| role for PKA signaling in both short- and long-term regulation of AQP2, characterizing a novel mouse model of diabetes insipidus | Expression of a dominant negative PKA mutation in the kidney elicits a diabetes insipidus phenotype.
Gilbert ML, Yang L, Su T, McKnight GS., Free PMC Article | 05/23/2015 |
| hypoxia/reoxygenation (H/R)-mediated decrease in PKARIalpha protein levels leads to activation of RSK1, which via phosphorylation of NHE1 induces cardiomyocyte apoptosis. | Interactions between the regulatory subunit of type I protein kinase A and p90 ribosomal S6 kinase1 regulate cardiomyocyte apoptosis.
Gao X, Lin B, Sadayappan S, Patel TB., Free PMC Article | 02/22/2014 |
| a key role for AKAP-targeted PKA in control of heart rate and contractile function | Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function.
Patel HH, Hamuro LL, Chun BJ, Kawaraguchi Y, Quick A, Rebolledo B, Pennypacker J, Thurston J, Rodriguez-Pinto N, Self C, Olson G, Insel PA, Giles WR, Taylor SS, Roth DM., Free PMC Article | 10/23/2010 |
| EPAC & PKA modulate both distinct & common exocytic steps to potentiate insulin exocytosis. EPAC mobilizes SGs to fuse at the PM. PKA & EPAC synergistically modulate SG-SG fusions underlying compound & sequential exocytoses. | Activation of exchange protein directly activated by cyclic adenosine monophosphate and protein kinase A regulate common and distinct steps in promoting plasma membrane exocytic and granule-to-granule fusions in rat islet beta cells.
Kwan EP, Gao X, Leung YM, Gaisano HY. | 01/21/2010 |
| dystrobrevin is a scaffold protein that may play a role in different cellular processes involving PKA signaling | Association of dystrobrevin and regulatory subunit of protein kinase A: a new role for dystrobrevin as a scaffold for signaling proteins.
Ceccarini M, Grasso M, Veroni C, Gambara G, Artegiani B, Macchia G, Ramoni C, Torreri P, Mallozzi C, Petrucci TC, Macioce P. | 01/21/2010 |
| protein kinase A is controlled by Fos-related antigen 2 and has a role in inducing CCAAT/enhancer-binding protein beta expression in osteoblasts | Fos-related antigen 2 controls protein kinase A-induced CCAAT/enhancer-binding protein beta expression in osteoblasts.
Chang W, Rewari A, Centrella M, McCarthy TL. | 01/21/2010 |
| the PKA RIalpha subunit dynamic C helix mediates isoform-specific domain reorganization upon C subunit binding | The conformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding.
Vigil D, Blumenthal DK, Taylor SS, Trewhella J. | 01/21/2010 |
| cAMP-Dependent PKA negatively regulates polyadenylation of c-mos mRNA in rat oocytes | cAMP-Dependent PKA negatively regulates polyadenylation of c-mos mRNA in rat oocytes.
Lazar S, Galiani D, Dekel N. | 01/21/2010 |
| PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching | PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching.
Martin NP, Whalen EJ, Zamah MA, Pierce KL, Lefkowitz RJ. | 01/21/2010 |
| GABA B receptor-mediated inhibitory action on GABA release was mediated via decreases in protein kinase A activity. | GABAB receptor transduction mechanisms, and cross-talk between protein kinases A and C, in GABAergic terminals synapsing onto neurons of the rat nucleus basalis of Meynert.
Kubota H, Katsurabayashi S, Moorhouse AJ, Murakami N, Koga H, Akaike N., Free PMC Article | 01/21/2010 |
| oocytes express AKAP140 that is phosphorylated during meiosis. AKAP140 and its phosphorylation state may influence the translocation of the R subunits of PKA throughout resumption of meiosis. | Expression and modification of PKA and AKAPs during meiosis in rat oocytes.
Kovo M, Schillace RV, Galiani D, Josefsberg LB, Carr DW, Dekel N. | 01/21/2010 |