron absorption in anaemic growing rats.
Marciano R, Santamarina AB, de Santana AA, Silva Mde L, Amancio OM, do Nascimento CM, Oyama LM, de Morais MB. | 06/20/2015 |
| All three isoforms of DMT1 are selectively expressed in different cell populations within the cochlea and, additionally, demonstrate their cellular and subcellular distribution changes with development. | Cellular localization and developmental changes of the different isoforms of divalent metal transporter 1 (DMT1) in the inner ear of rats.
Ding D, Salvi R, Roth JA. | 02/14/2015 |
| Dmt1 expression was significantly elevated through pro-inflammatory cytokines, whereas Ft expression was marginally increased. | Influence of cytokines on Dmt1 iron transporter and ferritin expression in insulin-secreting cells.
Lortz S, Schröter S, Stückemann V, Mehmeti I, Lenzen S. | 01/17/2015 |
| DMT1 protein levels are down-regulated in iron-loaded liver and up-regulated in iron-deficient liver and heart. | ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders.
Nam H, Wang CY, Zhang L, Zhang W, Hojyo S, Fukada T, Knutson MD., Free PMC Article | 07/12/2014 |
| DMT1 not only exports iron from endosomes, but also serves to import the metal into the mitochondria | Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1).
Wolff NA, Ghio AJ, Garrick LM, Garrick MD, Zhao L, Fenton RA, Thévenod F. | 06/21/2014 |
| DMT1 is a candidate for non-transferrin-bound iron uptake within the peripheral nervous system. | DMT1 as a candidate for non-transferrin-bound iron uptake in the peripheral nervous system.
Vivot RM, Goitia B, Usach V, Setton-Avruj PC. | 03/22/2014 |
| The data presented here establish for the first time a causal association between inflammation and iron accumulation in brain cells, probably promoted by changes in DMT1 and FPN1 expression and mediated in part by hepcidin. | Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells.
Urrutia P, Aguirre P, Esparza A, Tapia V, Mena NP, Arredondo M, González-Billault C, Núñez MT. | 10/26/2013 |
| Whole-genome profiling reveals that increasing dietary protein from 5 to 40% increases duodenal transcript expression of divalent metal transporter 1 (DMT1) 3.2-fold, duodenal cytochrome b (Dcytb) 1.8-fold, and transferrin receptor (TfR) 1.8-fold. | Increasing dietary protein acutely augments intestinal iron transporter expression and significantly increases iron absorption in rats.
Thomas CE, Gaffney-Stomberg E, Sun BH, O'Brien KO, Kerstetter JE, Insogna KL. | 08/3/2013 |
| analysis of synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1) | Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1).
Cadieux JA, Zhang Z, Mattice M, Brownlie-Cutts A, Fu J, Ratkay LG, Kwan R, Thompson J, Sanghara J, Zhong J, Goldberg YP. | 08/4/2012 |
| These data indicate that CTR1, but not DMT1, plays an essential role in transporting Cu by the blood-CSF barrier in the choroid plexus | Relative contribution of CTR1 and DMT1 in copper transport by the blood-CSF barrier: implication in manganese-induced neurotoxicity.
Zheng G, Chen J, Zheng W., Free PMC Article | 06/16/2012 |
| these results suggest that Ctr1, DMT1, ATOX1 and ATP7A contribute to Cu transport at the blood-CSF barrier | Mechanism of copper transport at the blood-cerebrospinal fluid barrier: influence of iron deficiency in an in vitro model.
Monnot AD, Zheng G, Zheng W., Free PMC Article | 05/12/2012 |
| Pulmonary inflammation can be modified by both DMT1 and iron status. | Influence of DMT1 and iron status on inflammatory responses in the lung.
Kim J, Molina RM, Donaghey TC, Buckett PD, Brain JD, Wessling-Resnick M., Free PMC Article | 09/17/2011 |